Elucidation of mitochondrial effects by tetrahydroaminoacridine (tacrine) in rat, dog, monkey and human hepatic parenchymal cells

Archives of Toxicology

Volumn 72, Issue 6, 1998, Pages 362-371

  Robertson, Donald G ^a   Braden, Timothy K ^a   Urda, Ellen R ^a   Lalwani, Narendra D ^a   De La Iglesia, Felix A ^a  

^a PFIZER INC   (United States)

Author keywords

Age related effects; Mitochondrial respiration; Tacrine hepatotoxicity; Tacrine metabolites; Tetrahydroaminoacridine

Indexed keywords

CHOLINESTERASE INHIBITOR; TACRINE;

AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DNA SYNTHESIS; DOG; DRUG POTENCY; ELECTRON TRANSPORT; ENDOPLASMIC RETICULUM; LIVER PARENCHYMA; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; MONKEY; NONHUMAN; PRIORITY JOURNAL; RAT;

ADULT; AGED; AGING; ANIMALS; DNA, MITOCHONDRIAL; DOGS; FEMALE; HAPLORHINI; HUMANS; LIVER; MALE; MIDDLE AGED; MITOCHONDRIA, LIVER; RATS; RATS, WISTAR; SPECIES SPECIFICITY; TACRINE;

EID: 0031813052     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050515     Document Type: Article

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