T-2 toxin induces apoptosis in differentiated murine embryonic stem cells through reactive oxygen species-mediated mitochondrial pathway

Apoptosis

Volumn 17, Issue 8, 2012, Pages 895-907

  Fang, Haiqin ^a,b   Wu, Yingliang ^b   Guo, Jiabin ^a   Rong, Jing ^a   Ma, Long ^a   Zhao, Zengming ^a   Zuo, Daiying ^b   Peng, Shuangqing ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Embryonic stem cells; Embryonic toxicity; Mitochondrial pathway; Oxidative stress; T 2 toxin

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; LIPID; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; T 2 TOXIN; TROLOX C;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; EMBRYOID BODY; EMBRYONIC STEM CELL; FIBROBLAST; FLOW CYTOMETRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

3T3 CELLS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL DIFFERENTIATION; CELL SURVIVAL; CHROMANS; COCULTURE TECHNIQUES; CYTOCHROMES C; DNA DAMAGE; EMBRYOID BODIES; EMBRYONIC STEM CELLS; G1 PHASE CELL CYCLE CHECKPOINTS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; T-2 TOXIN; TERATOGENS;

FUNGI; FUSARIUM; MURINAE;

EID: 84865111596     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0724-3     Document Type: Article

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