A potential mechanism of metformin-mediated regulation of glucose homeostasis: Inhibition of Thioredoxin-interacting protein (Txnip) gene expression

Cellular Signalling

Volumn 24, Issue 8, 2012, Pages 1700-1705

  Chai, Tin Fan ^a   Hong, Shin Yee ^a   He, Hongpeng ^b   Zheng, Liling ^b   Hagen, Thilo ^a   Luo, Yan ^b   Yu, Fa Xing ^c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b ZHEJIANG UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diabetes; Glycolysis; Metformin; OXPHOS; Txnip

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LACTIC ACID; MAX LIKE PROTEIN X; MESSENGER RNA; METFORMIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); THIOREDOXIN INTERACTING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; EMBRYO; ENZYME INHIBITION; GENE EXPRESSION; GENE REPRESSION; GENETIC CODE; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; GLYCOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN STABILITY; REDUCTION KINETICS; REGULATOR GENE; SIGNAL TRANSDUCTION; THIOREDOXIN INTERACTING PROTEIN GENE; TRANSCRIPTION REGULATION;

ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION PROFILING; HELA CELLS; HEP G2 CELLS; HOMEOSTASIS; HUMANS; METFORMIN; MICE; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXINS;

EID: 84861577144     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.04.017     Document Type: Article

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