Pestiviruses

Annual Review of Animal Biosciences

Volumn 2, Issue , 2014, Pages 141-163

  Schweizer, Matthias ^a   Peterhans, Ernst ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

BDV; Border disease virus; bovine viral diarrhea virus; BVDV; classical swine fever virus; CSFV; epidemiology; evolution; IFN antagonist; innate immunity

Indexed keywords

ANIMAL; GENETICS; IMMUNOLOGY; LIVESTOCK; PATHOGENICITY; PESTIVIRUS; PESTIVIRUS INFECTIONS; PHYSIOLOGY; TRANSMISSION; VETERINARY; VIROLOGY; VIRULENCE;

ANIMALS; LIVESTOCK; PESTIVIRUS; PESTIVIRUS INFECTIONS; VIRULENCE;

EID: 84895908452     PISSN: 21658102     EISSN: 21658110     Source Type: Journal    
DOI: 10.1146/annurev-animal-022513-114209     Document Type: Article

References (180)

1. Rümenapf T, Thiel H-J. 2008. Molecular biology of pestiviruses. In Animal Viruses: Molecular Biology, ed. TC Mettenleiter, F Sobrino, pp. 39-96. Norwich, UK: Caister Acad. Press
2. Peterhans E, Bachofen C, Stalder HP, Schweizer M. 2010. Cytopathic bovine viral diarrhea viruses (BVDV): emerging pestiviruses doomed to extinction. Vet. Res. 41:44
3. Peterhans E, Schweizer M. 2013. BVDV: a pestivirus inducing tolerance of the innate immune response. Biologicals 41:39-51
4. Kaden V, Steyer H, Schnabel J, Bruer W. 2005. Classical swine fever (CSF) in wild boar: the role of the transplacental infection in the perpetuation of CSF. J. Vet. Med. B 52:161-64
5. Paton DJ, Greiser-Wilke I. 2003. Classical swine fever-an update. Res. Vet. Sci. 75:169-78
6. Ganges L, Núñez JI, Sobrino F, Borrego B, Fernández-Borges N, et al. 2008. Recent advances in the development of recombinant vaccines against classical swine fever virus: cellular responses also play a role in protection. Vet. J. 177:169-77
7. Lange A, Blome S, Moennig V, Greiser-Wilke I. 2011. Pathogenesis of classical swine fever-similarities to viral haemorrhagic fevers: a review. Berl. Munchener Tierärztl. Wochenschr. 124:36-47
8. Penrith ML, Vosloo W, Mather C. 2011. Classical swine fever (hog cholera): review of aspects relevant to control. Transbound. Emerg. Dis. 58:187-96
9. Becher P, Thiel H-J. 2011. Genus Pestivirus (Flaviviridae). In The Springer Index of Viruses, ed. CA Tidona, G Darai, pp. 483-88. Heidelberg, Ger.: Springer Verlag
10. Pletnev A, Gould E, Heinz FX, Meyers G, Thiel H-J, et al. 2011. Flaviviridae. In Virus Taxonomy, ed. AMQ King, MJ Adams, EB Carstens, EJ Lefkowitz, pp. 1003-20. Oxford, UK: Acad. Press
11. Lavanchy D. 2011. Evolving epidemiology of hepatitis C virus. Clin. Microbiol. Infect. 17:107-15
12. Stapleton JT, Foung S, Muerhoff AS, Bukh J, Simmonds P. 2011. The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. J. Gen. Virol. 92:233-46
13. Olafson P, MacCallum AD, Fox FH. 1946. An apparently new transmissible disease of cattle. Cornell Vet. 36:205-13
14. Moennig V, Plagemann PGW. 1992. The pestiviruses. Adv. Virus Res. 41:53-98
15. Goens SD. 2002. The evolution of bovine viral diarrhea: a review. Can. Vet. J. 43:946-54
16. Deregt D. 2005. Introduction and history. In Bovine Viral Diarrhea Virus: Diagnosis, Management, and Control, ed. SM Goyal, JF Ridpath, pp. 3-34. Ames, IA: Blackwell
17. Ridpath JF. 2010. Bovine viral diarrhea virus: global status. Vet. Clin. North Am. Food Anim. Pract. 26:105-21
18. Danuser R, Vogt HR, Kaufmann T, Peterhans E, Zanoni R. 2009. Seroprevalence and characterization of pestivirus infections in small ruminants and new world camelids in Switzerland. Schweiz. Arch. Tierheilkd. 151:109-17
19. Passler T, Walz PH. 2010. Bovine viral diarrhea virus infections in heterologous species. Anim. Health Res. Rev. 11:191-205
20. Casaubon J, Vogt HR, Stalder H, Hug C, Ryser-Degiorgis MP. 2012. Bovine viral diarrhea virus in free-ranging wild ruminants in Switzerland: low prevalence of infection despite regular interactions with domestic livestock. BMC Vet. Res. 8:204
21. Hilbe M, Kaufmann C, Zlinszky K, Zanolari P, Ehrensperger F. 2012. New world camelids and bovine virus diarrhea virus (BVDV) infection in Switzerland. Schweiz. Arch. Tierheilkd. 154:155-58
22. Bachofen C, Stalder HP, Braun U, HilbeM, Ehrensperger F, Peterhans E. 2008. Co-existence of genetically and antigenically diverse bovine viral diarrhoea viruses in an endemic situation. Vet. Microbiol. 131:93-102
23. Kirkland PD, Frost M, Finlaison DS, King KR, Ridpath JF, Gu X. 2007. Identification of a novel virus in pigs-Bungowannah virus: a possible new species of pestivirus. Virus Res. 129:26-34
24. Ståhl K, BeerM, Schirrmeier H, Hoffmann B, Belák S, Alenius S. 2010. Atypical 'HoBi'-like pestiviruses-recent findings and implications thereof. Vet. Microbiol. 142:90-93
25. Mao L, Li WL, Zhang WW, Yang LL, Jiang JY. 2012. Genome sequence of a novel Hobi-like pestivirus in China. J. Virol. 86:12444
26. Decaro N, Losurdo M, Lucente MS, Sciarretta R, Mari V, et al. 2013. Persistent infection caused by Hobi-like pestivirus. J. Clin. Microbiol. 51:1241-43
27. Vil-cek-S, Ridpath JF, Van Campen H, Cavender JL, Warg J. 2005. Characterization of a novel pestivirus originating from a pronghorn antelope. Virus Res. 108:187-93
28. Becher P, Avalos-Ramirez R, Orlich M, Rosales SC, König M, et al. 2003. Genetic and antigenic characterization of novel pestivirus genotypes: implications for classification. Virology 311:96-104
29. Studer E, Bertoni G, Candrian U. 2002. Detection and characterization of pestivirus contaminations in human live viral vaccines. Biologicals 30:289-96
30. Kozasa T, Aoki H, Nakajima N, Fukusho A, Ishimaru M, Nakamura S. 2011. Methods to select suitable fetal bovine serum for use in quality control assays for the detection of adventitious viruses from biological products. Biologicals 39:242-48
31. Lindenbach BD, Thiel H-J, Rice CM. 2007. Flaviviridae: the viruses and their replication. In Fields Virology, ed. DM Knipe, PM Howley, pp. 1101-52. Philadelphia: Lippincott-Raven Publ. 5th ed.
32. Moennig V, Greiser-Wilke I. 2008. Classical swine fever virus. In Encyclopedia of Virology, ed. BWJ Mahy, MHV van Regenmortel, pp. 525-32. Oxford, UK: Academic
33. Nettleton P, Willoughby K. 2008. Border disease virus. In Encyclopedia of Virology, ed. BWJ Mahy, MHV van Regenmortel, pp. 335-41. Oxford, UK: Academic
34. Ridpath JF. 2008. Bovine viral diarrhea virus. In Encyclopedia of Virology, ed. BWJ Mahy, MHV van Regenmortel, pp. 374-80. Oxford, UK: Academic
35. Neill JD. 2013. Molecular biology of bovine viral diarrhea virus. Biologicals 41:2-7
36. Maurer K, Krey T, Moennig V, Thiel HJ, Rümenapf T. 2004. CD46 is a cellular receptor for bovine viral diarrhea virus. J. Virol. 78:1792-99
37. Krey T, Himmelreich A, HeimannM,Menge C, Thiel H-J, et al. 2006. Function of bovine CD46 as a cellular receptor for bovine viral diarrhea virus is determined by complement control protein 1. J. Virol. 80:3912-22
38. Krey T, Moussay E, Thiel H-J, Rümenapf T. 2006. Role of the low-density lipoprotein receptor in entry of bovine viral diarrhea virus. J. Virol. 80:10862-67
39. Krey T, Thiel H-J, Rümenapf T. 2005. Acid-resistant bovine pestivirus requires activation for pH-triggered fusion during entry. J. Virol. 79:4191-200
40. Grummer B, Grotha S, Greiser-Wilke I. 2004. Bovine viral diarrhoea virus is internalized by clathrindependent receptor-mediated endocytosis. J. Vet. Med. B 51:427-32
41. Lecot S, Belouzard S, Dubuisson J, Rouillé Y. 2005. Bovine viral diarrhea virus entry is dependent on clathrin-mediated endocytosis. J. Virol. 79:10826-29
42. Brownlie J. 1990. Pathogenesis of mucosal disease and molecular aspects of bovine virus diarrhoea virus. Vet. Microbiol. 23:371-82
43. Kümmerer BM, Tautz N, Becher P, Thiel H-J, Meyers G. 2000. The genetic basis for cytopathogenicity of pestiviruses. Vet. Microbiol. 77:117-28
44. Becher P, Tautz N. 2011.RNArecombination in pestiviruses- cellularRNAsequences in viral genomes highlight the role of host factors for viral persistence and lethal disease. RNA Biol. 8:216-24
45. Mendez E, Ruggli N, Collett MS, Rice CM. 1998. Infectious bovine viral diarrhea virus (strain NADL) RNAfrom stable cDNA clones: a cellular insert determines NS3 production and viral cytopathogenicity. J. Virol. 72:4737-45
46. Vassilev VB, Donis RO. 2000. Bovine viral diarrhea virus induced apoptosis correlates with increased intracellular viral RNA accumulation. Virus Res. 69:95-107
47. Yamane D, Kato K, Tohya Y, Akashi H. 2006. The double-stranded RNA-induced apoptosis pathway is involved in the cytopathogenicity of cytopathogenic Bovine viral diarrhea virus. J. Gen. Virol. 87:2961-70
48. Yamane D, Kato K, Tohya Y, Akashi H. 2008. The relationship between the viral RNA level and upregulation of innate immunity in spleen of cattle persistently infected with bovine viral diarrhea virus. Vet. Microbiol. 129:69-79
49. Mätzener P, Magkouras I, Rümenapf T, Peterhans E, Schweizer M. 2009. The viral RNase Erns prevents IFN type-I triggering by pestiviral single-and double-stranded RNAs. Virus Res. 140:15-23
50. Lattwein E, Klemens O, Schwindt S, Becher P, Tautz N. 2012. Pestivirus virion morphogenesis in the absence of uncleaved nonstructural protein 2-3. J. Virol. 86:427-37
51. Rinck G, Birghan C, Harada T, Meyers G, Thiel H-J, Tautz N. 2001. A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus. J. Virol. 75:9470-82
52. Lackner T, Müller A, König M, Thiel H-J, Tautz N. 2005. Persistence of bovine viral diarrhea virus is determined by a cellular cofactor of a viral autoprotease. J. Virol. 79:9746-55
53. Weber F, Wagner V, Rasmussen SB, Hartmann R, Paludan SR. 2006. Double-strandedRNAis produced by positive-strandRNAviruses andDNAviruses but not in detectable amounts by negative-strandRNA viruses. J. Virol. 80:5059-64
54. Randall RE, Goodbourn S. 2008. Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol. 89:1-47
55. Barbalat R, Ewald SE, Mouchess ML, Barton GM. 2011. Nucleic acid recognition by the innate immune system. Annu. Rev. Immunol. 29:185-214
56. Thompson MR, Kaminski JJ, Kurt-Jones EA, Fitzgerald KA. 2011. Pattern recognition receptors and the innate immune response to viral infection. Viruses 3:920-40
57. Marek LR, Kagan JC. 2011. Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time. Front. Biosci.16:2060-68
58. Randow F, MacMicking JD, James LC. 2013. Cellular self-defense: how cell-autonomous immunity protects against pathogens. Science 340:701-6
59. Windisch JM, Schneider R, Stark R, Weiland E, Meyers G, Thiel H-J. 1996. RNase of classical swine fever virus: biochemical characterization and inhibition by virus-neutralizing monoclonal antibodies. J. Virol. 70:352-58
60. Schweizer M, Mätzener P, Pfaffen G, Stalder HP, Peterhans E. 2006. "Self" and "nonself" manipulation of interferon defense during persistent infection: Bovine viral diarrhea virus resists alpha/beta interferon without blocking antiviral activity against unrelated viruses replicating in its host cells. J. Virol. 80:6926-35
61. Barkema HW, Bartels CJM, van Wuijckhuise L, Hesselink JW, Holzhauer M, et al. 2001. Outbreak of bovine viral diarrhea on Dutch dairy farms induced by aBHV1marker vaccine contaminated withBDVD type 2. Tijdschr. Diergeneeskd. 126:158-65
62. Brock KV. 2004. The many faces of bovine viral diarrhea virus. Vet. Clin. North Am. Food Anim. Pract. 20:1-3
63. Perdrizet JA, Rebhun WC, Dubovi EJ, Donis RO. 1987. Bovine virus diarrhea-clinical syndromes in dairy herds. Cornell Vet. 77:46-74
64. Rebhun WC, French TW, Perdrizet JA, Dubovi EJ, Dill SG, Karcher LF. 1989. Thrombocytopenia associated with acute bovine virus diarrhea infection in cattle. J. Vet. Intern. Med. 3:42-46
65. Ridpath JF, Neill JD, Frey M, Landgraf JG. 2000. Phylogenetic, antigenic and clinical characterization of type 2 BVDV from North America. Vet. Microbiol. 77:145-55
66. Ridpath JF. 2003. BVDV genotypes and biotypes: practical implications for diagnosis and control. Biologicals 31:127-31
67. Colloff A, Watson P, Duff JP, Scholes S. 2012. Haemorrhagic disease in cattle with genotype 1 bovine viral diarrhoea virus infection. Vet. Rec. 171:530
68. Hessman BE, Sjeklocha DB, Fulton RW, Ridpath JF, Johnson BJ, McElroy DR. 2012. Acute bovine viral diarrhea associated with extensive mucosal lesions, high morbidity, and mortality in a commercial feedlot. J. Vet. Diagn. Investig. 24:397-404
69. Fredriksen B, Sandvik T, Løken T, Odegaard SA. 1999. Level and duration of serum antibodies in cattle infected experimentally and naturally with bovine virus diarrhoea virus. Vet. Rec. 144:111-14
70. Bertoni G, Blacklaws B. 2010. Small ruminant lentiviruses and cross-species transmission. In Lentiviruses and Macrophages: Molecular and Cellular Interactions, ed.MDesport, pp. 277-306. Poole, UK: Caister Acad. Press
71. Brownlie J, Clarke MC, Howard CJ. 1984. Experimental production of fatal mucosal disease in cattle. Vet. Rec. 114:535-36
72. Collen T, Douglas AJ, Paton DJ, Zhang G, Morrison WI. 2000. Single amino acid differences are sufficient for CD4\+ T-cell recognition of a heterologous virus by cattle persistently infected with bovine viral diarrhea virus. Virology 276:70-82
73. Moennig V, Liess B. 1995. Pathogenesis of intrauterine infections with bovine viral diarrhea virus. Vet. Clin. North Am. Food Anim. Pract. 11:477-87
74. Ealy AD, Yang QE. 2009. Control of interferon-tau expression during early pregnancy in ruminants. Am. J. Reprod. Immunol. 61:95-106
75. Hewicker-Trautwein M, Liess B, Trautwein G. 1995. Brain lesions in calves following transplacental infection with bovine-virus diarrhoea virus. J. Vet. Med. B 42:65-77
76. Montgomery DL. 2007. Distribution and cellular heterogeneity of bovine viral diarrhea viral antigen expression in the brain of persistently infected calves: a new perspective. Vet. Pathol. 44:643-54
77. Kelling CL, Topliff CL. 2013. Bovine maternal, fetal and neonatal responses to bovine viral diarrhea virus infections. Biologicals 41:20-25
78. Nettleton PF, Gilray JA, Russo P, Dlissi E. 1998. Border disease of sheep and goats. Vet. Res. 29:327-40
79. Oguzoglu TC. 2012. A review of border disease virus infection in ruminants: molecular characterization, pathogenesis, diagnosis and control. Anim. Health Prod. Hyg. 1:1-9
80. Bachofen C, Vogt HR, Stalder HP, Mathys T, Zanoni R, et al. 2013. Persistent infections after natural transmission of bovine viral diarrhoea virus from cattle to goats and among goats. Vet. Res. 44:32
81. Løken T. 2000. Border disease in goats. In Recent Advances in Goat Diseases, ed. M Tempesta, artic. A0905.1100. Ithaca, NY: Int. Vet. Inf. Serv.
82. Krametter-Froetscher R, Duenser M, Preyler B, Theiner A, Benetka V, et al. 2010. Pestivirus infection in sheep and goats in West Austria. Vet. J. 186:342-46
83. Charleston B, Fray MD, Baigent S, Carr BV, Morrison WI. 2001. Establishment of persistent infection with non-cytopathic bovine viral diarrhoea virus in cattle is associated with a failure to induce type I interferon. J. Gen. Virol. 82:1893-97
84. Charleston B, Brackenbury LS, Carr BV, Fray MD, Hope JC, et al. 2002. Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo. J. Virol. 76:923-27
85. Brackenbury LS, Carr BV, Stamataki Z, Prentice H, Lefevre EA, et al. 2005. Identification of a cell population that produces alpha/beta interferon in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus. J. Virol. 79:7738-44
86. Smirnova NP, Bielefeldt-Ohmann H, Van Campen H, Austin KJ, Han H, et al. 2008. Acute noncytopathic bovine viral diarrhea virus infection induces pronounced type I interferon response in pregnant cows and fetuses. Virus Res. 132:49-58
87. ShoemakerML, Smirnova NP, Bielefeldt-Ohmann H, Austin KJ, Van Olphen A, et al. 2009. Differential expression of the type I interferon pathway during persistent and transient bovine viral diarrhea virus infection. J. Interferon Cytokine Res. 29:23-35
88. Smirnova NP,Webb BT, Bielefeldt-OhmannH, Van Campen H, Antoniazzi AQ, et al. 2012. Development of fetal and placental innate immune responses during establishment of persistent infection with bovine viral diarrhea virus. Virus Res. 167:329-36
89. Fray MD, Mann GE, Charleston B. 2001. Validation of an Mx/CAT reporter gene assay for the quantification of bovine type-I interferon. J. Immunol. Methods 249:235-44
90. Ramsey FK, Chivers WH. 1953. Mucosal disease of cattle. North Am. Vet. 34:629-33
91. LeeKM,Gillespie JH. 1957. Propagation of virus diarrhea virus of cattle in tissue culture. Am. J. Vet. Res. 18:952-53
92. Underdahl NR, Grace OD, Hoerlein AB. 1957. Cultivation in tissue-culture of cytopathogenic agent from bovine mucosal disease. Proc. Soc. Exp. Biol. Med. 94:795-97
93. Gillespie JH, Coggins L, Thompson J, Baker JA. 1961. Comparison by neutralization tests of strains of virus isolated from virus diarrhea and mucosal disease. Cornell Vet. 51:155-59
94. Thomson RG, Savan M. 1963. Studies on virus diarrhea and mucosal disease of cattle. Can. J. Comp. Med. Vet. Sci. 27:207-14
95. Peterhans E, Schweizer M. 2010. Pestiviruses: how to outmaneuver your hosts. Vet. Microbiol. 142:18-25
96. Bolin SR, McClurkin AW, Cutlip RC, Coria MF. 1985. Severe clinical disease induced in cattle persistently infected with noncytopathic bovine viral diarrhea virus by superinfection with cytopathic bovine viral diarrhea virus. Am. J. Vet. Res. 46:573-76
97. Flint SJ, Enquist LW, Racaniello VR, Skalka AM. 2009. Principles of Virology: Molecular Biology. Washington, DC: ASM Press. 592 pp.
98. Becher P, Orlich M, Thiel H-J. 2001. RNA recombination between persisting pestivirus and a vaccine strain: generation of cytopathogenic virus and induction of lethal disease. J. Virol. 75:6256-64
99. Bertoni G. 2007. Caprine arthritis encephalitis complex. In Recent Advances in Goat Diseases, ed. M Tempesta, artic. A0902.707. Ithaca, NY: Int. Vet. Inf. Serv.
100. Edwards S, Fukusho A, Lefevre PC, Lipowski A, Pejsak Z, et al. 2000. Classical swine fever: the global situation. Vet. Microbiol. 73:103-19
101. Moennig V. 2000. Introduction to classical swine fever: virus, disease and control policy. Vet. Microbiol. 73:93-102
102. Fernández-Sirera L, Cabezón O, Allepuz A, Rosell R, Riquelme C, et al. 2012. Two different epidemiological scenarios of border disease in the populations of Pyrenean chamois (Rupicapra p. pyrenaica) after the first disease outbreaks. PLoS ONE 7:e51031
103. Corapi WV, French TW, Dubovi EJ. 1989. Severe thrombocytopenia in young calves experimentally infected with noncytopathic bovine viral diarrhea virus. J. Virol. 63:3934-43
104. Pellerin C, van den Hurk J, Lecomte J, Tussen P. 1994. Identification of a new group of bovine viral diarrhea virus strains associated with severe outbreaks and high mortalities. Virology 203:260-68
105. Ridpath JF, Neill JD, Vilcek S, Dubovi EJ, Carman S. 2006. Multiple outbreaks of severe acute BVDV in North America occurring between 1993 and 1995 linked to the same BVDV2 strain. Vet. Microbiol. 114:196-204
106. Brownlie J, Clarke MC, Howard CJ, Pocock DH. 1987. Pathogenesis and epidemiology of bovine virus diarrhoea virus infection of cattle. Ann. Rech. Vet. 18:157-66
107. Rüfenacht J, Schaller P, Audigé L, StrasserM,Peterhans E. 2000. Prevalence of cattle infected with bovine viral diarrhoea virus in Switzerland. Vet. Rec. 147:413-17
108. Ridpath JF. 2013. Immunology of BVDV vaccines. Biologicals 41:14-19
109. O'Rourke K. 2002. BVDV: 40 years of effort and the disease still has a firm hold. J. Am. Vet. Med. Assoc. 220:1770-73
110. Ridpath J. 2012. Preventive strategy for BVDV infection in North America. Jpn. J. Vet. Res. 60:S41-49
111. Rupprecht CE, Hanlon CA, Slate D. 2004. Oral vaccination of wildlife against rabies: opportunities and challenges in prevention and control. In Control of Infectious Animal Diseases by Vaccination, ed. A Schudel, M Lombard, pp. 173-84. Basel, Switz.: Karger
112. Fenner F. 1993. Smallpox: emergence, global spread, and eradication. Hist. Philos. Life Sci. 15:397-420
113. Sandvik T, Greiser-Wilke I, Graham D, Lindberg A, Berriatua E, et al. 2006. BVDV control. Position Pap., EU Themat. Netw. Control Bov. Viral Diarrhoea Virus. http://www.bvdv-control.org/bilder/ Position%20paper%20BVDV%20Control%20EU%20TN.pdf
114. Lindberg ALE, Alenius S. 1999. Principles for eradication of bovine viral diarrhoea virus (BVDV) infections in cattle populations. Vet. Microbiol. 64:197-222
115. Moennig V, Houe H, Lindberg A. 2005. BVD control in Europe: current status and perspectives. Anim. Health Res. Rev. 6:63-74
116. Valle PS, Skjerve E, Martin SW, Larssen RB, Esterås O, Nyberg O. 2005. Ten years of bovine virus diarrhoea virus (BVDV) control in Norway: a cost-benefit analysis. Prev. Vet. Med. 72:189-207
117. Lindberg A, Brownlie J, Gunn GJ, Houe H, Moennig V, et al. 2006. The control of bovine viral diarrhoea virus in Europe: today and in the future. Rev. Sci. Tech. 25:961-79
118. Ståhl K, Alenius S. 2012. BVDV control and eradication in Europe-an update. Jpn. J. Vet. Res. 60:S31-39
119. Joly A, Fourichon C, Beaudeau F. 2005. Description and first results of a BVDV control scheme in Brittany (western France). Prev. Vet. Med. 72:209-13
120. Synge BA, Clark AM, Moar JAE, Nicolson JT, Nettleton PF, Herring JA. 1999. The control of bovine virus diarrhoea virus in Shetland. Vet. Microbiol. 64:223-29
121. Truyers IGR, Mellor DJ, Norquay R, Gunn GJ, Ellis KA. 2010. Eradication programme for bovine viral diarrhoea virus in Orkney 2001 to 2008. Vet. Rec. 167:566-70
122. Rossmanith W, Janacek R, Wilhelm E. 2005. Control of BVDV-infection on common grassland-the key for successful BVDV-eradication in Lower Austria. Prev. Vet. Med. 72:133-37
123. Schöpf K, Gaede W, Matt M. 2005. Experience in BVDV eradication in Tyrol's cattle with special consideration of the occurrence of BVDV genotypes. Wien. Tierärztl. Monatsschrift 92:254-58
124. Rossmanith W, Deinhofer M, Janacek R, Trampler R, Wilhelm E. 2010. Voluntary and compulsory eradication of bovine viral diarrhoea virus in Lower Austria. Vet. Microbiol. 142:143-49
125. Moennig V, Eicken K, Flebbe U, Frey HR, Grummer B, et al. 2005. Implementation of two-step vaccination in the control of bovine viral diarrhoea (BVD). Prev. Vet. Med. 72:109-14
126. Cranwell MP, Otter A, Errington J, Hogg RA, Wakeley P, Sandvik T. 2007. Detection of Border disease virus in cattle. Vet. Rec. 161:211-12
127. Strong R, La Rocca SA, Ibata G, Sandvik T. 2010. Antigenic and genetic characterisation of border disease viruses isolated from UK cattle. Vet. Microbiol. 141:208-15
128. Duffy S, Shackelton LA, Holmes EC. 2008. Rates of evolutionary change in viruses: patterns and determinants. Nat. Rev. Genet. 9:267-76
129. Sanjuan R, Nebot MR, Chirico N, Mansky LM, Belshaw R. 2010. Viral mutation rates. J. Virol. 84:9733-48
130. Barr J, Fearns R. 2010. How RNA viruses maintain their genome integrity. J. Gen. Virol. 91:1373-87
131. Manrubia SC, Lazaro E. 2006. Viral evolution. Phys. Life Rev. 3:65-92
132. Lauring AS, Andino R. 2010. Quasispecies theory and the behavior of RNA viruses. PLoS Pathog. 6:e1001005
133. Domingo E, Sheldon J, Perales C. 2012. Viral quasispecies evolution. Microbiol. Mol. Biol. Rev. 76:159-216
134. Grenfell BT, Pybus OG, Gog JR, Wood JLN, Daly JM, et al. 2004. Unifying the epidemiological and evolutionary dynamics of pathogens. Science 303:327-32
135. PybusOG, Rambaut A. 2009. Evolutionary analysis of the dynamics of viral infectious disease. Nat. Rev. Genet. 10:540-50
136. Pfeiffer JK, Kirkegaard K. 2006. Bottleneck-mediated quasispecies restriction during spread of an RNA virus from inoculation site to brain. Proc. Natl. Acad. Sci. USA 103:5520-25
137. Vignuzzi M, Stone JK, Arnold JJ, Cameron CE, Andino R. 2006. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 439:344-48
138. Töpfer A, Höper D, Blome S, Beer M, Beerenwinkel N, et al. 2013. Sequencing approach to analyze the role of quasispecies for classical swine fever. Virology 438:14-19
139. Leifer I, Ruggli N, Blome S. 2013. Approaches to define the viral genetic basis of classical swine fever virus virulence. Virology 438:51-55
140. Paton DJ. 1995. Pestivirus diversity. J. Comp. Pathol. 112:215-36
141. Hamers C, Dehan P, Couvreur B, Letellier C, Kerkhofs P, Pastoret PP. 2001. Diversity among bovine pestiviruses. Vet. J. 161:112-22
142. KönigM,Cedillo Rosales S, Becher P, Thiel H-J. 2003. Heterogeneity of ruminant pestiviruses: Academic interest or important basis for the development of vaccines and diagnostics? Berl. Munchener Tierärztl. Wochenschr. 116:216-21
143. Bolin SR, Grooms DL. 2004. Origination and consequences of bovine viral diarrhea virus diversity. Vet. Clin. North Am. Food Anim. Pract. 20:51-68
144. Domingo E, Martín V, Perales C, Grande-Pérez A, García-Arriaza J, Arias A. 2006. Viruses as quasispecies: biological implications. Curr. Top. Microbiol. Immunol. 299:51-82
145. Collins ME, Desport M, Brownlie J. 1999. Bovine viral diarrhea virus quasispecies during persistent infection. Virology 259:85-98
146. Jones LR, Zandomeni R, Weber EL. 2002. Quasispecies in the 50 untranslated genomic region of bovine viral diarrhoea virus from a single individual. J. Gen. Virol. 83:2161-68
147. Stokstad M, Brownlie J, Collins ME. 2004. Analysis of variation of bovine viral diarrhoea virus E2 sequence following transplacental infection of cattle. Vet. Microbiol. 102:141-45
148. Mignon B, Schwers A, Waxweiler S, Boulanger D, Dubuisson J, et al. 1990. Antigenic stability of a noncytopathogenic strain of BVD-MD pestivirus in experimentally obtained asymptomatic carriers. Ann. Med. Vet. 134:325-29
149. Paton DJ, Lowings JP, Ramirez GC. 1994. Stability of the gp53 gene of a bovine viral diarrhea virus isolated at different times from a persistently infected steer. Br. Vet. J. 150:603-7
150. Hertig C, Stalder HP, Peterhans E. 1995. Genetic heterogeneity within the coding regions of E2 and NS3 in strains of bovine viral diarrhea virus. Gene 153:191-95
151. Neill JD, Newcomer BW, Marley SD, Ridpath JF, Givens MD. 2012. Greater numbers of nucleotide substitutions are introduced into the genomicRNA of bovine viral diarrhea virus during acute infections of pregnant cattle than of non-pregnant cattle. Virol. J. 9:150
152. Paton DJ, Carlsson U, Lowings JP, Sands JJ, Vil-cek-S, Alenius S. 1995. Identification of herd-specific bovine viral diarrhoea virus isolates from infected cattle and sheep. Vet. Microbiol. 43:283-94
153. Hamers C, Lecomte C, Kulcsar G, Lambot M, Pastoret PP. 1998. Persistently infected cattle stabilise bovine viral diarrhea virus leading to herd specific strains. Vet. Microbiol. 61:177-82
154. Luzzago C, Bandi C, Bronzo V, Ruffo G, Zecconi A. 2001. Distribution pattern of bovine viral diarrhoea virus strains in intensive cattle herds in Italy. Vet. Microbiol. 83:265-74
155. Hornberg A, Fernández SR, Vogl C, Vil-cek-S, Matt M, et al. 2009. Genetic diversity of pestivirus isolates in cattle from Western Austria. Vet. Microbiol. 135:205-13
156. Hamers C, Lambot M, Onclin M, Lecomte C, Pastoret PP. 1998. Antigenic diversity of bovine viral diarrhoea viral isolates contradicts the concept of herd specific strain. Epidemiol. Infect. 121:451-57
157. Yeşilbag K, Burgu I. 2006. Antigenic diversity of bovine viral diarrhoea viruses (BVDV) isolated in Turkey. Turk. J. Vet. Anim. Sci. 30:571-76
158. Jones LR, Weber EL. 2004. Homologous recombination in bovine pestiviruses. Phylogenetic and statistic evidence. Infect. Genet. Evol. 4:335-43
159. Nagai M, Hayashi M, Sugita S, Sakoda Y, Mori M, et al. 2004. Phylogenetic analysis of bovine viral diarrhea viruses using five different genetic regions. Virus Res. 99:103-13
160. Paton D, Gunn M, Sands J, Yapp F, Drew T, et al. 1997. Establishment of serial persistent infections with bovine viral diarrhoea virus in cattle and sheep and changes in epitope expression related to host species. Arch. Virol. 142:929-38
161. Meier P, Adler B, Adler H, Stalder HP, Peterhans E. 1996. Passage in cultured cells exerts evolutionary pressure selecting minor populations of BVD virus (BVDV). Program and Abstracts Third ESVV Symp. Pestivirus Infect., Lelystad, Sept. 19-20, p. 65. Brussels: Eur. Soc. Vet. Virol.
162. Neill JD, Newcomer BW,Marley SD, Ridpath JF, Givens MD. 2011. Genetic change in the open reading frame of bovine viral diarrhea virus is introduced more rapidly during the establishment of a single persistent infection than from multiple acute infections. Virus Res. 158:140-45
163. Lobo FP, Mota BEF, Pena SDJ, Azevedo V, Macedo AM, et al. 2009. Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts. PLoS ONE 4:e6282
164. Coleman JR, Papamichail D, Skiena S, Futcher B, Wimmer E, Mueller S. 2008. Virus attenuation by genome-scale changes in codon pair bias. Science 320:1784-87
165. Ma MR, Hui L, Wang ML, Tang Y, Chang YW, et al. 2012. Analysis of codon contribution between the Pestivirus genus and their natural hosts. J. Anim. Vet. Adv. 11:3999-4004
166. Zhou JH, Gao ZL, Zhang J, Chen HT, Pejsak Z, et al. 2012. Comparative codon usage between the three main viruses in pestivirus genus and their natural susceptible livestock. Virus Genes 44:475-81
167. Bukh J. 2011. HepatitisChomolog in dogswith respiratory illness.Proc.Natl.Acad.Sci.USA108:12563-64
168. Kapoor A, Simmonds P, Gerold G, Qaisar N, Jain K, et al. 2011. Characterization of a canine homolog of hepatitis C virus. Proc. Natl. Acad. Sci. USA 108:11608-13
169. Burbelo PD, Dubovi EJ, Simmonds P, Medina JL, Henriquez JA, et al. 2012. Serology-enabled discovery of genetically diverse hepaciviruses in a new host. J. Virol. 86:6171-78
170. Epstein JH, Quan PL, Briese T, Street C, Jabado O, et al. 2010. Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh. PLoS Pathog. 6:e1000972
171. Kapoor A, Simmonds P, Scheel TK, Hjelle B, Cullen JM, et al. 2013. Identification of rodent homologs of hepatitis C virus and pegiviruses. mBio 4:e00216
172. Quan PL, Firth C, Conte JM,Williams SH, Zambrana-Torrelio CM, et al. 2013. Bats are a major natural reservoir for hepaciviruses and pegiviruses. Proc. Natl. Acad. Sci. USA 110:8194-99
173. Wu ZQ, Ren XW, Yang L, Hu YF, Yang J, et al. 2012. Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces. J. Virol. 86:10999-1012
174. Riedel C, Lamp B, Heimann M, König M, Blome S, et al. 2012. The core protein of classical swine fever virus is dispensable for virus propagation in vitro. PLoS Pathog. 8:e1002598
175. Calisher CH, Childs JE, Field HE, Holmes KV, Schountz T. 2006. Bats: important reservoir hosts of emerging viruses. Clin. Microbiol. Rev. 19:531-45
176. Donaldson EF, Haskew AN, Gates JE, Huynh J, Moore CJ, Frieman MB. 2010. Metagenomic analysis of the viromes of three North American bat species: viral diversity among different bat species that share a common habitat. J. Virol. 84:13004-18
177. Drexler JF, Corman VM, Müller MA,Maganga GD, Vallo P, et al. 2012. Bats host major mammalian paramyxoviruses. Nat. Commun. 3:796
178. Ge X, Li Y, Yang X, Zhang H, Zhou P, et al. 2012. Metagenomic analysis of viruses from bat fecal samples reveals many novel viruses in insectivorous bats in China. J. Virol. 86:4620-30
179. HeB, Li Z, Yang F, Zheng J, Feng Y, et al. 2013. Virome profiling of bats fromMyanmarby metagenomic analysis of tissue samples reveals more novel mammalian viruses. PLoS ONE 8:e61950
180. Smith I, Wang LF. 2013. Bats and their virome: an important source of emerging viruses capable of infecting humans. Curr. Opin. Virol. 3:84-91