메뉴 건너뛰기




Volumn 11, Issue 2, 2014, Pages 109-118

Rapid learning for precision oncology

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENTS; BIOMEDICAL RESEARCH; HUMANS; MEDICAL INFORMATICS; MEDICAL ONCOLOGY; NEOPLASMS; PHARMACOGENETICS; SIGNAL TRANSDUCTION;

EID: 84895900452     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2013.244     Document Type: Review
Times cited : (77)

References (89)
  • 1
    • 74449085934 scopus 로고    scopus 로고
    • A small-cell lung cancer genome with complex signatures of tobacco exposure
    • Pleasance, E. D. et al. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 463, 184-190 (2010).
    • (2010) Nature , vol.463 , pp. 184-190
    • Pleasance, E.D.1
  • 2
    • 74449093973 scopus 로고    scopus 로고
    • A comprehensive catalogue of somatic mutations from a human cancer genome
    • Pleasance, E. D. et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463, 191-196 (2010).
    • (2010) Nature , vol.463 , pp. 191-196
    • Pleasance, E.D.1
  • 3
    • 84871679432 scopus 로고    scopus 로고
    • Can we deconstruct cancer, one patient at a time
    • Blau, C. A. & Liakopoulou, E. Can we deconstruct cancer, one patient at a time Trends Genet. 29, 6-10 (2013).
    • (2013) Trends Genet. , vol.29 , pp. 6-10
    • Blau, C.A.1    Liakopoulou, E.2
  • 4
    • 84880452562 scopus 로고    scopus 로고
    • Genomics-driven oncology: Framework for an emerging paradigm
    • Garraway, L. A. Genomics-driven oncology: Framework for an emerging paradigm. J. Clin. Oncol. 31, 1806-1814 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 1806-1814
    • Garraway, L.A.1
  • 5
    • 79953066553 scopus 로고    scopus 로고
    • Trastuzumab and beyond: Sequencing cancer genomes and predicting molecular networks
    • Roukos, D. H. Trastuzumab and beyond: Sequencing cancer genomes and predicting molecular networks. Pharmacogenomics J. 11, 81-92 (2011).
    • (2011) Pharmacogenomics J. , vol.11 , pp. 81-92
    • Roukos, D.H.1
  • 6
    • 84872174533 scopus 로고    scopus 로고
    • Reverse-engineering the genetic circuitry of a cancer cell with predicted intervention in chronic lymphocytic leukemia
    • Vallat, L. et al. Reverse-engineering the genetic circuitry of a cancer cell with predicted intervention in chronic lymphocytic leukemia. Proc. Natl Acad. Sci. USA 110, 459-464 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 459-464
    • Vallat, L.1
  • 7
    • 84895907955 scopus 로고    scopus 로고
    • Centre for Integrated Diagnostics [online]
    • Centre for Integrated Diagnostics. Massachusetts General Hospital [online], http://www.massgeneral.org/pathology/clinical/molecular.aspx (2013).
    • (2013) Massachusetts General Hospital
  • 8
    • 84895903854 scopus 로고    scopus 로고
    • University of Washington [online]
    • UW-OncoPlex-Cancer Gene Panel. University of Washington [online], http://web.labmed.washington.edu/tests/genetics/UW-OncoPlex (2013).
    • (2013) UW-OncoPlex-Cancer Gene Panel
  • 9
    • 84895911205 scopus 로고    scopus 로고
    • [online]
    • Foundation Medicine [online], http://www.foundationmedicine.com/(2013).
    • (2013) Foundation Medicine
  • 10
    • 84895907555 scopus 로고    scopus 로고
    • News [online]
    • News. Caris life s ciences [online], http://www.carislifesciences.com/ news/caris-life-sciences-to-present-on-biomarker-expression-at-the-society-of- gynecologic-oncologists-2011-annual-meeting-on-womens-cancer/(2013).
    • (2013) Caris Life Sciences
  • 11
    • 84895902548 scopus 로고    scopus 로고
    • [online]
    • BGI [online], http://www.genomics.cn/en/index (2013).
    • (2013) BGI
  • 12
    • 84882837534 scopus 로고    scopus 로고
    • Signatures of mutational processes in human cancer
    • Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415-421 (2013).
    • (2013) Nature , vol.500 , pp. 415-421
    • Alexandrov, L.B.1
  • 13
    • 84862564150 scopus 로고    scopus 로고
    • Reverse-engineering human regulatory networks. Wiley interdiscip
    • Lefebvre, C., Rieckhof, G. & Califano, A. Reverse-engineering human regulatory networks. Wiley Interdiscip. Rev. Syst. Biol. Med. 4, 311-325 (2012).
    • (2012) Rev. Syst. Biol. Med. , vol.4 , pp. 311-325
    • Lefebvre, C.1    Rieckhof, G.2    Califano, A.3
  • 14
    • 75149195336 scopus 로고    scopus 로고
    • The transcriptional network for mesenchymal transformation of brain tumours
    • Carro, M. S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318-325 (2013).
    • (2013) Nature , vol.463 , pp. 318-325
    • Carro, M.S.1
  • 15
    • 77956690873 scopus 로고    scopus 로고
    • Towards patient-based cancer therapeutics
    • Schreiber, S. L. et al. Towards patient-based cancer therapeutics. Nat. Biotechnol. 28, 904-906 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 904-906
    • Schreiber, S.L.1
  • 16
    • 84864402194 scopus 로고    scopus 로고
    • Leveraging models of cell regulation and GWAS data in integrative network-based association studies
    • Califano, A., Butte, A. J., Friend, S., Ideker, T. & Schadt, E. Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat. Genet. 44, 841-847 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 841-847
    • Califano, A.1    Butte, A.J.2    Friend, S.3    Ideker, T.4    Schadt, E.5
  • 18
    • 49649111149 scopus 로고    scopus 로고
    • Perturbation of interaction networks for application to cancer therapy
    • Quayle, A. P., Siddiqui, A. S. & Jones, S. J. M. Perturbation of interaction networks for application to cancer therapy. Cancer Inform. 5, 45-65 (2007).
    • (2007) Cancer Inform. , vol.5 , pp. 45-65
    • Quayle, A.P.1    Siddiqui, A.S.2    Jones, S.J.M.3
  • 19
    • 79951865370 scopus 로고    scopus 로고
    • Clinical implications of the cancer genome
    • Macconaill, L. E. & Garraway, L. A. Clinical implications of the cancer genome. J. Clin. Oncol. 28, 5219-5228 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 5219-5228
    • Macconaill, L.E.1    Garraway, L.A.2
  • 20
    • 0042125048 scopus 로고    scopus 로고
    • Revising regulatory networks: From expression data to linear causal models
    • Bay, S. D., Shrager, J., Pohorille, A. & Langley, P. Revising regulatory networks: From expression data to linear causal models. J. Biomedical Informatics 35, 289-297 (2002).
    • (2002) J. Biomedical Informatics , vol.35 , pp. 289-297
    • Bay, S.D.1    Shrager, J.2    Pohorille, A.3    Langley, P.4
  • 21
    • 0036364830 scopus 로고    scopus 로고
    • Guiding revision of regulatory models with expr ession data
    • Shrager, J., Langley, P. & Pohorille, A. Guiding revision of regulatory models with expr ession data. Pac. Symp. Biocomput. 7, 486-497 (2002).
    • (2002) Pac. Symp. Biocomput. , vol.7 , pp. 486-497
    • Shrager, J.1    Langley, P.2    Pohorille, A.3
  • 22
    • 0033736476 scopus 로고    scopus 로고
    • Genetic network inference: From coexpression clustering to reverse engineering
    • D'haeseleer, P., Liang, S. & Somogyi, R. Genetic network inference: From coexpression clustering to reverse engineering. Bioinformatics 16, 707-726 (2000).
    • (2000) Bioinformatics , vol.16 , pp. 707-726
    • D'haeseleer, P.1    Liang, S.2    Somogyi, R.3
  • 23
    • 16844376909 scopus 로고    scopus 로고
    • Reverse engineering of regulatory networks in human B cells
    • Basso, K. et al. Reverse engineering of regulatory networks in human B cells. Nat. Genet. 37, 382-390 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 382-390
    • Basso, K.1
  • 24
    • 77954195272 scopus 로고    scopus 로고
    • Inf erence of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM
    • Vaske, C. J. et al. Inf erence of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM. Bioinformatics 26, i237-i245 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 237-245
    • Vaske, C.J.1
  • 25
    • 34249853738 scopus 로고    scopus 로고
    • Computational and experimenta l approaches for modeling gene regulatory networks
    • Goutsias, J. & Lee, N. H. Computational and experimenta l approaches for modeling gene regulatory networks. Curr. Pharm. Des. 13, 1415-1436 (2007).
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 1415-1436
    • Goutsias, J.1    Lee, N.H.2
  • 26
    • 84862776920 scopus 로고    scopus 로고
    • Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumour suppressor in T-ALL
    • Della Gatta, G. et al. Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumour suppressor in T-ALL. Nat. Med. 18, 436-440 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 436-440
    • Della Gatta, G.1
  • 27
    • 84867333656 scopus 로고    scopus 로고
    • Genome sequencing identifies a basis for everolimus sensitivity
    • Iyer, G. et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 338, 221 (2012).
    • (2012) Science , vol.338 , pp. 221
    • Iyer, G.1
  • 28
    • 84876305008 scopus 로고    scopus 로고
    • Rare cancer successes spawn 'exceptional' research efforts
    • Kaiser, J. Biomedicine. Rare cancer successes spawn 'exceptional' research efforts. Science 340, 263 (2013).
    • (2013) Science , vol.340 , pp. 263
    • Kaiser, J.1    Biomedicine2
  • 29
    • 84870664207 scopus 로고    scopus 로고
    • Comparative effectiveness research, ge nomics-enabled personalized medicine, and rapid learning health care: A common bond
    • Ginsburg, G. S. & Kuderer, N. M. Comparative effectiveness research, ge nomics-enabled personalized medicine, and rapid learning health care: A common bond. J. Clin. Oncol. 30, 4233-4242 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 4233-4242
    • Ginsburg, G.S.1    Kuderer, N.M.2
  • 30
    • 84876064523 scopus 로고    scopus 로고
    • A targeted next-generation sequencing of advanced prost ate cancer identifies potential therapeutic targets and disease heterogeneity
    • Beltran, H. et al. A targeted next-generation sequencing of advanced prost ate cancer identifies potential therapeutic targets and disease heterogeneity. Eur. Urol. 63, 920-926 (2013).
    • (2013) Eur. Urol. , vol.63 , pp. 920-926
    • Beltran, H.1
  • 31
    • 84880504574 scopus 로고    scopus 로고
    • Building a personalized medicine infrastructure at a major cancer centre
    • Meric-Bernstam, F., Farhangfar, C., Mendelsohn, J. & Mills G. B. Building a personalized medicine infrastructure at a major cancer centre. J. Clin. Oncol. 31, 1849-1857 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 1849-1857
    • Meric-Bernstam, F.1    Farhangfar, C.2    Mendelsohn, J.3    Mills, G.B.4
  • 32
    • 84886083037 scopus 로고    scopus 로고
    • Reconstructing targetable pathways in lung cancer by integrating diverse omics data
    • Balbin, O. A. et al. Reconstructing targetable pathways in lung cancer by integrating diverse omics data. Nat. Commun. http://dx.doi:10.1038/ncomms3617 (2013).
    • (2013) Nat. Commun.
    • Balbin, O.A.1
  • 34
    • 84895909508 scopus 로고    scopus 로고
    • [online]
    • GeneKey [online], http://www.genekey.com/.
    • GeneKey
  • 35
    • 84895901602 scopus 로고    scopus 로고
    • Tailored clinical molecular test interpretation [online]
    • Tailored clinical molecular test interpretation. N-of-One [online], http://www.n-of-one.com/.
    • N-of-One
  • 37
    • 33947311347 scopus 로고    scopus 로고
    • A rapid-learning health system
    • Etheredge, L. M. A rapid-learning health system. Health Aff. 26, w107-w118 (2007).
    • (2007) Health Aff. , vol.26 , pp. 107-118
    • Etheredge, L.M.1
  • 39
    • 77957949436 scopus 로고    scopus 로고
    • Rapid-learning system for cancer care
    • Abernethy A. P. et al. Rapid-learning system for cancer care. J. Clin. Oncol. 28, 4268-4274 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4268-4274
    • Abernethy, A.P.1
  • 41
    • 84895910321 scopus 로고    scopus 로고
    • JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations
    • Ren, Y. et al. JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations. Sci. Rep. 3, 3042 (2013).
    • (2013) Sci. Rep. , vol.3 , pp. 3042
    • Ren, Y.1
  • 42
    • 67449152488 scopus 로고    scopus 로고
    • Cancer genome sequencing: An interim analysis
    • Fox, E. J., Salk, J. J. & Loeb, L. A. Cancer genome sequencing: An interim analysis. Cancer Res. 69, 4948-4950 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 4948-4950
    • Fox, E.J.1    Salk, J.J.2    Loeb, L.A.3
  • 43
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch, J. S. et al. The origin and evolution of mutations in acute myeloid leukemia. Cell 150, 264-278 (2012).
    • (2012) Cell , vol.150 , pp. 264-278
    • Welch, J.S.1
  • 44
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012).
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1
  • 46
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein, B. & Kinzler, K. W. Cancer genes and the pathways they control. Nat. Med. 10, 789-799 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 47
    • 84895901777 scopus 로고    scopus 로고
    • Inside Teacher Cancer Centre [online]
    • Pathways to Cancer. Inside Teacher Cancer Centre [online], http://teachercentre.insidecancer.org/browse/Pathways%20to%20Cancer/(2013).
    • (2013) Pathways to Cancer
  • 48
    • 33749335282 scopus 로고    scopus 로고
    • The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
    • Lamb, J. et al. The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935 (2006).
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1
  • 49
    • 84862584058 scopus 로고    scopus 로고
    • Whole-genome analysis informs breast cancer response to aromatase inhibition
    • Ellis, M. J. et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 486, 353-360 (2012).
    • (2012) Nature , vol.486 , pp. 353-360
    • Ellis, M.J.1
  • 50
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2000 breast tumours reveals novel subgroups
    • Curtis, C. et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature 486, 346-352 (2012).
    • (2012) Nature , vol.486 , pp. 346-352
    • Curtis, C.1
  • 51
    • 79954998504 scopus 로고    scopus 로고
    • Medical Publishing for an N of One
    • Lundberg, G. D. Medical Publishing for an N of One. The Scientist 25, 31 (2011).
    • (2011) The Scientist , vol.25 , pp. 31
    • Lundberg, G.D.1
  • 53
    • 84895902741 scopus 로고    scopus 로고
    • [online]
    • PLoS Currents [online], http://currents.plos.org/(2013).
    • (2013) PLoS Currents
  • 54
    • 84874350660 scopus 로고    scopus 로고
    • Git can facilitate greater reproducibility and increased transparency in science
    • Ram, K. Git can facilitate greater reproducibility and increased transparency in science. Source Code Biol. Med. 8, 7 (2013).
    • (2013) Source Code Biol. Med. , vol.8 , pp. 7
    • Ram, K.1
  • 55
    • 33646245937 scopus 로고    scopus 로고
    • Adaptive designs in clinical drug development-an executive summary of the PhRMA working group
    • Gallo, P. et al. Adaptive designs in clinical drug development-an executive summary of the PhRMA working group. J. Biopharm. Stat. 16, 275-283 (2006).
    • (2006) J. Biopharm. Stat. , vol.16 , pp. 275-283
    • Gallo, P.1
  • 56
    • 79959220310 scopus 로고    scopus 로고
    • A point-of-care clinical trial comparing insulin administered using a sliding scale versus a weight-based regimen
    • Fiore, L. D. et al. A point-of-care clinical trial comparing insulin administered using a sliding scale versus a weight-based regimen. Clin. Trials 8, 183-195 (2011).
    • (2011) Clin. Trials , vol.8 , pp. 183-195
    • Fiore, L.D.1
  • 57
    • 79957857433 scopus 로고    scopus 로고
    • The battle trial: Personalizing therapy for lung cancer
    • Kim, E. S. et al. The BATTLE Trial: Personalizing therapy for lung cancer. Cancer Discov. 1, 44-53 (2011).
    • (2011) Cancer Discov. , vol.1 , pp. 44-53
    • Kim, E.S.1
  • 58
    • 84859438491 scopus 로고    scopus 로고
    • Adaptive clinical trials in oncology
    • Berry, D. A. Adaptive clinical trials in oncology. Nat. Rev. Clin. Oncol. 9, 199-207 (2012).
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , pp. 199-207
    • Berry, D.A.1
  • 59
    • 84863539781 scopus 로고    scopus 로고
    • Implementation of the department of veterans affairs' first point-of-care clinical trial
    • D'Avolio, L. et al. Implementation of the Department of Veterans Affairs' first point-of-care clinical trial. J. Am. Med. Inform. Assoc. 19, e170-e176 (2012).
    • (2012) J. Am. Med. Inform. Assoc. , vol.19 , pp. 170-176
    • D'avolio, L.1
  • 60
    • 80455173464 scopus 로고    scopus 로고
    • Adaptive clinical trial designs for simultaneous testing of matched diagnostics and therapeutics
    • Scher, H. I., Nasso, S. F., Rubin, E. H. & Simon, R. Adaptive clinical trial designs for simultaneous testing of matched diagnostics and therapeutics. Clin. Cancer Res. 17, 6634-6640 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6634-6640
    • Scher, H.I.1    Nasso, S.F.2    Rubin, E.H.3    Simon, R.4
  • 62
    • 63049093102 scopus 로고    scopus 로고
    • The clinically-integrated randomized trial: Proposed novel method for conducting large trials at low cost
    • Vickers, A. J. & Scardino, P. T. The clinically-integrated randomized trial: Proposed novel method for conducting large trials at low cost. Trials 10, 14 (2009).
    • (2009) Trials , vol.10 , pp. 14
    • Vickers, A.J.1    Scardino, P.T.2
  • 63
    • 84895907718 scopus 로고    scopus 로고
    • The digital future of molecular medicine: Rethinking FDA regulation
    • The Manhattan Institute [online]
    • Huber, P. The digital future of molecular medicine: Rethinking FDA regulation. Project FDA report no. The Manhattan Institute [online] http://www.manhattan-institute.org/pdf/fda-06.pdf (2013).
    • (2013) Project FDA Report
    • Huber, P.1
  • 65
    • 80051624353 scopus 로고    scopus 로고
    • A computational disease that AI can cure
    • Tenenbaum, J. M. & Shrager, J. Cancer: A computational disease that AI can cure. AI Magazine 32, 14-26 (2011).
    • (2011) AI Magazine , vol.32 , pp. 14-26
    • Tenenbaum, J.M.1    Cancer, S.J.2
  • 66
    • 84883295825 scopus 로고    scopus 로고
    • Asco's approach to a learning health care system in oncology
    • Sledge, G. W. et al. ASCO's Approach to a Learning Health Care System in Oncology. J. Oncol. Pract. 9, 145-148 (2013).
    • (2013) J. Oncol. Pract. , vol.9 , pp. 145-148
    • Sledge, G.W.1
  • 67
    • 84895900509 scopus 로고    scopus 로고
    • ASCO's CancerLinQ: Building a Transformation in Cancer Care [online]
    • ASCO's CancerLinQ: Building a Transformation in Cancer Care. ASCO [online] http://www.ascopost.com/issues/july-1-2012/asco%E2%80%99s-cancerlinq- building-a-transformation-in-cancer-care.aspx (2013).
    • (2013) ASCO
  • 68
    • 84895910764 scopus 로고    scopus 로고
    • ASCO Completes Prototype for CancerLinQ™, Marking First Demonstration of a Learnin g Health System to Transform Cancer Care [online]
    • ASCO Completes Prototype for CancerLinQ™, Marking First Demonstration of a "Learnin g Health System" to Transform Cancer Care. ASCO [online], http://www.asco.org/press-centre/asco-completes-prototype- cancerlinq%E2%84%A2-marking-first-demonstration-%E2%80%9Clearning-health (2013).
    • (2013) ASCO
  • 69
    • 84883271258 scopus 로고    scopus 로고
    • Envisioning Watson as a rapid-learning system for oncology
    • Malin, J. L. Envisioning Watson as a rapid-learning system for oncology. J. Oncol. Pract. 9, 155-157 (2013).
    • (2013) J. Oncol. Pract. , vol.9 , pp. 155-157
    • Malin, J.L.1
  • 71
    • 79953305486 scopus 로고    scopus 로고
    • A melanoma molecular disease model
    • Vidwans, S. et al. A melanoma molecular disease model. PLoS ONE 6, e18257 (2011).
    • (2011) PLoS ONE , vol.6
    • Vidwans, S.1
  • 72
    • 84857410524 scopus 로고    scopus 로고
    • A novel classification of lung cancer into molecular subtypes
    • West, L. et al. A novel classification of lung cancer into molecular subtypes. PLoS ONE 7, e31906 (2012).
    • (2012) PLoS ONE , vol.7
    • West, L.1
  • 73
    • 84895910704 scopus 로고    scopus 로고
    • Participate in rapid learning communities [online]
    • Participate in rapid learning communities. Cancer Commons [online], http://www.cancercommons.org/researchers-clinicians/(2013).
    • (2013) Cancer Commons
  • 74
    • 84895910704 scopus 로고    scopus 로고
    • Donate Your Data [online]
    • Donate Your Data. Cancer Commons [online], http://www.cancercommons.org/ donate-your-data/(2013).
    • (2013) Cancer Commons
  • 75
    • 80053135173 scopus 로고    scopus 로고
    • Rethinking clinical trials
    • Grove, A. Rethinking clinical trials. Science 23, 1679 (2011).
    • (2011) Science , vol.23 , pp. 1679
    • Grove, A.1
  • 76
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine [online]
    • US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01449279 (2013).
    • (2013) ClinicalTrials.gov
  • 77
    • 84872695626 scopus 로고    scopus 로고
    • Emerging therapies in melanoma
    • Wolchok, J. D. Emerging therapies in melanoma. Clin. Adv. Haematol. Oncol. 10, 742-743 (2012).
    • (2012) Clin. Adv. Haematol. Oncol. , vol.10 , pp. 742-743
    • Wolchok, J.D.1
  • 78
    • 84875909665 scopus 로고    scopus 로고
    • National Human Genome Research Institute [online]
    • DNA Sequencing Costs. National Human Genome Research Institute [online], http://www.genome.gov/sequencingcosts/(2013).
    • (2013) DNA Sequencing Costs
  • 79
    • 84879471843 scopus 로고    scopus 로고
    • A multi-site feasibility study for personalized medicine in canines with Osteosarcoma
    • Monks, N. R. et al. A multi-site feasibility study for personalized medicine in canines with Osteosarcoma. J. Transl. Med. 11, 158 (2013).
    • (2013) J. Transl. Med. , vol.11 , pp. 158
    • Monks, N.R.1
  • 80
    • 33845933082 scopus 로고    scopus 로고
    • Increased security through open source
    • Hoepman, J. H. & Jacobs, B. Increased security through open source. Commun. ACM 50, 79-83 (2007).
    • (2007) Commun. ACM , vol.50 , pp. 79-83
    • Hoepman, J.H.1    Jacobs, B.2
  • 81
    • 67650336988 scopus 로고    scopus 로고
    • Open a nd closed source systems are equivalent (that is, in an ideal world)
    • (The MIT Press, Cambridge, MA
    • Anderson, R. J. Open a nd closed source systems are equivalent (that is, in an ideal world). In Perspectives on free and open source software. 127-142 (The MIT Press, Cambridge, MA, 2005).
    • (2005) Perspectives on Free and Open Source Software , pp. 127-142
    • Anderson, R.J.1
  • 82
    • 77956517937 scopus 로고    scopus 로고
    • Soccer science and the Bayes community: Exploring the cognitive implications of modern scientific communication
    • Shrager, J., Billman, D., Converti no, G., Massar, J. P. & Pirolli, P. Soccer science and the Bayes community: Exploring the cognitive implications of modern scientific communication. Top. Cog. Sci. 2, 53-72 (2009).
    • (2009) Top. Cog. Sci. , vol.2 , pp. 53-72
    • Shrager, J.1    Billman, D.2    Convertino, G.3    Massar, J.P.4    Pirolli, P.5
  • 84
    • 80051954603 scopus 로고    scopus 로고
    • Opportunities and challenges in the development of experimental drug combinations for cancer
    • Humphrey, R. W. et al. Opportunities and challenges in the development of experimental drug combinations for cancer. J. Natl Cancer Inst. 103, 1222-1226 (2011).
    • (2011) J. Natl Cancer Inst. , vol.103 , pp. 1222-1226
    • Humphrey, R.W.1
  • 85
    • 84880991913 scopus 로고    scopus 로고
    • Basket studies' will hold intricate data for cancer drug approvals
    • Willyard, C. 'Basket studies' will hold intricate data for cancer drug approvals. Nat. Med. 19, 655 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 655
    • Willyard, C.1
  • 86
    • 84864283129 scopus 로고    scopus 로고
    • Off-label use of anti-cancer drugs between clinical practice and research: The Italian experience
    • Lerose, R., Musto, P., Aieta, M., Papa, C. & Tartarone, A. Off-label use of anti-cancer drugs between clinical practice and research: The Italian experience. Eur. J. Clin. Pharmacol. 68, 505-512 (2012).
    • (2012) Eur. J. Clin. Pharmacol. , vol.68 , pp. 505-512
    • Lerose, R.1    Musto, P.2    Aieta, M.3    Papa, C.4    Tartarone, A.5
  • 87
    • 61649124065 scopus 로고    scopus 로고
    • Market and patient access to new oncology products in Europe: A current, multidisciplinary perspective
    • McCabe, C. et al. Market and patient access to new oncology products in Europe: A current, multidisciplinary perspective. Ann. Oncol. 20, 403-412 (2009).
    • (2009) Ann. Oncol. , vol.20 , pp. 403-412
    • McCabe, C.1
  • 89
    • 84924809705 scopus 로고    scopus 로고
    • Cancer Research UK
    • Cancer Research UK. Stratified Medicine Programme [online], http://www.cancerresearchuk.org/science/research/how-we-deliver-our-research/ others/by-programme/stratified-medicine-programme/(2013).
    • (2013) Stratified Medicine Programme [Online]


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.