Chemical respiratory allergy: Reverse engineering an adverse outcome pathway

Toxicology

Volumn 318, Issue 1, 2014, Pages 32-39

  Kimber, Ian ^a   Dearman, Rebecca J ^a   Basketter, David A ^b   Boverhof, Darrell R ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b DABMEB CONSULTANCY LTD   (United Kingdom)

^c DOW CHEMICAL COMPANY   (United States)

Author keywords

Adverse outcome pathway; Occupational asthma; Respiratory allergy; Sensitisation of the respiratory tract

Indexed keywords

ALLERGEN;

ADVERSE OUTCOME; ENGINEERING; HUMAN; MOLECULAR INTERACTION; OCCUPATIONAL ASTHMA; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; REVIEW; TH2 CELL; TOXICOLOGY;

ADVERSE OUTCOME PATHWAY; OCCUPATIONAL ASTHMA; RESPIRATORY ALLERGY; SENSITISATION OF THE RESPIRATORY TRACT;

AIR POLLUTANTS, OCCUPATIONAL; ASTHMA, OCCUPATIONAL; HAZARDOUS SUBSTANCES; HUMANS; RESPIRATORY HYPERSENSITIVITY; RHINITIS; RISK ASSESSMENT;

EID: 84895827351     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.02.001     Document Type: Review

References (91)

1. Ainscough J.S., Gerberick G.F., Dearman R.J., Kimber I. Danger, intracellular signalling, and the orchestration of dendritic cell function in skin sensitization. J. Immunotoxicol. 2013, 10:223-234.
2. Ankley G.T., Bennett R.S., Erickson R.J., Hoff D.J., Hornung M.W., Johnson R.D., Mount D.R., Nichols J.W., Russom C.L., Schmieder P.K., Serrano J.A., Tietage J.E., Villeneuve D.L. Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment. Environ. Toxicol. Chem. 2010, 29:730-741.
3. Banchereau J., Steinman R.M. Dendritic cells and control of immunity. Nature 1998, 392:245-252.
4. Banks P.R., Paquette D.M. Comparison of three common amine reactive fluorescent probes used for conjugation to biomolecules by capillary zone electrophoresis. Bioconjug. Chem. 1995, 6:447-458.
5. Basketter D.A., Kimber I. Assessing the potency of respiratory allergens: uncertainties and challenges. Regul. Toxicol. Pharmacol. 2011, 61:365-372.
6. Baur X. A compendium of causative agents of occupational asthma. J. Occup. Med. Toxicol. 2013, 8:1-8.
7. Bentley A.M., Maestrelli P., Saetta M., Fabri L.M., Robinson D., Bradley B.L., Jeffery P.K., Durham S.R., Kay A.B. Activated T lymphocytes and eosinophils in the bronchial mucosa in isocyanate-induced asthma. J. Allergy Clin. Immunol. 1992, 89:821-829.
8. Bell B.D., Kitajima M., Larson R.P., Stoklasek T.A., Dang K., Sakamoto K., Wagner K-U., Kaplan D.H., Reizis B., Hennighausen L., Ziegler S.F. The transcription factor STAT5 is critical in dendritic cells for the development of TH2, but not TH1 responses. Nat. Immunol. 2013, 14:364-371.
9. Bello D., Herrick C.A., Smith T.J., Woskie S.R., Streicher R.P., Cullen M.R., Liu Y., Redlich C.A. Skin exposure to isocyanates: reasons for concern. Environ. Health Perspect. 2007, 115:328-335.
10. Botham P.A., Rattray N.J., Woodcock D.R., Walsh S.T., Hext P.M. The induction of respiratory allergy in guinea pigs following intradermal injection of trimellitic anhydride: a comparison of the response to 2,4-dinitrochlorobenzene. Toxicol. Lett. 1989, 47:25-39.
11. Boverhof D.R., Billington R., Gollapudi B.B., Hotchkiss J.R., Krieger S.M., Poole A., Wiecinski C.M., Woolhiser M.R. Respiratory sensitization and allergy. Current research approaches and needs. Toxicol. Appl. Pharmacol. 2008, 226:1-13.
12. Campo P., Wisnewski A.V., Lummus Z., Cartier A., Malo J-L., Boulet L.P., Bernstein D.I. Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI-exposed workers. Clin. Exp. Allergy 2007, 37:1095-1102.
13. Caron G., Delnest Y., Roelandts E., Duez C., Bonnefoy J.Y., Pestel J., Jeannin P. Histamine polarizes human dendritic cells into Th2cell-promoting effector dendritic cells. J. Immunol. 2001, 167:3682-3686.
14. Cartier A., Grammer L.C., Maol J-L., Lagier F., Chezzo H., Harris K., Patterson R. Specific serum antibodies against isocyanates: associations with occupational asthma. J. Allergy Clin. Immunol. 1989, 84:507-514.
15. + T cell responses: the alternative approaches. Ann. Rev. Immunol. 1997, 15:297-322.
16. Cullinan P. Occupational asthma, IgE and IgG. Clin. Exp. Allergy 1998, 28:688-690.
17. Cumberbatch M., Clelland K., Dearman R.J., Kimber I. Impact of cutaneous IL-10 on resident epidermal Langerhans cells and development of polarized immune responses. J. Immunol. 2005, 175:43-50.
18. Dearman R.J., Kimber I. Cytokine fingerprinting and hazard assessment of chemical respiratory allergy. J. App. Toxicol. 2001, 21:153-163.
19. De Groot A. Patch Testing 2008, acdgroot Publishing, Wapserveen. third ed.
20. De Jong E.C., Viera P.L., Kalinski P., Schultemaker J.H., Tanaka Y., Wierenga E.A., Yazdanbakhsh M., Kapsenberg M.L. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J. Immunol. 2002, 168:1704-1709.
21. D'Ostiani C.F., del Sero G., Bracci A., Montagnoli C., Spreca A., Mencacci A., Ricciardi-Castagnoli P., Romani L. Dendritic cells discriminate between yeats and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J. Exp. Med. 2000, 191:1661-1674.
22. Diar Bakerly N., Moore V.C., Vellore A.D., Jaakola M.S., Robertson A.S., Burge P.S. Fifteen year trends in occupational asthma: data from the Shield surveillance scheme. Occup. Med. 2008, 58:169-174.
23. Edwards A.D., Manickasingham S.P., Sporri R., Diebold S.S., Schulz O., Sher A., Kaisho T., Akira S., Reis Sousa C. Microbial recognition via Toll-like receptor-dependent and-independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J. Immunol. 2002, 169:3652-3660.
24. Eisenbarth S.C., Piggott D.A., Bottomly K. The master regulators of allergic inflammation: dendritic cells in Th2 sensitization. Curr. Opin. Immunol. 2003, 15:620-626.
25. Enoch S.J., Seed M.J., Roberts D.W., Cronin M.T.D., Stocks S.J., Agius R.M. Development of mechanism-based structural alerts for respiratory sensitization hazard identification. Chem. Res. Toxicol. 2012, 25:2490-2498.
26. Geginat J., Paroni M., Facciotti F., Kastirr I., Caprioli F., Pagani M., Abrignani S. The CD4-centered universe of human T cell subsets. Semin. Immunol. 2013, 25:252-262. Epub ahead of print.
27. Gerberick G.F., Vassallo J.D., Bailey R.E., Chaney J.G., Morrall S.W., Lepoittevin J.P. Development of a peptide reactivity assay for screening contact allergens. Toxicol. Sci. 2004, 81:332-343.
28. Gerberick G.F., Vassallo J.D., Foertsch L.M., Price B.B., Chaney J.G., Lepoittevin J.P. Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. Toxicol. Sci. 2007, 97:417-427.
29. Ghaemmaghami A.M., Gough L., Sewell H.F., Shakib F. The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level. Clin. Exp. Allergy 2002, 32:1468-1475.
30. Holsapple M.P., Jones D., Kawabata T.T., Kimber I., Sarlo K., Selgrade M.K., Shah J., Woolhiser M.R. Assessing the potential to induce respiratory hypersensitivity. Toxicol. Sci. 2006, 91:4-13.
31. Hopkins J.E., Naisbitt D.J., Kitteringham N.R., Dearman R.J., Kimber I., Park B.K. Selective haptenationof cellular or extracellular proteins by chemical allergens: association with cytokine polarization. Chem. Res. Toxicol. 2005, 18:375-381.
32. Howe W., Venables K.M., Topping M.D., Dally M.B., Hawkins R., Law J.S., Taylor A.J. Tetrachlorophthalic anhydride: evidence for specific IgE antibody. J. Allergy Clin. Immunol. 1983, 71:5-11.
33. Isola D., Kimber I., Sarlo K., Lalko J., Sipes I.G. Chemical respiratory allergy and occupational asthma; what are the key areas of uncertainty. J. Appl. Toxicol. 2008, 28:249-253.
34. Jones M.G., Floyd A., Nouri-Aria K.T., Jacobson M.R., Durham S.R., Newman Tayor A., Cullinan P. Is occupational asthma to diisocyanates a non-IgE-mediated disease. J. Allergy Clin. Immunol. 2006, 117:663-669.
35. Jonsson B.A., Wishnok J.S., Skipper P.L., Stillwell W.G., Tannenbaum S.R. Lysine adducts between methyltetrahydrophthalic anhydride and collagen in guinea pig lung. Toxicol. Appl. Pharmacol. 1995, 135:156-162.
36. Johannesson G., Rosqvist S., Lindh C.H., Welinder H., Jonsson B.A. Serum albumins are the major site for in vivo formation of hapten-carrier protein adducts in plasma from humans and guinea-pigs exposed to type-1 allergy inducing hexahydrophthalic anhydride. Clin. Exp. Allergy 2001, 31:1021-1030.
37. Karol M.H., Hauth B.A., Riley E.J., Megreni C.M. Dermal contact with toluene diisocyanate (TDI) produces respiratory tract hypersensitivity in guinea pigs. Toxicol. Appl. Pharmacol. 1981, 58:221-230.
38. Kimber I., Agius R., Basketter D.A., Corsini E., Cullinan P., Dearman R.J., Gimenez-Arnau E., Greenwell L., Hartung T., Kuper F., Maestrelli P., Roggen E., Rovida C. Chemical respiratory allergy: opportunities for hazard identification and characterization. Alter. Lab. Anim. 2007, 35:243-265.
39. Kimber I., Basketter D.A., Gerberick G.F., Ryan C.A., Dearman R.J. Chemical allergy: translating biology into hazard characterization. Toxicol. Sci. 2011, 120(S1):S238-S268.
40. Kimber I., Cumberbatch M., Dearman R.J., Griffiths C.E.M. Danger signals and skin sensitisation. Br. J. Dermatol. 2002, 147:613-614.
41. Kimber I., Dearman R.J. Cell and molecular biology of chemical allergy. Clin. Rev. Allergy Immunol. 1995, 15:145-168.
42. Kimber I., Dearman R.J. Chemical respiratory allergy: an introduction. Toxicology of Chemical Respiratory Hypersensitivity 1997, 1-6. Taylor & Francis, London. I.R. Kimber, J. Dearman (Eds.).
43. Kimber I., Dearman R.J. Chemical respiratory allergy: role of IgE antibody and relevance of route of exposure. Toxicology 2002, 181-182:311-315.
44. Kimber I., Dearman R.J. Allergic contact dermatitis: the cellular effectors. Contact Dermatitis 2002, 46:1-5.
45. Kimber I., Dearman R.J. What makes a chemical a respiratory sensitizer. Curr. Opin. Allergy Clin. Immunol. 2005, 5:119-124.
46. Kimber I., Warbrick E.V., Dearman R.J. Chemical respiratory allergy, IgE and the relevance of predictive test methods. Hum. Exp. Toxicol. 1998, 17:537-540.
47. + dermal dendritic cells. Immunity 2008, 29:497-510.
48. Kristiansson M.H., Lindh C.H., Jonsson B.A. Determination of hexahydrophthalic anhydride adducts to human serum albumin. Biomarkers 2003, 8:343-359.
49. Lalko J.F., Kimber I., Dearman R.J., Api A.M., Gerberick G.F. The selective peptide reactivity of chemical respiratory allergens under competitive and non-competitive conditions. J. Immunotoxicol. 2013, 10:292-301.
50. Lalko J.F., Kimber I., Dearman R.J., Gerberick G.F., Sarlo K., Api A.M. Chemical reactivity measurements: potential for characterization of respiratory chemical allergens. Toxicol. in Vitro 2011, 25:433-445.
51. Lalko J.F., Kimber I., Gerberick G.F., Foertsch L.M., Api A.M., Dearman R.J. The direct peptide reactivity assay: selectivity of chemical respiratory allergens. Toxicol. Sci. 2012, 129:421-431.
52. Langenkamp A., Messi M., Lanzavecchia A., Sallusto F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat. Immunol. 2000, 1:311-316.
53. Liu Y-J., Kanzler H., Soumelis V., Gilliet M. Dendritic cell lineage, plasticity and cross-regulation. Nat. Immunol. 2001, 2:585-589.
54. Maldonado-Lopez R., De Smedt T., Michel P., Godfroid J., Pajak B., Heirman C., Thielemans K., Leo O., Urbain J., Moser M. CD8α+ and CD8α- subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J. Exp. Med 1999, 189:587-592.
55. Mamessier E., Milhe F., Guillot C., Birnbaum J., Dupuy P., Lorec A.M., Vervloet D., Magnan A. T-cell activation in occupational asthma and rhinitis. Allergy 2007, 62:162-169.
56. Mapp C.E., Boschetto P., Maestrelli P., Fabbri L.M. Occupational asthma. Am. J. Respir. Crit. Care Med. 2005, 172:280-305.
57. Martin S.F. The role of the innate immune system in allergic contact dermatitis. Allergologie 2010, 33:66-70.
58. Martin S.F., Jakob T. From innate to adaptive immune responses in contact hypersensitivity. Curr. Opin. Allegy Clin. Immunol. 2008, 8:289-293.
59. Matzinger P. Tolerance, danger and the extended family. Ann. Rev. Immunol. 1994, 12:991-1045.
60. Matzinger P. An innate sense of danger. Semin. Immunol. 1998, 10:399-415.
61. McFadden J.P., Basketter D.A. Contact allergy, irritancy and 'danger'. Contact Dermatitis 2000, 42:123-127.
62. Murphy K.M. Transcriptional control of dendritic cell development. Adv. Immunol. 2013, 120:239-267.
63. Natsch A. The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for slin sensitizers-functional relevance and a hypothesis on innate reactions to skin sensitizers. Toxicol. Sci. 2010, 113:284-292.
64. Natsch A., Emter R. Skin sesnitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals. Toxicol. Sci. 2008, 102:110-119.
65. Natsch A., Gfeller H. LC-MS-based characterization of the peptide reactivity of chemicals to improve the in vitro prediction of the skin sensitization potential. Toxicol. Sci. 2008, 106:464-478.
66. Newell L., Polak M.E., Perera J., Owen C., Pickard C., Howarth P.H., Healy E., Holloway J.W., Friedmann P.S., Ardern-Jones M.R. Sensitization through healthy skin programs Th2 responses in individuals with atopic dermatitis. J. Invest. Dermatol. 2013, 133:2372-2380.
67. Organisation for Economic Cooperation and Development (OECD) The adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins, OECD ENV/JM/MONO 2012, Organisation for Economic Cooperation and Development, 10.
68. Oppenheim J.J., Tewary P., de la Rosa G., Yang D. Alarmins initiate host defence. Adv. Exp. Biol. Med. 2007, 601:185-194.
69. + T cells. Science 2010, 327:1098-1102.
70. Ouyang B., Bernstein D.I., Lummus Z.L., Ying J., Boulet L-P., Cartier A., Gautrin D., Ho S-M. Interferon-γ promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma. Toxicol. Sci. 2013, 133:218-224.
71. Pulendran B., Smith J.L., Caspary G., Brasel K., Pettit D., Maraskovsky E., Maliszewski C.R. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. PNAS 1999, 96:1036-1041.
72. Pulendran B., Tang H., Manicassamy S. Programming dendritic cells to induce Th2 and tolerogenic signals. Nat. Immunol. 2010, 11:647-655.
73. Rattray N.J., Botham P.A., Hext P.M., Woodcock D.R., Fielding I., Dearman R.J., Kimber I. Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guinea pigs, Influence of route of exposure. Toxicology 1994, 88:15-30.
74. Redlich C.A. Skin exposure and asthma: is there a connection. Proc. Am. Thorac. Soc. 2010, 7:134-137.
75. Redich C.A., Herrick C.A. Lung/skin connections in occupational lung disease. Curr. Opin. Allergy Clin. Immunol. 2008, 8:115-119.
76. Romagnani S. Immunologic influences on allergy and the TH1/TH2 balance. J. Allergy Clin. Immunol. 2004, 113:395-400.
77. Ross D.J., McDonald J.C. Asthma following inhalation accidents reported to the SWORD project. Ann. Occup. Hyg. 1996, 40:645-650.
78. Sastre J., Vandenplas O., Park H-S. Pathogenesis of occupational asthma. Eur. Respir. J. 2003, 22:364-373.
79. Soumelis V., Reche P., Kanzler H., Yuan W., Edward G., Homey B., Gillet M., Ho S., Antonenko S., Lauerma A., Smith K., Gorman D., Zurawski S., Abrams J., Menon S., McClanahan T., de Waal-Malefyt R.D., Bazan F., Kastelein R.A., Liu Y.J. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 2002, 3:673-680.
80. Stumbles P.A., Thomas J.A., Pimm C.L., Lee P.T., Venaille T.J., Proksch S., Holt P.G. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med. 1998, 188:2019-2031.
81. Tang H., Cao W., Kasturi S.P., Ravindran R., Nakaya H.I., Kundu K., Murthy N., Kepler T.B., Malissen B., Pulendran B. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signalling. Nat. Immunol. 2010, 11:608-617.
82. Tarlo S.M. Disocyanate sensitisation and antibody production. J. Allergy Clin. Immunol. 1999, 103:739-741.
83. Tarlo S., Malo J.L. An ATS/ERS report: 100 key questions and needs in occupational asthma. Eur. Respir. J. 2006, 27:607-614.
84. Tee R.D., Cullinan P., Welch J., Burge P.S., Newman-Taylor A.J. Specific IgE to isocyanates: a useful diagnostic role in occupational asthma. J. Allergy Clin. Immunol. 1998, 101:709-715.
85. Traidl-Hoffmann C., Mariani V., Hochrein H., Karg K., Wagner H., Ring J., Mueller M.J., Jakob T., Behrendt H. Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J. Exp. Med. 2005, 201:627-636.
86. Vandebriel R.J., De Jon W.H., Spiekstra S.W., Van Dijk M., Fluitman A., Garssen J., Van Loveren H. Assessment of preferential Y-helper 1 or T-helper 1 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4. Toxicol. Appl. Pharmacol. 2000, 162:77-85.
87. Vandenplas O., Cartier A., Lesage J., Cloutier Y., Perreault G., Grammer L.C., Shaugnessy M.A., Malo J-L. Prepolymers of hexamethylene diisocyanate as a cause of occupational asthma. J. Allergy Clin. Immunol. 1993, 91:850-861.
88. Van Och F.M.M., Van Loveren H., De Jong W.H., Vandebriel R.J. Cytokine production induced by low-molecular-weight chemicals as a function of the stimulation index in a modified local lymph node assay: an approach to discriminate contact sensitizers from respiratory sensitizers. Toxicol. Appl. Pharmacol. 2002, 184:46-56.
89. Vento K.L., Dearman R.J., Kimber I., Basketter D.A., Coleman J.W. Selectivity of IgE responses, mast cell sensitization, and cytokine expression in the immune response of Brown Norway rats to chemical allergen. Cell. Immunol. 1996, 172:246-253.
90. Vinken M. The adverse outcome pathway concept: a pragmatic tool in toxicology. Toxicology 2013, 312:158-165.
91. Whelan M., Harnett M.M., Houston K.M., Patel V., Harnett W., Rigley K.P. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells. J. Immunol. 2000, 164:6453-6460.