Design, synthesis and anti colon cancer activity evaluation of phosphorylated derivatives of Lamivudine (3TC)

Letters in Drug Design and Discovery

Volumn 8, Issue 1, 2011, Pages 59-64

  Rao, Valasani Koteswara ^a   Reddy, Sanapalli S ^a   Krishna, Balam S ^a   Reddy, Cirandur S ^a   Reddy, Nimmanapalli P ^b   Reddy, Tamatam C M ^b   Raju, Chamarthi N ^a   Ghosh, S K ^c  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

^c BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Anti colon cancer activity; COLO 205 cell lines; MTT assay; Phosphorylated derivatives of lamivudine

Indexed keywords

[5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYL (2 AMINOETHYLAMIDO)(4 NITROPHENYL)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYL (2 DIHYDROGENPHOSPHATO)(4 NITROPHENYL)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYL (2 HYDROXYETHYLOXY)(4 NITROPHENYL)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYL (4 CHLOROPHENYL)(2 AMINOETHYLAMIDO)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYL (4 CHLOROPHENYL)(2 DIHYDROGENPHOSPHATO)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYL (4 CHLOROPHENYL)(2 HYDROXYETHYLOXY)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYL (4 CHLOROPHENYL)(4 METHYLPIPERAZINO)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYL (4 METHYLPIPERAZINO)(4 NITROPHENYL)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYLBIS (2 CHLOROETHYL)AMINO (2 DIHYDROGENPHOSPHATO)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYLBIS (2 CHLOROETHYL)AMINO (2 HYDROXYETHYLOXY)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYLBIS (2 CHLOROETHYL)AMINO (4 METHYLPIPERAZINO)PHOSPHATE; [5 (4 AMINO 2 OXO 1,2 DIHYDRO 1 PYRIMIDINYL) 1,3 OXATHIOLAN 2 YL]METHYLBIS (2 CHLOROETHYLAMINO)(2 AMINOETHYLAMIDO)PHOSPHATE; ANTINEOPLASTIC AGENT; LAMIVUDINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GROWTH; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 78650900676     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018011793663921     Document Type: Article

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