A BMP-FGF Morphogen Toggle Switch Drives the Ultrasensitive Expression of Multiple Genes in the Developing Forebrain

PLoS Computational Biology

Volumn 10, Issue 2, 2014, Pages

  Srinivasan, Shyam ^a,b   Hu, Jia Sheng ^a   Currle, D Spencer ^a,c   Fung, Ernest S ^d   Hayes, Wayne B ^b   Lander, Arthur D ^a   Monuki, Edwin S ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Irvine   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL SIGNALING; GENE EXPRESSION;

BONE MORPHOGENETIC PROTEINS; CELLULAR RESPONSE; CROSS-INHIBITION; FIBROBLAST GROWTH FACTOR; MORPHOGENS; MULTIPLE GENES; SWITCH DRIVES; TOGGLE SWITCH; ULTRASENSITIVE; ULTRASENSITIVITY;

TISSUE;

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; FIBROBLAST GROWTH FACTOR; BMP4 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR RECEPTOR; MSX1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR MSX1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BMP GENE; BRAIN DEVELOPMENT; BRAIN TISSUE; CELL CULTURE; CELLULAR ULTRASENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTICAL CELL; CROSS INHIBITORY POSITIVE FEEDBACK; DOWN REGULATION; FGF GENE; FOREBRAIN; GENE; GENE EXPRESSION; GENE INTERACTION; MATHEMATICAL MODEL; MOUSE; MSX1 GENE; MSX2 GENE; NERVE CELL; NONHUMAN; POSITIVE FEEDBACK; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; TOGGLE SWITCH; TTR GENE; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; BIOLOGY; DRUG EFFECTS; EMBRYO CULTURE; EMBRYOLOGY; FEEDBACK SYSTEM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PREGNANCY; TELENCEPHALON; TRANSGENIC MOUSE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEINS; COMPUTATIONAL BIOLOGY; EMBRYO CULTURE TECHNIQUES; FEEDBACK, PHYSIOLOGICAL; FEMALE; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MSX1 TRANSCRIPTION FACTOR; PREGNANCY; PROSENCEPHALON; RECEPTORS, FIBROBLAST GROWTH FACTOR; SIGNAL TRANSDUCTION; TELENCEPHALON;

EID: 84895746496     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003463     Document Type: Article

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