Dynamic interpretation of hedgehog signaling in the Drosophila wing disc

PLoS Biology

Volumn 7, Issue 9, 2009, Pages

  Nahmad, Marcos ^a   Stathopoulos, Angelike ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN PATCHED; SONIC HEDGEHOG PROTEIN; DROSOPHILA PROTEIN;

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DROSOPHILA; GENE EXPRESSION; MATHEMATICAL MODEL; STEADY STATE; ANIMAL; BIOLOGICAL MODEL; DROSOPHILA MELANOGASTER; FORELIMB; GENE EXPRESSION PROFILING; GROWTH, DEVELOPMENT AND AGING; METABOLISM; SIGNAL TRANSDUCTION; TIME;

ERINACEIDAE;

ANIMALS; COMPUTER SIMULATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION PROFILING; HEDGEHOG PROTEINS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; TIME FACTORS; WING;

EID: 70349771959     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000202     Document Type: Article

References (51)

1. Gurdon JB, Bourillot PY (2001) Morphogen gradient interpretation. Nature 413: 797-803.
2. Wolpert L (1968) The French Flag problem: a contribution to the discussion on pattern development and regulation. In: Waddington CH, ed. Towards a theoretical biology. Edinburgh (United Kingdom): Edinburgh University Press. pp 125-133.
3. Cooke J (1995) Morphogens in vertebrate development: how do they work? Bioessays 17: 93-96.
4. Gurdon JB, Dyson S, St Johnston D (1998) Cells' perception of position in a concentration gradient. Cell 95: 159-162. (Pubitemid 28473777)
5. Tabata T, Takei Y (2004) Morphogens, their identification and regulation. Development 131: 703-712.
6. Strigini M, Cohen SM (1997) A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124: 4697-4705. (Pubitemid 27519263)
7. Jiang J, Hui CC (2008) Hedgehog signaling in development and cancer. Dev Cell 15: 801-812.
8. Mullor JL, Guerrero I (2000) A gain-of-function mutant of patched dissects different responses to the hedgehog gradient. Dev Biol 228: 211-224.
9. Vervoort M, Crozatier M, Valle D, Vincent A (1999) The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr Biol 9: 632-639. (Pubitemid 29291943)
10. Ho KS, Suyama K, Fish M, Scott MP (2005) Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Development 132: 1401-1412. (Pubitemid 40528798)
11. Mullor JL, Calleja M, Capdevila J, Guerrero I (1997) Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning. Development 124: 1227-1237. (Pubitemid 27142076)
12. Denef N, Neubuser D, Perez L, Cohen SM (2000) Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102: 521-531.
13. Taipale J, Cooper MK, Maiti T, Beachy PA (2002) Patched acts catalytically to suppress the activity of Smoothened. Nature 418: 892-897. (Pubitemid 34966310)
14. Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A (2005) Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol 7: 86-92. (Pubitemid 40123387)
15. Jia J, Tong C, Wang B, Luo L, Jiang J (2004) Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432: 1045-1050. (Pubitemid 40052237)
16. Methot N, Basler K (1999) Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96: 819-831. (Pubitemid 29165085)
17. Casali A, Struhl G (2004) Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Nature 431: 76-80. (Pubitemid 39215110)
18. Chen Y, Struhl G (1996) Dual roles for patched in sequestering and transducing Hedgehog. Cell 87: 553-563. (Pubitemid 26374328)
19. Saha K, Schaffer DV (2006) Signal dynamics in Sonic hedgehog tissue patterning. Development 133: 889-900.
20. Gunbin KV, Omelyanchuk LV, Kogai VV, Fadeev SI, Kolchanov NA (2007) Model of the reception of hedgehog morphogen concentration gradient: comparison with an extended range of experimental data. J Bioinform Comput Biol 5: 491-506.
21. Lai K, Robertson MJ, Schaffer DV (2004) The sonic hedgehog signaling system as a bistable genetic switch. Biophys J 86: 2748-2757. (Pubitemid 38552681)
22. Eldar A, Rosin D, Shilo BZ, Barkai N (2003) Self-enhanced ligand degradation underlies robustness of morphogen gradients. Dev Cell 5: 635-646. (Pubitemid 37243051)
23. Gonzalez A, Chaouiya C, Thieffry D (2008) Logical modelling of the role of the Hh pathway in the patterning of the Drosophila wing disc. Bioinformatics 24: i234-240.
24. Kicheva A, Gonzalez-Gaitan M (2008) The Decapentaplegic morphogen gradient: a precise definition. Curr Opin Cell Biol 20: 137-143.
25. Bergmann S, Sandler O, Sberro H, Shnider S, Schejter E, et al. (2007) Pre-steady- state decoding of the Bicoid morphogen gradient. PLoS Biol 5: e46. doi:10.1371/journal.pbio.0050046. (Pubitemid 46256672)
26. Jaeger J, Surkova S, Blagov M, Janssens H, Kosman D, et al. (2004) Dynamic control of positional information in the early Drosophila embryo. Nature 430: 368-371. (Pubitemid 38937746)
27. Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, et al. (2004) Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118: 517-528. (Pubitemid 39485670)
28. Su VF, Jones KA, Brodsky M, The I (2007) Quantitative analysis of Hedgehog gradient formation using an inducible expression system. BMC Dev Biol 7: 43.
29. Ma C, Zhou Y, Beachy PA, Moses K (1993) The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell 75: 927-938. (Pubitemid 24014549)
30. Johnson RL, Grenier JK, Scott MP (1995) patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. Development 121: 4161-4170. (Pubitemid 3011019)
31. Hsiung F, Ramirez-Weber FA, Iwaki DD, Kornberg TB (2005) Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic. Nature 437: 560-563. (Pubitemid 41613554)
32. Han C, Belenkaya TY, Wang B, Lin X (2004) Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process. Development 131: 601-611. (Pubitemid 38240003)
33. Burke R, Nellen D, Bellotto M, Hafen E, Senti KA, et al. (1999) Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 99: 803-815. (Pubitemid 30017650)
34. Panakova D, Sprong H, Marois E, Thiele C, Eaton S (2005) Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435: 58-65. (Pubitemid 40655904)
35. Chamoun Z, Mann RK, Nellen D, von Kessler DP, Bellotto M, et al. (2001) Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science 293: 2080-2084. (Pubitemid 32848055)
36. Dessaud E, Yang LL, Hill K, Cox B, Ulloa F, et al. (2007) Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature 450: 717-720. (Pubitemid 350207693)
37. Blair SS (1992) Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila. Development 115: 21-33.
38. de Celis JF, Ruiz-Gomez M (1995) groucho and hedgehog regulate engrailed expression in the anterior compartment of the Drosophila wing. Development 121: 3467-3476.
39. Hepker J, Blackman RK, Holmgren R (1999) Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer. Development 126: 3669-3677. (Pubitemid 29419522)
40. Jazwinska A, Rushlow C, Roth S (1999) The role of brinker in mediating the graded response to Dpp in early Drosophila embryos. Development 126: 3323-3334. (Pubitemid 29396773)
41. Biehs B, Francois V, Bier E (1996) The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. Genes Dev 10: 2922-2934. (Pubitemid 26394252)
42. Methot N, Basler K (2001) An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development 128: 733-742. (Pubitemid 32229250)
43. Lewis J, Slack JM, Wolpert L (1977) Thresholds in development. J Theor Biol 65: 579-590.
44. Meinhardt H (1978) Space-dependent cell determination under the control of morphogen gradient. J Theor Biol 74: 307-321.
45. Chuang PT, McMahon AP (1999) Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397: 617-621. (Pubitemid 29091947)
46. Jeong J, McMahon AP (2005) Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 132: 143-154. (Pubitemid 40207974)
47. Golembo M, Schweitzer R, Freeman M, Shilo BZ (1996) Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122: 223-230. (Pubitemid 26038434)
48. Nakagoshi H, Shirai T, Nabeshima Y, Matsuzaki F (2002) Refinement of wingless expression by a wingless- and notch-responsive homeodomain protein, defective proventriculus. Dev Biol 249: 44-56.
49. Drossopoulou G, Lewis KE, Sanz-Ezquerro JJ, Nikbakht N, McMahon AP, et al. (2000) A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. Development 127: 1337-1348. (Pubitemid 30232586)
50. Capdevila J, Estrada MP, Sanchez-Herrero E, Guerrero I (1994) The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J 13: 71-82. (Pubitemid 24017176)
51. Strutt H, Thomas C, Nakano Y, Stark D, Neave B, et al. (2001) Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr Biol 11: 608-613. (Pubitemid 32324764)