Pattern, growth, and control

Cell

Volumn 144, Issue 6, 2011, Pages 955-969

  Lander, Arthur D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEVELOPMENTAL BIOLOGY; GROWTH REGULATION; MORPHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SYSTEMS BIOLOGY;

INVERTEBRATA; VERTEBRATA;

EID: 79952633685     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2011.03.009     Document Type: Review

References (128)

1. Aegerter-Wilmsen, T., Aegerter, C.M., Hafen, E., and Basler, K. (2007). Model for the regulation of size in the wing imaginal disc of Drosophila. Mech. Dev. 124, 318-326.
2. Aegerter-Wilmsen, T., Smith, A.C., Christen, A.J., Aegerter, C.M., Hafen, E., and Basler, K. (2010). Exploring the effects of mechanical feedback on epithelial topology. Development 137, 499-506.
3. Alon, U., Surette, M.G., Barkai, N., and Leibler, S. (1999). Robustness in bacterial chemotaxis. Nature 397, 168-171.
4. Aquino, G., and Endres, R.G. (2010). Increased accuracy of ligand sensing by receptor internalization. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 81, 021909.
5. Artavanis-Tsakonas, S., Rand, M.D., and Lake, R.J. (1999). Notch signaling: cell fate control and signal integration in development. Science 284, 770-776. (Pubitemid 29291335)
6. Baena-Lopez, L.A., and Garcia-Bellido, A. (2006). Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 103, 13734-13739.
7. Baena-Lopez, L.A., Franch-Marro, X., and Vincent, J.P. (2009). Wingless promotes proliferative growth in a gradient-independent manner. Sci. Signal. 2, ra60.
8. Barkai, N., and Shilo, B.Z. (2009). Robust generation and decoding of morphogen gradients. Cold Spring Harb. Perspect. Biol. 1, a001990.
9. Belenkaya, T.Y., Han, C., Yan, D., Opoka, R.J., Khodoun, M., Liu, H., and Lin, X. (2004). Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans. Cell 119, 231-244. (Pubitemid 39360905)
10. Ben-Zvi, D., and Barkai, N. (2010). Scaling of morphogen gradients by an expansion-repression integral feedback control. Proc. Natl. Acad. Sci. USA 107, 6924-6929.
11. Ben-Zvi, D., Shilo, B.Z., Fainsod, A., and Barkai, N. (2008). Scaling of the BMP activation gradient in Xenopus embryos. Nature 453, 1205-1211. (Pubitemid 351913602)
12. Biehs, B., Sturtevant, M.A., and Bier, E. (1998). Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs. Development 125, 4245-4257. (Pubitemid 28528932)
13. Blair, S.S. (2007). Wing vein patterning in Drosophila and the analysis of intercellular signaling. Annu. Rev. Cell Dev. Biol. 23, 293-319.
14. Bokel, C., Schwabedissen, A., Entchev, E., Renaud, O., and Gonzalez-Gaitan, M. (2006). Sara endosomes and the maintenance of Dpp signaling levels across mitosis. Science 314, 1135-1139. (Pubitemid 44789042)
15. Box, G.E.P. (1979). Robustness in the strategy of scientific model building. In Robustness in Statistics, R.L. Launer and G.N. Wilkinson, eds. (New York: Academic Press), pp. 201-236.
16. Briscoe, J. (2009). Making a grade: Sonic Hedgehog signalling and the control of neural cell fate. EMBO J. 28, 457-465.
17. Buttitta, L.A., and Edgar, B.A. (2007). How size is controlled: from Hippos to Yorkies. Nat. Cell Biol. 9, 1225-1227.
18. Casali, A., and Struhl, G. (2004). Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Nature 431, 76-80. (Pubitemid 39215110)
19. Chang, H.H., Hemberg, M., Barahona, M., Ingber, D.E., and Huang, S. (2008). Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature 453, 544-547. (Pubitemid 351733323)
20. Clayton, E., Doupe, D.P., Klein, A.M., Winton, D.J., Simons, B.D., and Jones, P.H. (2007). A single type of progenitor cell maintains normal epidermis. Nature 446, 185-189. (Pubitemid 46398664)
21. Cohen, M., Georgiou, M., Stevenson, N.L., Miodownik, M., and Baum, B. (2010). Dynamic filopodia transmit intermittent Delta-Notch signaling to drive pattern refinement during lateral inhibition. Dev. Cell 19, 78-89.
22. Crick, F.H.C. (1970). Diffusion in embryogenesis. Nature 225, 420-422.
23. Csikasz-Nagy, A., Novak, B., and Tyson, J.J. (2008). Reverse engineering models of cell cycle regulation. Adv. Exp. Med. Biol. 641, 88-97.
24. Dessaud, E., Yang, L.L., Hill, K., Cox, B., Ulloa, F., Ribeiro, A., Mynett, A., Novitch, B.G., and Briscoe, J. (2007). Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature 450, 717-720. (Pubitemid 350207693)
25. Dessaud, E., Ribes, V., Balaskas, N., Yang, L.L., Pierani, A., Kicheva, A., Novitch, B.G., Briscoe, J., and Sasai, N. (2010). Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. PLoS Biol. 8, e1000382.
26. Doyle, J., and Csete, M. (2007). Rules of engagement. Nature 446, 860. (Pubitemid 46633149)
27. Edgar, B.A. (2006). How flies get their size: genetics meets physiology. Nat. Rev. Genet. 7, 907-916.
28. Edgar, B.A., Odell, G.M., and Schubiger, G. (1989). A genetic switch, based on negative regulation, sharpens stripes in Drosophila embryos. Dev. Genet. 10, 124-142.
29. Eldar, A., Rosin, D., Shilo, B.Z., and Barkai, N. (2003). Self-enhanced ligand degradation underlies robustness of morphogen gradients. Dev. Cell 5, 635-646. (Pubitemid 37243051)
30. Eldar, A., Shilo, B.Z., and Barkai, N. (2004). Elucidating mechanisms underlying robustness of morphogen gradients. Curr. Opin. Genet. Dev. 14, 435-439.
31. Elgjo, K., and Reichelt, K.L. (2004). Chalones: from aqueous extracts to oligopeptides. Cell Cycle 3, 1208-1211. (Pubitemid 40268641)
32. Erdmann, T., Howard, M., and ten Wolde, P.R. (2009). Role of spatial averaging in the precision of gene expression patterns. Phys. Rev. Lett. 103, 258101.
33. Filmus, J., and Capurro, M. (2008). The role of glypican-3 in the regulation of body size and cancer. Cell Cycle 7, 2787-2790.
34. Franch-Marro, X., Marchand, O., Piddini, E., Ricardo, S., Alexandre, C., and Vincent, J.P. (2005). Glypicans shunt the Wingless signal between local signalling and further transport. Development 132, 659-666. (Pubitemid 40352826)
35. Francois, P., Vonica, A., Brivanlou, A.H., and Siggia, E.D. (2009). Scaling of BMP gradients in Xenopus embryos. Nature 461, E1.
36. Galli, A., Roure, A., Zeller, R., and Dono, R. (2003). Glypican 4 modulates FGF signalling and regulates dorsoventral forebrain patterning in Xenopus embryos. Development 130, 4919-4929. (Pubitemid 37321874)
37. Gierer, A., and Meinhardt, H. (1972). A theory of biological pattern formation. Kybernetik 12, 30-39.
38. Gomes, F.L., Zhang, G., Carbonell, F., Correa, J.A., Harris, W.A., Simons, B.D., and Cayouette, M. (2011). Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions. Development 138, 227-235.
39. Gregor, T., Tank, D.W., Wieschaus, E.F., and Bialek, W. (2007). Probing the limits to positional information. Cell 130, 153-164. (Pubitemid 47031318)
40. Grusche, F.A., Degoutin, J.L., Richardson, H.E., and Harvey, K.F. (2010a). The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. Dev. Biol. 350, 255-266.
41. Grusche, F.A., Richardson, H.E., and Harvey, K.F. (2010b). Upstream regulation of the hippo size control pathway. Curr. Biol. 20, R574-R582.
42. Halder, G., and Johnson, R.L. (2011). Hippo signaling: growth control and beyond. Development 138, 9-22.
43. Han, C., Belenkaya, T.Y., Wang, B., and Lin, X. (2004). Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process. Development 131, 601-611. (Pubitemid 38240003)
44. Han, C., Yan, D., Belenkaya, T.Y., and Lin, X. (2005). Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Development 132, 667-679. (Pubitemid 40352827)
45. Hasty, J., Pradines, J., Dolnik, M., and Collins, J.J. (2000). Noise-based switches and amplifiers for gene expression. Proc. Natl. Acad. Sci. USA 97, 2075-2080.
46. Hoffmann, M., Chang, H.H., Huang, S., Ingber, D.E., Loeffler, M., and Galle, J. (2008). Noise-driven stem cell and progenitor population dynamics. PLoS ONE 3, e2922.
47. Hufnagel, L., Teleman, A.A., Rouault, H., Cohen, S.M., and Shraiman, B.I. (2007). On the mechanism of wing size determination in fly development. Proc. Natl. Acad. Sci. USA 104, 3835-3840.
48. Ishihara, S., and Kaneko, K. (2006). Turing pattern with proportion preservation. J. Theor. Biol. 238, 683-693.
49. Jiao, Y., and Meyerowitz, E.M. (2010). Cell-type specific analysis of translating RNAs in developing flowers reveals new levels of control. Mol. Syst. Biol. 6, 419.
50. Kawauchi, S., Shou, J., Santos, R., Hebert, J.M., McConnell, S.K., Mason, I., and Calof, A.L. (2005). Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development 132, 5211-5223. (Pubitemid 43020176)
51. Kawauchi, S., Kim, J., Santos, R., Wu, H.H., Lander, A.D., and Calof, A.L. (2009). Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development 136, 1453-1464.
52. Khammash, M. (2008). Reverse engineering: the architecture of biological networks. Biotechniques 44, 323-329.
53. Kim, J., Wu, H.H., Lander, A.D., Lyons, K.M., Matzuk, M.M., and Calof, A.L. (2005). GDF11 controls the timing of progenitor cell competence in developing retina. Science 308, 1927-1930. (Pubitemid 40941879)
54. Kirouac, D.C., Madlambayan, G.J., Yu, M., Sykes, E.A., Ito, C., and Zandstra, P.W. (2009). Cell-cell interaction networks regulate blood stem and progenitor cell fate. Mol. Syst. Biol. 5, 293.
55. Koch, A.J., and Meinhardt, H. (1994). Biological pattern formation: from basic mechanisms to complex structures. Rev. Mod. Phys. 66, 1481-1510.
56. Kondo, S., and Miura, T. (2010). Reaction-diffusion model as a framework for understanding biological pattern formation. Science 329, 1616-1620.
57. Kreuger, J., Perez, L., Giraldez, A.J., and Cohen, S.M. (2004). Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. Dev. Cell 7, 503-512. (Pubitemid 39341836)
58. Lacalli, T.C., Wilkinson, D.A., and Harrison, L.G. (1988). Theoretical aspects of stripe formation in relation to Drosophila segmentation. Development 104, 105-113.
59. Lander, A.D., Gokoffski, K.K., Wan, F.Y., Nie, Q., and Calof, A.L. (2009a). Cell lineages and the logic of proliferative control. PLoS Biol. 7, e15.
60. Lander, A.D., Lo, W.C., Nie, Q., and Wan, F.Y. (2009b). The measure of success: Constraints, objectives, and tradeoffs in morphogen-mediated patterning. Cold Spring Harb. Perspect. Biol. 1, a002022.
61. Lander, A.D., Nie, Q., Vargas, B., and Wan, F.Y.M. (2011). Size-normalized robustness of Dpp gradient in Drosophila wing imaginal disc. J. Mech. Mater. Struct., in press.
62. Lauffenburger, D.A., and Linderman, J.J. (1993). Receptors. Models for Binding, Trafficking and Signaling (New York: Oxford University Press).
63. Lek, M., Dias, J.M., Marklund, U., Uhde, C.W., Kurdija, S., Lei, Q., Sussel, L., Rubenstein, J.L., Matise, M.P., Arnold, H.H., et al. (2010). A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development 137, 4051-4060.
64. Lewis, J. (2003). Autoinhibition with transcriptional delay: A simple mechanism for the zebrafish somitogenesis oscillator. Curr. Biol. 13, 1398-1408.
65. Lo, W.C., Chou, C.S., Gokoffski, K.K., Wan, F.Y., Lander, A.D., Calof, A.L., and Nie, Q. (2009). Feedback regulation in multistage cell lineages. Math. Biosci. Eng. 6, 59-82.
66. Lucchetta, E.M., Vincent, M.E., and Ismagilov, R.F. (2008). A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm. PLoS ONE 3, e3651.
67. Mammoto, A., and Ingber, D.E. (2009). Cytoskeletal control of growth and cell fate switching. Curr. Opin. Cell Biol. 21, 864-870.
68. Manu, Surkova, S., Spirov, A.V., Gursky, V.V., Janssens, H., Kim, A.R., Radulescu, O., Vanario-Alonso, C.E., Sharp, D.H., Samsonova, M., et al. (2009a). Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors. PLoS Comput. Biol. 5, e1000303.
69. Manu, Surkova, S., Spirov, A.V., Gursky, V.V., Janssens, H., Kim, A.R., Radulescu, O., Vanario-Alonso, C.E., Sharp, D.H., Samsonova, M., et al. (2009b). Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation. PLoS Biol. 7, e1000049.
70. Marciniak-Czochra, A., Stiehl, T., Ho, A.D., Jager, W., and Wagner, W. (2009). Modeling of asymmetric cell division in hematopoietic stem cells-regulation of self-renewal is essential for efficient repopulation. Stem Cells Dev. 18, 377-385.
71. Martin-Castellanos, C., and Edgar, B.A. (2002). A characterization of the effects of Dpp signaling on cell growth and proliferation in the Drosophila wing. Development 129, 1003-1013. (Pubitemid 34874124)
72. Maves, L., and Kimmel, C.B. (2005). Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Dev. Biol. 285, 593-605.
73. McHale, P., Rappel, W.J., and Levine, H. (2006). Embryonic pattern scaling achieved by oppositely directed morphogen gradients. Phys. Biol. 3, 107-120.
74. Meinhardt, H., and Gierer, A. (2000). Pattern formation by local self-activation and lateral inhibition. Bioessays 22, 753-760. (Pubitemid 30613307)
75. Meir, E., von Dassow, G., Munro, E., and Odell, G.M. (2002). Robustness, flexibility, and the role of lateral inhibition in the neurogenic network. Curr. Biol. 12, 778-786.
76. Mii, Y., and Taira, M. (2009). Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range. Development 136, 4083-4088.
77. Moolten, F.L., and Bucher, N.L. (1967). Regeneration of rat liver: transfer of humoral agent by cross circulation. Science 158, 272-274.
78. Nahmad, M., and Stathopoulos, A. (2009). Dynamic interpretation of hedgehog signaling in the Drosophila wing disc. PLoS Biol. 7, e1000202.
79. Nakamura, T., Mine, N., Nakaguchi, E., Mochizuki, A., Yamamoto, M., Yashiro, K., Meno, C., and Hamada, H. (2006). Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system. Dev. Cell 11, 495-504. (Pubitemid 44467724)
80. Nienhaus, U., Aegerter-Wilmsen, T., and Aegerter, C.M. (2009). Determination of mechanical stress distribution in Drosophila wing discs using photoelasticity. Mech. Dev. 126, 942-949.
81. Nijhout, H.F., and Grunert, L.W. (2010). The cellular and physiological mechanism of wing-body scaling in Manduca sexta. Science 330, 1693-1695.
82. Nowakowski, R.S., Caviness, V.S., Jr., Takahashi, T., and Hayes, N.L. (2002). Population dynamics during cell proliferation and neuronogenesis in the developing murine neocortex. Results Probl. Cell Differ. 39, 1-25.
83. Ochoa-Espinosa, A., Yu, D., Tsirigos, A., Struffi, P., and Small, S. (2009). Anterior-posterior positional information in the absence of a strong Bicoid gradient. Proc. Natl. Acad. Sci. USA 106, 3823-3828.
84. Okabe-Oho, Y., Murakami, H., Oho, S., and Sasai, M. (2009). Stable, precise, and reproducible patterning of bicoid and hunchback molecules in the early Drosophila embryo. PLoS Comput. Biol. 5, e1000486.
85. Othmer, H.G., and Pate, E. (1980). Scale-invariance in reaction-diffusion models of spatial pattern formation. Proc. Natl. Acad. Sci. USA 77, 4180-4184.
86. Pan, D. (2007). Hippo signaling in organ size control. Genes Dev. 21, 886-897.
87. Papatsenko, D. (2009). Stripe formation in the early fly embryo: principles, models, and networks. Bioessays 31, 1172-1180.
88. Paulsson, J., Berg, O.G., and Ehrenberg, M. (2000). Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. Proc. Natl. Acad. Sci. USA 97, 7148-7153.
89. Piddini, E., and Vincent, J.P. (2009). Interpretation of the wingless gradient requires signaling-induced self-inhibition. Cell 136, 296-307.
90. Raj, A., Peskin, C.S., Tranchina, D., Vargas, D.Y., and Tyagi, S. (2006). Stochastic mRNA synthesis in mammalian cells. PLoS Biol. 4, e309.
91. Reddy, B.V., and Irvine, K.D. (2008). The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation. Development 135, 2827-2838.
92. Ren, F., Wang, B., Yue, T., Yun, E.Y., Ip, Y.T., and Jiang, J. (2010). Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc. Natl. Acad. Sci. USA 107, 21064-21069.
93. Reversade, B., and De Robertis, E.M. (2005). Regulation of ADMP and BMP2/4/7 at opposite embryonic poles generates a self-regulating morphogenetic field. Cell 123, 1147-1160. (Pubitemid 41785427)
94. Rodriguez, I., Baena-Lopez, L.A., and Baonza, A. (2008). Upregulation of glypicans in Hippo mutants alters the coordinated activity of morphogens. Fly (Austin) 2, 320-322.
95. Rogulja, D., Rauskolb, C., and Irvine, K.D. (2008). Morphogen control of wing growth through the Fat signaling pathway. Dev. Cell 15, 309-321.
96. Sahlin, P., Melke, P., and Jonsson, H. (2011). Models of sequestration and receptor cross-talk for explaining multiple mutants in plant stem cell regulation. BMC Syst. Biol. 5, 2.
97. Sauro, H.M., and Kholodenko, B.N. (2004). Quantitative analysis of signaling networks. Prog. Biophys. Mol. Biol. 86, 5-43.
98. Schwank, G., and Basler, K. (2010). Regulation of organ growth by morphogen gradients. Cold Spring Harb. Perspect. Biol. 2, a001669.
99. Schwank, G., Tauriello, G., Yagi, R., Kranz, E., Koumoutsakos, P., and Basler, K. (2011). Antagonistic growth regulation by dpp and fat drives uniform cell proliferation. Dev. Cell 20, 123-130.
100. Selleck, S.B. (1999). Overgrowth syndromes and the regulation of signaling complexes by proteoglycans. Am. J. Hum. Genet. 64, 372-377.
101. Shraiman, B.I. (2005). Mechanical feedback as a possible regulator of tissue growth. Proc. Natl. Acad. Sci. USA 102, 3318-3323.
102. Shvartsman, S.Y., Wiley, H.S., Deen, W.M., and Lauffenburger, D.A. (2001). Spatial range of autocrine signaling: modeling and computational analysis. Biophys. J. 81, 1854-1867.
103. Snippert, H.J., van der Flier, L.G., Sato, T., van Es, J.H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A.M., van Rheenen, J., Simons, B.D., et al. (2010). Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134-144.
104. Staley, B.K., and Irvine, K.D. (2010). Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation. Curr. Biol. 20, 1580-1587.
105. Sun, G., and Irvine, K.D. (2011). Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev. Biol. 350, 139-151.
106. Takeo, S., Akiyama, T., Firkus, C., Aigaki, T., and Nakato, H. (2005). Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev. Biol. 284, 204-218.
107. Teleman, A.A., and Cohen, S.M. (2000). Dpp gradient formation in the Drosophila wing imaginal disc. Cell 103, 971-980.
108. Turing, A.M. (1952). The chemical basis of morphogenesis. Philos. Trans. R. Soc. Lond., B 237, 37-72.
109. Umulis, D., O'Connor, M.B., and Othmer, H.G. (2008). Robustness of embryonic spatial patterning in Drosophila melanogaster. Curr. Top. Dev. Biol. 81, 65-111.
110. Umulis, D.M., Serpe, M., O'Connor, M.B., and Othmer, H.G. (2006). Robust, bistable patterning of the dorsal surface of the Drosophila embryo. Proc. Natl. Acad. Sci. USA 103, 11613-11618.
111. von Dassow, G., Meir, E., Munro, E.M., and Odell, G.M. (2000). The segment polarity network is a robust developmental module. Nature 406, 188-192. (Pubitemid 30469001)
112. Vuilleumier, R., Springhorn, A., Patterson, L., Koidl, S., Hammerschmidt, M., Affolter, M., and Pyrowolakis, G. (2010). Control of Dpp morphogen signalling by a secreted feedback regulator. Nat. Cell Biol. 12, 611-617.
113. Wang, Y.-C., and Ferguson, E.L. (2005). Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning. Nature 434, 229-234. (Pubitemid 40388055)
114. Weiss, P. (1950). An Introduction to Genetic Neurology (Chicago: University of Chicago Press).
115. Williams, R.W. (2000). Mapping genes that modulate mouse brain development: A quantitative genetic approach. In Mouse Brain Development, A.M. Goffient and P. Rakic, eds. (New York: Springer Verlag), pp. 21-49.
116. Wolpert, L. (1969). Positional information and the spatial pattern of cellular differentiation. J. Theor. Biol. 25, 1-47.
117. Wolpert, L. (2009). Diffusible gradients are out - an interview with Lewis Wolpert. Interviewed by Richardson, Michael K. Int. J. Dev. Biol. 53, 659-662.
118. Wolpert, L. (2010). Arms and the man: the problem of symmetric growth. PLoS Biol. 8, e1000477.
119. Wolpert, L. (2011). Positional information and patterning revisited. J. Theor. Biol. 269, 359-365.
120. Wu, H.H., Ivkovic, S., Murray, R.C., Jaramillo, S., Lyons, K.M., Johnson, J.E., and Calof, A.L. (2003). Autoregulation of neurogenesis by GDF11. Neuron 37, 197-207. (Pubitemid 36143816)
121. Yamaguchi, M., Yoshimoto, E., and Kondo, S. (2007). Pattern regulation in the stripe of zebrafish suggests an underlying dynamic and autonomous mechanism. Proc. Natl. Acad. Sci. USA 104, 4790-4793.
122. Yan, S.J., Zartman, J.J., Zhang, M., Scott, A., Shvartsman, S.Y., and Li, W.X. (2009). Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation. Mol. Syst. Biol. 5, 278.
123. Yi, T.M., Huang, Y., Simon, M.I., and Doyle, J. (2000). Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc. Natl. Acad. Sci. USA 97, 4649-4653.
124. Zecca, M., and Struhl, G. (2007). Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation. Development 134, 3001-3010. (Pubitemid 47386911)
125. Zecca, M., and Struhl, G. (2010). A feed-forward circuit linking wingless, fatdachsous signaling, and the warts-hippo pathway to Drosophila wing growth. PLoS Biol. 8, e1000386.
126. Zecca, M., Basler, K., and Struhl, G. (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 121, 2265-2278.
127. Zhao, B., Wei, X., Li, W., Udan, R.S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007). Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21, 2747-2761. (Pubitemid 350070721)
128. Zhu, H. (2011). Spatiotemporally modulated Vestigial gradient by Wingless signaling adaptively regulates cell division for precise wing size control. J. Theor. Biol. 268, 131-140.