메뉴 건너뛰기




Volumn 124, Issue 2, 2014, Pages 180-191

Downregulation of CYP3A and P-glycoprotein in the secondary inflammatory response of mice with dextran sulfate sodium-induced colitis and its contribution to cyclosporine a blood concentrations

Author keywords

Cyclosporine A; Cytochrome P450 3A; Dextran sulfate sodium; Experimental colitis model; P glycoprotein

Indexed keywords

CELL NUCLEUS RECEPTOR; CYCLOSPORIN A; CYTOCHROME P450 3A; DEXTRAN; INDUCIBLE NITRIC OXIDE SYNTHASE; MULTIDRUG RESISTANCE PROTEIN; MYELOPEROXIDASE; PREGNANE X RECEPTOR;

EID: 84895543072     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13141FP     Document Type: Article
Times cited : (29)

References (46)
  • 1
    • 16444377083 scopus 로고    scopus 로고
    • Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs
    • Zhou S, Chan SY, Goh BC, Chan E, Duan W, Huang M, et al. Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet. 2005;44: 279-304.
    • (2005) Clin Pharmacokinet , vol.44 , pp. 279-304
    • Zhou, S.1    Chan, S.Y.2    Goh, B.C.3    Chan, E.4    Duan, W.5    Huang, M.6
  • 3
    • 33748539303 scopus 로고    scopus 로고
    • Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice
    • Jin M, Shimada T, Yokogawa K, Nomura M, Ishizaki J, Piao Y, et al. Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice. Biochem Pharmacol. 2006;72: 1042-1050.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1042-1050
    • Jin, M.1    Shimada, T.2    Yokogawa, K.3    Nomura, M.4    Ishizaki, J.5    Piao, Y.6
  • 5
    • 0031837161 scopus 로고    scopus 로고
    • Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted
    • Smit JW, Schinkel AH, Weert B, Meijer DK. Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted. Br J Pharmacol. 1998;124: 416-424.
    • (1998) Br J Pharmacol , vol.124 , pp. 416-424
    • Smit, J.W.1    Schinkel, A.H.2    Weert, B.3    Meijer, D.K.4
  • 6
    • 9444267085 scopus 로고    scopus 로고
    • Functional interaction of intestinal CYP3A4 and P-glycoprotein
    • Kivistö KT, Niemi M, Fromm MF. Functional interaction of intestinal CYP3A4 and P-glycoprotein. Fundam Clin Pharmacol. 2004;18: 621-626.
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 621-626
    • Kivistö, K.T.1    Niemi, M.2    Fromm, M.F.3
  • 7
    • 31144450001 scopus 로고    scopus 로고
    • Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone
    • Jin M, Shimada T, Yokogawa K, Nomura M, Kato Y, Tsuji A, et al. Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone. Int J Pharm. 2006;309: 81-86.
    • (2006) Int J Pharm , vol.309 , pp. 81-86
    • Jin, M.1    Shimada, T.2    Yokogawa, K.3    Nomura, M.4    Kato, Y.5    Tsuji, A.6
  • 8
    • 71549157438 scopus 로고    scopus 로고
    • Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity
    • van Waterschoot RA, Lagas JS, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Song JY, et al. Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity. Cancer Res. 2009;69: 8996-9002.
    • (2009) Cancer Res , vol.69 , pp. 8996-9002
    • Van Waterschoot, R.A.1    Lagas, J.S.2    Wagenaar, E.3    Van Der Kruijssen, C.M.4    Van Herwaarden, A.E.5    Song, J.Y.6
  • 9
    • 1842536819 scopus 로고    scopus 로고
    • Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis
    • Masubuchi Y, Horie T. Endotoxin-mediated disturbance of hepatic cytochrome P450 function and development of endotoxin tolerance in the rat model of dextran sulfate sodium-induced experimental colitis. Drug Metab Dispos. 2004;32: 437-441.
    • (2004) Drug Metab Dispos , vol.32 , pp. 437-441
    • Masubuchi, Y.1    Horie, T.2
  • 10
    • 58249125116 scopus 로고    scopus 로고
    • TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease
    • Chaluvadi MR, Nyagode BA, Kinloch RD, Morgan ET. TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease. Biochem Pharmacol. 2009;77: 464-471.
    • (2009) Biochem Pharmacol , vol.77 , pp. 464-471
    • Chaluvadi, M.R.1    Nyagode, B.A.2    Kinloch, R.D.3    Morgan, E.T.4
  • 11
    • 0024209382 scopus 로고
    • Disposition of a flow-limited drug (lidocaine) and a metabolic capacity-limited drug (theophylline) in liver cirrhosis
    • Colli A, Buccino G, Cocciolo M, Parravicini R, Scaltrini G. Disposition of a flow-limited drug (lidocaine) and a metabolic capacity-limited drug (theophylline) in liver cirrhosis. Clin Pharmacol Ther. 1988;44: 642-649.
    • (1988) Clin Pharmacol Ther , vol.44 , pp. 642-649
    • Colli, A.1    Buccino, G.2    Cocciolo, M.3    Parravicini, R.4    Scaltrini, G.5
  • 12
    • 0031750862 scopus 로고    scopus 로고
    • Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation
    • Piquette-Miller M, Pak A, Kim H, Anari R, Shahzamani A. Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation. Pharm Res. 1998;15: 706-711.
    • (1998) Pharm Res , vol.15 , pp. 706-711
    • Piquette-Miller, M.1    Pak, A.2    Kim, H.3    Anari, R.4    Shahzamani, A.5
  • 14
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002;347: 417-429.
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 16
    • 0028128047 scopus 로고
    • Liver disease in ulcerative colitis: An epidemiological and follow up study in the county of Stockholm
    • Broomé U, Glaumann H, Hellers G, Nilsson B, Sörstad J, Hultcrantz R. Liver disease in ulcerative colitis: an epidemiological and follow up study in the county of Stockholm. Gut. 1994;35: 84-89.
    • (1994) Gut , vol.35 , pp. 84-89
    • Broomé, U.1    Glaumann, H.2    Hellers, G.3    Nilsson, B.4    Sörstad, J.5    Hultcrantz, R.6
  • 17
    • 0033305621 scopus 로고    scopus 로고
    • Hepatobiliary manifestations of inflammatory bowel disease
    • Memon MI, Memon B, Memon MA. Hepatobiliary manifestations of inflammatory bowel disease. HPB Surg. 2000;11: 363-371.
    • (2000) HPB Surg , vol.11 , pp. 363-371
    • Memon, M.I.1    Memon, B.2    Memon, M.A.3
  • 18
    • 0027224059 scopus 로고
    • Clinicopathologic study of dextran sulfate sodium experimental murine colitis
    • Cooper HS, Murthy SN, Shah RS, Sedergran DJ. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69: 238-249.
    • (1993) Lab Invest , vol.69 , pp. 238-249
    • Cooper, H.S.1    Murthy, S.N.2    Shah, R.S.3    Sedergran, D.J.4
  • 19
    • 33144485558 scopus 로고    scopus 로고
    • Role of interleukin 15 in colitis induced by dextran sulfate sodium in mice
    • Yoshihara K, Yajima T, Kubo C, Yoshikai Y. Role of interleukin 15 in colitis induced by dextran sulfate sodium in mice. Gut. 2006;55: 334-341.
    • (2006) Gut , vol.55 , pp. 334-341
    • Yoshihara, K.1    Yajima, T.2    Kubo, C.3    Yoshikai, Y.4
  • 21
    • 34547843601 scopus 로고    scopus 로고
    • Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats
    • Okayama M, Hayashi S, Aoi Y, Nishio H, Kato S, Takeuchi K. Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. Dig Dis Sci. 2007;52: 2095-2103.
    • (2007) Dig Dis Sci , vol.52 , pp. 2095-2103
    • Okayama, M.1    Hayashi, S.2    Aoi, Y.3    Nishio, H.4    Kato, S.5    Takeuchi, K.6
  • 22
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 23
    • 20344386201 scopus 로고    scopus 로고
    • Intestinal inflammation induces adaptation of P-glycoprotein expression and activity
    • Buyse M, Radeva G, Bado A, Farinotti R. Intestinal inflammation induces adaptation of P-glycoprotein expression and activity. Biochem Pharmacol. 2005;69: 1745-1754.
    • (2005) Biochem Pharmacol , vol.69 , pp. 1745-1754
    • Buyse, M.1    Radeva, G.2    Bado, A.3    Farinotti, R.4
  • 25
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 1990;98: 694-702.
    • (1990) Gastroenterology , vol.98 , pp. 694-702
    • Okayasu, I.1    Hatakeyama, S.2    Yamada, M.3    Ohkusa, T.4    Inagaki, Y.5    Nakaya, R.6
  • 26
    • 0032798911 scopus 로고    scopus 로고
    • Dextran sulfate sodium (DSS) colitis in rats: Clinical, structural, and ultrastructural aspects
    • Gaudio E, Taddei G, Vetuschi A, Sferra R, Frieri G, Ricciardi G, et al. Dextran sulfate sodium (DSS) colitis in rats: clinical, structural, and ultrastructural aspects. Dig Dis Sci. 1999;44: 1458-1475.
    • (1999) Dig Dis Sci , vol.44 , pp. 1458-1475
    • Gaudio, E.1    Taddei, G.2    Vetuschi, A.3    Sferra, R.4    Frieri, G.5    Ricciardi, G.6
  • 27
    • 30844462367 scopus 로고    scopus 로고
    • NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats
    • Reed KL, Fruin AB, Gower AC, Gonzales KD, Stucchi AF, Andry CD, et al. NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci. 2005;50: 2366-2378.
    • (2005) Dig Dis Sci , vol.50 , pp. 2366-2378
    • Reed, K.L.1    Fruin, A.B.2    Gower, A.C.3    Gonzales, K.D.4    Stucchi, A.F.5    Andry, C.D.6
  • 28
    • 66149137296 scopus 로고    scopus 로고
    • Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis
    • Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, Conklin LS, et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 2009;15: 341-352.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 341-352
    • Alex, P.1    Zachos, N.C.2    Nguyen, T.3    Gonzales, L.4    Chen, T.E.5    Conklin, L.S.6
  • 29
    • 0033768784 scopus 로고    scopus 로고
    • Characterisation of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency
    • Egger B, Bajaj-Elliott M, MacDonald TT, Inglin R, Eysselein VE, Büchler MW. Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency. Digestion. 2000;62: 240-248.
    • (2000) Digestion , vol.62 , pp. 240-248
    • Egger, B.1    Bajaj-Elliott, M.2    Macdonald, T.T.3    Inglin, R.4    Eysselein, V.E.5    Büchler, M.W.6
  • 30
    • 0000245759 scopus 로고
    • Portal bacteraemia in ulcerative colitis
    • Brooke BN, Slaney G. Portal bacteraemia in ulcerative colitis. Lancet. 1958;1: 1206-1207.
    • (1958) Lancet , vol.1 , pp. 1206-1207
    • Brooke, B.N.1    Slaney, G.2
  • 31
    • 0014682099 scopus 로고
    • Portal bacteraemia in cases of ulcerative colitis submitted to colectomy
    • Eade MN, Brook BN. Portal bacteraemia in cases of ulcerative colitis submitted to colectomy. Lancet. 1969;1: 1008-1009.
    • (1969) Lancet , vol.1 , pp. 1008-1009
    • Eade, M.N.1    Brook, B.N.2
  • 32
    • 40849134144 scopus 로고    scopus 로고
    • Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis
    • Masubuchi Y, Enoki K, Horie T. Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis. Drug Metab Dispos. 2008;36: 597-603.
    • (2008) Drug Metab Dispos , vol.36 , pp. 597-603
    • Masubuchi, Y.1    Enoki, K.2    Horie, T.3
  • 34
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003;83: 633-671.
    • (2003) Physiol Rev , vol.83 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 36
    • 33645839049 scopus 로고    scopus 로고
    • Coordinated induction of bile acid detoxification and alternative elimination in mice: Role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids
    • Zollner G, Wagner M, Moustafa T, Fickert P, Silbert D, Gumhold J, et al. Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids. Am J Physiol Gastrointest Liver Physiol. 2006;290:G923-G932.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Zollner, G.1    Wagner, M.2    Moustafa, T.3    Fickert, P.4    Silbert, D.5    Gumhold, J.6
  • 37
    • 0035115303 scopus 로고    scopus 로고
    • Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice
    • Hartmann G, Kim H, Piquette-Miller M. Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice. Int Immunopharmacol. 2001;1: 189-199.
    • (2001) Int Immunopharmacol , vol.1 , pp. 189-199
    • Hartmann, G.1    Kim, H.2    Piquette-Miller, M.3
  • 38
    • 0036786429 scopus 로고    scopus 로고
    • Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia
    • Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002;303: 273-281.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 273-281
    • Hartmann, G.1    Cheung, A.K.2    Piquette-Miller, M.3
  • 40
    • 34250758597 scopus 로고    scopus 로고
    • Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways
    • Cerveny L, Svecova L, Anzenbacherova E, Vrzal R, Staud F, Dvorak Z, et al. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos. 2007;35: 1032-1041.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1032-1041
    • Cerveny, L.1    Svecova, L.2    Anzenbacherova, E.3    Vrzal, R.4    Staud, F.5    Dvorak, Z.6
  • 41
    • 77949911622 scopus 로고    scopus 로고
    • Activation of xenobiotic receptors: Driving into the nucleus
    • Li H, Wang H. Activation of xenobiotic receptors: driving into the nucleus. Expert Opin Drug Metab Toxicol. 2010;6: 409-426.
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , pp. 409-426
    • Li, H.1    Wang, H.2
  • 42
    • 1642579697 scopus 로고    scopus 로고
    • Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats
    • Kalitsky-Szirtes J, Shayeganpour A, Brocks DR, Piquette-Miller M. Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats. Drug Metab Dispos. 2004;32: 20-27.
    • (2004) Drug Metab Dispos , vol.32 , pp. 20-27
    • Kalitsky-Szirtes, J.1    Shayeganpour, A.2    Brocks, D.R.3    Piquette-Miller, M.4
  • 43
    • 33745805833 scopus 로고    scopus 로고
    • Role of NF-kappaB in regulation of PXR-mediated gene expression: A mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents
    • Gu X, Ke S, Liu D, Sheng T, Thomas PE, Rabson AB, et al. Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents. J Biol Chem. 2006;281: 17882-17889.
    • (2006) J Biol Chem , vol.281 , pp. 17882-17889
    • Gu, X.1    Ke, S.2    Liu, D.3    Sheng, T.4    Thomas, P.E.5    Rabson, A.B.6
  • 44
    • 38149062111 scopus 로고    scopus 로고
    • Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins
    • Lee CM, Kim BY, Li L, Morgan ET. Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins. J Biol Chem. 2008;283: 889-898.
    • (2008) J Biol Chem , vol.283 , pp. 889-898
    • Lee, C.M.1    Kim, B.Y.2    Li, L.3    Morgan, E.T.4
  • 45
    • 84869122030 scopus 로고    scopus 로고
    • Involvement of ubiquitination in the decrease of intestinal P-glycoprotein in a streptozotocin-induced diabetic mouse model
    • Nawa A, Fujita-Hamabe W, Tokuyama S. Involvement of ubiquitination in the decrease of intestinal P-glycoprotein in a streptozotocin-induced diabetic mouse model. Drug Metab Pharmacokinet. 2012;27: 548-552.
    • (2012) Drug Metab Pharmacokinet , vol.27 , pp. 548-552
    • Nawa, A.1    Fujita-Hamabe, W.2    Tokuyama, S.3
  • 46
    • 12644272784 scopus 로고    scopus 로고
    • Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine
    • Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, et al. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther. 1997;62: 248-260.
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 248-260
    • Lown, K.S.1    Mayo, R.R.2    Leichtman, A.B.3    Hsiao, H.L.4    Turgeon, D.K.5    Schmiedlin-Ren, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.