Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone

International Journal of Pharmaceutics

Volumn 309, Issue 1-2, 2006, Pages 81-86

  Jin, Mingji ^a   Shimada, Tsutomu ^a   Yokogawa, Koichi ^a   Nomura, Masaaki ^a   Kato, Yukio ^a   Tsuji, Akira ^a   Miyamoto, Ken Ichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Bioavailability; Cyclosporin A; CYP3A; Dexamethasone; mdr1a 1b knockout mice; P glycoprotein

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450 3A; DEXAMETHASONE; GLYCOPROTEIN P;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; DUODENUM; ILEUM; INTESTINE; JEJUNUM; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

ADMINISTRATION, ORAL; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL AVAILABILITY; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; INTESTINE, SMALL; LIVER; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEINS; RNA, MESSENGER;

EID: 31144450001     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.11.015     Document Type: Article

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