Dextran sulfate sodium (DSS) colitis in rats: Clinical, structural, and ultrastructural aspects

Digestive Diseases and Sciences

Volumn 44, Issue 7, 1999, Pages 1458-1475

  Gaudio, Eugenio ^a,b,c   Taddei, Gennaro ^a,b   Vetuschi, Antonella ^a,b   Sferra, Roberta ^a,b   Frieri, Giuseppe ^a,b   Ricciardi, Giuseppe ^a,b   Caprilli, Renzo ^a,b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Dextrane sulfate sodium; Rat model; Structure; Ulcerative colitis; Ultrastructure

Indexed keywords

DEXTRAN SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; COLITIS; COLON MUCOSA; CONTROLLED STUDY; CYTOARCHITECTURE; DESCENDING COLON; DIARRHEA; FECES ANALYSIS; GOBLET CELL; IMMUNOHISTOCHEMISTRY; INTESTINE CRYPT; MALE; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SUBMUCOSA; ULTRASTRUCTURE; WEIGHT GAIN;

ANIMALS; COLITIS; COLITIS, ULCERATIVE; CROHN DISEASE; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; HUMANS; INTESTINAL MUCOSA; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROVILLI; RATS;

EID: 0032798911     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026620322859     Document Type: Article

References (35)

1. 1. Duerr RH: Genetics of inflammatory bowel disease. Inflam Bowel Dis 2:48-60, 1996
2. 2. Sartor RB: Cytokines in intestinal inflammation: Pathophysiological and clinical considerations. Gastroenterology 106:533-539, 1994
3. 3. Jarnerot G: Dietary factors in inflammatory bowel disease. In Inflammatory Bowel Disease. G Jarnerot (ed). Malmo, Corona Astra, 1992, pp 37-47
4. 4. Sartor B: Microbial agents in the pathogenesis, differential diagnosis, and complications of inflammatory bowel disease. In Infections of the Gastrointestinal Tract. MJ Blaser, PD Smith, JI Ravdin, HB Greenberg, RI. Guerrant (eds). New York, Raven Press, 1995, pp 435-458
5. 5. Strober W: Animal models in inflammatory bowel disease - an overview. Dig Dis Sci 12:35, 1985
6. 6. Elson CO, Sartor RB, Tennyson GS, Riddel RH: Experimental models of inflammatory bowel disease. Gastroenterology 109:1344-1367, 1995
7. 7. Dieleman LA, Pena AS, Meuwissen SGM, Van Rees EP: Role of animal models for the pathogenesis and treatment of inflammatory bowel disease. Scand J Gastroenterol 32(suppl 223):66-104, 1997
8. 8. Familiari G, Familiari A, Machiarelli G, Didio LJA, Motta PM: The use of sonic frequencies as a cleaning agent of specimens to be observed by scanning electron microscopy. Scan Microsc 7:107-114, 1993
9. 9. Gibson PR, Anderson RP, Mariadason JM, Wilson AJ: Protective role of the epithelium of the mall intestine and colon. Inflam Bowel Dis 2:279-302, 1996
10. 10. Okayasu I, Hatakeyama S, Yamada M, Okhusa T, Inagaki Y, Nakaya R: A novel method of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694-702, 1990
11. 11. Cooper HS, Murthy SN, Shah RS, Sedergran DJ: Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69:238-249, 1993
12. 12. Dieleman LA, Ridwan BU, Tennyson GS, Beagley KW, Busy RP, Elson CO: Dextran sodium sulfate (DSS) induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107:1643-1652, 1994
13. 13. Roediger WEW, Duncan A, Kapanaris O, Millard S: Sulphide impairment of substrate oxydation in rat colonocytes: A biochemical basis of ulcerative colitis? Clin Sci 85:623-627, 1993
14. 14. Roediger WEW, Moore J, Babidge W: Colonic sulfide in pathogenesis and treatment of ulcerative colitis. Dig Dis Sci 42:1571-1579, 1997
15. 15. Collins SM, Van Assche G, Hageboam C: Alterations in enteric nerve and smooth muscle function in inflammatory bowel disease. Inflam Bowel Dis 3:38-48, 1997
16. 16. Collins SM: The immunomodulation of enteric neuromuscular function: Implications for motility and inflammatory disorders. Gastroenterology 111:1683-1699, 1996
17. 17. Fedorak RN: Naturally occurring and experimental models of inflammatory bowel disease. In Inflammatory Bowel Disease. JB Kirshner, RG Shorter (eds). Baltimore, Williams and Wilkins, 1995, pp 71-94
18. 18. Okhusa T: Production of experimental colitis in hamsters by dextran sulfate sodium and change in intestinal microflora. Gastroenterol Jpn 82:1327-1336, 1985 (in Japanese, abstract in English)
19. 19. Iwanaga T, Hoshi O, Han H, Fujita T: Morphological analysis of acute ulcerative colitis experimentally induced by dextran sulfate sodium in the guinea pig: Some possible mechanisms of cecal ulcerations. Gastroenterol Jpn 29:430-438, 1994 (in Japanese, abstract in English)
20. 20. Kishimoto S, Kobayashi H, Shimizu S, Haruma K, Tamaru T, Kijiyama G, Myoshi A: Changes of colonic vasoactive intestinal peptide and cholinergic activity in rats with chemical colitis. Dig Dis Sci 37:1729-1737, 1992
21. 21. Tamaru T, Kobayashi H, Kishimoto S, Kajiyama G, Shimamoto F, Brown WR: Histochemical study of colonic cancer in experimental colitis in rats. Dig Dis Sci 38:529-537, 1993
22. 22. Bjorck S, Jennische E, Dahlstrom A, Ahlman H: Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats. Dig Dis Sci 42:824-832, 1997
23. 23. Kimura I, Kamiya A, Nagahama S, Yoshida J, Tanigawa H, Kataoka H: Study on the experimental ulcerative colitis model induced by the alcian-blue staining method. Nippon Yakurigaku Zasshi 102:343-350, 1993 (in Japanese, abstract in English)
24. 24. Kimura I, Nagahama S, Kawasaki M, Kamiya A, Kataoka M: Study on the experimental ulcerative colitis (UC) model induced by dextran sulfate sodium (DSS) in rats. Nippon Yakurigaku Zasshi 105:145-152, 1995 (in Japanese, abstract in English)
25. 25. Jewel DP: Ulcerative colitis. In Gastrointestinal Diseases, MH Sleisenger, JS Fordtran (eds). Philadelphia, WB Saunders, 1993, pp 1305-1330
26. 26. Goldman H: Ulcerative colitis and Crohn's colitis. In Pathology of the Gastrointestinal Tract, SC Ming, H Goldman (eds). Philadelphia, WB Saunders, 1992, pp 643-688
27. 27. Shields HH, Bates ML, Goldman H, Zuckerman GR, Mills BA, Best CJ, Bair FA, Goran DA, De Schryver-Kecskemeti K: Scanning electron microscopic appearance of chronic ulcerative colitis with and without dysplasia. Gastroenterology 89:62-72, 1985
28. 28. Myllaremi H, Nickels J: Scanning electron microscopy of Crohn's disease and ulcerative colitis of the colon. Virchows Arch Pathol Anat 385:343-350, 1980
29. 29. Trabucchi E, Mukenge S, Baratti C, Colombo R, Fregoni F, Montorsi W. Differential diagnosis of Crohn's disease of the colon from ulcerative colitis: Ultrastructure study with the scanning electron microscope. Int J Tissue React 8:79-84, 1986
30. 30. Trabucchi E, Pace M, Micheletto G, Abelli P, Radaelli E, Foschi D: Colite ulcerosa: Aspetti ultrastrutturali e di diagnostica differenziale. Minerv Chir 47:461-467, 1992
31. 31. Marin ML, Geller SA, Greenstein AJ, Marin RH, Gordon RE, Aufses AH Jr: Ultrastructural pathology of Crohn's disease: Correlated transmission electron microscopy, scanning electron microscopy, and freeze fracture studies. Gastroenterology 78:355-364, 1983
32. 32. Stanisz A, Collins SM: Increased levels of substance P in myenteric plexus in Trichinella-infected rats. Gastroenterology 102:1913-1919, 1992
33. 33. Miller MJS, Sodowska-Krowicka H, Jena AY, Chotinarnemal S, Wong M, Clark DA, Ho W, Sharkey KA: Substance P levels in experimental ileitis in guinea pigs: effects of misoprostol. Am J Physiol 265:G321-G330, 1993
34. 34. Reinshagen M, Egger B, Procaccino F, Eysselein VE: Neuropeptides in inflammatory bowel disease: An update. JBD 3:303-317, 1997
35. 35. Holzer P, Holzer-Petsche U: Tachykinins in the gut. Part II, Roles in neural excitation, secretion and inflammation. Pharmacol Ther 73:219-263, 1997