Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Xu, Qiong ^a   Xia, Pu ^a   Li, Xi ^b   Wang, Wei ^a   Liu, Zhenqi ^c   Gao, Xin ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROGENIC ACID; CROCIN; FERULIC ACID; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIRTUIN 1; TETRAMETHYLPYRAZINE; TRANSCRIPTION FACTOR NRF1;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOGENESIS; CHEMOLUMINESCENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR DYNAMICS; MORPHOLOGY; NONHUMAN; PROTEIN BINDING; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIOXIDANTS; AORTA; ELECTRON TRANSPORT COMPLEX III; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MEDICINE, CHINESE TRADITIONAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIAL TURNOVER; NITRIC OXIDE; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; UP-REGULATION; VASODILATION;

EID: 84895538240     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088243     Document Type: Article

References (41)

1. Xu J, Zou MH (2009) Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation 120: 1266-1286.
2. Versari D, Daghini E, Virdis A, Ghiadoni L, Taddei S (2009) Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care 32 Suppl 2: S314-321.
3. Ding H, Triggle CR (2010) Endothelial dysfunction in diabetes: multiple targets for treatment. Pflugers Arch 459: 977-994.
4. Thomas SR, Witting PK, Drummond GR (2008) Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 10: 1713-1765.
5. Forstermann U (2010) Nitric oxide and oxidative stress in vascular disease. Pflugers Arch 459: 923-939.
6. Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107: 1058-1070.
7. Victor VM, Apostolova N, Herance R, Hernandez-Mijares A, Rocha M (2009) Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy. Curr Med Chem 16: 4654-4667.
8. Fearon IM, Faux SP (2009) Oxidative stress and cardiovascular disease: novel tools give (free) radical insight. J Mol Cell Cardiol 47: 372-381.
9. Zoungas S, McGrath BP, Branley P, Kerr PG, Muske C, et al. (2006) Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial. J Am Coll Cardiol 47: 1108-1116.
10. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, et al. (2008) Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA 300: 2123-2133.
11. Lee IM, Cook NR, Gaziano JM, Gordon D, Ridker PM, et al. (2005) Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 294: 56-65. (Pubitemid 41002839)
12. Steinhubl SR (2008) Why have antioxidants failed in clinical trials? Am J Cardiol 101: 14D-19D.
13. Gori T, Münzel T (2011) Oxidative stress and endothelial dysfunction: Therapeutic implications. Ann Med.
14. Munzel T, Gori T, Bruno RM, Taddei S (2010) Is oxidative stress a therapeutic target in cardiovascular disease? Eur Heart J 31: 2741-2748.
15. Sheikh-Ali M, Chehade JM, Mooradian AD (2011) The antioxidant paradox in diabetes mellitus. Am J Ther 18: 266-278.
16. Xu Q, Zhang B, Li XM, Gao X (2012) Traditional Chinese medicine formula Qing Huo Yi Hao as superoxide anion scavenger in high glucose-treated endothelial cells. Acta Pharmacol Sin 33: 496-502.
17. Kang Y, Hu M, Zhu Y, Gao X, Wang MW (2009) Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells. Life Sci 84: 428-436.
18. Valle I, Alvarez-Barrientos A, Arza E, Lamas S, Monsalve M (2005) PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc Res 66: 562-573. (Pubitemid 40725768)
19. Orimo M, Minamino T, Miyauchi H, Tateno K, Okada S, et al. (2009) Protective role of SIRT1 in diabetic vascular dysfunction. Arterioscler Thromb Vasc Biol 29: 889-894.
20. Jaffe EA, Nachman RL, Becker CG, Minick CR (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52: 2745-2756.
21. Gao YJ, Lee RM (2001) Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production. Br J Pharmacol 134: 1639-1646. (Pubitemid 34038096)
22. de Moura RS, Lima JS (1983) Effect of disopyramide on isolated aortic ring of the rat. Br J Pharmacol 78: 449-451. (Pubitemid 13162986)
23. Kojima H, Urano Y, Kikuchi K, Higuchi T, Hirata Y, et al. (1999) Fluorescent Indicators for Imaging Nitric Oxide Production. Angew Chem Int Ed Engl 38: 3209-3212. (Pubitemid 29533899)
24. Wang H, Joseph JA (1999) Quantifying cellular oxidative stress by dichloro-fluorescein assay using microplate reader. Free Radic Biol Med 27: 612-616. (Pubitemid 29408648)
25. Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, et al. (2006) Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A 103: 15038-15043. (Pubitemid 44583160)
26. Gao X, Zhao XL, Zhu YH, Li XM, Xu Q, et al. (2011) Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes. Life Sci 88: 803-809.
27. Brownlee M (2005) The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54: 1615-1625.
28. Madamanchi NR, Runge MS (2007) Mitochondrial dysfunction in atherosclerosis. Circ Res 100: 460-473. (Pubitemid 46673256)
29. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, et al. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127: 397-408. (Pubitemid 44572377)
30. Austin S, Klimcakova E, St-Pierre J (2011) Impact of PGC-1alpha on the topology and rate of superoxide production by the mitochondrial electron transport chain. Free Radic Biol Med 51: 2243-2248.
31. Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, et al. (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285: 8340-8351.
32. Yu DQ, Li XM, Li X, Teng Y, Zhang JZ, et al. (2004) Effect and security of traditional Chinese medicine prescription on urine albumin excreting rate of type 2 diabetes. Shanghai Med J 27: 466-469.
33. Tsioufis C, Dimitriadis K, Antoniadis D, Stefanadis C, Kallikazaros I (2004) Inter-relationships of microalbuminuria with the other surrogates of the atherosclerotic cardiovascular disease in hypertensive subjects. Am J Hypertens 17: 470-476. (Pubitemid 38529972)
34. Schrauwen P, Hesselink MK (2004) Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 53: 1412-1417. (Pubitemid 38697650)
35. Srinivasan S, Hatley ME, Bolick DT, Palmer LA, Edelstein D, et al. (2004) Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells. Diabetologia 47: 1727-1734. (Pubitemid 40022408)
36. Scarpulla RC (2008) Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann N Y Acad Sci 1147: 321-334.
37. Chen SD, Yang DI, Lin TK, Shaw FZ, Liou CW, et al. (2011) Roles of Oxidative Stress, Apoptosis, PGC-1alpha and Mitochondrial Biogenesis in Cerebral Ischemia. Int J Mol Sci 12: 7199-7215.
38. Scarpulla RC (2011) Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 1813: 1269-1278.
39. Ren J, Pulakat L, Whaley-Connell A, Sowers JR (2010) Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med (Berl) 88: 993-1001.
40. Pillai VB, Sundaresan NR, Jeevanandam V, Gupta MP (2010) Mitochondrial SIRT3 and heart disease. Cardiovasc Res 88: 250-256.
41. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, et al. (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J 26: 1913-1923. (Pubitemid 46624046)