메뉴 건너뛰기




Volumn 15, Issue 3, 2014, Pages 3746-3767

Killing me softly-future challenges in apoptosis research

Author keywords

Apoptosis; Cancer therapy; Chronification; Combination therapy; Microenvironment

Indexed keywords

BORTEZOMIB; CYTARABINE; DAUNORUBICIN; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; HEAT SHOCK PROTEIN 70; LENALIDOMIDE; MELPHALAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOXANTRONE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; RAF PROTEIN; RITUXIMAB; TIPIFARNIB; TREOSULFAN; VINCRISTINE; TARGET OF RAPAMYCIN KINASE;

EID: 84895421055     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15033746     Document Type: Review
Times cited : (27)

References (110)
  • 1
    • 84874263775 scopus 로고    scopus 로고
    • Necroptosis: The release of damage-associated molecular patterns and its physiological relevance
    • Kaczmarek, A.; Vandenabeele, P.; Krysko, D.V. Necroptosis: The release of damage-associated molecular patterns and its physiological relevance. Immunity 2013, 38, 209-223.
    • (2013) Immunity , vol.38 , pp. 209-223
    • Kaczmarek, A.1    Vandenabeele, P.2    Krysko, D.V.3
  • 2
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • Levine, B.; Yuan, J. Autophagy in cell death: An innocent convict? J. Clin. Investig. 2005, 115, 2679-2688.
    • (2005) J. Clin. Investig. , vol.115 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 3
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516.
    • (2007) Toxicol. Pathol. , vol.35 , pp. 495-516
    • Elmore, S.1
  • 4
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J.F.; Wyllie, A.H.; Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 5
    • 84872475100 scopus 로고    scopus 로고
    • Programmed cell death and apoptosis-Where it came from and where it is going: From elie metchnikoff to the control of caspases
    • Maghsoudi, N.; Zakeri, Z.; Lockshin, R.A. Programmed cell death and apoptosis-Where it came from and where it is going: From elie metchnikoff to the control of caspases. Exp. Oncol. 2012, 34, 146-152.
    • (2012) Exp. Oncol. , vol.34 , pp. 146-152
    • Maghsoudi, N.1    Zakeri, Z.2    Lockshin, R.A.3
  • 6
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell 2000, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 9
    • 0015435638 scopus 로고
    • Radiation-resistant tumor cells may be more sensitive in vitro
    • Durand, R.E.; Sutherland, R.M. Radiation-resistant tumor cells may be more sensitive in vitro. Cancer Res. 1972, 32, 2587-2588.
    • (1972) Cancer Res. , vol.32 , pp. 2587-2588
    • Durand, R.E.1    Sutherland, R.M.2
  • 10
    • 0015419137 scopus 로고
    • Cell contact as a possible contribution to radiation resistance of some tumours
    • Sutherland, R.M.; Durand, R.E. Cell contact as a possible contribution to radiation resistance of some tumours. Br. J. Radiol. 1972, 45, 788-789.
    • (1972) Br. J. Radiol. , vol.45 , pp. 788-789
    • Sutherland, R.M.1    Durand, R.E.2
  • 11
    • 55949128465 scopus 로고    scopus 로고
    • Anoikis: A necessary death program for anchorage-dependent cells
    • Chiarugi, P.; Giannoni, E. Anoikis: A necessary death program for anchorage-dependent cells. Biochem. Pharmacol. 2008, 76, 1352-1364.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 1352-1364
    • Chiarugi, P.1    Giannoni, E.2
  • 12
    • 0034893416 scopus 로고    scopus 로고
    • Cell adhesion-mediated drug resistance (cam-dr) protects the k562 chronic myelogenous leukemia cell line from apoptosis induced by bcr/abl inhibition, cytotoxic drugs, and gamma-irradiation
    • Damiano, J.S.; Hazlehurst, L.A.; Dalton, W.S. Cell adhesion-mediated drug resistance (cam-dr) protects the k562 chronic myelogenous leukemia cell line from apoptosis induced by bcr/abl inhibition, cytotoxic drugs, and gamma-irradiation. Leukemia 2001, 15, 1232-1239.
    • (2001) Leukemia , vol.15 , pp. 1232-1239
    • Damiano, J.S.1    Hazlehurst, L.A.2    Dalton, W.S.3
  • 13
    • 4444282702 scopus 로고    scopus 로고
    • The hmg-coa reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of rho protein and activation of rho kinase
    • Schmidmaier, R.; Baumann, P.; Simsek, M.; Dayyani, F.; Emmerich, B.; Meinhardt, G. The hmg-coa reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of rho protein and activation of rho kinase. Blood 2004, 104, 1825-1832.
    • (2004) Blood , vol.104 , pp. 1825-1832
    • Schmidmaier, R.1    Baumann, P.2    Simsek, M.3    Dayyani, F.4    Emmerich, B.5    Meinhardt, G.6
  • 16
    • 39149106436 scopus 로고    scopus 로고
    • Combination therapy of an anticancer drug with the fniii14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia
    • Matsunaga, T.; Fukai, F.; Miura, S.; Nakane, Y.; Owaki, T.; Kodama, H.; Tanaka, M.; Nagaya, T.; Takimoto, R.; Takayama, T.; et al. Combination therapy of an anticancer drug with the fniii14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia. Leukemia 2008, 22, 353-360.
    • (2008) Leukemia , vol.22 , pp. 353-360
    • Matsunaga, T.1    Fukai, F.2    Miura, S.3    Nakane, Y.4    Owaki, T.5    Kodama, H.6    Tanaka, M.7    Nagaya, T.8    Takimoto, R.9    Takayama, T.10
  • 17
    • 47649111320 scopus 로고    scopus 로고
    • Hsp70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma
    • Nimmanapalli, R.; Gerbino, E.; Dalton, W.S.; Gandhi, V.; Alsina, M. Hsp70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma. Br. J. Haematol. 2008, 142, 551-561.
    • (2008) Br. J. Haematol. , vol.142 , pp. 551-561
    • Nimmanapalli, R.1    Gerbino, E.2    Dalton, W.S.3    Gandhi, V.4    Alsina, M.5
  • 18
    • 41349090416 scopus 로고    scopus 로고
    • The association of up-regulation of x-linked inhibitor of apoptosis protein with cell adhesion-mediated drug resistance in u937 cells
    • Wang, X.; Wang, C.; Qin, Y.W.; Yan, S.K.; Gao, Y.R. The association of up-regulation of x-linked inhibitor of apoptosis protein with cell adhesion-mediated drug resistance in u937 cells. Hematol. Oncol. 2008, 26, 21-26.
    • (2008) Hematol. Oncol. , vol.26 , pp. 21-26
    • Wang, X.1    Wang, C.2    Qin, Y.W.3    Yan, S.K.4    Gao, Y.R.5
  • 19
    • 58249120680 scopus 로고    scopus 로고
    • Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of vla-4 expression in multiple myeloma
    • Noborio-Hatano, K.; Kikuchi, J.; Takatoku, M.; Shimizu, R.; Wada, T.; Ueda, M.; Nobuyoshi, M.; Oh, I.; Sato, K.; Suzuki, T.; et al. Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of vla-4 expression in multiple myeloma. Oncogene 2009, 28, 231-242.
    • (2009) Oncogene , vol.28 , pp. 231-242
    • Noborio-Hatano, K.1    Kikuchi, J.2    Takatoku, M.3    Shimizu, R.4    Wada, T.5    Ueda, M.6    Nobuyoshi, M.7    Oh, I.8    Sato, K.9    Suzuki, T.10
  • 21
    • 80052570271 scopus 로고    scopus 로고
    • Bone marrow stromal cells protect lymphoma b-cells from rituximab-induced apoptosis and targeting integrin α-4-β-1 (vla-4) with natalizumab can overcome this resistance
    • Mraz, M.; Zent, C.S.; Church, A.K.; Jelinek, D.F.; Wu, X.; Pospisilova, S.; Ansell, S.M.; Novak, A.J.; Kay, N.E.; Witzig, T.E.; et al. Bone marrow stromal cells protect lymphoma b-cells from rituximab-induced apoptosis and targeting integrin α-4-β-1 (vla-4) with natalizumab can overcome this resistance. Br. J. Haematol. 2011, 155, 53-64.
    • (2011) Br. J. Haematol. , vol.155 , pp. 53-64
    • Mraz, M.1    Zent, C.S.2    Church, A.K.3    Jelinek, D.F.4    Wu, X.5    Pospisilova, S.6    Ansell, S.M.7    Novak, A.J.8    Kay, N.E.9    Witzig, T.E.10
  • 23
    • 0035885933 scopus 로고    scopus 로고
    • Reduction in drug-induced DNA double-strand breaks associated with β1 integrin-mediated adhesion correlates with drug resistance in u937 cells
    • Hazlehurst, L.A.; Valkov, N.; Wisner, L.; Storey, J.A.; Boulware, D.; Sullivan, D.M.; Dalton, W.S. Reduction in drug-induced DNA double-strand breaks associated with β1 integrin-mediated adhesion correlates with drug resistance in u937 cells. Blood 2001, 98, 1897-1903.
    • (2001) Blood , vol.98 , pp. 1897-1903
    • Hazlehurst, L.A.1    Valkov, N.2    Wisner, L.3    Storey, J.A.4    Boulware, D.5    Sullivan, D.M.6    Dalton, W.S.7
  • 24
    • 84862817427 scopus 로고    scopus 로고
    • Oroxylin a reverses cam-dr of hepg2 cells by suppressing integrinβ1 and its related pathway
    • Zhu, B.; Zhao, L.; Zhu, L.; Wang, H.; Sha, Y.; Yao, J.; Li, Z.; You, Q.; Guo, Q. Oroxylin a reverses cam-dr of hepg2 cells by suppressing integrinβ1 and its related pathway. Toxicol. Appl. Pharmacol. 2012, 259, 387-394.
    • (2012) Toxicol. Appl. Pharmacol. , vol.259 , pp. 387-394
    • Zhu, B.1    Zhao, L.2    Zhu, L.3    Wang, H.4    Sha, Y.5    Yao, J.6    Li, Z.7    You, Q.8    Guo, Q.9
  • 25
  • 26
    • 84886788330 scopus 로고    scopus 로고
    • Cell adhesion to fibronectin down-regulates the expression of spy1 and contributes to drug resistance in multiple myeloma cells
    • Fei, M.; Hang, Q.; Hou, S.; Ruan, C. Cell adhesion to fibronectin down-regulates the expression of spy1 and contributes to drug resistance in multiple myeloma cells. Int. J. Hematol. 2013, 98, 446-455.
    • (2013) Int. J. Hematol. , vol.98 , pp. 446-455
    • Fei, M.1    Hang, Q.2    Hou, S.3    Ruan, C.4
  • 27
    • 0033105537 scopus 로고    scopus 로고
    • Cell adhesion mediated drug resistance (cam-dr): Role of integrins and resistance to apoptosis in human myeloma cell lines
    • Damiano, J.S.; Cress, A.E.; Hazlehurst, L.A.; Shtil, A.A.; Dalton, W.S. Cell adhesion mediated drug resistance (cam-dr): Role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 1999, 93, 1658-1667.
    • (1999) Blood , vol.93 , pp. 1658-1667
    • Damiano, J.S.1    Cress, A.E.2    Hazlehurst, L.A.3    Shtil, A.A.4    Dalton, W.S.5
  • 28
    • 51349083548 scopus 로고    scopus 로고
    • Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells
    • Westhoff, M.A.; Zhou, S.; Bachem, M.G.; Debatin, K.M.; Fulda, S. Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells. Oncogene 2008, 27, 5169-5181.
    • (2008) Oncogene , vol.27 , pp. 5169-5181
    • Westhoff, M.A.1    Zhou, S.2    Bachem, M.G.3    Debatin, K.M.4    Fulda, S.5
  • 29
    • 0036499140 scopus 로고    scopus 로고
    • Adhesion-mediated intracellular redistribution of c-fas-associated death domain-like il-1-converting enzyme-like inhibitory protein-long confers resistance to cd95-induced apoptosis in hematopoietic cancer cell lines
    • Shain, K.H.; Landowski, T.H.; Dalton, W.S. Adhesion-mediated intracellular redistribution of c-fas-associated death domain-like il-1-converting enzyme-like inhibitory protein-long confers resistance to cd95-induced apoptosis in hematopoietic cancer cell lines. J. Immunol. 2002, 168, 2544-2553.
    • (2002) J. Immunol. , vol.168 , pp. 2544-2553
    • Shain, K.H.1    Landowski, T.H.2    Dalton, W.S.3
  • 30
    • 0034606657 scopus 로고    scopus 로고
    • Epigenetic determinants of resistance to etoposide regulation of bcl-x(l) and bax by tumor microenvironmental factors
    • Taylor, S.T.; Hickman, J.A.; Dive, C. Epigenetic determinants of resistance to etoposide regulation of bcl-x(l) and bax by tumor microenvironmental factors. J. Natl. Cancer Inst. 2000, 92, 18-23.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 18-23
    • Taylor, S.T.1    Hickman, J.A.2    Dive, C.3
  • 31
    • 34250788040 scopus 로고    scopus 로고
    • Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-κB (relb/p52) in non-hodgkin's lymphoma cells
    • Lwin, T.; Hazlehurst, L.A.; Li, Z.; Dessureault, S.; Sotomayor, E.; Moscinski, L.C.; Dalton, W.S.; Tao, J. Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-κB (relb/p52) in non-hodgkin's lymphoma cells. Leukemia 2007, 21, 1521-1531.
    • (2007) Leukemia , vol.21 , pp. 1521-1531
    • Lwin, T.1    Hazlehurst, L.A.2    Li, Z.3    Dessureault, S.4    Sotomayor, E.5    Moscinski, L.C.6    Dalton, W.S.7    Tao, J.8
  • 32
    • 0034882278 scopus 로고    scopus 로고
    • Bone marrow stromal cells regulate caspase 3 activity in leukemic cells during chemotherapy
    • Fortney, J.E.; Zhao, W.; Wenger, S.L.; Gibson, L.F. Bone marrow stromal cells regulate caspase 3 activity in leukemic cells during chemotherapy. Leuk. Res. 2001, 25, 901-907.
    • (2001) Leuk. Res. , vol.25 , pp. 901-907
    • Fortney, J.E.1    Zhao, W.2    Wenger, S.L.3    Gibson, L.F.4
  • 33
    • 67049137382 scopus 로고    scopus 로고
    • Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit cxcr4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: A novel therapeutic approach
    • Niedermeier, M.; Hennessy, B.T.; Knight, Z.A.; Henneberg, M.; Hu, J.; Kurtova, A.V.; Wierda, W.G.; Keating, M.J.; Shokat, K.M.; Burger, J.A. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit cxcr4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: A novel therapeutic approach. Blood 2009, 113, 5549-5557.
    • (2009) Blood , vol.113 , pp. 5549-5557
    • Niedermeier, M.1    Hennessy, B.T.2    Knight, Z.A.3    Henneberg, M.4    Hu, J.5    Kurtova, A.V.6    Wierda, W.G.7    Keating, M.J.8    Shokat, K.M.9    Burger, J.A.10
  • 34
    • 0035899331 scopus 로고    scopus 로고
    • Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells
    • Aoudjit, F.; Vuori, K. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene 2001, 20, 4995-5004.
    • (2001) Oncogene , vol.20 , pp. 4995-5004
    • Aoudjit, F.1    Vuori, K.2
  • 35
    • 0033032317 scopus 로고    scopus 로고
    • Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
    • Sethi, T.; Rintoul, R.C.; Moore, S.M.; MacKinnon, A.C.; Salter, D.; Choo, C.; Chilvers, E.R.; Dransfield, I.; Donnelly, S.C.; Strieter, R.; et al. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo. Nat. Med. 1999, 5, 662-668.
    • (1999) Nat. Med. , vol.5 , pp. 662-668
    • Sethi, T.1    Rintoul, R.C.2    Moore, S.M.3    McKinnon, A.C.4    Salter, D.5    Choo, C.6    Chilvers, E.R.7    Dransfield, I.8    Donnelly, S.C.9    Strieter, R.10
  • 36
    • 0033021996 scopus 로고    scopus 로고
    • Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death
    • Uhm, J.H.; Dooley, N.P.; Kyritsis, A.P.; Rao, J.S.; Gladson, C.L. Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clin. Cancer Res. 1999, 5, 1587-1594.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1587-1594
    • Uhm, J.H.1    Dooley, N.P.2    Kyritsis, A.P.3    Rao, J.S.4    Gladson, C.L.5
  • 37
    • 57449100243 scopus 로고    scopus 로고
    • E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating bcl-2 expression
    • Wang, L.; Li, Z.; Wang, C.; Yang, Y.; Sun, L.; Yao, W.; Cai, X.; Wu, G.; Zhou, F.; Zha, X. E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating bcl-2 expression. Arch. Biochem. Biophys. 2009, 481, 116-122.
    • (2009) Arch. Biochem. Biophys. , vol.481 , pp. 116-122
    • Wang, L.1    Li, Z.2    Wang, C.3    Yang, Y.4    Sun, L.5    Yao, W.6    Cai, X.7    Wu, G.8    Zhou, F.9    Zha, X.10
  • 38
    • 0037799517 scopus 로고    scopus 로고
    • Cell adhesion-mediated radioresistance (cam-rr). Extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro
    • Cordes, N.; Meineke, V. Cell adhesion-mediated radioresistance (cam-rr). Extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro. Strahlenther. Onkol. 2003, 179, 337-344.
    • (2003) Strahlenther. Onkol. , vol.179 , pp. 337-344
    • Cordes, N.1    Meineke, V.2
  • 39
    • 36849089031 scopus 로고    scopus 로고
    • Cell adhesion-mediated radioresistance revisited
    • Sandfort, V.; Koch, U.; Cordes, N. Cell adhesion-mediated radioresistance revisited. Int. J. Radiat. Biol. 2007, 83, 727-732.
    • (2007) Int. J. Radiat. Biol. , vol.83 , pp. 727-732
    • Sandfort, V.1    Koch, U.2    Cordes, N.3
  • 40
    • 70349732865 scopus 로고    scopus 로고
    • Adhesion-mediated apoptosis resistance in cancer
    • Westhoff, M.A.; Fulda, S. Adhesion-mediated apoptosis resistance in cancer. Drug Resist. Updat. 2009, 12, 127-136.
    • (2009) Drug Resist. Updat. , vol.12 , pp. 127-136
    • Westhoff, M.A.1    Fulda, S.2
  • 41
    • 0021190160 scopus 로고
    • Inability of rous sarcoma virus to cause sarcomas in the avian embryo
    • Dolberg, D.S.; Bissell, M.J. Inability of rous sarcoma virus to cause sarcomas in the avian embryo. Nature 1984, 309, 552-556.
    • (1984) Nature , vol.309 , pp. 552-556
    • Dolberg, D.S.1    Bissell, M.J.2
  • 43
    • 36048994736 scopus 로고    scopus 로고
    • Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment
    • Hoelzinger, D.B.; Demuth, T.; Berens, M.E. Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J. Natl. Cancer Inst. 2007, 99, 1583-1593.
    • (2007) J. Natl. Cancer Inst. , vol.99 , pp. 1583-1593
    • Hoelzinger, D.B.1    Demuth, T.2    Berens, M.E.3
  • 45
    • 34250365241 scopus 로고    scopus 로고
    • Desmosomes: A role in cancer?
    • Chidgey, M.; Dawson, C. Desmosomes: A role in cancer? Br. J. Cancer 2007, 96, 1783-1787.
    • (2007) Br. J. Cancer , vol.96 , pp. 1783-1787
    • Chidgey, M.1    Dawson, C.2
  • 46
    • 27544448588 scopus 로고    scopus 로고
    • Claudin proteins in human cancer: Promising new targets for diagnosis and therapy
    • Morin, P.J. Claudin proteins in human cancer: Promising new targets for diagnosis and therapy. Cancer Res. 2005, 65, 9603-9606.
    • (2005) Cancer Res. , vol.65 , pp. 9603-9606
    • Morin, P.J.1
  • 47
    • 78650838225 scopus 로고    scopus 로고
    • The pten phosphatase controls intestinal epithelial cell polarity and barrier function: Role in colorectal cancer progression
    • Langlois, M.J.; Bergeron, S.; Bernatchez, G.; Boudreau, F.; Saucier, C.; Perreault, N.; Carrier, J.C.; Rivard, N. The pten phosphatase controls intestinal epithelial cell polarity and barrier function: Role in colorectal cancer progression. PLoS One 2010, 5, e15742.
    • (2010) PLoS One , vol.5
    • Langlois, M.J.1    Bergeron, S.2    Bernatchez, G.3    Boudreau, F.4    Saucier, C.5    Perreault, N.6    Carrier, J.C.7    Rivard, N.8
  • 48
    • 79958026380 scopus 로고    scopus 로고
    • The ras-erk and pi3k-mtor pathways: Cross-talk and compensation
    • Mendoza, M.C.; Er, E.E.; Blenis, J. The ras-erk and pi3k-mtor pathways: Cross-talk and compensation. Trends Biochem. Sci. 2011, 36, 320-328.
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 320-328
    • Mendoza, M.C.1    Er, E.E.2    Blenis, J.3
  • 51
    • 79952741178 scopus 로고    scopus 로고
    • Cilengitide: The first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation
    • Mas-Moruno, C.; Rechenmacher, F.; Kessler, H. Cilengitide: The first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med. Chem. 2010, 10, 753-768.
    • (2010) Anticancer Agents Med. Chem. , vol.10 , pp. 753-768
    • Mas-Moruno, C.1    Rechenmacher, F.2    Kessler, H.3
  • 54
    • 43649085395 scopus 로고    scopus 로고
    • Microenvironmental regulation of cancer development
    • Hu, M.; Polyak, K. Microenvironmental regulation of cancer development. Curr. Opin. Genet. Dev. 2008, 18, 27-34.
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 27-34
    • Hu, M.1    Polyak, K.2
  • 55
    • 33845811455 scopus 로고    scopus 로고
    • Preparing the "Soil": The premetastatic niche
    • Kaplan, R.N.; Rafii, S.; Lyden, D. Preparing the "Soil": The premetastatic niche. Cancer Res. 2006, 66, 11089-11093.
    • (2006) Cancer Res. , vol.66 , pp. 11089-11093
    • Kaplan, R.N.1    Rafii, S.2    Lyden, D.3
  • 56
    • 84890314061 scopus 로고    scopus 로고
    • The pre-metastatic niche: Finding common ground
    • Sceneay, J.; Smyth, M.J.; Moller, A. The pre-metastatic niche: Finding common ground. Cancer Metastasis Rev. 2013, 32, 449-464.
    • (2013) Cancer Metastasis Rev. , vol.32 , pp. 449-464
    • Sceneay, J.1    Smyth, M.J.2    Moller, A.3
  • 58
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast. 1889
    • Paget, S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 1989, 8, 98-101.
    • (1989) Cancer Metastasis Rev. , vol.8 , pp. 98-101
    • Paget, S.1
  • 59
    • 77955985510 scopus 로고    scopus 로고
    • Bcr-abl tyrosine kinase inhibitors in the treatment of philadelphia chromosome positive chronic myeloid leukemia: A review
    • An, X.; Tiwari, A.K.; Sun, Y.; Ding, P.R.; Ashby, C.R., Jr.; Chen, Z.S. Bcr-abl tyrosine kinase inhibitors in the treatment of philadelphia chromosome positive chronic myeloid leukemia: A review. Leuk. Res. 2010, 34, 1255-1268.
    • (2010) Leuk. Res. , vol.34 , pp. 1255-1268
    • An, X.1    Tiwari, A.K.2    Sun, Y.3    Ding, P.R.4    Ashby Jr., C.R.5    Chen, Z.S.6
  • 60
    • 0035461919 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of lower dose cancer chemotherapy
    • Gately, S.; Kerbel, R. Antiangiogenic scheduling of lower dose cancer chemotherapy. Cancer J. 2001, 7, 427-436.
    • (2001) Cancer J. , vol.7 , pp. 427-436
    • Gately, S.1    Kerbel, R.2
  • 61
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel, R.; Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2002, 2, 727-739.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 62
    • 51849111556 scopus 로고    scopus 로고
    • Pi3k pathway alterations in cancer: Variations on a theme
    • Yuan, T.L.; Cantley, L.C. Pi3k pathway alterations in cancer: Variations on a theme. Oncogene 2008, 27, 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 63
    • 84877936512 scopus 로고    scopus 로고
    • Targeting the akt kinase to modulate survival, invasiveness and drug resistance of cancer cells
    • Cassinelli, G.; Zuco, V.; Gatti, L.; Lanzi, C.; Zaffaroni, N.; Colombo, D.; Perego, P. Targeting the akt kinase to modulate survival, invasiveness and drug resistance of cancer cells. Curr. Med. Chem. 2013, 20, 1923-1945.
    • (2013) Curr. Med. Chem. , vol.20 , pp. 1923-1945
    • Cassinelli, G.1    Zuco, V.2    Gatti, L.3    Lanzi, C.4    Zaffaroni, N.5    Colombo, D.6    Perego, P.7
  • 64
    • 54949109808 scopus 로고    scopus 로고
    • Pi3k/akt: Getting it right matters
    • Franke, T.F. Pi3k/akt: Getting it right matters. Oncogene 2008, 27, 6473-6488.
    • (2008) Oncogene , vol.27 , pp. 6473-6488
    • Franke, T.F.1
  • 66
    • 66149141021 scopus 로고    scopus 로고
    • Pten and the pi3-kinase pathway in cancer
    • Chalhoub, N.; Baker, S.J. Pten and the pi3-kinase pathway in cancer. Annu. Rev. Pathol. 2009, 4, 127-150.
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 67
    • 84870680416 scopus 로고    scopus 로고
    • Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment
    • Brana, I.; Siu, L.L. Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment. BMC Med. 2012, 10, 161.
    • (2012) BMC Med. , vol.10 , pp. 161
    • Brana, I.1    Siu, L.L.2
  • 68
    • 51849086880 scopus 로고    scopus 로고
    • Pten: A new guardian of the genome
    • Yin, Y.; Shen, W.H. Pten: A new guardian of the genome. Oncogene 2008, 27, 5443-5453.
    • (2008) Oncogene , vol.27 , pp. 5443-5453
    • Yin, Y.1    Shen, W.H.2
  • 69
    • 84878831559 scopus 로고    scopus 로고
    • Overcoming acquired resistance to anticancer therapy: Focus on the pi3k/akt/mtor pathway
    • Burris, H.A., 3rd, Overcoming acquired resistance to anticancer therapy: Focus on the pi3k/akt/mtor pathway. Cancer Chemother. Pharmacol. 2013, 71, 829-842.
    • (2013) Cancer Chemother. Pharmacol. , vol.71 , pp. 829-842
    • Burris III, H.A.1
  • 70
    • 84878834146 scopus 로고    scopus 로고
    • Targeting pi3k and mtorc2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to vegfr and mtorc1 inhibitors
    • Figlin, R.A.; Kaufmann, I.; Brechbiel, J. Targeting pi3k and mtorc2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to vegfr and mtorc1 inhibitors. Int. J. Cancer 2013, 133, 788-796.
    • (2013) Int. J. Cancer , vol.133 , pp. 788-796
    • Figlin, R.A.1    Kaufmann, I.2    Brechbiel, J.3
  • 71
    • 70349115668 scopus 로고    scopus 로고
    • The pi3k/akt/mtor pathway as therapeutic target in neuroblastoma
    • Fulda, S. The pi3k/akt/mtor pathway as therapeutic target in neuroblastoma. Curr. Cancer Drug Targets 2009, 9, 729-737.
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 729-737
    • Fulda, S.1
  • 72
    • 84878437544 scopus 로고    scopus 로고
    • Pi3k/akt/mtor pathway inhibitors in the therapy of pancreatic neuroendocrine tumors
    • Wolin, E.M. Pi3k/akt/mtor pathway inhibitors in the therapy of pancreatic neuroendocrine tumors. Cancer Lett. 2013, 335, 1-8.
    • (2013) Cancer Lett. , vol.335 , pp. 1-8
    • Wolin, E.M.1
  • 74
    • 84862895654 scopus 로고    scopus 로고
    • Current clinical development of pi3k pathway inhibitors in glioblastoma
    • Wen, P.Y.; Lee, E.Q.; Reardon, D.A.; Ligon, K.L.; Alfred Yung, W.K. Current clinical development of pi3k pathway inhibitors in glioblastoma. Neuro Oncol. 2012, 14, 819-829.
    • (2012) Neuro Oncol. , vol.14 , pp. 819-829
    • Wen, P.Y.1    Lee, E.Q.2    Reardon, D.A.3    Ligon, K.L.4    Alfred Yung, W.K.5
  • 75
    • 84860851412 scopus 로고    scopus 로고
    • Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
    • Lee, M.J.; Ye, A.S.; Gardino, A.K.; Heijink, A.M.; Sorger, P.K.; MacBeath, G.; Yaffe, M.B. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 2012, 149, 780-794.
    • (2012) Cell , vol.149 , pp. 780-794
    • Lee, M.J.1    Ye, A.S.2    Gardino, A.K.3    Heijink, A.M.4    Sorger, P.K.5    McBeath, G.6    Yaffe, M.B.7
  • 79
    • 84869500651 scopus 로고    scopus 로고
    • Tumor heterogeneity and its implication for drug delivery
    • Denison, T.A.; Bae, Y.H. Tumor heterogeneity and its implication for drug delivery. J. Control. Release 2012, 164, 187-191.
    • (2012) J. Control. Release , vol.164 , pp. 187-191
    • Denison, T.A.1    Bae, Y.H.2
  • 80
    • 84890313470 scopus 로고    scopus 로고
    • Genetic and non-genetic instability in tumor progression: Link between the fitness landscape and the epigenetic landscape of cancer cells
    • Huang, S. Genetic and non-genetic instability in tumor progression: Link between the fitness landscape and the epigenetic landscape of cancer cells. Cancer Metastasis Rev. 2013, 32, 423-448.
    • (2013) Cancer Metastasis Rev. , vol.32 , pp. 423-448
    • Huang, S.1
  • 81
    • 67349284051 scopus 로고    scopus 로고
    • Non-genetic heterogeneity-A mutation-independent driving force for the somatic evolution of tumours
    • Brock, A.; Chang, H.; Huang, S. Non-genetic heterogeneity-A mutation-independent driving force for the somatic evolution of tumours. Nat. Rev. Genet. 2009, 10, 336-342.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 336-342
    • Brock, A.1    Chang, H.2    Huang, S.3
  • 82
    • 84872771409 scopus 로고    scopus 로고
    • Cancer as a moving target: Understanding the composition and rebound growth kinetics of recurrent tumors
    • Foo, J.; Leder, K.; Mumenthaler, S.M. Cancer as a moving target: Understanding the composition and rebound growth kinetics of recurrent tumors. Evol. Appl. 2013, 6, 54-69.
    • (2013) Evol. Appl. , vol.6 , pp. 54-69
    • Foo, J.1    Leder, K.2    Mumenthaler, S.M.3
  • 84
    • 70350236539 scopus 로고    scopus 로고
    • Lessons from applied ecology: Cancer control using an evolutionary double bind
    • Gatenby, R.A.; Brown, J.; Vincent, T. Lessons from applied ecology: Cancer control using an evolutionary double bind. Cancer Res. 2009, 69, 7499-7502.
    • (2009) Cancer Res. , vol.69 , pp. 7499-7502
    • Gatenby, R.A.1    Brown, J.2    Vincent, T.3
  • 85
    • 84879629520 scopus 로고    scopus 로고
    • Population genetics of neutral mutations in exponentially growing cancer cell populations
    • Durrett, R. Population genetics of neutral mutations in exponentially growing cancer cell populations. Ann. Appl. Probab. 2013, 23, 230-250.
    • (2013) Ann. Appl. Probab. , vol.23 , pp. 230-250
    • Durrett, R.1
  • 87
    • 65449117656 scopus 로고    scopus 로고
    • Enhanced activation of stat pathways and overexpression of survivin confer resistance to flt3 inhibitors and could be therapeutic targets in aml
    • Zhou, J.; Bi, C.; Janakakumara, J.V.; Liu, S.C.; Chng, W.J.; Tay, K.G.; Poon, L.F.; Xie, Z.; Palaniyandi, S.; Yu, H.; et al. Enhanced activation of stat pathways and overexpression of survivin confer resistance to flt3 inhibitors and could be therapeutic targets in aml. Blood 2009, 113, 4052-4062.
    • (2009) Blood , vol.113 , pp. 4052-4062
    • Zhou, J.1    Bi, C.2    Janakakumara, J.V.3    Liu, S.C.4    Chng, W.J.5    Tay, K.G.6    Poon, L.F.7    Xie, Z.8    Palaniyandi, S.9    Yu, H.10
  • 88
    • 77953070292 scopus 로고    scopus 로고
    • Mechanisms of resistance against pkc412 in resistant flt3-itd positive human acute myeloid leukemia cells
    • Stolzel, F.; Steudel, C.; Oelschlagel, U.; Mohr, B.; Koch, S.; Ehninger, G.; Thiede, C. Mechanisms of resistance against pkc412 in resistant flt3-itd positive human acute myeloid leukemia cells. Ann. Hematol. 2010, 89, 653-662.
    • (2010) Ann. Hematol. , vol.89 , pp. 653-662
    • Stolzel, F.1    Steudel, C.2    Oelschlagel, U.3    Mohr, B.4    Koch, S.5    Ehninger, G.6    Thiede, C.7
  • 90
    • 84877879582 scopus 로고    scopus 로고
    • Baldwin effect under multipeaked fitness landscapes: Phenotypic fluctuation accelerates evolutionary rate
    • Saito, N.; Ishihara, S.; Kaneko, K. Baldwin effect under multipeaked fitness landscapes: Phenotypic fluctuation accelerates evolutionary rate. Phys. Rev. E 2013, 87, 052701.
    • (2013) Phys. Rev. E , vol.87 , pp. 052701
    • Saito, N.1    Ishihara, S.2    Kaneko, K.3
  • 92
    • 84863562673 scopus 로고    scopus 로고
    • Glioblastoma survival in the united states before and during the temozolomide era
    • Johnson, D.R.; O'Neill, B.P. Glioblastoma survival in the united states before and during the temozolomide era. J. Neurooncol. 2011, 107, 359-364.
    • (2011) J. Neurooncol. , vol.107 , pp. 359-364
    • Johnson, D.R.1    O'Neill, B.P.2
  • 93
    • 84895475003 scopus 로고    scopus 로고
    • Analytical tools and databases for metagenomics in the next-generation sequencing era
    • Kim, M.; Lee, K.H.; Yoon, S.W.; Kim, B.S.; Chun, J.; Yi, H. Analytical tools and databases for metagenomics in the next-generation sequencing era. Genomics Inform. 2013, 11, 102-113.
    • (2013) Genomics Inform. , vol.11 , pp. 102-113
    • Kim, M.1    Lee, K.H.2    Yoon, S.W.3    Kim, B.S.4    Chun, J.5    Yi, H.6
  • 94
    • 84895461286 scopus 로고    scopus 로고
    • Application of cancer genomics to solve unmet clinical needs
    • Lee, S.H.; Sim, S.H.; Kim, J.Y.; Cha, S.; Song, A. Application of cancer genomics to solve unmet clinical needs. Genomics Inform. 2013, 11, 174-179.
    • (2013) Genomics Inform. , vol.11 , pp. 174-179
    • Lee, S.H.1    Sim, S.H.2    Kim, J.Y.3    Cha, S.4    Song, A.5
  • 96
    • 83655198589 scopus 로고    scopus 로고
    • Advancing cancer drug discovery towards more agile development of targeted combination therapies
    • Carragher, N.O.; Unciti-Broceta, A.; Cameron, D.A. Advancing cancer drug discovery towards more agile development of targeted combination therapies. Future Med. Chem. 2012, 4, 87-105.
    • (2012) Future Med. Chem. , vol.4 , pp. 87-105
    • Carragher, N.O.1    Unciti-Broceta, A.2    Cameron, D.A.3
  • 97
    • 77951599543 scopus 로고    scopus 로고
    • Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma
    • Huse, J.T.; Holland, E.C. Targeting brain cancer: Advances in the molecular pathology of malignant glioma and medulloblastoma. Nat. Rev. Cancer 2010, 10, 319-331.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 319-331
    • Huse, J.T.1    Holland, E.C.2
  • 100
    • 84862211488 scopus 로고    scopus 로고
    • Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?
    • Seyfried, T.N.; Marsh, J.; Shelton, L.M.; Huysentruyt, L.C.; Mukherjee, P. Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? Epilepsy Res. 2011, 100, 310-326.
    • (2011) Epilepsy Res. , vol.100 , pp. 310-326
    • Seyfried, T.N.1    Marsh, J.2    Shelton, L.M.3    Huysentruyt, L.C.4    Mukherjee, P.5
  • 101
    • 84879165730 scopus 로고    scopus 로고
    • A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (cusp9) by the international initiative for accelerated improvement of glioblastoma care
    • Kast, R.E.; Boockvar, J.A.; Bruning, A.; Cappello, F.; Chang, W.W.; Cvek, B.; Dou, Q.P.; Duenas-Gonzalez, A.; Efferth, T.; Focosi, D.; et al. A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (cusp9) by the international initiative for accelerated improvement of glioblastoma care. Oncotarget 2013, 4, 502-530.
    • (2013) Oncotarget , vol.4 , pp. 502-530
    • Kast, R.E.1    Boockvar, J.A.2    Bruning, A.3    Cappello, F.4    Chang, W.W.5    Cvek, B.6    Dou, Q.P.7    Duenas-Gonzalez, A.8    Efferth, T.9    Focosi, D.10
  • 102
    • 37549056216 scopus 로고    scopus 로고
    • The roles of therapy-induced autophagy and necrosis in cancer treatment
    • Amaravadi, R.K.; Thompson, C.B. The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin. Cancer Res. 2007, 13, 7271-7279.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7271-7279
    • Amaravadi, R.K.1    Thompson, C.B.2
  • 103
  • 106
    • 84868633053 scopus 로고    scopus 로고
    • Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through wnt16b
    • Sun, Y.; Campisi, J.; Higano, C.; Beer, T.M.; Porter, P.; Coleman, I.; True, L.; Nelson, P.S. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through wnt16b. Nat. Med. 2012, 18, 1359-1368.
    • (2012) Nat. Med. , vol.18 , pp. 1359-1368
    • Sun, Y.1    Campisi, J.2    Higano, C.3    Beer, T.M.4    Porter, P.5    Coleman, I.6    True, L.7    Nelson, P.S.8
  • 107
    • 84858060155 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor-1 and nuclear factor kappab are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation
    • Basu, S.; Rajakaruna, S.; Menko, A.S. Insulin-like growth factor receptor-1 and nuclear factor kappab are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation. J. Biol. Chem. 2012, 287, 8384-8397.
    • (2012) J. Biol. Chem. , vol.287 , pp. 8384-8397
    • Basu, S.1    Rajakaruna, S.2    Menko, A.S.3
  • 108
    • 26444537963 scopus 로고    scopus 로고
    • Neural stem cell differentiation is dependent upon endogenous caspase 3 activity
    • Fernando, P.; Brunette, S.; Megeney, L.A. Neural stem cell differentiation is dependent upon endogenous caspase 3 activity. FASEB J. 2005, 19, 1671-1673.
    • (2005) FASEB J. , vol.19 , pp. 1671-1673
    • Fernando, P.1    Brunette, S.2    Megeney, L.A.3
  • 109
    • 84883119308 scopus 로고    scopus 로고
    • Overdiagnosis and overtreatment in cancer: An opportunity for improvement
    • Esserman, L.J.; Thompson, I.M., Jr.; Reid, B. Overdiagnosis and overtreatment in cancer: An opportunity for improvement. JAMA 2013, 310, 797-798.
    • (2013) JAMA , vol.310 , pp. 797-798
    • Esserman, L.J.1    Thompson Jr., I.M.2    Reid, B.3
  • 110
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen, P.Y.; Kesari, S. Malignant gliomas in adults. N. Engl. J. Med. 2008, 359, 492-507.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.