메뉴 건너뛰기




Volumn 25, Issue 3, 2014, Pages 270-281

Artemisinin triggers a G1 cell cycle arrest of human Ishikawa endometrial cancer cells and inhibits cyclin-dependent kinase-4 promoter activity and expression by disrupting nuclear factor-κB transcriptional signaling

Author keywords

Artemisinin antiproliferative signaling; CDK4 gene expression; Endometrial cancer cells; Nuclear factor B

Indexed keywords

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARTEMISIA ANNUA; ARTEMISININS; BASE SEQUENCE; CYCLIN-DEPENDENT KINASE 4; ENDOMETRIAL NEOPLASMS; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84895075884     PISSN: 09594973     EISSN: 14735741     Source Type: Journal    
DOI: 10.1097/CAD.0000000000000054     Document Type: Article
Times cited : (60)

References (58)
  • 5
    • 38649135366 scopus 로고    scopus 로고
    • Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol
    • Gagnon V, Van Themsche C, Turner S, Leblanc V, Asselin E. Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis 2008; 13: 259-271.
    • (2008) Apoptosis , vol.13 , pp. 259-271
    • Gagnon, V.1    Van Themsche, C.2    Turner, S.3    Leblanc, V.4    Asselin, E.5
  • 6
    • 33846211856 scopus 로고    scopus 로고
    • Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus)
    • Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, et al. Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). Cancer Res 2006; 66: 12026-12034.
    • (2006) Cancer Res , vol.66 , pp. 12026-12034
    • Chen, S.1    Oh, S.R.2    Phung, S.3    Hur, G.4    Ye, J.J.5    Kwok, S.L.6
  • 7
    • 0043286304 scopus 로고    scopus 로고
    • Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals
    • Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003; 78:517S-520S.
    • (2003) Am J Clin Nutr , vol.78
    • Liu, R.H.1
  • 8
    • 34447330714 scopus 로고    scopus 로고
    • Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
    • Nonn L, Duong D, Peehl DM. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis 2007; 28: 1188-1196.
    • (2007) Carcinogenesis , vol.28 , pp. 1188-1196
    • Nonn, L.1    Duong, D.2    Peehl, D.M.3
  • 9
    • 33846021239 scopus 로고    scopus 로고
    • Cranberry and its phytochemicals: A review of in vitro anticancer studies
    • Neto CC. Cranberry and its phytochemicals: a review of in vitro anticancer studies. J Nutr 2007; 137:186S-193S.
    • (2007) J Nutr , vol.137
    • Neto, C.C.1
  • 10
    • 31044452188 scopus 로고    scopus 로고
    • Anticancer activities of pomegranate extracts and genistein in human breast cancer cells
    • Jeune MA, Kumi-Diaka J, Brown J. Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. J Med Food 2005; 8: 469-475.
    • (2005) J Med Food , vol.8 , pp. 469-475
    • Jeune, M.A.1    Kumi-Diaka, J.2    Brown, J.3
  • 11
    • 0035031547 scopus 로고    scopus 로고
    • Anticarcinogenic activity of strawberry, blueberry, and raspberry extracts to breast and cervical cancer cells
    • Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL. Anticarcinogenic activity of strawberry, blueberry, and raspberry extracts to breast and cervical cancer cells. J Med Food 2001; 4: 49-51.
    • (2001) J Med Food , vol.4 , pp. 49-51
    • Wedge, D.E.1    Meepagala, K.M.2    Magee, J.B.3    Smith, S.H.4    Huang, G.5    Larcom, L.L.6
  • 12
    • 34250659001 scopus 로고    scopus 로고
    • Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity
    • He X, Liu RH. Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity. J Agric Food Chem 2007; 55: 4366-4370.
    • (2007) J Agric Food Chem , vol.55 , pp. 4366-4370
    • He, X.1    Liu, R.H.2
  • 13
    • 0037662260 scopus 로고    scopus 로고
    • Indole-3-carbinol and 3-30-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter - Sp1 transcription factor interactions
    • Firestone GL, Bjeldanes LF. Indole-3-carbinol and 3-30-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter - Sp1 transcription factor interactions. J Nutr 2003; 133:2448S-2455S.
    • (2003) J Nutr , vol.133
    • Firestone, G.L.1    Bjeldanes, L.F.2
  • 14
    • 0035161486 scopus 로고    scopus 로고
    • Cytostatic effects of 3, 30- diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression
    • Leong H, Firestone GL, Bjeldanes LF. Cytostatic effects of 3, 30- diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression. Carcinogenesis 2001; 22: 1809-1817.
    • (2001) Carcinogenesis , vol.22 , pp. 1809-1817
    • Leong, H.1    Firestone, G.L.2    Bjeldanes, L.F.3
  • 15
    • 0037427563 scopus 로고    scopus 로고
    • Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana
    • Jayaprakasam B, Seeram NP, Nair MG. Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. Cancer Lett 2003; 189: 11-16.
    • (2003) Cancer Lett , vol.189 , pp. 11-16
    • Jayaprakasam, B.1    Seeram, N.P.2    Nair, M.G.3
  • 17
    • 79960593285 scopus 로고    scopus 로고
    • Changing patterns of malaria during 1996-2010 in an area of moderate transmission in southern Senegal
    • Brasseur P, Badiane M, Cisse M, Agnamey P, Vaillant MT, Olliaro PL. Changing patterns of malaria during 1996-2010 in an area of moderate transmission in southern Senegal. Malar J 2011; 10:203.
    • (2011) Malar J , vol.10 , pp. 203
    • Brasseur, P.1    Badiane, M.2    Cisse, M.3    Agnamey, P.4    Vaillant, M.T.5    Olliaro, P.L.6
  • 18
    • 68949192688 scopus 로고    scopus 로고
    • Development of dietary phytochemical chemopreventive agents: Biomarkers and choice of dose for early clinical trials
    • Scott EN, Gescher AJ, Steward WP, Brown K. Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials. Cancer Prev Res (Phila) 2009; 2: 525-530.
    • (2009) Cancer Prev Res (Phila) , vol.2 , pp. 525-530
    • Scott, E.N.1    Gescher, A.J.2    Steward, W.P.3    Brown, K.4
  • 19
    • 0043270405 scopus 로고    scopus 로고
    • Artemisinin and heme
    • author reply 2712-2713
    • Meshnick SR. Artemisinin and heme. Antimicrob Agents Chemother 2003; 47:2712 author reply 2712-2713.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 2712
    • Meshnick, S.R.1
  • 20
    • 0037021405 scopus 로고    scopus 로고
    • Artemisinin: Mechanisms of action, resistance and toxicity
    • Meshnick SR. Artemisinin: mechanisms of action, resistance and toxicity. Int J Parasitol 2002; 32: 1655-1660.
    • (2002) Int J Parasitol , vol.32 , pp. 1655-1660
    • Meshnick, S.R.1
  • 22
    • 79960555687 scopus 로고    scopus 로고
    • Anti-cancer natural products isolated from Chinese medicinal herbs
    • Tan W, Lu J, Huang M, Li Y, Chen M, Wu G, et al. Anti-cancer natural products isolated from Chinese medicinal herbs. Chin Med 2011; 6:27.
    • (2011) Chin Med , vol.6 , pp. 27
    • Tan, W.1    Lu, J.2    Huang, M.3    Li, Y.4    Chen, M.5    Wu, G.6
  • 23
    • 84866741435 scopus 로고    scopus 로고
    • The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis
    • Cabello CM, Lamore SD, Bair WB III, Qiao S, Azimian S, Lesson JL, et al. The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis. Invest New Drugs 2012; 30: 1289-1301.
    • (2012) Invest New Drugs , vol.30 , pp. 1289-1301
    • Cabello, C.M.1    Lamore, S.D.2    Bair III, W.B.3    Qiao, S.4    Azimian, S.5    Lesson, J.L.6
  • 24
    • 33646461526 scopus 로고    scopus 로고
    • Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity
    • Paik IH, Xie S, Shapiro TA, Labonte T, Narducci Sarjeant AA, Baege AC, et al. Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity. J Med Chem 2006; 49: 2731-2734.
    • (2006) J Med Chem , vol.49 , pp. 2731-2734
    • Paik, I.H.1    Xie, S.2    Shapiro, T.A.3    Labonte, T.4    Narducci Sarjeant, A.A.5    Baege, A.C.6
  • 25
    • 77952795743 scopus 로고    scopus 로고
    • Anticancer activities of artemisinin and its bioactive derivatives
    • Firestone GL, Sundar SN. Anticancer activities of artemisinin and its bioactive derivatives. Expert Rev Mol Med 2009; 11:e32.
    • (2009) Expert Rev Mol Med , vol.11
    • Firestone, G.L.1    Sundar, S.N.2
  • 26
    • 33646024956 scopus 로고    scopus 로고
    • Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells
    • Efferth T. Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells. Curr Drug Targets 2006; 7: 407-421.
    • (2006) Curr Drug Targets , vol.7 , pp. 407-421
    • Efferth, T.1
  • 27
    • 34250344275 scopus 로고    scopus 로고
    • Willmar Schwabe Award 2006: Antiplasmodial and antitumor activity of artemisinin - From bench to bedside
    • Efferth T. Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin - from bench to bedside. Planta Med 2007; 73: 299-309.
    • (2007) Planta Med , vol.73 , pp. 299-309
    • Efferth, T.1
  • 28
    • 0030596209 scopus 로고    scopus 로고
    • Hemoglobin catabolism and iron utilization by malaria parasites
    • Rosenthal PJ, Meshnick SR. Hemoglobin catabolism and iron utilization by malaria parasites. Mol Biochem Parasitol 1996; 83: 131-139.
    • (1996) Mol Biochem Parasitol , vol.83 , pp. 131-139
    • Rosenthal, P.J.1    Meshnick, S.R.2
  • 29
    • 0026014249 scopus 로고
    • Artemisinin (qinghaosu): The role of intracellular hemin in its mechanism of antimalarial action
    • Meshnick SR, Thomas A, Ranz A, Xu CM, Pan HZ. Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action. Mol Biochem Parasitol 1991; 49: 181-189.
    • (1991) Mol Biochem Parasitol , vol.49 , pp. 181-189
    • Meshnick, S.R.1    Thomas, A.2    Ranz, A.3    Xu, C.M.4    Pan, H.Z.5
  • 30
    • 0028072380 scopus 로고
    • In-vitro tests on Philippine isolates of Plasmodium falciparum against four standard antimalarials and four qinghaosu derivatives
    • Bustos MD, Gay F, Diquet B. In-vitro tests on Philippine isolates of Plasmodium falciparum against four standard antimalarials and four qinghaosu derivatives. Bull World Health Organ 1994; 72: 729-735.
    • (1994) Bull World Health Organ , vol.72 , pp. 729-735
    • Bustos, M.D.1    Gay, F.2    Diquet, B.3
  • 31
    • 59049096024 scopus 로고    scopus 로고
    • Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression
    • Willoughby JA Sr, Sundar SN, Cheung M, Tin AS, Modiano J, Firestone GL. Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression. J Biol Chem 2009; 284: 2203-2213.
    • (2009) J Biol Chem , vol.284 , pp. 2203-2213
    • Willoughby Sr., J.A.1    Sundar, S.N.2    Cheung, M.3    Tin, A.S.4    Modiano, J.5    Firestone, G.L.6
  • 32
    • 0037103574 scopus 로고    scopus 로고
    • MRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether
    • Efferth T, Olbrich A, Bauer R. mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether. Biochem Pharmacol 2002; 64: 617-623.
    • (2002) Biochem Pharmacol , vol.64 , pp. 617-623
    • Efferth, T.1    Olbrich, A.2    Bauer, R.3
  • 33
    • 53049086416 scopus 로고    scopus 로고
    • Experimental therapy of hepatoma with artemisinin and its derivatives: In vitro and in vivo activity, chemosensitization, and mechanisms of action
    • Hou J, Wang D, Zhang R, Wang H. Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action. Clin Cancer Res 2008; 14: 5519-5530.
    • (2008) Clin Cancer Res , vol.14 , pp. 5519-5530
    • Hou, J.1    Wang, D.2    Zhang, R.3    Wang, H.4
  • 34
    • 84858284701 scopus 로고    scopus 로고
    • Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes
    • Tin AS, Sundar SN, Tran KQ, Park AH, Poindexter KM, Firestone GL. Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes. Anticancer Drugs 2012; 23: 370-379.
    • (2012) Anticancer Drugs , vol.23 , pp. 370-379
    • Tin, A.S.1    Sundar, S.N.2    Tran, K.Q.3    Park, A.H.4    Poindexter, K.M.5    Firestone, G.L.6
  • 35
    • 77950667476 scopus 로고    scopus 로고
    • Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop
    • Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF, Firestone GL. Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop. Mol Biol Cell 2010; 21: 1166-1177.
    • (2010) Mol Biol Cell , vol.21 , pp. 1166-1177
    • Marconett, C.N.1    Sundar, S.N.2    Poindexter, K.M.3    Stueve, T.R.4    Bjeldanes, L.F.5    Firestone, G.L.6
  • 36
    • 57349179869 scopus 로고    scopus 로고
    • Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells
    • Sundar SN, Marconett CN, Doan VB, Willoughby JA Sr, Firestone GL. Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells. Carcinogenesis 2008; 29: 2252-2258.
    • (2008) Carcinogenesis , vol.29 , pp. 2252-2258
    • Sundar, S.N.1    Marconett, C.N.2    Doan, V.B.3    Willoughby Sr., J.A.4    Firestone, G.L.5
  • 37
    • 77954382800 scopus 로고    scopus 로고
    • 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells
    • Nguyen HH, Lavrenov SN, Sundar SN, Nguyen DH, Tseng M, Marconett CN, et al. 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells. Chem Biol Interact 2010; 186: 255-266.
    • (2010) Chem Biol Interact , vol.186 , pp. 255-266
    • Nguyen, H.H.1    Lavrenov, S.N.2    Sundar, S.N.3    Nguyen, D.H.4    Tseng, M.5    Marconett, C.N.6
  • 38
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: The enemy within
    • Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell 2004; 6: 203-208.
    • (2004) Cancer Cell , vol.6 , pp. 203-208
    • Aggarwal, B.B.1
  • 39
    • 79952714771 scopus 로고    scopus 로고
    • Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis
    • Mizumoto Y, Kyo S, Kiyono T, Takakura M, Nakamura M, Maida Y, et al. Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis. Clin Cancer Res 2011; 17: 1341-1350.
    • (2011) Clin Cancer Res , vol.17 , pp. 1341-1350
    • Mizumoto, Y.1    Kyo, S.2    Kiyono, T.3    Takakura, M.4    Nakamura, M.5    Maida, Y.6
  • 40
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • Darnell JE Jr. Transcription factors as targets for cancer therapy. Nat Rev Cancer 2002; 2: 740-749.
    • (2002) Nat Rev Cancer , vol.2 , pp. 740-749
    • Darnell Jr., J.E.1
  • 41
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441: 431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 42
    • 9244239811 scopus 로고    scopus 로고
    • G1 cell-cycle control and cancer
    • Massague J. G1 cell-cycle control and cancer. Nature 2004; 432: 298-306.
    • (2004) Nature , vol.432 , pp. 298-306
    • Massague, J.1
  • 43
    • 84873367867 scopus 로고    scopus 로고
    • Sesamin synergistically potentiates the anticancer effects of gamma-tocotrienol in mammary cancer cell lines
    • Akl MR, Ayoub NM, Abuasal BS, Kaddoumi A, Sylvester PW. Sesamin synergistically potentiates the anticancer effects of gamma-tocotrienol in mammary cancer cell lines. Fitoterapia 2013; 84: 347-359.
    • (2013) Fitoterapia , vol.84 , pp. 347-359
    • Akl, M.R.1    Ayoub, N.M.2    Abuasal, B.S.3    Kaddoumi, A.4    Sylvester, P.W.5
  • 44
    • 84868712140 scopus 로고    scopus 로고
    • In vitro and in vivo anti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma
    • Luo Q, Hu D, Hu S, Yan M, Sun Z, Chen F. In vitro and in vivo anti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma. BMC Cancer 2012; 12:517.
    • (2012) BMC Cancer , vol.12 , pp. 517
    • Luo, Q.1    Hu, D.2    Hu, S.3    Yan, M.4    Sun, Z.5    Chen, F.6
  • 45
    • 84872376513 scopus 로고    scopus 로고
    • Induction of G1 cell cycle arrest and cyclin D1 down-regulation in response to pericarp extract of Baneh in human breast cancer T47D cells
    • Rezaei PF, Fouladdel S, Ghaffari SM, Amin G, Azizi E. Induction of G1 cell cycle arrest and cyclin D1 down-regulation in response to pericarp extract of Baneh in human breast cancer T47D cells. Daru 2012; 20:101.
    • (2012) Daru , vol.20 , pp. 101
    • Rezaei, P.F.1    Fouladdel, S.2    Ghaffari, S.M.3    Amin, G.4    Azizi, E.5
  • 46
    • 77957173100 scopus 로고    scopus 로고
    • BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype
    • Marconett CN, Morgenstern TJ, San Roman AK, Sundar SN, Singhal AK, Firestone GL. BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. Cancer Biol Ther 2010; 10: 397-405.
    • (2010) Cancer Biol Ther , vol.10 , pp. 397-405
    • Marconett, C.N.1    Morgenstern, T.J.2    San Roman, A.K.3    Sundar, S.N.4    Singhal, A.K.5    Firestone, G.L.6
  • 47
    • 84866641762 scopus 로고    scopus 로고
    • NF-kappaB in cancer: A matter of life and death
    • Aggarwal BB, Sung B. NF-kappaB in cancer: a matter of life and death. Cancer Discov 2011; 1: 469-471.
    • (2011) Cancer Discov , vol.1 , pp. 469-471
    • Aggarwal, B.B.1    Sung, B.2
  • 49
    • 84866026922 scopus 로고    scopus 로고
    • Blockade of NFkappaB activity by sunitinib increases cell death in bortezomibtreated endometrial carcinoma cells
    • Sorolla A, Yeramian A, Valls J, Dolcet X, Bergada L, Llombart-Cussac A, et al. Blockade of NFkappaB activity by sunitinib increases cell death in bortezomibtreated endometrial carcinoma cells. Mol Oncol 2012; 6: 530-541.
    • (2012) Mol Oncol , vol.6 , pp. 530-541
    • Sorolla, A.1    Yeramian, A.2    Valls, J.3    Dolcet, X.4    Bergada, L.5    Llombart-Cussac, A.6
  • 50
    • 78349276864 scopus 로고    scopus 로고
    • Pin1 acts as a modulator of cell proliferation through alteration in NF-kappaB but not beta-catenin/TCF4 signalling in a subset of endometrial carcinoma cells
    • Saegusa M, Hashimura M, Kuwata T. Pin1 acts as a modulator of cell proliferation through alteration in NF-kappaB but not beta-catenin/TCF4 signalling in a subset of endometrial carcinoma cells. J Pathol 2010; 222: 410-420.
    • (2010) J Pathol , vol.222 , pp. 410-420
    • Saegusa, M.1    Hashimura, M.2    Kuwata, T.3
  • 51
    • 77953496625 scopus 로고    scopus 로고
    • The NF-kappaB family of transcription factors and its regulation
    • Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 2009; 1:a000034.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Oeckinghaus, A.1    Ghosh, S.2
  • 52
    • 79551718724 scopus 로고    scopus 로고
    • NF-kappaB: Much learned, much to learn
    • Razani B, Cheng G. NF-kappaB: much learned, much to learn. Sci Signal 2010; 3:pe29.
    • (2010) Sci Signal , vol.3
    • Razani, B.1    Cheng, G.2
  • 53
    • 78650656795 scopus 로고    scopus 로고
    • The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-kappaB canonical signaling pathway in PMA-induced THP-1 monocytes
    • Wang Y, Huang Z, Wang L, Meng S, Fan Y, Chen T, et al. The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-kappaB canonical signaling pathway in PMA-induced THP-1 monocytes. Int J Mol Med 2011; 27: 233-241.
    • (2011) Int J Mol Med , vol.27 , pp. 233-241
    • Wang, Y.1    Huang, Z.2    Wang, L.3    Meng, S.4    Fan, Y.5    Chen, T.6
  • 54
    • 84859726259 scopus 로고    scopus 로고
    • Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-kappaB pathway in microglia cells
    • Zhu C, Xiong Z, Chen X, Peng F, Hu X, Chen Y, et al. Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-kappaB pathway in microglia cells. PLoS One 2012; 7:e35125.
    • (2012) PLoS One , vol.7
    • Zhu, C.1    Xiong, Z.2    Chen, X.3    Peng, F.4    Hu, X.5    Chen, Y.6
  • 55
    • 78049283326 scopus 로고    scopus 로고
    • Artemisinin, an antimalarial agent, inhibits rat cardiac hypertrophy via inhibition of NF-kappaB signaling
    • Xiong Z, Sun G, Zhu C, Cheng B, Zhang C, Ma Y, et al. Artemisinin, an antimalarial agent, inhibits rat cardiac hypertrophy via inhibition of NF-kappaB signaling. Eur J Pharmacol 2010; 649: 277-284.
    • (2010) Eur J Pharmacol , vol.649 , pp. 277-284
    • Xiong, Z.1    Sun, G.2    Zhu, C.3    Cheng, B.4    Zhang, C.5    Ma, Y.6
  • 57
    • 77951651771 scopus 로고    scopus 로고
    • Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: Involvement of cell cycle arrest and inactivation of nuclear factor-kappaB
    • Chen H, Sun B, Wang S, Pan S, Gao Y, Bai X, et al. Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-kappaB. J Cancer Res Clin Oncol 2010; 136: 897-903.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 897-903
    • Chen, H.1    Sun, B.2    Wang, S.3    Pan, S.4    Gao, Y.5    Bai, X.6
  • 58
    • 79954480233 scopus 로고    scopus 로고
    • Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo
    • Xu Q, Li ZX, Peng HQ, Sun ZW, Cheng RL, Ye ZM, et al. Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo. J Zhejiang Univ Sci B 2011; 12: 247-255.
    • (2011) J Zhejiang Univ Sci B , vol.12 , pp. 247-255
    • Xu, Q.1    Li, Z.X.2    Peng, H.Q.3    Sun, Z.W.4    Cheng, R.L.5    Ye, Z.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.