Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Zhu, Cansheng ^a   Xiong, Zhaojun ^a   Chen, Xiaohong ^a   Peng, Fuhua ^a   Hu, Xueqiang ^a   Chen, Yanming ^a   Wang, Qing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; ARTEMISININ DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL MIGRATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; GEL MOBILITY SHIFT ASSAY; GENE SILENCING; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN BINDING; PROTEIN SYNTHESIS INHIBITION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CELL MOTION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; METABOLISM; PHOSPHORYLATION;

ANIMALS; ARTEMISININS; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RATS;

EID: 84859726259     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035125     Document Type: Article

References (37)

1. Barron KD, (1995) The microglial cell. A historical review. J Neurol Sci 134 (Suppl.): 57-68.
2. Kaur G, Han SJ, Yang I, Crane C, (2010) Microglia and central nervous system immunity. Neurosurg Clin N Am 21: 43-51.
3. Zielasek J, Hartung HP, (1996) Molecular mechanisms of microglial activation. Adv Neuroimmunol 6: 191-222.
4. Graeber MB, Streit WJ, (2010) Microglia: biology and pathology. Acta Neuropathol 119: 89-105.
5. Eikelenboom P, van Gool WA, (2004) Neuroinflammatory perspectives on the two faces of Alzheimer's disease. J Neural Transm 111: 281-294.
6. Koning N, Bö L, Hoek RM, Huitinga I, (2007) Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Ann Neurol 62: 504-514.
7. Krause DL, Müller N, (2010) Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease. Int J Alzheimers Dis 14: 732806.
8. Liu B, Hong JS, (2003) Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304: 1-7.
9. Qian L, Flood PM, Hong JS, (2010) Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm 117: 971-979.
10. Schieven GL, (2005) The biology of p38 kinase: a central role in inflammation. Curr Top Med Chem 5: 921-928.
11. White NJ, (2004) Antimalarial drug resistance. J Clin Invest 113: 1084-1092.
12. Wartenberg M, Wolf S, Budde P, Grünheck F, Acker H, et al. (2003) The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab Invest 83: 1647-1655.
13. Efferth T, (2006) Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells. Curr Drug Targets 7: 407-421.
14. Aldieri E, Atragene D, Bergandi L, Riganti C, Costamagna C, et al. (2003) Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-κB activation. FEBS Lett 552: 141-144.
15. Wang Z, Qiu J, Guo TB, Liu A, Wang Y, et al. (2007) Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. J Immunol 179: 5958-5965.
16. Nomura Y, (2001) NF-kappaB activation and IkappaB alpha dynamism involved in iNOS and chemokine induction in astroglial cells. Life Sci 68: 1695-1701.
17. Fiebich BL, Lieb K, Engels S, Heinrich M, (2002) Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells. J Neuroimmunol 132: 18-24.
18. Carmody RJ, Chen YH, (2007) Nuclear factor-kappa B: activation and regulation during toll-like receptor signaling. Cell Mol Immunol 4: 31-41.
19. Xu H, He Y, Yang X, Liang L, Zhan Z, et al. (2007) Antimalarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology (Oxford) 46: 920-926.
20. Haynes RK, (2001) Artemisinin and derivatives: the future for malaria treatment? Curr Opin Infect Dis 14: 719-726.
21. McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, et al. (1993) Microglia in degenerative neurological disease. Glia 7: 84-92.
22. Minghetti L, Levi G, (1998) Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol 54: 99-125.
23. Choi DK, Pennathur S, Perier C, (2005) Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. J Neurosci 28: 6594-6600.
24. McGeer PL, Itagaki S, Boyes BE, McGeer EG, (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38: 1285-1291.
25. Le W, Rowe D, Xie W, Ortiz I, He Y, et al. (2001) Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J Neurosci 21: 8447-8455.
26. Hashioka S, Klegeris A, Monji A, Kato T, Sawada M, et al. (2007) Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide. Exp Neurol 206: 33-42.
27. Park JS, Woo MS, Kim DH, Hyun JW, Kim WK, et al. (2007) Antiinflammatory mechanisms of isoflavone metabolites in lipopolysaccharidestimulated microglial cells. J Pharmacol Exp Ther 320: 1237-1245.
28. Ullrich O, Diestel A, Bechmann I, Homberg M, Grune T, et al. (2001) Turnover of oxidatively damaged nuclear proteins in BV-2 microglial cells is linked to their activation state by poly-ADP-ribose polymerase. FASEB J 15: 1460-1462.
29. Wang MJ, Lin WW, Chen HL, Chang YH, Ou HC, et al. (2002) Silymarin protects dopaminergic neurons against lipopolysaccharideinduced neurotoxicity by inhibiting microglia activation. Eur J NeuroSci 16: 2103-2112.
30. Lee SM, Yune TY, Kim SJ, Kim YC, Oh YJ, et al. (2004) Minocycline inhibits apoptotic cell death via attenuation of TNF-alpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures. J Neurochem 91: 568-578.
31. Wang JX, Hou LF, Yang Y, Tang W, Li Y, et al. (2009) SM905, an artemisinin derivative, inhibited NO and pro-inflammatory cytokine production by suppressing MAPK and NF-kappaB pathways in RAW 264.7 macrophages. Acta Pharmacol Sin 30: 1428-1435.
32. Wang Y, Huang Z, Wang L, Meng S, Fan Y, et al. (2011) The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes. Int J Mol Med 27: 233-241.
33. Karin M, Ben-Neriah Y, (2000) Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18: 621-633.
34. Baldwin AS Jr, (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14: 649-683.
35. Akundi RS, Candelario-Jalil E, Hess S, Hüll M, Lieb K, et al. (2005) Signal transduction pathways regulating cyclooxygenase-2 in lipopolysaccharide-activated primary rat microglia. Glia 51: 199-208.
36. Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, et al. (2010) Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation 7: 3.
37. Dignam DJ, Lebovitz RM, Roeder RG, (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11: 1475-1489.