Affinity maturation of a computationally designed binding protein affords a functional but disordered polypeptide

Journal of Structural Biology

Volumn 185, Issue 2, 2014, Pages 168-177

  Butz, Maren ^a   Kast, Peter ^a   Hilvert, Donald ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Computational design; Directed evolution; Intrinsically disordered proteins; Molten globule; Protein protein interactions; Protein receptor interface; Yeast surface display

Indexed keywords

COMPUTATIONAL DESIGN; DIRECTED EVOLUTION; INTRINSICALLY DISORDERED PROTEINS; MOLTEN GLOBULE; PROTEIN-PROTEIN INTERACTIONS; PROTEIN-RECEPTOR INTERFACE; YEAST SURFACE DISPLAY;

AMINO ACID SEQUENCE; COMPUTER SIMULATION; DIRECTED MOLECULAR EVOLUTION; FLOW CYTOMETRY; FLUORESCENCE POLARIZATION; HUMANS; INTRINSICALLY DISORDERED PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; P21-ACTIVATED KINASES; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 84895001455     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2013.03.008     Document Type: Article

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