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Volumn 35, Issue 9, 2014, Pages 2924-2933

Tumor-suppressive effect of a telomerase-derived peptide by inhibiting hypoxia-induced HIF-1α-VEGF signaling axis

Author keywords

Cancer; Heat shock protein 70; Heat shock protein 90; Peptide; Telomerase

Indexed keywords

CANCER; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PEPTIDE; TELOMERASE;

EID: 84894974715     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.12.077     Document Type: Article
Times cited : (26)

References (45)
  • 1
    • 25844494542 scopus 로고    scopus 로고
    • Sick chaperones, cellular stress, and disease
    • Macario A.J., Conway de Macario E. Sick chaperones, cellular stress, and disease. NEngl J Med 2005, 353:1489-1501.
    • (2005) NEngl J Med , vol.353 , pp. 1489-1501
    • Macario, A.J.1    Conway de Macario, E.2
  • 2
    • 35548948037 scopus 로고    scopus 로고
    • New tricks for an old dog: the evolving world of Hsp70
    • Morano K.A. New tricks for an old dog: the evolving world of Hsp70. Ann N Y Acad Sci 2007, 1113:1-14.
    • (2007) Ann N Y Acad Sci , vol.1113 , pp. 1-14
    • Morano, K.A.1
  • 4
    • 21744445069 scopus 로고    scopus 로고
    • Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications
    • Ciocca D.R., Calderwood S.K. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 2005, 10:86-103.
    • (2005) Cell Stress Chaperones , vol.10 , pp. 86-103
    • Ciocca, D.R.1    Calderwood, S.K.2
  • 5
    • 1842691021 scopus 로고    scopus 로고
    • PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation
    • Zhou J., Schmid T., Frank R., Brune B. PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. JBiol Chem 2004, 279:13506-13513.
    • (2004) JBiol Chem , vol.279 , pp. 13506-13513
    • Zhou, J.1    Schmid, T.2    Frank, R.3    Brune, B.4
  • 6
    • 84876451950 scopus 로고    scopus 로고
    • Aheat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair
    • Bruns A.F., Yuldasheva N., Latham A.M., Bao L., Pellet-Many C., Frankel P., et al. Aheat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. PLoS One 2012, 7:e48539.
    • (2012) PLoS One , vol.7
    • Bruns, A.F.1    Yuldasheva, N.2    Latham, A.M.3    Bao, L.4    Pellet-Many, C.5    Frankel, P.6
  • 7
    • 10644261537 scopus 로고    scopus 로고
    • Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase
    • Sun J., Liao J.K. Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol 2004, 24:2238-2244.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 2238-2244
    • Sun, J.1    Liao, J.K.2
  • 8
    • 84880610121 scopus 로고    scopus 로고
    • Invasion potential of H22 hepatocarcinoma cells is increased by HMGB1-induced tumor NF-kappaB signaling via initiation of HSP70
    • Gong W., Wang Z.Y., Chen G.X., Liu Y.Q., Gu X.Y., Liu W.W. Invasion potential of H22 hepatocarcinoma cells is increased by HMGB1-induced tumor NF-kappaB signaling via initiation of HSP70. Oncol Rep 2013, 30:1249-1256.
    • (2013) Oncol Rep , vol.30 , pp. 1249-1256
    • Gong, W.1    Wang, Z.Y.2    Chen, G.X.3    Liu, Y.Q.4    Gu, X.Y.5    Liu, W.W.6
  • 9
    • 11344280957 scopus 로고    scopus 로고
    • Extracellular roles for the molecular chaperone, hsp90
    • Eustace B.K., Jay D.G. Extracellular roles for the molecular chaperone, hsp90. Cell Cycle 2004, 3:1098-1100.
    • (2004) Cell Cycle , vol.3 , pp. 1098-1100
    • Eustace, B.K.1    Jay, D.G.2
  • 10
    • 2942716692 scopus 로고    scopus 로고
    • Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
    • Eustace B.K., Sakurai T., Stewart J.K., Yimlamai D., Unger C., Zehetmeier C., et al. Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. Nat Cell Biol 2004, 6:507-514.
    • (2004) Nat Cell Biol , vol.6 , pp. 507-514
    • Eustace, B.K.1    Sakurai, T.2    Stewart, J.K.3    Yimlamai, D.4    Unger, C.5    Zehetmeier, C.6
  • 11
    • 0028961801 scopus 로고
    • Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells
    • Jaattela M. Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells. Int J Cancer 1995, 60:689-693.
    • (1995) Int J Cancer , vol.60 , pp. 689-693
    • Jaattela, M.1
  • 13
    • 0033578065 scopus 로고    scopus 로고
    • Oncogenic potential of Hsp72
    • Volloch V.Z., Sherman M.Y. Oncogenic potential of Hsp72. Oncogene 1999, 18:3648-3651.
    • (1999) Oncogene , vol.18 , pp. 3648-3651
    • Volloch, V.Z.1    Sherman, M.Y.2
  • 14
    • 84878964181 scopus 로고    scopus 로고
    • The HSP70 family and cancer
    • Murphy M.E. The HSP70 family and cancer. Carcinogenesis 2013, 34:1181-1188.
    • (2013) Carcinogenesis , vol.34 , pp. 1181-1188
    • Murphy, M.E.1
  • 15
    • 84880787644 scopus 로고    scopus 로고
    • Inhibition of HSP90 molecular chaperones: moving into the clinic
    • Garcia-Carbonero R., Carnero A., Paz-Ares L. Inhibition of HSP90 molecular chaperones: moving into the clinic. Lancet Oncol 2013, 14:e358-e369.
    • (2013) Lancet Oncol , vol.14
    • Garcia-Carbonero, R.1    Carnero, A.2    Paz-Ares, L.3
  • 16
    • 12344312254 scopus 로고    scopus 로고
    • Liposomal Hsp90 cDNA induces neovascularization via nitric oxide in chronic ischemia
    • Pfosser A., Thalgott M., Buttner K., Brouet A., Feron O., Boekstegers P., et al. Liposomal Hsp90 cDNA induces neovascularization via nitric oxide in chronic ischemia. Cardiovasc Res 2005, 65:728-736.
    • (2005) Cardiovasc Res , vol.65 , pp. 728-736
    • Pfosser, A.1    Thalgott, M.2    Buttner, K.3    Brouet, A.4    Feron, O.5    Boekstegers, P.6
  • 17
    • 0026749295 scopus 로고
    • Unusual expression and localization of heat-shock proteins in human tumor cells
    • Ferrarini M., Heltai S., Zocchi M.R., Rugarli C. Unusual expression and localization of heat-shock proteins in human tumor cells. Int J Cancer 1992, 51:613-619.
    • (1992) Int J Cancer , vol.51 , pp. 613-619
    • Ferrarini, M.1    Heltai, S.2    Zocchi, M.R.3    Rugarli, C.4
  • 18
    • 0024392717 scopus 로고
    • Apeptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family
    • Vanbuskirk A., Crump B.L., Margoliash E., Pierce S.K. Apeptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. JExp Med 1989, 170:1799-1809.
    • (1989) JExp Med , vol.170 , pp. 1799-1809
    • Vanbuskirk, A.1    Crump, B.L.2    Margoliash, E.3    Pierce, S.K.4
  • 19
    • 77950090840 scopus 로고    scopus 로고
    • Clinical correlation of circulating heat shock protein 70 in acute leukemia
    • Yeh C.H., Tseng R., Hannah A., Estrov Z., Estey E., Kantarjian H., et al. Clinical correlation of circulating heat shock protein 70 in acute leukemia. Leuk Res 2010, 34:605-609.
    • (2010) Leuk Res , vol.34 , pp. 605-609
    • Yeh, C.H.1    Tseng, R.2    Hannah, A.3    Estrov, Z.4    Estey, E.5    Kantarjian, H.6
  • 20
    • 77950342849 scopus 로고    scopus 로고
    • Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis
    • Kocsis J., Madaras B., Toth E.K., Fust G., Prohaszka Z. Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis. Cell Stress Chaperones 2010, 15:143-151.
    • (2010) Cell Stress Chaperones , vol.15 , pp. 143-151
    • Kocsis, J.1    Madaras, B.2    Toth, E.K.3    Fust, G.4    Prohaszka, Z.5
  • 21
    • 77950365397 scopus 로고    scopus 로고
    • Differential heat shock protein localization in chronic lymphocytic leukemia
    • Dempsey N.C., Leoni F., Ireland H.E., Hoyle C., Williams J.H. Differential heat shock protein localization in chronic lymphocytic leukemia. JLeukoc Biol 2010, 87:467-476.
    • (2010) JLeukoc Biol , vol.87 , pp. 467-476
    • Dempsey, N.C.1    Leoni, F.2    Ireland, H.E.3    Hoyle, C.4    Williams, J.H.5
  • 22
    • 84866549191 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibition: rationale and clinical potential
    • Den R.B., Lu B. Heat shock protein 90 inhibition: rationale and clinical potential. Ther Adv Med Oncol 2012, 4:211-218.
    • (2012) Ther Adv Med Oncol , vol.4 , pp. 211-218
    • Den, R.B.1    Lu, B.2
  • 23
    • 84884812874 scopus 로고    scopus 로고
    • Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1alpha and STAT-3
    • Ganji P.N., Park W., Wen J., Mahaseth H., Landry J., Farris A.B., et al. Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1alpha and STAT-3. Angiogenesis 2013, 16:903-917.
    • (2013) Angiogenesis , vol.16 , pp. 903-917
    • Ganji, P.N.1    Park, W.2    Wen, J.3    Mahaseth, H.4    Landry, J.5    Farris, A.B.6
  • 24
    • 83455213667 scopus 로고    scopus 로고
    • Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation
    • Bohonowych J.E., Peng S., Gopal U., Hance M.W., Wing S.B., Argraves K.M., et al. Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer 2011, 11:520.
    • (2011) BMC Cancer , vol.11 , pp. 520
    • Bohonowych, J.E.1    Peng, S.2    Gopal, U.3    Hance, M.W.4    Wing, S.B.5    Argraves, K.M.6
  • 25
    • 77953734857 scopus 로고    scopus 로고
    • Heat shock protein 70 (hsp70) as an emerging drug target
    • Evans C.G., Chang L., Gestwicki J.E. Heat shock protein 70 (hsp70) as an emerging drug target. JMed Chem 2010, 53:4585-4602.
    • (2010) JMed Chem , vol.53 , pp. 4585-4602
    • Evans, C.G.1    Chang, L.2    Gestwicki, J.E.3
  • 26
    • 77953576838 scopus 로고    scopus 로고
    • Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?
    • Powers M.V., Jones K., Barillari C., Westwood I., van Montfort R.L., Workman P. Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?. Cell Cycle 2010, 9:1542-1550.
    • (2010) Cell Cycle , vol.9 , pp. 1542-1550
    • Powers, M.V.1    Jones, K.2    Barillari, C.3    Westwood, I.4    van Montfort, R.L.5    Workman, P.6
  • 27
    • 77954662908 scopus 로고    scopus 로고
    • Anovel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
    • Massey A.J., Williamson D.S., Browne H., Murray J.B., Dokurno P., Shaw T., et al. Anovel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol 2010, 66:535-545.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 535-545
    • Massey, A.J.1    Williamson, D.S.2    Browne, H.3    Murray, J.B.4    Dokurno, P.5    Shaw, T.6
  • 28
    • 84865618692 scopus 로고    scopus 로고
    • Inhibition of HSP70: a challenging anti-cancer strategy
    • Goloudina A.R., Demidov O.N., Garrido C. Inhibition of HSP70: a challenging anti-cancer strategy. Cancer Lett 2012, 325:117-124.
    • (2012) Cancer Lett , vol.325 , pp. 117-124
    • Goloudina, A.R.1    Demidov, O.N.2    Garrido, C.3
  • 29
    • 0033493173 scopus 로고    scopus 로고
    • Telomerase activity in human solid tumors. Diagnostic utility and clinical applications
    • Vasef M.A., Ross J.S., Cohen M.B. Telomerase activity in human solid tumors. Diagnostic utility and clinical applications. Am J Clin Pathol 1999, 112:S68-S75.
    • (1999) Am J Clin Pathol , vol.112
    • Vasef, M.A.1    Ross, J.S.2    Cohen, M.B.3
  • 30
    • 0032745120 scopus 로고    scopus 로고
    • Differential gene expression of human telomerase-associated protein hTERT and TEP1 in human hematopoietic cells
    • Uchida N., Otsuka T., Shigematsu H., Maeda M., Sugio Y., Itoh Y., et al. Differential gene expression of human telomerase-associated protein hTERT and TEP1 in human hematopoietic cells. Leuk Res 1999, 23:1127-1132.
    • (1999) Leuk Res , vol.23 , pp. 1127-1132
    • Uchida, N.1    Otsuka, T.2    Shigematsu, H.3    Maeda, M.4    Sugio, Y.5    Itoh, Y.6
  • 31
    • 67649598300 scopus 로고    scopus 로고
    • Cancer vaccination with telomerase peptide GV1001
    • Kyte J.A. Cancer vaccination with telomerase peptide GV1001. Expert Opin Investig Drugs 2009, 18:687-694.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 687-694
    • Kyte, J.A.1
  • 32
    • 33845247353 scopus 로고    scopus 로고
    • Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study
    • Bernhardt S.L., Gjertsen M.K., Trachsel S., Moller M., Eriksen J.A., Meo M., et al. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study. Br J Cancer 2006, 95:1474-1482.
    • (2006) Br J Cancer , vol.95 , pp. 1474-1482
    • Bernhardt, S.L.1    Gjertsen, M.K.2    Trachsel, S.3    Moller, M.4    Eriksen, J.A.5    Meo, M.6
  • 34
    • 79960329487 scopus 로고    scopus 로고
    • Telomerase peptide vaccination combined with temozolomide: a clinical trial in stage IV melanoma patients
    • Kyte J.A., Gaudernack G., Dueland S., Trachsel S., Julsrud L., Aamdal S. Telomerase peptide vaccination combined with temozolomide: a clinical trial in stage IV melanoma patients. Clin Cancer Res 2011, 17:4568-4580.
    • (2011) Clin Cancer Res , vol.17 , pp. 4568-4580
    • Kyte, J.A.1    Gaudernack, G.2    Dueland, S.3    Trachsel, S.4    Julsrud, L.5    Aamdal, S.6
  • 35
    • 80455140226 scopus 로고    scopus 로고
    • Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial
    • Brunsvig P.F., Kyte J.A., Kersten C., Sundstrom S., Moller M., Nyakas M., et al. Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial. Clin Cancer Res 2011, 17:6847-6857.
    • (2011) Clin Cancer Res , vol.17 , pp. 6847-6857
    • Brunsvig, P.F.1    Kyte, J.A.2    Kersten, C.3    Sundstrom, S.4    Moller, M.5    Nyakas, M.6
  • 36
    • 77953963578 scopus 로고    scopus 로고
    • Aphase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma
    • Greten T.F., Forner A., Korangy F., N'Kontchou G., Barget N., Ayuso C., et al. Aphase II open label trial evaluating safety and efficacy of a telomerase peptide vaccination in patients with advanced hepatocellular carcinoma. BMC Cancer 2010, 10:209.
    • (2010) BMC Cancer , vol.10 , pp. 209
    • Greten, T.F.1    Forner, A.2    Korangy, F.3    N'Kontchou, G.4    Barget, N.5    Ayuso, C.6
  • 37
    • 84880507288 scopus 로고    scopus 로고
    • Heat shock protein-mediated cell penetration and cytosolic delivery of macromolecules by a telomerase-derived peptide vaccine
    • Lee S.A., Kim B.R., Kim B.K., Kim D.W., Shon W.J., Lee N.R., et al. Heat shock protein-mediated cell penetration and cytosolic delivery of macromolecules by a telomerase-derived peptide vaccine. Biomaterials 2013, 34:7495-7505.
    • (2013) Biomaterials , vol.34 , pp. 7495-7505
    • Lee, S.A.1    Kim, B.R.2    Kim, B.K.3    Kim, D.W.4    Shon, W.J.5    Lee, N.R.6
  • 38
    • 0141708701 scopus 로고    scopus 로고
    • Natural product origins of Hsp90 inhibitors
    • Uehara Y. Natural product origins of Hsp90 inhibitors. Curr Cancer Drug Targets 2003, 3:325-330.
    • (2003) Curr Cancer Drug Targets , vol.3 , pp. 325-330
    • Uehara, Y.1
  • 39
    • 39849102836 scopus 로고    scopus 로고
    • HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    • Du R., Lu K.V., Petritsch C., Liu P., Ganss R., Passegue E., et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008, 13:206-220.
    • (2008) Cancer Cell , vol.13 , pp. 206-220
    • Du, R.1    Lu, K.V.2    Petritsch, C.3    Liu, P.4    Ganss, R.5    Passegue, E.6
  • 40
    • 28844451001 scopus 로고    scopus 로고
    • Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice
    • Shen H.Y., He J.C., Wang Y., Huang Q.Y., Chen J.F. Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. JBiol Chem 2005, 280:39962-39969.
    • (2005) JBiol Chem , vol.280 , pp. 39962-39969
    • Shen, H.Y.1    He, J.C.2    Wang, Y.3    Huang, Q.Y.4    Chen, J.F.5
  • 41
    • 15044350606 scopus 로고    scopus 로고
    • Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure
    • Elo M.A., Kaarniranta K., Helminen H.J., Lammi M.J. Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure. Biochim Biophys Acta 2005, 1743:115-119.
    • (2005) Biochim Biophys Acta , vol.1743 , pp. 115-119
    • Elo, M.A.1    Kaarniranta, K.2    Helminen, H.J.3    Lammi, M.J.4
  • 43
    • 84857535891 scopus 로고    scopus 로고
    • Critical role of hypoxia sensor-HIF-1alpha in VEGF gene activation. Implications for angiogenesis and tissue injury healing
    • Ahluwalia A., Tarnawski A.S. Critical role of hypoxia sensor-HIF-1alpha in VEGF gene activation. Implications for angiogenesis and tissue injury healing. Curr Med Chem 2012, 19:90-97.
    • (2012) Curr Med Chem , vol.19 , pp. 90-97
    • Ahluwalia, A.1    Tarnawski, A.S.2
  • 44
    • 0242573102 scopus 로고    scopus 로고
    • Role of hypoxia in tumor angiogenesis-molecular and cellular angiogenic crosstalk
    • Acker T., Plate K.H. Role of hypoxia in tumor angiogenesis-molecular and cellular angiogenic crosstalk. Cell Tissue Res 2003, 314:145-155.
    • (2003) Cell Tissue Res , vol.314 , pp. 145-155
    • Acker, T.1    Plate, K.H.2
  • 45
    • 24944587964 scopus 로고    scopus 로고
    • Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
    • De Palma M., Venneri M.A., Galli R., Sergi Sergi L., Politi L.S., Sampaolesi M., et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 2005, 8:211-226.
    • (2005) Cancer Cell , vol.8 , pp. 211-226
    • De Palma, M.1    Venneri, M.A.2    Galli, R.3    Sergi Sergi, L.4    Politi, L.S.5    Sampaolesi, M.6


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