메뉴 건너뛰기




Volumn 35, Issue 9, 2014, Pages 3132-3144

The potential of pH-responsive PEG-hyperbranched polyacylhydrazone micelles for cancer therapy

Author keywords

Drug delivery; Hyperbranched polymers; PH responsive

Indexed keywords

DRUG DELIVERY; HYPERBRANCHED POLYMERS; PH-RESPONSIVE;

EID: 84894965908     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.12.074     Document Type: Article
Times cited : (55)

References (47)
  • 2
    • 84862804633 scopus 로고    scopus 로고
    • Polymeric micelles drug delivery system in oncology
    • Gong J., Chen M., Zheng Y., Wang S., Wang Y. Polymeric micelles drug delivery system in oncology. JControl Release 2012, 159:312-323.
    • (2012) JControl Release , vol.159 , pp. 312-323
    • Gong, J.1    Chen, M.2    Zheng, Y.3    Wang, S.4    Wang, Y.5
  • 4
    • 32244443852 scopus 로고    scopus 로고
    • Polymer architecture and drug delivery
    • Qiu L.Y., Bae Y.H. Polymer architecture and drug delivery. Pharm Res 2006, 23:1-30.
    • (2006) Pharm Res , vol.23 , pp. 1-30
    • Qiu, L.Y.1    Bae, Y.H.2
  • 5
    • 33644781456 scopus 로고    scopus 로고
    • Multi-functional polymeric nanoparticles for tumour-targeted drug delivery
    • van Vlerken L.E., Amiji M.M. Multi-functional polymeric nanoparticles for tumour-targeted drug delivery. Expert Opin Drug Deliv 2006, 3:205-216.
    • (2006) Expert Opin Drug Deliv , vol.3 , pp. 205-216
    • van Vlerken, L.E.1    Amiji, M.M.2
  • 6
    • 84869006303 scopus 로고    scopus 로고
    • Poly (ethylene glycol)-armed hyperbranched polyoxetanes for anticancer drug delivery
    • Sharma K., Zolotarskaya O.Y., Wynne K.J., Yang H. Poly (ethylene glycol)-armed hyperbranched polyoxetanes for anticancer drug delivery. JBioact Compat Polym 2012, 27:525-539.
    • (2012) JBioact Compat Polym , vol.27 , pp. 525-539
    • Sharma, K.1    Zolotarskaya, O.Y.2    Wynne, K.J.3    Yang, H.4
  • 9
    • 80355142206 scopus 로고    scopus 로고
    • Doubly hydrophilic multiarm hyperbranched polymers with acylhydrazone linkages as acid-sensitive drug carriers
    • Wang Q., Zhu L., Li G., Tu C., Pang Y., Jin C., et al. Doubly hydrophilic multiarm hyperbranched polymers with acylhydrazone linkages as acid-sensitive drug carriers. Macromol Biosci 2011, 11:1553-1562.
    • (2011) Macromol Biosci , vol.11 , pp. 1553-1562
    • Wang, Q.1    Zhu, L.2    Li, G.3    Tu, C.4    Pang, Y.5    Jin, C.6
  • 10
    • 34548120614 scopus 로고    scopus 로고
    • Water-soluble pH-responsive dendritic core-shell nanocarriers for polar dyes based on poly(ethylene imine)
    • Xu S., Luo Y., Haag R. Water-soluble pH-responsive dendritic core-shell nanocarriers for polar dyes based on poly(ethylene imine). Macromol Biosci 2007, 7:968-974.
    • (2007) Macromol Biosci , vol.7 , pp. 968-974
    • Xu, S.1    Luo, Y.2    Haag, R.3
  • 11
    • 78149427797 scopus 로고    scopus 로고
    • Self-assembly of hyperbranched polymers and its biomedical applications
    • Zhou Y., Huang W., Liu J., Zhu X., Yan D. Self-assembly of hyperbranched polymers and its biomedical applications. Adv Mater 2010, 22:4567-4590.
    • (2010) Adv Mater , vol.22 , pp. 4567-4590
    • Zhou, Y.1    Huang, W.2    Liu, J.3    Zhu, X.4    Yan, D.5
  • 12
    • 84870190040 scopus 로고    scopus 로고
    • Biocompatible or biodegradable hyperbranched polymers: from self-assembly to cytomimetic applications
    • Jin H., Huang W., Zhu X., Zhou Y., Yan D. Biocompatible or biodegradable hyperbranched polymers: from self-assembly to cytomimetic applications. Chem Soc Rev 2012, 41:5986-5997.
    • (2012) Chem Soc Rev , vol.41 , pp. 5986-5997
    • Jin, H.1    Huang, W.2    Zhu, X.3    Zhou, Y.4    Yan, D.5
  • 13
    • 84875633511 scopus 로고    scopus 로고
    • PH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors
    • Chen C.Y., Kim T.H., Wu W.C., Huang C.M., Wei H., Mount C.W., et al. pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. Biomaterials 2013, 34:4501-4509.
    • (2013) Biomaterials , vol.34 , pp. 4501-4509
    • Chen, C.Y.1    Kim, T.H.2    Wu, W.C.3    Huang, C.M.4    Wei, H.5    Mount, C.W.6
  • 14
    • 66149140264 scopus 로고    scopus 로고
    • Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery
    • Onaca O., Enea R., Hughes D.W., Meier W. Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery. Macromol Biosci 2009, 9:129-139.
    • (2009) Macromol Biosci , vol.9 , pp. 129-139
    • Onaca, O.1    Enea, R.2    Hughes, D.W.3    Meier, W.4
  • 15
    • 79960222186 scopus 로고    scopus 로고
    • Polymer assemblies for controlled delivery of bioactive molecules from surfaces
    • Pavlukhina S., Sukhishvili S. Polymer assemblies for controlled delivery of bioactive molecules from surfaces. Adv Drug Deliv Rev 2011, 63:822-836.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 822-836
    • Pavlukhina, S.1    Sukhishvili, S.2
  • 16
    • 55749102507 scopus 로고    scopus 로고
    • Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery
    • Shen Y., Zhan Y., Tang J., Xu P., Johnson P.A., Radosz M., et al. Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery. AIChE J 2008, 54:2979-2989.
    • (2008) AIChE J , vol.54 , pp. 2979-2989
    • Shen, Y.1    Zhan, Y.2    Tang, J.3    Xu, P.4    Johnson, P.A.5    Radosz, M.6
  • 17
    • 84862878268 scopus 로고    scopus 로고
    • Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery
    • Zhang C.Y., Yang Y.Q., Huang T.X., Zhao B., Guo X.D., Wang J.F., et al. Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery. Biomaterials 2012, 33:6273-6283.
    • (2012) Biomaterials , vol.33 , pp. 6273-6283
    • Zhang, C.Y.1    Yang, Y.Q.2    Huang, T.X.3    Zhao, B.4    Guo, X.D.5    Wang, J.F.6
  • 18
    • 33746149756 scopus 로고    scopus 로고
    • Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    • Rofstad E.K., Mathiesen B., Kindem K., Galappathi K. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res 2006, 66:6699-6707.
    • (2006) Cancer Res , vol.66 , pp. 6699-6707
    • Rofstad, E.K.1    Mathiesen, B.2    Kindem, K.3    Galappathi, K.4
  • 19
    • 77957746194 scopus 로고    scopus 로고
    • Metabolic microenvironment of tumor cells: a key factor in malignant progression
    • Vaupel P. Metabolic microenvironment of tumor cells: a key factor in malignant progression. Exp Oncol 2010, 32:125-127.
    • (2010) Exp Oncol , vol.32 , pp. 125-127
    • Vaupel, P.1
  • 20
    • 79955918786 scopus 로고    scopus 로고
    • Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells
    • Zhou K., Wang Y., Huang X., Luby-Phelps K., Sumer B.D., Gao J. Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells. Angew Chem Int Ed Engl 2011, 50:6109-6114.
    • (2011) Angew Chem Int Ed Engl , vol.50 , pp. 6109-6114
    • Zhou, K.1    Wang, Y.2    Huang, X.3    Luby-Phelps, K.4    Sumer, B.D.5    Gao, J.6
  • 21
    • 77951924919 scopus 로고    scopus 로고
    • Lysosomal degradation of membrane lipids
    • Kolter T., Sandhoff K. Lysosomal degradation of membrane lipids. FEBS Lett 2010, 584:1700-1712.
    • (2010) FEBS Lett , vol.584 , pp. 1700-1712
    • Kolter, T.1    Sandhoff, K.2
  • 22
    • 79960316698 scopus 로고    scopus 로고
    • Construction and application of pH-triggered cleavable hyperbranched polyacylhydrazone for drug delivery
    • Zhu L.J., Tu C.L., Zhu B.S., Su Y., Pang Y., Yan D.Y., et al. Construction and application of pH-triggered cleavable hyperbranched polyacylhydrazone for drug delivery. Polym Chem 2011, 2:1761-1768.
    • (2011) Polym Chem , vol.2 , pp. 1761-1768
    • Zhu, L.J.1    Tu, C.L.2    Zhu, B.S.3    Su, Y.4    Pang, Y.5    Yan, D.Y.6
  • 23
    • 79955777649 scopus 로고    scopus 로고
    • Ku70 and Rad51 vary in their importance for the repair of doxorubicin- versus etoposide-induced DNA damage
    • Schonn I., Hennesen J., Dartsch D.C. Ku70 and Rad51 vary in their importance for the repair of doxorubicin- versus etoposide-induced DNA damage. Apoptosis 2011, 16:359-369.
    • (2011) Apoptosis , vol.16 , pp. 359-369
    • Schonn, I.1    Hennesen, J.2    Dartsch, D.C.3
  • 25
    • 77954554783 scopus 로고    scopus 로고
    • Construction and application of a pH-sensitive nanoreactor via a double-hydrophilic multiarm hyperbranched polymer
    • Zhu L., Shi Y., Tu C., Wang R., Pang Y., Qiu F., et al. Construction and application of a pH-sensitive nanoreactor via a double-hydrophilic multiarm hyperbranched polymer. Langmuir 2010, 26:8875-8881.
    • (2010) Langmuir , vol.26 , pp. 8875-8881
    • Zhu, L.1    Shi, Y.2    Tu, C.3    Wang, R.4    Pang, Y.5    Qiu, F.6
  • 26
    • 84861152297 scopus 로고    scopus 로고
    • Enhanced stability of polymeric micelles based on postfunctionalized poly(ethylene glycol)-b-poly(γ-propargyl L-glutamate): the substituent effect
    • Zhao X., Poon Z., Engler A.C., Bonner D.K., Hammond P.T. Enhanced stability of polymeric micelles based on postfunctionalized poly(ethylene glycol)-b-poly(γ-propargyl L-glutamate): the substituent effect. Biomacromolecules 2012, 13:1315-1322.
    • (2012) Biomacromolecules , vol.13 , pp. 1315-1322
    • Zhao, X.1    Poon, Z.2    Engler, A.C.3    Bonner, D.K.4    Hammond, P.T.5
  • 27
    • 84874782064 scopus 로고    scopus 로고
    • Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer
    • Xu Q., Sun Q., Zhang J., Yu J., Chen W., Zhang Z. Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer. Carcinogenesis 2013, 34:539-549.
    • (2013) Carcinogenesis , vol.34 , pp. 539-549
    • Xu, Q.1    Sun, Q.2    Zhang, J.3    Yu, J.4    Chen, W.5    Zhang, Z.6
  • 28
    • 82255181803 scopus 로고    scopus 로고
    • Increase in docetaxel-resistance of ovarian carcinoma-derived RMG-1 cells with enhanced expression of Lewis Y antigen
    • Zhang F., Liu J., Lin B., Liu Q., Zhao Y., Zhu L., et al. Increase in docetaxel-resistance of ovarian carcinoma-derived RMG-1 cells with enhanced expression of Lewis Y antigen. Int J Mol Sci 2011, 12:7323-7334.
    • (2011) Int J Mol Sci , vol.12 , pp. 7323-7334
    • Zhang, F.1    Liu, J.2    Lin, B.3    Liu, Q.4    Zhao, Y.5    Zhu, L.6
  • 29
    • 33745110220 scopus 로고    scopus 로고
    • Tumor pH controls the invivo efficacy of weak acid and base chemotherapeutics
    • Gerweck L.E., Vijayappa S., Kozin S. Tumor pH controls the invivo efficacy of weak acid and base chemotherapeutics. Mol Cancer Ther 2006, 5:1275-1279.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1275-1279
    • Gerweck, L.E.1    Vijayappa, S.2    Kozin, S.3
  • 30
    • 0027274811 scopus 로고
    • Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia
    • Prescott D.M., Charles H.C., Sostman H.D., Page R.L., Thrall D.E., Moore D., et al. Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia. Int J Hyperth 1993, 9:745-754.
    • (1993) Int J Hyperth , vol.9 , pp. 745-754
    • Prescott, D.M.1    Charles, H.C.2    Sostman, H.D.3    Page, R.L.4    Thrall, D.E.5    Moore, D.6
  • 31
    • 0032747954 scopus 로고    scopus 로고
    • Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice
    • van Tellingen O., Beijnen J.H., Verweij J., Scherrenburg E.J., Nooijen W.J., Sparreboom A. Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice. Clin Cancer Res 1999, 5:2918-2924.
    • (1999) Clin Cancer Res , vol.5 , pp. 2918-2924
    • van Tellingen, O.1    Beijnen, J.H.2    Verweij, J.3    Scherrenburg, E.J.4    Nooijen, W.J.5    Sparreboom, A.6
  • 32
    • 33744909346 scopus 로고    scopus 로고
    • Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3-hydroxybutyrate) and poly(ethylene glycol) as drug carriers
    • Chen C., Yu C.H., Cheng Y.C., Yu P.H., Cheung M.K. Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3-hydroxybutyrate) and poly(ethylene glycol) as drug carriers. Biomaterials 2006, 27:4804-4814.
    • (2006) Biomaterials , vol.27 , pp. 4804-4814
    • Chen, C.1    Yu, C.H.2    Cheng, Y.C.3    Yu, P.H.4    Cheung, M.K.5
  • 33
    • 84880419497 scopus 로고    scopus 로고
    • Synthesis and characterization of a new multifunctional polymeric prodrug paclitaxel-polyphosphoester-folic acid for targeted drug delivery
    • Zhang G., Zhang M.Z., He J.L., Ni P.H. Synthesis and characterization of a new multifunctional polymeric prodrug paclitaxel-polyphosphoester-folic acid for targeted drug delivery. Polym Chem 2013, 4:4515-4525.
    • (2013) Polym Chem , vol.4 , pp. 4515-4525
    • Zhang, G.1    Zhang, M.Z.2    He, J.L.3    Ni, P.H.4
  • 34
    • 67650227231 scopus 로고    scopus 로고
    • Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3-hydroxybutyrate) for drug delivery
    • Cheng J., Wang J. Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3-hydroxybutyrate) for drug delivery. Sci China Ser B Chem 2012, 52:961-968.
    • (2012) Sci China Ser B Chem , vol.52 , pp. 961-968
    • Cheng, J.1    Wang, J.2
  • 35
    • 1142274292 scopus 로고    scopus 로고
    • Surface functionalized cationic lipid-DNA complexes for gene delivery: PEGylated lamellar complexes exhibit distinct DNA-DNA interaction regimes
    • Martin-Herranz A., Ahmad A., Evans H.M., Ewert K., Schulze U., Safinya C.R. Surface functionalized cationic lipid-DNA complexes for gene delivery: PEGylated lamellar complexes exhibit distinct DNA-DNA interaction regimes. Biophys J 2004, 86:1160-1168.
    • (2004) Biophys J , vol.86 , pp. 1160-1168
    • Martin-Herranz, A.1    Ahmad, A.2    Evans, H.M.3    Ewert, K.4    Schulze, U.5    Safinya, C.R.6
  • 36
    • 34548482374 scopus 로고    scopus 로고
    • Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential
    • Immordino M.L., Dosio F., Cattel L. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomedicine 2006, 1:297-315.
    • (2006) Int J Nanomedicine , vol.1 , pp. 297-315
    • Immordino, M.L.1    Dosio, F.2    Cattel, L.3
  • 37
    • 84883887168 scopus 로고    scopus 로고
    • Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery
    • [Epub ahead of print]
    • Kulkarni S.A., Feng S.S. Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery. Pharm Res 2013, [Epub ahead of print].
    • (2013) Pharm Res
    • Kulkarni, S.A.1    Feng, S.S.2
  • 38
    • 40949127319 scopus 로고    scopus 로고
    • Therapeutic nanoparticles for drug delivery in cancer
    • Cho K., Wang X., Nie S., Chen Z.G., Shin D.M. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 2008, 14:1310-1316.
    • (2008) Clin Cancer Res , vol.14 , pp. 1310-1316
    • Cho, K.1    Wang, X.2    Nie, S.3    Chen, Z.G.4    Shin, D.M.5
  • 39
    • 0242584817 scopus 로고    scopus 로고
    • Micellar nanocontainers distribute to defined cytoplasmic organelles
    • Savic R., Luo L., Eisenberg A., Maysinger D. Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 2003, 300:615-618.
    • (2003) Science , vol.300 , pp. 615-618
    • Savic, R.1    Luo, L.2    Eisenberg, A.3    Maysinger, D.4
  • 40
    • 4143074645 scopus 로고    scopus 로고
    • Micellar carriers based on block copolymers of poly(epsilon-caprolactone) and poly(ethylene glycol) for doxorubicin delivery
    • Shuai X., Ai H., Nasongkla N., Kim S., Gao J. Micellar carriers based on block copolymers of poly(epsilon-caprolactone) and poly(ethylene glycol) for doxorubicin delivery. JControl Release 2004, 98:415-426.
    • (2004) JControl Release , vol.98 , pp. 415-426
    • Shuai, X.1    Ai, H.2    Nasongkla, N.3    Kim, S.4    Gao, J.5
  • 41
    • 78649315943 scopus 로고    scopus 로고
    • To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    • Danhier F., Feron O., Préat V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. JControl Release 2010, 148:135-146.
    • (2010) JControl Release , vol.148 , pp. 135-146
    • Danhier, F.1    Feron, O.2    Préat, V.3
  • 42
    • 78049444148 scopus 로고    scopus 로고
    • Intracellular distribution-based anticancer drug targeting: exploiting a lysosomal acidification defect associated with cancer cells
    • Ndolo R.A., Jacobs D.T., Forrest M.L., Krise J.P. Intracellular distribution-based anticancer drug targeting: exploiting a lysosomal acidification defect associated with cancer cells. Mol Cell Pharmacol 2010, 2:131-136.
    • (2010) Mol Cell Pharmacol , vol.2 , pp. 131-136
    • Ndolo, R.A.1    Jacobs, D.T.2    Forrest, M.L.3    Krise, J.P.4
  • 43
    • 84862197399 scopus 로고    scopus 로고
    • Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity
    • Stern S.T., Adiseshaiah P.P., Crist R.M. Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part Fibre Toxicol 2012, 9:20.
    • (2012) Part Fibre Toxicol , vol.9 , pp. 20
    • Stern, S.T.1    Adiseshaiah, P.P.2    Crist, R.M.3
  • 44
    • 0036324712 scopus 로고    scopus 로고
    • Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery
    • Panyam J., Zhou W.Z., Prabha S., Sahoo S.K., Labhasetwar V. Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery. FASEB J 2002, 16:1217-1226.
    • (2002) FASEB J , vol.16 , pp. 1217-1226
    • Panyam, J.1    Zhou, W.Z.2    Prabha, S.3    Sahoo, S.K.4    Labhasetwar, V.5
  • 45
    • 33847083585 scopus 로고    scopus 로고
    • Multifunctional core/shell nanoparticles self-assembled from pH-induced thermosensitive polymers for targeted intracellular anticancer drug delivery
    • Soppimath K.S., Liu L.H., Seow W.Y., Liu S.Q., Powell R., Chan P., et al. Multifunctional core/shell nanoparticles self-assembled from pH-induced thermosensitive polymers for targeted intracellular anticancer drug delivery. Adv Funct Mater 2007, 17:355-362.
    • (2007) Adv Funct Mater , vol.17 , pp. 355-362
    • Soppimath, K.S.1    Liu, L.H.2    Seow, W.Y.3    Liu, S.Q.4    Powell, R.5    Chan, P.6
  • 46
    • 77955472111 scopus 로고    scopus 로고
    • Anovel Doxorubicin prodrug with controllable photolysis activation for cancer chemotherapy
    • Ibsen S., Zahavy E., Wrasdilo W., Berns M., Chan M., Esener S. Anovel Doxorubicin prodrug with controllable photolysis activation for cancer chemotherapy. Pharm Res 2010, 27:1848-1860.
    • (2010) Pharm Res , vol.27 , pp. 1848-1860
    • Ibsen, S.1    Zahavy, E.2    Wrasdilo, W.3    Berns, M.4    Chan, M.5    Esener, S.6
  • 47
    • 18144377999 scopus 로고    scopus 로고
    • Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
    • Neuberger T., Schöpf B., Hofmann H., Hofmannc M., von Rechenberg B. Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. JMagn Magn Mater 2005, 293:483-496.
    • (2005) JMagn Magn Mater , vol.293 , pp. 483-496
    • Neuberger, T.1    Schöpf, B.2    Hofmann, H.3    Hofmannc, M.4    von Rechenberg, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.