Surface Functionalized Cationic Lipid-DNA Complexes for Gene Delivery: PEGylated Lamellar Complexes Exhibit Distinct DNA-DNA Interaction Regimes

Biophysical Journal

Volumn 86, Issue 2, 2004, Pages 1160-1168

  Martin Herranz, Ana ^a,c   Ahmad, Ayesha ^a   Evans, Heather M ^a   Ewert, Kai ^a   Schulze, Uwe ^a   Safinya, Cyrus R ^a,b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNILEVER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; MACROGOL; POLYMER;

ARTICLE; BIOCOMPATIBILITY; CATIONIC LIPID DNA INTERACTION; DNA DNA INTERACTION; FORCE; GENE VECTOR; HYDRATION; MICROSCOPY; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NONVIRAL GENE DELIVERY SYSTEM; REPORTER GENE; STRUCTURE ANALYSIS; SURFACE PROPERTY; TECHNIQUE; X RAY DIFFRACTION;

EID: 1142274292     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(04)74190-9     Document Type: Article

References (38)

1. Allen, T. M. 1994. Long-circulating (sterically stabilized) liposomes for targeted drug-delivery. Trends Pharmacol. Sci. 15:215-220.
2. Bradley, A. J., D. V. Devine, S. M. Ansell, J. Janzen, and D. E. Brooks. 1998. Inhibition of liposome-induced complement activation by incorporated poly(ethylene glycol) lipids. Arch. Biochem. Biophys. 357:185-194.
3. Bruinsma, R., and J. Mashl. 1998. Long-range electrostatic interaction in DNA cationic lipid complexes. Europhys. Lett. 41:165-170.
4. Chesnoy, S., and L. Huang. 2000. Structure and function of lipid-DNA complexes for gene delivery. Annu. Rev. Biophys. Biomol. Struct. 29:27-47.
5. Devanand, K., and J. C. Selser. 1991. Asymptotic behavior and long-range interactions in aqueous solutions of poly(ethylene oxide). Macromolecules. 24:5943-5947.
6. Ewert, K., A. Ahmad, H. M. Evans, H. W. Schmidt, and C. R. Safinya. 2002. Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery. J. Med. Chem. 45:5023-5029.
7. Felgner, P. L. 1997. Nonviral strategies for gene therapy. Sci. Am. 276:102-106.
8. Felgner, P. L., and G. Rhodes. 1991. Gene therapeutics. Nature. 349:351-352.
9. Gruner, S. M., M. W. Tate, G. L. Kirk, P. T. C. So, D. C. Turner, D. T. Keane, C. P. S. Tilcock, and P. R. Cullis. 1988. X-ray diffraction study of the polymorphic behavior of N-methylated dioleoylphosphatidylethanolamine. Biochemistry. 27:2853-2866.
10. Harries, D., S. May, W. M. Gelbart, and A. Ben-Shaul. 1998. Structure, stability, and thermodynamics of lamellar DNA-lipid complexes. Biophys. J. 75:159-173.
11. Harris, J. M., and S. Zalipsky, editors. 1997. Poly(ethylene glycol) Chemistry and Biological Applications. American Chemical Society, Washington, DC.
12. Harvie, P., F. M. P. Wong, and M. B. Bally. 2000. Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. J. Pharm. Sci. 89:652-663.
13. Israelachvili, J. 1992. Intermolecular and Surface Forces. Academic Press, London.
14. Koltover, I., T. Salditt, J. O. Rädler, and C. R. Safinya. 1998. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery. Science. 281:78-81.
15. Koltover, I., T. Salditt, and C. R. Safinya. 1999. Phase Diagram, Stability, and Overcharging of Lamellar Cationic Lipid-DNA Self-Assembled Complexes. Biophys. J. 77:915-924.
16. Koltover, I., K. Wagner, and C. R. Safinya. 2000. DNA condensation in two dimensions. Proc. Natl. Acad. Sci. USA. 97:14046-14051.
17. Lasic, D. D., and F. J. Martin, editors. 1995a. Stealth Liposomes. CRC Press, Boca Raton, FL.
18. Lasic, D. D., and D. Papahadjopoulos. 1995b. Liposomes revisited. Science. 267:1275-1276.
19. Lasic, D. D., H. Strey, M. C. A. Stuart, R. Podgomik, and P. M. Frederik. 1997. The structure of DNA-liposome complexes. J. Am. Chem. Soc. 119:832-833.
20. Lin, A. J., N. L. Slack, A. Ahmad, C. X. George, C. E. Samuel, and C. R. Safinya. 2003. Three-dimensional imaging of lipid gene-carriers: membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes. Biophys. J. 84:3307-3316.
21. Lin, A. J., N. L. Slack, A. Ahmad, I. Koltover, C. X. George, C. E. Samuel, and C. R. Safinya. 2000. Structure and structure-function studies of lipid/plasmid DNA complexes. J. Drug Target. 8:13-27.
22. Mahato, R. I., and S. W. Kim, editors. 2002. Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics. Taylor & Francis, London.
23. Midoux, P., and C. Pichon. 2002. Peptide-based gene delivery systems. In Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics. S. W. Kim, editor. Taylor & Francis, London. 334-366.
24. Mislick, K. A., and J. D. Baldeschwieler. 1996. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc. Natl. Acad. Sci. USA. 93:12349-12354.
25. Pitard, B., N. Oudrhiri, O. Lambert, E. Vivien, C. Masson, B. Wetzer, M. Hauchecome, D. Scherman, J. L. Rigaud, J. P. Vigneron, J. M. Lehn, and P. Lehn. 2001. Sterically stabilized BGTC-based lipoplexes: structural features and gene transfection into the mouse airways in vivo. J. Gene Med. 3:478-487.
26. Rädler, J. O., I. Koltover, T. Salditt, and C. R. Safinya. 1997. Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes. Science. 275:810-814.
27. Safinya, C. R. 2001. Structures of lipid-DNA complexes: supramolecular assembly and gene delivery. Curr. Opin. Struct. Biol. 11:440-448.
28. Salditt, T., I. Koltover, O. Radler, and C. R. Safinya. 1998. Self-assembled DNA-cationic-lipid complexes: Two-dimensional smectic ordering, correlations, and interactions. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 58:889-904.
29. Schulze, U., H. W. Schmidt, and C. R. Safinya. 1999. Synthesis of novel cationic poly(ethylene glycol) containing lipids. Bioconjug. Chem. 10:548-552.
30. Suh, W., S. O. Han, L. Yu, and S. W. Kim. 2002. An angiogenic, endothelial-cell-targeted polymeric gene carrier. Mol. Ther. 6:664-672.
31. Tristram-Nagle, S., H. I. Petrache, and J. F. Nagle. 1998. Structure and interactions of fully hydrated dioleoylphosphatidylcholine bilayers. Biophys. J. 75:917-925.
32. Vasilevskaya, V. V., A. R. Khokhlov, Y. Matsuzawa, and K. Yoshikawa. 1995. Collapse of single DNA molecule in poly(ethylene glycol) solutions. J. Chem. Phys. 102:6595-6602.
33. Vroege, G. J., and H. N. W. Lekkerkerker. 1992. Phase transitions in lyotropic colloidal and polymer liquid crystals. Rep. Prog. Phys. 55:1241-1309.
34. Warriner, H. E., S. H. J. Idziak, N. L. Slack, P. Davidson, and C. R. Safinya. 1996. Lamellar bioid-membrane-based hydrogels containing polymer lipids. Science. 271:969-973.
35. Wheeler, J. J., L. Palmer, M. Ossanlou, I. MacLachlan, R. W. Graham, Y. P. Zhang, M. J. Hope, P. Scherrer, and P. R. Cullis. 1999. Stabilized plasmid-lipid particles: construction and characterization. Gene Ther. 6:271-281.
36. Woodle, M. C. 1995. Sterically stabilized liposome therapeutics. Adv. Drug Deliv. Rev. 16:249-265.
37. Woodle, M. C., P. Scaria, S. Ganesh, K. Subramanian, R. Titmas, C. Cheng, J. Yang, Y. Pan, K. Weng, C. Gu, and S. Torkelson. 2001. Sterically stabilized polyplex: ligand-mediated activity. J. Control. Release. 74:309-311.
38. Zalipsky, S. 1995. Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates. Bioconjug. Chem. 6:150-165.