Altered expression of αEβ7 integrin on intra-epithelial and lamina propria lymphocytes in patients with Crohn's disease

Acta Gastro-Enterologica Belgica

Volumn 61, Issue 3, 1998, Pages 288-294

  Elewaut, D ^a   Van Damme, N ^a   De Keyser, F ^a   Baeten, D ^a   De Paepe, P ^a   Van Vlierberghe, H ^a   Mielants, H ^a   Cuvelier, C ^a   Verbruggen, G ^a   Veys, E M ^a   De Vos, M ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

E 7 integrin; Adhesion molecules; Crohn's disease

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CELL ADHESION MOLECULE; INTEGRIN; INTERLEUKIN 2 RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; COLON; CONTROLLED STUDY; CROHN DISEASE; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; LYMPHOCYTE SUBPOPULATION; MALE; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BIOLOGICAL MARKERS; BIOPSY, NEEDLE; CD4-CD8 RATIO; CELL ADHESION MOLECULES; CELLS, CULTURED; COLON; CROHN DISEASE; EPITHELIUM; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; ILEUM; INTEGRIN BETA CHAINS; INTEGRINS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; MUSCLE, SKELETAL; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTES;

EID: 7844248659     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. SALMI M, GRANFORS K., MACDERMOTT R, JALKANEN S. Aberrant binding of lamina propria lymphocytes to vascular endothehum in inflammatory bowel diseases. Gastroenterology, 1994, 106 596-605
2. PODOLSKY D.K. Inflammatory bowel disease (2). N Engl. J. Med, 1991,325: 1008-1016.
3. PODOLSKY D.K. Inflammatory bowel disease (1) N Engl. J. Med., 1991, 325:928-937.
4. MACDERMOTT R.P., STENSON W F Alterations of the immune system in ulcerative colitis and Crohn's disease Adv. Immunol., 1988, 42 285-328.
5. STROBER W., JAMES S. P. The immunologic basis of inflammatory bowel disease J Clin. Immunol., 1986, 6 : 415-432.
6. SIMPSON S.J., MIZOGUCHI E., ALLEN D, BHAN A.K , TERHORST C Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur. J. lmmunol., 1995, 25. 2618-2625.
7. NIESSNER M , YOLK B.A. Phenotypic and immunoregulatory analysis of intestinal T-cells in patients with inflammatory bowel disease . evalution of an in vitro model. Eur. J. Clin. Invest., 1995, 25 . 155-164.
8. BRANDTZAEG P., HALSTENSEN T.S., KETT K., KRAJCI P., KVALE D., ROGNUM T.O , SCOTT H , SOLLID L M. Immunobiology and immunopathology of human gut mucosa . humoral immunity and intraepithelial lymphocytes. Gastroenterology, 1989, 97: 1562-1584.
9. SENJU M., HULSTAERT F., LOWDER J., JEWELL D.P. Flow cytometric analysis of peripheral blood lymphocytes in ulcerative colitis and Crohn's disease. Gut, 1991, 32 : 779-783.
10. SELBY WS., JANOSSY G., BOFILL M., JEWEL DP. Intestinal lymphocyte subpopulations in inflammatory bowel disease : an analysis by immunohistological and cell isolation techniques. Gut, 1984, 25 : 32-40.
11. CERF-BENSUSSAN N., JARRY A., BROUSSE N., LISOWSKA GROSPIERRE B., GUY-GRAND D., GRISCELLI C A monoclonal antibody (HML-I) definfing a novel membrane molecule present on human intestinal lymphocytes. Eur. J Immunol., 1987, 17 : 1279-1285.
12. JARRY A., CERF-BENSUSSAN N., BROUSSE N., SELZ F., GUYGRAND D. Subsets of CD3+ (T cell receptor alpha/beta or gamma/ delta) and CD3- lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur. J. Immunol. 1990, 20 : 1097-1103.
13. KRUSCHWITZ M., FRITZSCHE G, SCHWARTING R, MICKLEM K., MASON D.Y., FALINI B., STEIN H. Ber-ACT8 : new monoclonal antibody to the mucosa lymphocyte antigen. J. Clin. Pathol., 1991,44: 636-645
14. SCHIEFERDECKER H.L , ULLRICH R., HIRSELAND H., ZEITZ M. T cell differentation antigens on lymphocytes in the human intestinal lamina propria. J. Immunol., 1992, 149 : 2816-2822.
15. KAULFERSCH W., FIOCCHI C., WALDMANN TA. Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease. A molecular genetic evaluation of the immunoglobulin and T-cell antigen receptors. Gastroenterology, 1998, 95 : 364-370.
16. HARVEY J., JONES D.B., WRIGHT D.H. Leucocyte common antigen expression on T cells in normal and inflamed human gut Immunology, 1989,68: 13-17
17. SCHREIBER S , MACDERMOTT R P., RAEDLER A., PINNAU R., BERTOVICH M.J., NASH G.S. Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease. Gastroenterology, 1991, 101 : 1020-1030.
18. PODOLSKY D.K., LOBB R., KING N., BENJAMIN C D., PEPINSKY B., SEGHAL P., DEBEAUMONT M. Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody. J. Clin. Invest., 1993, 92 : 372-380.
19. HESTERBERG P.E , WINSORHINES D . BRISKIS M.J., SOLERFERRAN D., MERRIL C., MACKAY C.R., NEWMAN W., RINGLER D.J , WINSOR HINES D., SOLER FERRAN D. Rapid resolution of chronic colitis in the cotton top tamarin with an antibody to a gut homing integrin alpha 4 beta 7. Gastroenterology, 1996, 111 : 1373-1380.
20. HERMISTON M.L., GORDON J.I. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin Science, 1995,270 : 1203-1207.
21. MACDONALD T.T., SPENCER J Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J. Exp. Med., 1988, 167 : 1341-1349
22. LYNCH S , KELLEHER D , FEIGHERY C., WEIR D.G., O'FARRELLY C. Flow cytometric analysis of intra-epithelial lymphocytes from human small intestinal biopsies reveals populations of CD4+CD8+ and CD8aa+ cells. Eur. J. Gastr Hepat., 1993, 5 : 907-912
23. BALZANO A., BOVE A., GRANDE G., BEVILACQUA N. Flow cytometric analysis of lymphocytes isolated from endoscopic biopsies in ulcerative colitis Eur. J. Gastr. Hept., 1994, 6 : 203-208.
24. HIRATA I., BERREBI G., AUSTIN L.L., KEREN D.F., DOBBINS W O.I. Immunohistological characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon and in inflammatory bowel disease. Dig. Dis. Sci, 1986, 31 : 593-603.
25. SCHIEFERDECKER H.L, ULLRICH R., WEISS BRECKWOLDT A.N., SCHWARTING R , STEIN RIECKEN E.O., ZEITZ M. The HML-1 antigen of intestinal lymphocytes is an activation antigen. J. Immunol., 1990, 144 . 2541-2549.
26. ROBERTS A.I., O'CONNELL S M , EBERT E.C. Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1 and CD11a. Cancer Res , 1993,53: 1608-1611.
27. RUTHLEIN J., HEINZE G., AUER I.O. Anti CD-2 and anti CD-3 induced T cell cytotoxicity of human intraepithelial and lamina propria lymphocytes. Gut, 1992, 33 : 1626-1632.
28. TREJDOSIEWICZ L K. Intestinal intraepithelial lymphocytes and lymphocpithelial interactions in the human gastrointestinal mucosa. Immunology Letters. 1992, 32 : 13-19.
29. JAMES S P., FIOCCHI C., GRAEFF A.S., STROBER W. Immunoregulatory function of lamina propria T cells in Crohn's disease. Gastroenterology. 1985. 88: 1143-1150.
30. SMITH K.A. Interleukin-2. Annu. Rev. Immunol, 1984,2 : 319-333.
31. ROBB R.J. Interleukin-2 : the molecule and its function. Immunol. Today, 1984, 5 : 319-333.
32. ABUZAKOUK M., KELLEHER D., FEIGHERY C., O'FARRELLY C. Increased HLA-DR and decreased CD3 on human intestinal intraepithelial lymphocytes : evidence of activation ? Gut, 1996, 39 : 396-400
33. JARRY A., CERF-BENSUSSAN N., BROUSSE N., GUY-GRAND D., MUZEAU F., POTET F. Same peculiar subsets of HMLI + lymphocytes present within normal intestinal epithelium is associated with tumoral epithelium of gastromtestina carcinomas. Gut. 1988, 29 : 1632-1638.
34. ULLRICH R., SCHIEFERDECKER H L., ZIEGLER K., RIECKEN E O., ZEITZ M. γδ T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium. Cellular Immunology, 1990. 128 619-627.
35. SNIJDERS F., MEENAN J., VAN DEN BLINK B., VAN DEVENTER S.J.H., TEN KATE F.J.W. Duodenal intraepithelial and lamina propria T lymphocytes in human immunodeficiency virus-infected patients with and without diarrhoea. Scan. J. Gastroenterol., 1996, 31 : 1176-1181.
36. ECKMANN L., KAGNOFF M.F., FIERER J Intestinal epithelial cells as watchdogs for the natural immune system. Trends Microbiol., 1995, 3: 118-120.
37. JUNG H.C., ECKMANN L., YANG S.K., PANJA A., FIERER L, MORZYCKA WROBLEWSKA E., KAGNOFF M.F. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response ot bacterial invasion J. Clin. Invest., 1995, 95 : 55-65.
38. ELEWAUT D., GRANFORS K., DE KEYSER F., HOFFMAN I., VEYS E.M. Extra-intestinal manifestations of enteropathies : why are the joints involved ? Rheumatology in Europe, 1997, 26 : 18-23.
39. SALMI M., ANDREW D.P., BUTCHER EC, JALKANEN S. Dual binding capacity of mucosal immunoblasts to mucosal and synovial endothelium in humans . dissection of the molecular mechanisms. J. Exp. Med., 1995. 181 . 137-149.
40. SALMI M., GRANFORS K., LEIRSALO REPO M., HAMALAINEN M., MACDERMOTT R., LEINO R., HAVIA T., JALKANEN S. Selective endothelial binding of interleukin-2-dependent human T-cell lines derived from different tissues. Proc. Nail Acad. Sci. USA, 1992, 89: 11436-11440
41. YACYSHYN B., WOLOSCHUK B., YACYSHYN M.B., MARTINI D., DOAN K., TAMI J, BENNET F, KISNER D, SHANAHAN W. Efficacy and safety of ISIS 2302 (ICAM-1 antisense oligonucleotide) treatment of steroid-dependent Crohn's disease. Gastroenterology, 1997, 112 : A1 123.