-
1
-
-
77952101271
-
Challenges in the Clinical Application of Whole-Genome Sequencing
-
Ormond, K. E.; Wheeler, M. T.; Hudgins, L.; Klein, T. E.; Butte, A. J.; Altman, R. B.; Ashley, E. A.; Greely, H. T. Challenges in the Clinical Application of Whole-Genome Sequencing Lancet 2010, 375, 1749-1751
-
(2010)
Lancet
, vol.375
, pp. 1749-1751
-
-
Ormond, K.E.1
Wheeler, M.T.2
Hudgins, L.3
Klein, T.E.4
Butte, A.J.5
Altman, R.B.6
Ashley, E.A.7
Greely, H.T.8
-
2
-
-
80053047560
-
Correlating Disease-Related Mutations to Their Effect on Protein Stability: A Large-Scale Analysis of the Human Proteome
-
Casadio, R.; Vassura, M.; Tiwari, S.; Fariselli, P.; Martelli, P. L. Correlating Disease-Related Mutations to Their Effect on Protein Stability: A Large-Scale Analysis of the Human Proteome Hum. Mutat. 2011, 32, 1161-1170
-
(2011)
Hum. Mutat.
, vol.32
, pp. 1161-1170
-
-
Casadio, R.1
Vassura, M.2
Tiwari, S.3
Fariselli, P.4
Martelli, P.L.5
-
3
-
-
77954743785
-
Mutational Effects and the Evolution of New Protein Functions
-
Soskine, M.; Tawfik, D. S. Mutational Effects and the Evolution of New Protein Functions Nat. Rev. Genet. 2010, 11, 572-582
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 572-582
-
-
Soskine, M.1
Tawfik, D.S.2
-
4
-
-
41949103740
-
The Structure of Protein Evolution and the Evolution of Protein Structure
-
Goldstein, R. A. The Structure of Protein Evolution and the Evolution of Protein Structure Curr. Opin. Struct. Biol. 2008, 18, 170-177
-
(2008)
Curr. Opin. Struct. Biol.
, vol.18
, pp. 170-177
-
-
Goldstein, R.A.1
-
5
-
-
84865730325
-
Protein Biophysics Explains Why Highly Abundant Proteins Evolve Slowly
-
Serohijos, A. W. R.; Rimas, Z.; Shakhnovich, E. I. Protein Biophysics Explains Why Highly Abundant Proteins Evolve Slowly Cell 2012, 2, 249-256
-
(2012)
Cell
, vol.2
, pp. 249-256
-
-
Serohijos, A.W.R.1
Rimas, Z.2
Shakhnovich, E.I.3
-
6
-
-
84864258618
-
A Whole-Cell Computational Model Predicts Phenotype from Genotype
-
Karr, J. R.; Sanghvi, J. C.; Macklin, D. N.; Gutschow, M. V.; Jacobs, J. M.; Bolival, B., Jr.; Assad-Garcia, N.; Glass, J. I.; Covert, M. W. A Whole-Cell Computational Model Predicts Phenotype from Genotype Cell 2012, 150, 389-401
-
(2012)
Cell
, vol.150
, pp. 389-401
-
-
Karr, J.R.1
Sanghvi, J.C.2
Macklin, D.N.3
Gutschow, M.V.4
Jacobs, J.M.5
Bolival Jr., B.6
Assad-Garcia, N.7
Glass, J.I.8
Covert, M.W.9
-
7
-
-
80052659359
-
Bridging the Gap between Chemistry, Physiology, and Evolution: Quantifying the Functionality of Sperm Whale Myoglobin Mutants
-
Dasmeh, P.; Kepp, K. P. Bridging the Gap between Chemistry, Physiology, and Evolution: Quantifying the Functionality of Sperm Whale Myoglobin Mutants Comp. Biochem. Physiol., Part A: Mol. Integr. Physiol. 2012, 161, 9-17
-
(2012)
Comp. Biochem. Physiol., Part A: Mol. Integr. Physiol.
, vol.161
, pp. 9-17
-
-
Dasmeh, P.1
Kepp, K.P.2
-
8
-
-
84875986323
-
Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability
-
Dasmeh, P.; Serohijos, A.; Kepp, K. P.; Shakhnovich, E. I. Positively Selected Sites in Cetacean Myoglobins Contribute to Protein Stability PLoS Comput. Biol. 2013, 9 e1002929
-
(2013)
PLoS Comput. Biol.
, vol.9
-
-
Dasmeh, P.1
Serohijos, A.2
Kepp, K.P.3
Shakhnovich, E.I.4
-
9
-
-
74649085703
-
The Structural Biochemistry of the Superoxide Dismutases
-
Perry, J. J. P.; Shin, D. S.; Getzoff, E. D.; Tainer, J. A. The Structural Biochemistry of the Superoxide Dismutases Biochim. Biophys. Acta 2010, 1804, 245-262
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 245-262
-
-
Perry, J.J.P.1
Shin, D.S.2
Getzoff, E.D.3
Tainer, J.A.4
-
10
-
-
0346034910
-
Production of Reactive Oxygen Species by Isolated Mitochondria of the Antarctic Bivalve Laternula Elliptica (King and Broderip) under Heat Stress
-
Heise, K.; Puntarulo, S.; Pörtner, H. O.; Abele, D. Production of Reactive Oxygen Species by Isolated Mitochondria of the Antarctic Bivalve Laternula Elliptica (King and Broderip) under Heat Stress Comp. Biochem. Physiol., Part C: Pharmacol., Toxicol. Endocrinol. 2003, 134, 79-90
-
(2003)
Comp. Biochem. Physiol., Part C: Pharmacol., Toxicol. Endocrinol.
, vol.134
, pp. 79-90
-
-
Heise, K.1
Puntarulo, S.2
Pörtner, H.O.3
Abele, D.4
-
11
-
-
74449091635
-
Superoxide Dismutases - A Review of the Metal-Associated Mechanistic Variations
-
Abreu, I. A.; Cabelli, D. E. Superoxide Dismutases-A Review of the Metal-Associated Mechanistic Variations Biochim. Biophys. Acta 2010, 1804, 263-274
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 263-274
-
-
Abreu, I.A.1
Cabelli, D.E.2
-
12
-
-
80755163102
-
Molecular Pathways of Motor Neuron Injury in Amyotrophic Lateral Sclerosis
-
Ferraiuolo, L.; Kirby, J.; Grierson, A. J.; Sendtner, M.; Shaw, P. J. Molecular Pathways of Motor Neuron Injury in Amyotrophic Lateral Sclerosis Nat. Rev. Neurol. 2011, 7, 616-630
-
(2011)
Nat. Rev. Neurol.
, vol.7
, pp. 616-630
-
-
Ferraiuolo, L.1
Kirby, J.2
Grierson, A.J.3
Sendtner, M.4
Shaw, P.J.5
-
13
-
-
84875896727
-
Clinical and Genetic Heterogeneity of Amyotrophic Lateral Sclerosis
-
Sabatelli, M.; Conte, A.; Zollino, M. Clinical and Genetic Heterogeneity of Amyotrophic Lateral Sclerosis Clin. Genet. 2013, 83, 408-416
-
(2013)
Clin. Genet.
, vol.83
, pp. 408-416
-
-
Sabatelli, M.1
Conte, A.2
Zollino, M.3
-
14
-
-
79952486262
-
Amyotrophic Lateral Sclerosis
-
Kiernan, M. C.; Vucic, S.; Cheah, B. C.; Turner, M. R.; Eisen, A.; Hardiman, O.; Burrell, J. R.; Zoing, M. C. Amyotrophic Lateral Sclerosis Lancet 2011, 377, 942-955
-
(2011)
Lancet
, vol.377
, pp. 942-955
-
-
Kiernan, M.C.1
Vucic, S.2
Cheah, B.C.3
Turner, M.R.4
Eisen, A.5
Hardiman, O.6
Burrell, J.R.7
Zoing, M.C.8
-
15
-
-
70849113863
-
Transient Structural Distortion of Metal-Free Cu/Zn Superoxide Dismutase Triggers Aberrant Oligomerization
-
Teilum, K.; Smith, M. H.; Schultz, E.; Christensen, L. C.; Solomentsev, G.; Oliveberg, M.; Akke, M. Transient Structural Distortion of Metal-Free Cu/Zn Superoxide Dismutase Triggers Aberrant Oligomerization Proc. Natl. Acad. Sci. U. S. A. 2009, 106, 18273-18278
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 18273-18278
-
-
Teilum, K.1
Smith, M.H.2
Schultz, E.3
Christensen, L.C.4
Solomentsev, G.5
Oliveberg, M.6
Akke, M.7
-
16
-
-
33645737741
-
Rapid Disease Progression Correlates with Instability of Mutant SOD1 in Familial ALS
-
Sato, T.; Nakanishi, T.; Yamamoto, Y.; Andersen, P. M.; Ogawa, Y.; Fukada, K.; Zhou, Z.; Aoike, F.; Sugai, F.; Nagano, S. Rapid Disease Progression Correlates with Instability of Mutant SOD1 in Familial ALS Neurology 2005, 65, 1954-1957
-
(2005)
Neurology
, vol.65
, pp. 1954-1957
-
-
Sato, T.1
Nakanishi, T.2
Yamamoto, Y.3
Andersen, P.M.4
Ogawa, Y.5
Fukada, K.6
Zhou, Z.7
Aoike, F.8
Sugai, F.9
Nagano, S.10
-
17
-
-
20444504724
-
Amyotrophic Lateral Sclerosis Mutations have the Greatest Destabilizing Effect on the Apo- and Reduced Form of SOD1, Leading to Unfolding and Oxidative Aggregation
-
Furukawa, Y.; O'Halloran, T. V. Amyotrophic Lateral Sclerosis Mutations have the Greatest Destabilizing Effect on the Apo- and Reduced Form of SOD1, Leading to Unfolding and Oxidative Aggregation J. Biol. Chem. 2005, 280, 17266-17274
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17266-17274
-
-
Furukawa, Y.1
O'Halloran, T.V.2
-
18
-
-
80051791216
-
Biochemical Properties and in Vivo Effects of the SOD1 Zinc-Binding Site Mutant (H80G)
-
Son, M.; Srikanth, U.; Puttaparthi, K.; Luther, C.; Elliott, J. L. Biochemical Properties and in Vivo Effects of the SOD1 Zinc-Binding Site Mutant (H80G) J. Neurochem. 2011, 118, 891-901
-
(2011)
J. Neurochem.
, vol.118
, pp. 891-901
-
-
Son, M.1
Srikanth, U.2
Puttaparthi, K.3
Luther, C.4
Elliott, J.L.5
-
20
-
-
79953848210
-
Structural and Thermodynamic Effects of Post-Translational Modifications in Mutant and Wild Type Cu, Zn Superoxide Dismutase
-
Proctor, E. A.; Ding, F.; Dokholyan, N. V. Structural and Thermodynamic Effects of Post-Translational Modifications in Mutant and Wild Type Cu, Zn Superoxide Dismutase J. Mol. Biol. 2011, 408, 555-567
-
(2011)
J. Mol. Biol.
, vol.408
, pp. 555-567
-
-
Proctor, E.A.1
Ding, F.2
Dokholyan, N.V.3
-
21
-
-
0037013264
-
Decreased Metallation and Activity in Subsets of Mutant Superoxide Dismutases Associated with Familial Amyotrophic Lateral Sclerosis
-
Hayward, L. J.; Rodriguez, J. A.; Kim, J. W.; Tiwari, A.; Goto, J. J.; Cabelli, D. E.; Valentine, J. S.; Brown, R. H., Jr. Decreased Metallation and Activity in Subsets of Mutant Superoxide Dismutases Associated with Familial Amyotrophic Lateral Sclerosis J. Biol. Chem. 2002, 277, 15923-15931
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 15923-15931
-
-
Hayward, L.J.1
Rodriguez, J.A.2
Kim, J.W.3
Tiwari, A.4
Goto, J.J.5
Cabelli, D.E.6
Valentine, J.S.7
Brown, Jr.R.H.8
-
22
-
-
80051503291
-
Glutathionylation at Cys-111 Induces Dissociation of Wild Type and FALS Mutant SOD1 Dimers
-
Redler, R. L.; Wilcox, K. C.; Proctor, E. A.; Fee, L.; Caplow, M.; Dokholyan, N. V. Glutathionylation at Cys-111 Induces Dissociation of Wild Type and FALS Mutant SOD1 Dimers Biochemistry 2011, 50, 7057-7066
-
(2011)
Biochemistry
, vol.50
, pp. 7057-7066
-
-
Redler, R.L.1
Wilcox, K.C.2
Proctor, E.A.3
Fee, L.4
Caplow, M.5
Dokholyan, N.V.6
-
23
-
-
74549207309
-
Assessing Computational Methods for Predicting Protein Stability upon Mutation: Good on Average but Not in the Details
-
Potapov, V.; Cohen, M.; Schreiber, G. Assessing Computational Methods for Predicting Protein Stability upon Mutation: Good on Average but Not in the Details Protein Eng., Des. Sel. 2009, 22, 553-560
-
(2009)
Protein Eng., Des. Sel.
, vol.22
, pp. 553-560
-
-
Potapov, V.1
Cohen, M.2
Schreiber, G.3
-
24
-
-
14144256681
-
Energy Functions for Protein Design: Adjustment with Protein-Protein Complex Affinities, Models for the Unfolded State, and Negative Design of Solubility and Specificity
-
Pokala, N.; Handel, T. M. Energy Functions for Protein Design: Adjustment with Protein-Protein Complex Affinities, Models for the Unfolded State, and Negative Design of Solubility and Specificity J. Mol. Biol. 2005, 347, 203-227
-
(2005)
J. Mol. Biol.
, vol.347
, pp. 203-227
-
-
Pokala, N.1
Handel, T.M.2
-
25
-
-
23144461249
-
I-Mutant2.0: Predicting Stability Changes upon Mutation from the Protein Sequence or Structure
-
Capriotti, E.; Fariselli, P.; Casadio, R. I-Mutant2.0: Predicting Stability Changes upon Mutation from the Protein Sequence or Structure Nucleic Acids Res. 2005, 33, W306-W310
-
(2005)
Nucleic Acids Res.
, vol.33
-
-
Capriotti, E.1
Fariselli, P.2
Casadio, R.3
-
26
-
-
58149247893
-
Predicting Free Energy Changes using Structural Ensembles
-
Benedix, A.; Becker, C. M.; de Groot, B. L.; Caflisch, A.; Böckmann, R. A. Predicting Free Energy Changes using Structural Ensembles Nat. Methods 2009, 6, 3-4
-
(2009)
Nat. Methods
, vol.6
, pp. 3-4
-
-
Benedix, A.1
Becker, C.M.2
De Groot, B.L.3
Caflisch, A.4
Böckmann, R.A.5
-
27
-
-
0036291145
-
Predicting Changes in the Stability of Proteins and Protein Complexes: A Study of more than 1000 Mutations
-
Guerois, R.; Nielsen, J. E.; Serrano, L. Predicting Changes in the Stability of Proteins and Protein Complexes: A Study of more than 1000 Mutations J. Mol. Biol. 2002, 320, 369-387
-
(2002)
J. Mol. Biol.
, vol.320
, pp. 369-387
-
-
Guerois, R.1
Nielsen, J.E.2
Serrano, L.3
-
28
-
-
1642464839
-
Protein Structure Prediction using Rosetta
-
Rohl, C. A.; Strauss, C. E.; Misura, K. M.; Baker, D. Protein Structure Prediction using Rosetta Methods Enzymol. 2004, 383, 66-93
-
(2004)
Methods Enzymol.
, vol.383
, pp. 66-93
-
-
Rohl, C.A.1
Strauss, C.E.2
Misura, K.M.3
Baker, D.4
-
29
-
-
77952706843
-
Performance of Protein Stability Predictors
-
Khan, S.; Vihinen, M. Performance of Protein Stability Predictors Hum. Mutat. 2010, 31, 675-684
-
(2010)
Hum. Mutat.
, vol.31
, pp. 675-684
-
-
Khan, S.1
Vihinen, M.2
-
30
-
-
34248674895
-
The Stability Effects of Protein Mutations Appear to be Universally Distributed
-
Tokuriki, N.; Stricher, F.; Schymkowitz, J.; Serrano, L.; Tawfik, D. S. The Stability Effects of Protein Mutations Appear to be Universally Distributed J. Mol. Biol. 2007, 369, 1318-1332
-
(2007)
J. Mol. Biol.
, vol.369
, pp. 1318-1332
-
-
Tokuriki, N.1
Stricher, F.2
Schymkowitz, J.3
Serrano, L.4
Tawfik, D.S.5
-
31
-
-
79959942908
-
SDM - A Server for Predicting Effects of Mutations on Protein Stability and Malfunction
-
Worth, C. L.; Preissner, R.; Blundell, T. L. SDM-A Server for Predicting Effects of Mutations on Protein Stability and Malfunction Nucleic Acids Res. 2011, 39, W215-W222
-
(2011)
Nucleic Acids Res.
, vol.39
-
-
Worth, C.L.1
Preissner, R.2
Blundell, T.L.3
-
32
-
-
0034460414
-
PoPMuSiC, an Algorithm for Predicting Protein Mutant Stability Changes: Application to Prion Proteins
-
Gilis, D.; Rooman, M. PoPMuSiC, an Algorithm for Predicting Protein Mutant Stability Changes: Application to Prion Proteins Protein Eng. 2000, 13, 849-856
-
(2000)
Protein Eng.
, vol.13
, pp. 849-856
-
-
Gilis, D.1
Rooman, M.2
-
33
-
-
0036948069
-
PoPMuSiC, Rationally Designing Point Mutations in Protein Structures
-
Kwasigroch, J. M.; Gilis, D.; Dehouck, Y.; Rooman, M. PoPMuSiC, Rationally Designing Point Mutations in Protein Structures Bioinformatics 2002, 18, 1701-1702
-
(2002)
Bioinformatics
, vol.18
, pp. 1701-1702
-
-
Kwasigroch, J.M.1
Gilis, D.2
Dehouck, Y.3
Rooman, M.4
-
34
-
-
84864555615
-
Structure-Based Mutant Stability Predictions on Proteins of Unknown Structure
-
Gonnelli, G.; Rooman, M.; Dehouck, Y. Structure-Based Mutant Stability Predictions on Proteins of Unknown Structure J. Biotechnol. 2012, 161, 287-293
-
(2012)
J. Biotechnol.
, vol.161
, pp. 287-293
-
-
Gonnelli, G.1
Rooman, M.2
Dehouck, Y.3
-
35
-
-
37749052245
-
Prediction of Protein Stability upon Point Mutations
-
Gromiha, M. M. Prediction of Protein Stability upon Point Mutations Biochem. Soc. Trans. 2007, 35, 1569-1573
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 1569-1573
-
-
Gromiha, M.M.1
-
36
-
-
33747838537
-
CUPSAT: Prediction of Protein Stability upon Point Mutations
-
Partiban, V.; Gromiha, M. M.; Schomburg, D. CUPSAT: Prediction of Protein Stability upon Point Mutations Nucleic Acids Res. 2006, 34, W239-W242
-
(2006)
Nucleic Acids Res.
, vol.34
-
-
Partiban, V.1
Gromiha, M.M.2
Schomburg, D.3
-
37
-
-
84870051131
-
Accurate Stabilities of Laccase Mutants Predicted with a Modified FoldX Protocol
-
Christensen, N. J.; Kepp, K. P. Accurate Stabilities of Laccase Mutants Predicted with a Modified FoldX Protocol J. Chem. Inf. Model. 2012, 52, 3028-3042
-
(2012)
J. Chem. Inf. Model.
, vol.52
, pp. 3028-3042
-
-
Christensen, N.J.1
Kepp, K.P.2
-
38
-
-
84880023622
-
Stability Mechanisms of Laccase Isoforms using a Modified FoldX Protocol Applicable to Widely Different Proteins
-
Christensen, N. J.; Kepp, K. P. Stability Mechanisms of Laccase Isoforms using a Modified FoldX Protocol Applicable to Widely Different Proteins J. Chem. Theory Comput. 2013, 9, 3210-3223
-
(2013)
J. Chem. Theory Comput.
, vol.9
, pp. 3210-3223
-
-
Christensen, N.J.1
Kepp, K.P.2
-
39
-
-
84868133037
-
Assessing Predictors of Changes in Protein Stability upon Mutation using Self-Consistency
-
Thiltgen, G.; Goldstein, R. A. Assessing Predictors of Changes in Protein Stability upon Mutation using Self-Consistency PLoS One 2012, 7 e46084
-
(2012)
PLoS One
, vol.7
-
-
Thiltgen, G.1
Goldstein, R.A.2
-
40
-
-
33745889333
-
Folding of Cu/Zn Superoxide Dismutase Suggests Structural Hotspots for Gain of Neurotoxic Function in ALS: Parallels to Precursors in Amyloid Disease
-
Nordlund, A.; Oliveberg, M. Folding of Cu/Zn Superoxide Dismutase Suggests Structural Hotspots for Gain of Neurotoxic Function in ALS: Parallels to Precursors in Amyloid Disease Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 10218-10223
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 10218-10223
-
-
Nordlund, A.1
Oliveberg, M.2
-
41
-
-
22244489417
-
Systematically Perturbed Folding Patterns of Amyotrophic Lateral Sclerosis (ALS)-Associated SOD1Mutants
-
Lindberg, M. J.; Byström, R.; Boknäs, N.; Andersen, P. M.; Oliveberg, M. Systematically Perturbed Folding Patterns of Amyotrophic Lateral Sclerosis (ALS)-Associated SOD1Mutants Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 9754-9759
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 9754-9759
-
-
Lindberg, M.J.1
Byström, R.2
Boknäs, N.3
Andersen, P.M.4
Oliveberg, M.5
-
42
-
-
33646549337
-
Calorimetric Analysis of Thermodynamic Stability and Aggregation for Apo and Holo Amyotrophic Lateral Sclerosis-Associated Gly-93 Mutants of Superoxide Dismutase
-
Stathopulos, P. B.; Rumfeldt, J. A.; Karbassi, F.; Siddall, C. A.; Lepock, J. R.; Meiering, E. M. Calorimetric Analysis of Thermodynamic Stability and Aggregation for Apo and Holo Amyotrophic Lateral Sclerosis-Associated Gly-93 Mutants of Superoxide Dismutase J. Biol. Chem. 2006, 281, 6184-6193
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6184-6193
-
-
Stathopulos, P.B.1
Rumfeldt, J.A.2
Karbassi, F.3
Siddall, C.A.4
Lepock, J.R.5
Meiering, E.M.6
-
43
-
-
77953532917
-
SOD1Mutations Targeting Surface Hydrogen Bonds Promote Amyotrophic Lateral Sclerosis without Reducing Apo-State Stability
-
Byström, R.; Andersen, P. M.; Gröbner, G.; Oliveberg, M. SOD1Mutations Targeting Surface Hydrogen Bonds Promote Amyotrophic Lateral Sclerosis without Reducing Apo-State Stability J. Biol. Chem. 2010, 285, 19544-19552
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 19544-19552
-
-
Byström, R.1
Andersen, P.M.2
Gröbner, G.3
Oliveberg, M.4
-
44
-
-
79955866957
-
PoPMuSiC 2.1: A Web Server for the Estimation of Protein Stability Changes upon Mutation and Sequence Optimality
-
Dehouck, Y.; Kwasigroch, J. M.; Gilis, D.; Rooman, M. PoPMuSiC 2.1: A Web Server for the Estimation of Protein Stability Changes upon Mutation and Sequence Optimality BMC Bioinf. 2011, 12, 151
-
(2011)
BMC Bioinf.
, vol.12
, pp. 151
-
-
Dehouck, Y.1
Kwasigroch, J.M.2
Gilis, D.3
Rooman, M.4
-
45
-
-
0031023842
-
Prediction of the Stability of Protein Mutants Based on Structural Environment-Dependent Amino Acid Substitution and Propensity Tables
-
Topham, C. M.; Srinivasan, N.; Blundell, T. L. Prediction of the Stability of Protein Mutants Based on Structural Environment-Dependent Amino Acid Substitution and Propensity Tables Protein Eng. 1997, 10, 7-21
-
(1997)
Protein Eng.
, vol.10
, pp. 7-21
-
-
Topham, C.M.1
Srinivasan, N.2
Blundell, T.L.3
-
46
-
-
0347755642
-
ProTherm, Version 4.0: Thermodynamic Database for Proteins and Mutants
-
Bava, K. A.; Gromiha, M. M.; Uedaira, H.; Kitajima, K.; Sarai, A. ProTherm, Version 4.0: Thermodynamic Database for Proteins and Mutants Nucleic Acids Res. 2004, 32, D120-D121
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Bava, K.A.1
Gromiha, M.M.2
Uedaira, H.3
Kitajima, K.4
Sarai, A.5
-
47
-
-
32044475396
-
Variable Metallation of Human Superoxide Dismutase: Atomic Resolution Crystal Structures of Cu-Zn, Zn-Zn and As-Isolated Wild-Type Enzymes
-
Strange, R. W.; Antonyuk, S. V.; Hough, M. A.; Doucette, P. A.; Valentine, J. S.; Hasnain, S. S. Variable Metallation of Human Superoxide Dismutase: Atomic Resolution Crystal Structures of Cu-Zn, Zn-Zn and As-Isolated Wild-Type Enzymes J. Mol. Biol. 2006, 356, 1152-1162
-
(2006)
J. Mol. Biol.
, vol.356
, pp. 1152-1162
-
-
Strange, R.W.1
Antonyuk, S.V.2
Hough, M.A.3
Doucette, P.A.4
Valentine, J.S.5
Hasnain, S.S.6
-
48
-
-
34547165170
-
Molecular Dynamics using Atomic-Resolution Structure Reveal Structural Fluctuations that may Lead to Polymerization of Human Cu-Zn Superoxide Dismutase
-
Strange, R. W.; Yong, C. W.; Smith, W.; Hasnain, S. S. Molecular Dynamics using Atomic-Resolution Structure Reveal Structural Fluctuations that may Lead to Polymerization of Human Cu-Zn Superoxide Dismutase Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 10040-10044
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 10040-10044
-
-
Strange, R.W.1
Yong, C.W.2
Smith, W.3
Hasnain, S.S.4
-
49
-
-
0042736853
-
ALS Mutants of Human Superoxide Dismutase form Fibrous Aggregates via Framework Destabilization
-
DiDonato, M.; Craig, L.; Huff, M. E.; Thayer, M. M.; Cardoso, R. M.; Kassmann, C. J.; Lo, T. P.; Bruns, C. K.; Powers, E. T.; Kelly, J. W. ALS Mutants of Human Superoxide Dismutase form Fibrous Aggregates via Framework Destabilization J. Mol. Biol. 2003, 332, 601-615
-
(2003)
J. Mol. Biol.
, vol.332
, pp. 601-615
-
-
Didonato, M.1
Craig, L.2
Huff, M.E.3
Thayer, M.M.4
Cardoso, R.M.5
Kassmann, C.J.6
Lo, T.P.7
Bruns, C.K.8
Powers, E.T.9
Kelly, J.W.10
-
50
-
-
0037427449
-
The Structure of Holo and Metal-Deficient Wild-Type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis
-
Strange, R. W.; Antonyuk, S.; Hough, M. A.; Doucette, P. A.; Rodriguez, J. A.; Hart, P. J.; Hayward, L. J.; Valentine, J. S.; Hasnain, S. S. The Structure of Holo and Metal-Deficient Wild-Type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis J. Mol. Biol. 2003, 328, 877-891
-
(2003)
J. Mol. Biol.
, vol.328
, pp. 877-891
-
-
Strange, R.W.1
Antonyuk, S.2
Hough, M.A.3
Doucette, P.A.4
Rodriguez, J.A.5
Hart, P.J.6
Hayward, L.J.7
Valentine, J.S.8
Hasnain, S.S.9
-
51
-
-
84876917870
-
Stability Mechanisms of a Thermophilic Laccase Probed by Molecular Dynamics
-
Christensen, N. J.; Kepp, K. P. Stability Mechanisms of a Thermophilic Laccase Probed by Molecular Dynamics PloS ONE 2013, 8, e61985
-
(2013)
PloS ONE
, vol.8
, pp. 61985
-
-
Christensen, N.J.1
Kepp, K.P.2
|