Structure-based mutant stability predictions on proteins of unknown structure

Journal of Biotechnology

Volumn 161, Issue 3, 2012, Pages 287-293

  Gonnelli, Giulia ^a   Rooman, Marianne ^a   Dehouck, Yves ^a,b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b FRITZ HABER INSTITUT DER MAX PLANCK GESELLSCHAFT   (Germany)

Author keywords

Amino acid mutation; Comparative modeling; Computational design; Folding free energy; Protein engineering; Protein stability

Indexed keywords

COARSE-GRAINED; COMPARATIVE MODELING; COMPLEX DISEASE; COMPUTATIONAL DESIGN; GENETIC BACKGROUNDS; HIGH QUALITY; LOW QUALITIES; MODIFIED PROTEINS; PHARMACEUTICAL APPLICATIONS; PHYSICOCHEMICAL PROPERTY; PREDICTIVE POWER; PROTEIN ENGINEERING; PROTEIN STABILITY; RATIONAL DESIGN; STABILITY PREDICTION; STRUCTURAL MODELS; STRUCTURE-BASED;

AMINO ACIDS; FORECASTING; GENETIC ENGINEERING; MODEL STRUCTURES;

PROTEINS;

AMINO ACID SEQUENCE; ARTICLE; MATHEMATICAL MODEL; MUTATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; DATABASES, PROTEIN; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PROTEIN STABILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84864555615     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2012.06.020     Document Type: Article

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