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Volumn 15, Issue 3, 2014, Pages 294-304

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SEPARATION; CELL SURVIVAL; DISEASE PROGRESSION; DNA-BINDING PROTEINS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; IKAROS TRANSCRIPTION FACTOR; IMMUNOBLOTTING; MICE; MICE, TRANSGENIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR CELLS, B-LYMPHOID;

EID: 84894504942     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2821     Document Type: Article
Times cited : (135)

References (56)
  • 1
    • 33645310982 scopus 로고    scopus 로고
    • ITAM-mediated tonic signalling through pre-BCR and BCR complexes
    • Monroe, J.G. ITAM-mediated tonic signalling through pre-BCR and BCR complexes. Nat. Rev. Immunol. 6, 283-294 (2006).
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 283-294
    • Monroe, J.G.1
  • 2
    • 61349179407 scopus 로고    scopus 로고
    • Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signaling
    • Herzog, S., Reth, M. & Jumaa, H. Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat. Rev. Immunol. 9, 195-205 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 195-205
    • Herzog, S.1    Reth, M.2    Jumaa, H.3
  • 3
    • 7944235830 scopus 로고    scopus 로고
    • Src-family kinases in B-cell development and signaling
    • Gauld, S.B. & Cambier, J.C. Src-family kinases in B-cell development and signaling. Oncogene 23, 8001-8006 (2004).
    • (2004) Oncogene , vol.23 , pp. 8001-8006
    • Gauld, S.B.1    Cambier, J.C.2
  • 4
    • 0026652354 scopus 로고
    • A critical role of λ5 protein in B cell development
    • Kitamura, D. et al. A critical role of λ5 protein in B cell development. Cell 69, 823-831 (1992).
    • (1992) Cell , vol.69 , pp. 823-831
    • Kitamura, D.1
  • 5
    • 0029913115 scopus 로고    scopus 로고
    • Regulation of an early developmental checkpoint in the B cell pathway by Ig β
    • Gong, S. & Nussenzweig, M.C. Regulation of an early developmental checkpoint in the B cell pathway by Ig β. Science 272, 411-414 (1996).
    • (1996) Science , vol.272 , pp. 411-414
    • Gong, S.1    Nussenzweig, M.C.2
  • 6
    • 0035920563 scopus 로고    scopus 로고
    • Interference with immunoglobulin (Ig)α immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igß cytoplasmic tail
    • Kraus, M. et al. Interference with immunoglobulin (Ig)α immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igß cytoplasmic tail. J. Exp. Med. 194, 455-469 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 455-469
    • Kraus, M.1
  • 7
    • 0037100435 scopus 로고    scopus 로고
    • B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β
    • Pelanda, R., Braun, U., Hobeika, E., Nussenzweig, M.C. & Reth, M. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β. J. Immunol. 169, 865-872 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 865-872
    • Pelanda, R.1    Braun, U.2    Hobeika, E.3    Nussenzweig, M.C.4    Reth, M.5
  • 8
    • 0028783322 scopus 로고
    • Syk tyrosine kinase required for mouse viability and B-cell development
    • Cheng, A.M. et al. Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378, 303-306 (1995).
    • (1995) Nature , vol.378 , pp. 303-306
    • Cheng, A.M.1
  • 9
    • 0037396717 scopus 로고    scopus 로고
    • Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion
    • Schweighoffer, E., Vanes, L., Mathiot, A., Nakamura, T. & Tybulewicz, V.L. Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity 18, 523-533 (2003).
    • (2003) Immunity , vol.18 , pp. 523-533
    • Schweighoffer, E.1    Vanes, L.2    Mathiot, A.3    Nakamura, T.4    Tybulewicz, V.L.5
  • 10
    • 0037342034 scopus 로고    scopus 로고
    • Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development
    • Saijo, K. et al. Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development. Nat. Immunol. 4, 274-279 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 274-279
    • Saijo, K.1
  • 11
    • 0032402316 scopus 로고    scopus 로고
    • Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression
    • Marshall, A.J., Fleming, H.E., Wu, G.E. & Paige, C.J. Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression. J. Immunol. 161, 6038-6045 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 6038-6045
    • Marshall, A.J.1    Fleming, H.E.2    Wu, G.E.3    Paige, C.J.4
  • 12
    • 0034748389 scopus 로고    scopus 로고
    • Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway
    • Fleming, H.E. & Paige, C.J. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity 15, 521-531 (2001).
    • (2001) Immunity , vol.15 , pp. 521-531
    • Fleming, H.E.1    Paige, C.J.2
  • 13
    • 75649093758 scopus 로고    scopus 로고
    • Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
    • Malin, S. et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat. Immunol. 11, 171-179 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 171-179
    • Malin, S.1
  • 14
    • 41549103208 scopus 로고    scopus 로고
    • Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion
    • Yasuda, T. et al. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28, 499-508 (2008).
    • (2008) Immunity , vol.28 , pp. 499-508
    • Yasuda, T.1
  • 15
    • 0037815206 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells
    • Kersseboom, R. et al. Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells. J. Exp. Med. 198, 91-98 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 91-98
    • Kersseboom, R.1
  • 16
    • 11144238277 scopus 로고    scopus 로고
    • Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity
    • Middendorp, S. et al. Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity. Blood 105, 259-265 (2005).
    • (2005) Blood , vol.105 , pp. 259-265
    • Middendorp, S.1
  • 17
    • 33845383712 scopus 로고    scopus 로고
    • Essential role of phospholipase Cγ2 in early B-cell development and Myc-mediated lymphomagenesis
    • Wen, R. et al. Essential role of phospholipase Cγ2 in early B-cell development and Myc-mediated lymphomagenesis. Mol. Cell. Biol. 26, 9364-9376 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 9364-9376
    • Wen, R.1
  • 18
    • 44049101651 scopus 로고    scopus 로고
    • SLP-65 regulates immunoglobulin light chain gene recombination through the PI (3)K-PKB-Foxo pathway
    • Herzog, S. et al. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat. Immunol. 9, 623-631 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 623-631
    • Herzog, S.1
  • 19
    • 40249112989 scopus 로고    scopus 로고
    • Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
    • Johnson, K. et al. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity 28, 335-345 (2008).
    • (2008) Immunity , vol.28 , pp. 335-345
    • Johnson, K.1
  • 20
    • 84857195761 scopus 로고    scopus 로고
    • A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation
    • Ochiai, K. et al. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat. Immunol. 13, 300-307 (2012).
    • (2012) Nat. Immunol. , vol.13 , pp. 300-307
    • Ochiai, K.1
  • 21
    • 67650173322 scopus 로고    scopus 로고
    • B-cell acute lymphoblastic leukaemia: Towards understanding its cellular origin
    • Cobaleda, C. & Sanchez-Garcia, I. B-cell acute lymphoblastic leukaemia: towards understanding its cellular origin. Bioessays 31, 600-609 (2009).
    • (2009) Bioessays , vol.31 , pp. 600-609
    • Cobaleda, C.1    Sanchez-Garcia, I.2
  • 22
    • 34147224008 scopus 로고    scopus 로고
    • Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
    • Mullighan, C.G. et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446, 758-764 (2007).
    • (2007) Nature , vol.446 , pp. 758-764
    • Mullighan, C.G.1
  • 23
    • 58749109707 scopus 로고    scopus 로고
    • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    • Mullighan, C.G. et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N. Engl. J. Med. 360, 470-480 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 470-480
    • Mullighan, C.G.1
  • 24
    • 55749102434 scopus 로고    scopus 로고
    • Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: Implications for a new mechanism of resistance
    • Iacobucci, I. et al. Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance. Blood 112, 3847-3855 (2008).
    • (2008) Blood , vol.112 , pp. 3847-3855
    • Iacobucci, I.1
  • 25
    • 70349242044 scopus 로고    scopus 로고
    • Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: On behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)
    • Iacobucci, I. et al. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood 114, 2159-2167 (2009).
    • (2009) Blood , vol.114 , pp. 2159-2167
    • Iacobucci, I.1
  • 26
    • 78649742010 scopus 로고    scopus 로고
    • Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: Correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
    • Harvey, R.C. et al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood. 116, 4874-4884 (2010).
    • (2010) Blood. , vol.116 , pp. 4874-4884
    • Harvey, R.C.1
  • 27
    • 59449091025 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia-on the wings of IKAROS
    • Georgopoulos, K. Acute lymphoblastic leukemia-on the wings of IKAROS. N. Engl. J. Med. 360, 524-526 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 524-526
    • Georgopoulos, K.1
  • 28
    • 0028001362 scopus 로고
    • The Ikaros gene is required for the development of all lymphoid lineages
    • Georgopoulos, K. et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 79, 143-156 (1994).
    • (1994) Cell , vol.79 , pp. 143-156
    • Georgopoulos, K.1
  • 29
    • 64049102658 scopus 로고    scopus 로고
    • Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells
    • Ng, S.Y., Yoshida, T., Zhang, J. & Georgopoulos, K. Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity 30, 493-507 (2009).
    • (2009) Immunity , vol.30 , pp. 493-507
    • Ng, S.Y.1    Yoshida, T.2    Zhang, J.3    Georgopoulos, K.4
  • 30
    • 0030972497 scopus 로고    scopus 로고
    • Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
    • Morgan, B. et al. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16, 2004-2013 (1997).
    • (1997) EMBO J. , vol.16 , pp. 2004-2013
    • Morgan, B.1
  • 31
    • 33947153094 scopus 로고    scopus 로고
    • Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits
    • Thompson, E.C. et al. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity 26, 335-344 (2007).
    • (2007) Immunity , vol.26 , pp. 335-344
    • Thompson, E.C.1
  • 32
    • 0029831978 scopus 로고    scopus 로고
    • Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
    • Sun, L., Liu, A. & Georgopoulos, K. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J. 15, 5358-5369 (1996).
    • (1996) EMBO J. , vol.15 , pp. 5358-5369
    • Sun, L.1    Liu, A.2    Georgopoulos, K.3
  • 33
    • 0030249394 scopus 로고    scopus 로고
    • A prematurely expressed Igκ transgene, but not VκJκ gene segment targeted into the Igκ locus, can rescue B cell development in λ5-deficient mice
    • Pelanda, R., Schaal, S., Torres, R.M. & Rajewsky, K. A prematurely expressed Igκ transgene, but not VκJκ gene segment targeted into the Igκ locus, can rescue B cell development in λ5-deficient mice. Immunity 5, 229-239 (1996).
    • (1996) Immunity , vol.5 , pp. 229-239
    • Pelanda, R.1    Schaal, S.2    Torres, R.M.3    Rajewsky, K.4
  • 34
    • 0034598353 scopus 로고    scopus 로고
    • Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment
    • Rolink, A.G., Winkler, T., Melchers, F. & Andersson, J. Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment. J. Exp. Med. 191, 23-32 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 23-32
    • Rolink, A.G.1    Winkler, T.2    Melchers, F.3    Andersson, J.4
  • 35
    • 0023584024 scopus 로고
    • Lymphocyte Precursors and Myeloid Progenitors Survive in Diffusion chamber cultures but B cell differentiation requires close association with stromal cells
    • Kierney, P.C. & Dorshkind, K. B lymphocyte precursors and myeloid progenitors survive in diffusion chamber cultures but B cell differentiation requires close association with stromal cells. Blood 70, 1418-1424 (1987).
    • (1987) Blood , vol.70 , pp. 1418-1424
    • Kierney, P.C.1    Dorshkind, K.B.2
  • 36
    • 0025353632 scopus 로고
    • Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules
    • Hayashi, S. et al. Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules. J. Exp. Med. 171, 1683-1695 (1990).
    • (1990) J. Exp. Med. , vol.171 , pp. 1683-1695
    • Hayashi, S.1
  • 37
    • 34447649909 scopus 로고    scopus 로고
    • Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells
    • Glodek, A.M. et al. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia 21, 1723-1732 (2007).
    • (2007) Leukemia , vol.21 , pp. 1723-1732
    • Glodek, A.M.1
  • 38
    • 69249089318 scopus 로고    scopus 로고
    • B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading
    • Tse, K.W. et al. B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J. Biol. Chem. 284, 22865-22877 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 22865-22877
    • Tse, K.W.1
  • 39
    • 0026000034 scopus 로고
    • The c-kit-encoded tyrosine kinase regulates the proliferation of early pre-B cells
    • Rolink, A., Streb, M., Nishikawa, S. & Melchers, F. The c-kit-encoded tyrosine kinase regulates the proliferation of early pre-B cells. Eur. J. Immunol. 21, 2609-2612 (1991).
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2609-2612
    • Rolink, A.1    Streb, M.2    Nishikawa, S.3    Melchers, F.4
  • 40
    • 0027443753 scopus 로고
    • Expression and function of the interleukin 7 receptor in murine lymphocytes
    • Sudo, T. et al. Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. USA 90, 9125-9129 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9125-9129
    • Sudo, T.1
  • 41
    • 0028866897 scopus 로고
    • A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
    • Winandy, S., Wu, P. & Georgopoulos, K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83, 289-299 (1995).
    • (1995) Cell , vol.83 , pp. 289-299
    • Winandy, S.1    Wu, P.2    Georgopoulos, K.3
  • 42
    • 84862924585 scopus 로고    scopus 로고
    • Reconstruction of integrin activation
    • Ye, F., Kim, C. & Ginsberg, M.H. Reconstruction of integrin activation. Blood 119, 26-33 (2012).
    • (2012) Blood , vol.119 , pp. 26-33
    • Ye, F.1    Kim, C.2    Ginsberg, M.H.3
  • 43
    • 84857686971 scopus 로고    scopus 로고
    • Structure and function of focal adhesions
    • Wehrle-Haller, B. Structure and function of focal adhesions. Curr. Opin. Cell Biol. 24, 116-124 (2012).
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 116-124
    • Wehrle-Haller, B.1
  • 44
    • 33847159264 scopus 로고    scopus 로고
    • Polymerizing actin fibers position integrins primed to probe for adhesion sites
    • Galbraith, C.G., Yamada, K.M. & Galbraith, J.A. Polymerizing actin fibers position integrins primed to probe for adhesion sites. Science 315, 992-995 (2007).
    • (2007) Science , vol.315 , pp. 992-995
    • Galbraith, C.G.1    Yamada, K.M.2    Galbraith, J.A.3
  • 45
  • 46
    • 22244438250 scopus 로고    scopus 로고
    • A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes
    • Smith, A. et al. A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. J. Cell Biol. 170, 141-151 (2005).
    • (2005) J. Cell Biol. , vol.170 , pp. 141-151
    • Smith, A.1
  • 47
    • 51049104617 scopus 로고    scopus 로고
    • Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner
    • Choi, C.K. et al. Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat. Cell Biol. 10, 1039-1050 (2008).
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1039-1050
    • Choi, C.K.1
  • 48
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: New insights into their functions from in vivo studies
    • Heasman, S.J. & Ridley, A.J. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell Biol. 9, 690-701 (2008).
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 49
    • 84872727730 scopus 로고    scopus 로고
    • Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments
    • Park, S.Y. et al. Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J. Immunol. 190, 1094-1102 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 1094-1102
    • Park, S.Y.1
  • 50
    • 79751538993 scopus 로고    scopus 로고
    • Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia
    • Waanders, E. et al. Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia. Leukemia 25, 254-258 (2011).
    • (2011) Leukemia , vol.25 , pp. 254-258
    • Waanders, E.1
  • 52
    • 0026032665 scopus 로고
    • Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription
    • Schlissel, M.S., Corcoran, L.M. & Baltimore, D. Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med. 173, 711-720 (1991).
    • (1991) J. Exp. Med. , vol.173 , pp. 711-720
    • Schlissel, M.S.1    Corcoran, L.M.2    Baltimore, D.3
  • 53
    • 1542343974 scopus 로고    scopus 로고
    • Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene
    • Fuxa, M. et al. Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes Dev. 18, 411-422 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 411-422
    • Fuxa, M.1
  • 54
    • 0021282023 scopus 로고
    • Pre-B cells in mouse bone marrow: In vitro maturation of peanut agglutinin binding B lymphocyte precursors separated from bone marrow by fluorescence-activated cell sorting
    • Osmond, D.G., Melchers, F. & Paige, C.J. Pre-B cells in mouse bone marrow: in vitro maturation of peanut agglutinin binding B lymphocyte precursors separated from bone marrow by fluorescence-activated cell sorting. J. Immunol. 133, 86-90 (1984).
    • (1984) J. Immunol. , vol.133 , pp. 86-90
    • Osmond, D.G.1    Melchers, F.2    Paige, C.J.3
  • 55
    • 0023253946 scopus 로고
    • Lymphoid precursor cells adhere to two different sites on fibronectin
    • Bernardi, P., Patel, V.P. & Lodish, H.F. Lymphoid precursor cells adhere to two different sites on fibronectin. J. Cell Biol. 105, 489-498 (1987).
    • (1987) J. Cell Biol. , vol.105 , pp. 489-498
    • Bernardi, P.1    Patel, V.P.2    Lodish, H.F.3
  • 56
    • 0035166003 scopus 로고    scopus 로고
    • The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase
    • Roumiantsev, S., de Aos, I.E., Varticovski, L., Ilaria, R.L. & Van Etten, R.A. The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase. Blood 97, 4-13 (2001).
    • (2001) Blood , vol.97 , pp. 4-13
    • Roumiantsev, S.1    De Aos, I.E.2    Varticovski, L.3    Ilaria, R.L.4    Van Etten, R.A.5


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