Crystal structures of leukotriene C4 synthase in complex with product analogs: Implications for the enzyme mechanism

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 5199-5207

  Niegowski, Damian ^a   Kleinschmidt, Thea ^a   Olsson, Ulrika ^a   Ahmad, Shabbir ^a   Rinaldo Matthis, Agnes ^a   Haeggström, Jesper Z ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES;

ACTIVE SITE; BINDING MODES; ENZYME MECHANISM; LEUKOTRIENE C; MECHANISTIC MODELING; MEMBRANE PROTEINS; MOLECULAR MECHANISM; SYNTHASES;

BINDING ENERGY;

2 AMINO 5 (1 (CARBOXYMETHYLAMINO) 1 OXO 3 (PHENYLBUTYLTHIO)PROPAN 2 YLAMINO) 5 OXOPENTHANOIC ACID; 2 AMINO 5 (1 (CARBOXYMETHYLAMINO) 3 (HEXYLTHIO) 1 OXOPROPAN 2 YLAMINO) 5 OXOPENTANOIC ACID; 2 AMINO 5 (1 (CARBOXYMETHYLAMINO) 3 (HYDROXY 4 PHENYLBUTYLTHIO) 1 OXOPROPAN 2 YLAMINO) 5 OXOPENTHANOIC ACID; GLUTATHIONE DERIVATIVE; LEUKOTRIENE C4 SYNTHASE; TRYPTOPHAN; TRYPTOPHAN 116; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN STABILITY;

ASTHMA; GLUTATHION; LEUKOTRIENE; LIPID-BINDING PROTEIN; LTA4; LTC4; LTC4 SYNTHASE; MEMBRANE PROTEINS;

BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; KINETICS; LEUKOTRIENE A4; LEUKOTRIENE C4; MODELS, MOLECULAR; MUTANT PROTEINS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TRYPTOPHAN;

EID: 84894488420     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.534628     Document Type: Article

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