Role of basic science in the development of new medicines: Examples from the eicosanoid field

Journal of Biological Chemistry

Volumn 287, Issue 13, 2012, Pages 10070-10080

  Samuelsson, Bengt ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSIS; ENDOTHELIAL CELLS; MOLECULES;

BASIC SCIENCE; EICOSANOIDS; MOLECULAR MECHANISM; NEW THERAPEUTIC AGENT; PHENOTYPIC SCREENING; SMALL MOLECULES; THERAPEUTIC TARGETS;

GENE THERAPY;

ACETYLSALICYLIC ACID; ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 2; GLUCOCORTICOID; HYPERFORIN; ICOSANOID; ILOPROST; INDOMETACIN; LEUKOTRIENE; LEUKOTRIENE B4; LIPOXIN; MONTELUKAST; NEW DRUG; PROSTACYCLIN; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN SYNTHASE; SLOW REACTING SUBSTANCE; THROMBOXANE; THROMBOXANE A2; THROMBOXANE B2; TREPROSTINIL; ZAFIRLUKAST; ZILEUTON;

ANAPHYLAXIS; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; ASTHMA; ATHEROSCLEROSIS; BASIC RESEARCH; CEREBROVASCULAR ACCIDENT; HEART INFARCTION; HUMAN; INFLAMMATION; LOW DRUG DOSE; NEUTROPHILIA; NONHUMAN; PAIN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PULMONARY HYPERTENSION; RHINITIS; STEREOCHEMISTRY; THROMBOCYTE AGGREGATION; VASOCONSTRICTION; ANIMAL; ART; GENETICS; HISTORY; MEDICAL RESEARCH; METABOLISM; METHODOLOGY; PHARMACOKINETICS; REVIEW;

ANIMALS; BIOMEDICAL RESEARCH; EICOSANOIDS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; PHARMACOKINETICS; PORTRAITS AS TOPIC;

EID: 84861120187     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.X112.351437     Document Type: Article

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