Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrinαIIbβ3 in mice

Journal of Biological Chemistry

Volumn 289, Issue 8, 2014, Pages 5051-5060

  Hughan, Sascha C ^a   Spring, Christopher M ^a   Schoenwaelder, Simone M ^a   Sturgeon, Sharelle ^a   Alwis, Imala ^a   Yuan, Yuping ^a   McFadyen, James D ^a   Westein, Erik ^a   Goddard, Duncan ^a   Ono, Akiko ^a   Yamanashi, Yuji ^b   Nesbitt, Warwick S ^a   Jackson, Shaun P ^a,c  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; ADHESIVES; MAMMALS; PROTEINS;

ADAPTOR PROTEINS; ADHESION RECEPTORS; BLOOD CLOT FORMATION; IMMUNORECEPTORS; INTEGRINS; NEGATIVE REGULATORS; PLATELET ADHESION;

PLATELETS;

ADAPTOR PROTEIN; DOK 2 ADAPTOR PROTEIN; FIBRINOGEN; INTEGRIN; INTEGRIN ALPHA2BBETA3; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PROTEIN KINASE LYN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CONTROLLED STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SHEAR FLOW; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBUS;

ADAPTOR PROTEINS; INTEGRINS; MECHANOTRANSDUCTION; PLATELETS; SHEAR STRESS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOOD PLATELETS; CALCIUM; CELL MEMBRANE; FIBRINOGEN; HEMORHEOLOGY; HUMANS; IMMOBILIZED PROTEINS; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOPROTEINS; PLATELET ADHESIVENESS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SHEAR STRENGTH; THROMBOSIS; TIME FACTORS;

EID: 84894471945     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.520148     Document Type: Article

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