Neuroprotective action of halogenated derivatives of L-phenylalanine

Stroke

Volumn 35, Issue 5, 2004, Pages 1192-1196

  Kagiyama, Tomoko ^b   Glushakov, Alexander V ^a   Sumners, Colin ^a,b   Roose, Brandy ^b   Dennis, Donn M ^a   Phillips, M Ian ^b   Ozcan, Mehmet S ^a   Seubert, Christoph N ^a   Martynyuk, Anatoly E ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Excitotoxicity; Neuroprotection; Receptors, glutamate; Stroke

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; DIBROMOTYROSINE; DIIODOTYROSINE; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENT; PHENYLALANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; BLOOD PRESSURE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; ENZYME ANALYSIS; ENZYME RELEASE; HEART RATE; HEART VENTRICLE CONDUCTION; HYPOTHESIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL CULTURE; NEUROPROTECTION; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; STROKE;

ANIMALS; CEREBROVASCULAR ACCIDENT; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; L-LACTATE DEHYDROGENASE; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; PHENYLALANINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE; SYNAPTIC TRANSMISSION; TYROSINE;

EID: 2142762516     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000125722.10606.07     Document Type: Article

References (19)

1. Bullock R, Zauner A, Woodward J, Young HF. Massive persistent release of excitatory amino acids following human occlusive stroke. Stroke. 1995;26:2187-2189.
2. Kemp JA, McKernan RM. NMDA receptor pathways as drug targets. Nat Neurosci. 2002;5(suppl):1039-1042.
3. 2+ accumulation and neuronal loss in hippocampal pyramidal neurons. J Neurosci. 2002;22:1273-1279.
4. Martinez-Vila E, Sieira PI. Current status and perspectives of neuroprotection in ischemic stroke treatment. Cerebrovasc Dis. 2001;11(suppl 1):60-70.
5. Yam PS, Dunn LT, Graham DI, Dewar D, McCulloch J. NMDA receptor blockade fails to alter axonal injury in focal cerebral ischemia. J Cereb Blood Flow Metab. 2000;20:772-779.
6. Akins PT, Atkinson RP. Glutamate AMPA receptor antagonist treatment for ischaemic stroke. Curr Med Res Opin. 2002;18(suppl 2):9-13.
7. Glushakov AV, Dennis DM, Morey TE, Sumners C, Cucchiara RF, Seubert CN, Martynyuk AE. Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry. 2002;7:359-367.
8. Glushakov AV, Dennis DM, Sumners C, Seubert CN, Martynyuk AE. L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res. 2003;72:116-124.
9. Krause W, Halminski M, McDonald L, Dembure P, Salvo R, Freides D, Elsas L. Biochemical and neuropsychological effects of elevated plasma phenylalanine in patients with treated phenylketonuria. A model for the study of phenylalanine and brain function in man. J Clin Invest. 1985;75:40-48.
10. Chandler LJ, Sutton G, Norwood D, Sumners C, Crews FT. Chronic ethanol increases N-methyl-D-aspartate-stimulated nitric oxide formation but not receptor density in cultured cortical neurons. Mol Pharmacol. 1997;51:733-740.
11. Jenkins JR, Belardinelli L. Atrioventricular nodal accommodation in isolated guinea pig hearts: physiological significance and role of adenosine. Circ Res. 1988;63:97-116.
12. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G. Experimental studies of ischemic brain edema, I. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area. Jpn J Stroke. 1986;8:1-8.
13. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84-91.
14. Lin TN, He YY, Wu G, Khan M, Hsu CY. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke. 1993;24:117-121.
15. Scriver CR, Kaufman S. The hyperphenylalanenemia: phenylalanine hydroxylase deficiency. In: Scriver CR, William SS, Childs B, Beaudet AL, Valle D, Kinzler KW, Vogelstein B, eds. The Metabolic and Molecular Bases of Inherited Disease. New York, New York: McGraw-Hill; 2001:1667-1724.
16. Wu W, Chen Y, d'Avignon A, Hazen SL. 3-Bromotyrosine and 3,5-dibromotyrosine are major products of protein oxidation by eosinophil peroxidase: potential markers for eosinophil-dependent tissue injury in vivo. Biochemistry. 1999;38:3538-3548.
17. Dunn JT, Dunn AD. Update on intrathyroidal iodine metabolism. Thyroid. 2001;11:407-414.
18. Zhang B, Sannajust F. Diurnal rhythms of blood pressure, heart rate, and locomotor activity in adult and old male Wistar rats. Physiol Behav. 2000;70:375-380.
19. Lipton P. Ischemic cell death in brain neurons. Physiol Rev. 1999;79:1431-1568.