Nuclear factor-κB, an unappreciated tumor suppressor

Cancer Research

Volumn 67, Issue 23, 2007, Pages 11093-11098

  Chen, Fei ^a   Castranova, Vince ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL XL; VASCULOTROPIN;

APOPTOSIS; CANCER INHIBITION; CARCINOGENESIS; CELL COMMUNICATION; CELL CYCLE PROGRESSION; CELL LINE; CELL MOTILITY; CELL PROLIFERATION; DNA SYNTHESIS; EPIDERMIS CELL; HUMAN; LIVER CANCER; METASTASIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR PROMOTION; UPREGULATION; DRUG ANTAGONISM; NEOPLASM; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

GENES, TUMOR SUPPRESSOR; HUMANS; NEOPLASMS; NF-KAPPA B;

EID: 37049027338     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1576     Document Type: Review

References (20)

1. Karin M. Nuclear factor-κB in cancer development and progression. Nature 2006;441:431-6.
2. Kluiver J, van den Berg A, de Jong D, et al. Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma. Oncogene 2007;26:3769-76.
3. Fernandez-Majada V, Aguilera C, Villanueva A, et al. Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer. Proc Natl Acad Sci U S A 2007;104:276-81.
4. Prajapati S, Tu Z, Yamamoto Y, Gaynor RB. IKKα regulates the mitotic phase of the cell cycle by modulating Aurora A phosphorylation. Cell Cycle 2006; 5:2371-80.
5. Hu MC, Lee DF, Xia W, et al. IκB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004;117:225-37.
6. Lee DF, Kuo HP, Chen CT, et al. IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 2007;130:440-55.
7. Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. p53 stabilization is decreased upon NFκB activation: a role for NFκB in acquisition of resistance to chemotherapy. Cancer Cell 2002;1:493-503.
8. Perkins ND. NF-κB: tumor promoter or suppressor? Trends Cell Biol 2004;14:64-9.
9. Furuya K, Ozaki T, Hanamoto T, et al. Stabilization of p73 by nuclear IKK-α mediates cisplatin-induced apoptosis. J Biol Chem 2007;282:18365-78.
10. Zhu F, Xia X, Liu B, et al. IKKa shields 14-3-3σ, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. Mol Cell 2007;27:214-27.
11. Seitz CS, Lin Q, Deng H, Khavari PA. Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB. Proc Natl Acad Sci U S A 1998;95:2307-12.
12. Liu B, Park E, Zhu F, et al. A critical role for I κB kinase α in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci U S A 2006;103:17202-7.
13. Kisseleva T, Song L, Vorontchikhina M, Feirt N, Kitajewski J, Schindler C. NF-κB regulation of endothelial cell function during LPS-induced toxemia and cancer. J Clin Invest 2006;116:2955-63.
14. Chen F, Lu Y, Castranova V, Li Z, Karin M. Loss of Ikkβ promotes migration and proliferation of mouse embryo fibroblast cells. J Biol Chem 2006;281:37142-9.
15. Oshima K, Takeda M, Kuranaga E, et al. IKK epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis. Curr Biol 2006;16:1531-7.
16. Gapuzan ME, Schmah O, Pollock AD, Hoffmann A, Gilmore TD. Immortalized fibroblasts from NF-κB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor α after transformation by v-Ras. Oncogene 2005;24:6574-83.
17. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKβ couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-90.
18. Luedde T, Beraza N, Kotsikoris V, et al. Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007;11:119-32.
19. Zhang Y, Chen F. Reactive oxygen species (ROS), troublemakers between nuclear factor-κB (NF-κB) and c-Jun NH(2)-terminal kinase ( JNK). Cancer Res 2004;64:1902-5.
20. Peng Z, Peng L, Fan Y, Zandi E, Shertzer HG, Xia Y. A critical role for IκB kinase β in metallothionein-1 expression and protection against arsenic toxicity. J Biol Chem 2007;282:21487-96.