-
1
-
-
19644366033
-
Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kB activation
-
Farhana L, Dawson MI, Fontana JA. Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kB activation. Cancer Res 2005; 65: 4909-4917.
-
(2005)
Cancer Res
, vol.65
, pp. 4909-4917
-
-
Farhana, L.1
Dawson, M.I.2
Fontana, J.A.3
-
2
-
-
22844448317
-
Synthesis and structure-activity relationships of a new series of retinoid related biphenyl-4-ylacrylic acids endowed with anti-proliferative and proapoptotic activity
-
Cincinelli R, Dallavalle S, Nannei R, De Zani D, Merlini L, Penco S et al. Synthesis and structure-activity relationships of a new series of retinoid related biphenyl-4-ylacrylic acids endowed with anti-proliferative and proapoptotic activity. J Med Chem 2005; 48: 4931-4946.
-
(2005)
J Med Chem
, vol.48
, pp. 4931-4946
-
-
Cincinelli, R.1
Dallavalle, S.2
Nannei, R.3
De Zani, D.4
Merlini, L.5
Penco, S.6
-
3
-
-
54049139269
-
Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: Significance for the cytotoxic and antiproliferative activity
-
Valli C, Paroni G, Di Francesco AM, Riccardi R, Tavecchio M, Erba E et al. Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity. Mol Cancer Ther 2008; 7: 2941-2954.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2941-2954
-
-
Valli, C.1
Paroni, G.2
Di Francesco, A.M.3
Riccardi, R.4
Tavecchio, M.5
Erba, E.6
-
4
-
-
0037089487
-
The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells
-
Sun SY, Yue P, Chen X, Hong WK, Lotan R. The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells. Cancer Res 2002; 62: 2430-2436.
-
(2002)
Cancer Res
, vol.62
, pp. 2430-2436
-
-
Sun, S.Y.1
Yue, P.2
Chen, X.3
Hong, W.K.4
Lotan, R.5
-
5
-
-
0242494811
-
Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog
-
Zhang Y, Dawson MI, Ning Y, Polin L, Parchment RE, Corbett T et al. Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog. Blood 2003; 102: 3743-3752.
-
(2003)
Blood
, vol.102
, pp. 3743-3752
-
-
Zhang, Y.1
Dawson, M.I.2
Ning, Y.3
Polin, L.4
Parchment, R.E.5
Corbett, T.6
-
6
-
-
22244477083
-
Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells
-
Jin F, Liu X, Zhou Z, Yue P, Lotan R, Khuri FR et al. Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Res 2005; 65: 6354-6363.
-
(2005)
Cancer Res
, vol.65
, pp. 6354-6363
-
-
Jin, F.1
Liu, X.2
Zhou, Z.3
Yue, P.4
Lotan, R.5
Khuri, F.R.6
-
7
-
-
33845768987
-
Integrating cell-signalling pathways with NF-kappaB and IKK function
-
Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007; 8: 49-62.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 49-62
-
-
Perkins, N.D.1
-
8
-
-
36148967696
-
Signal responsiveness of IB kinases is determined by Cdc37-assisted transient interaction with HSP90
-
Hinz M, Broemer M, Arslan SC, Otto A, Mueller E-C, Dettmer R et al. Signal responsiveness of IB kinases is determined by Cdc37-assisted transient interaction with HSP90. J Biol Chem 2007; 282: 32311-32319.
-
(2007)
J Biol Chem
, vol.282
, pp. 32311-32319
-
-
Hinz, M.1
Broemer, M.2
Arslan, S.C.3
Otto, A.4
Mueller, E.-C.5
Dettmer, R.6
-
9
-
-
33646006734
-
Signals from within: The DNA-damage-induced NF-kappaB response
-
Janssens S, Tschopp J. Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ 2006; 13: 773-784.
-
(2006)
Cell Death Differ
, vol.13
, pp. 773-784
-
-
Janssens, S.1
Tschopp, J.2
-
10
-
-
0029059060
-
Embryonic lethality and liver degeneration in mice lacking the RelA component of the NF-kB
-
Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of the NF-kB. Nature 1995; 376: 167-170.
-
(1995)
Nature
, vol.376
, pp. 167-170
-
-
Beg, A.A.1
Sha, W.C.2
Bronson, R.T.3
Ghosh, S.4
Baltimore, D.5
-
11
-
-
0030298294
-
Dissection of the TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
-
Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of the TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 1996; 87: 565-576.
-
(1996)
Cell
, vol.87
, pp. 565-576
-
-
Liu, Z.G.1
Hsu, H.2
Goeddel, D.V.3
Karin, M.4
-
12
-
-
43249106841
-
Regulation of programmed cell death by NF-kappaB and its role in tumorigenesis and therapy
-
Fan Y, Dutta J, Gupta N, Fan G, Gelinas C. Regulation of programmed cell death by NF-kappaB and its role in tumorigenesis and therapy. Adv Exp Med Biol 2008; 615: 223-250.
-
(2008)
Adv Exp Med Biol
, vol.615
, pp. 223-250
-
-
Fan, Y.1
Dutta, J.2
Gupta, N.3
Fan, G.4
Gelinas, C.5
-
14
-
-
0037374470
-
Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand signaling
-
Chen X, Kandasamy K, Srivastava RK. Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand signaling. Cancer Res 2003; 3: 1059-1066.
-
(2003)
Cancer Res
, vol.3
, pp. 1059-1066
-
-
Chen, X.1
Kandasamy, K.2
Srivastava, R.K.3
-
15
-
-
3343015617
-
Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation
-
Shin HM, Kim MH, Kim BH, Jung SH, Kim YS, Park HJ et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett 2004; 571: 50-54.
-
(2004)
FEBS Lett
, vol.571
, pp. 50-54
-
-
Shin, H.M.1
Kim, M.H.2
Kim, B.H.3
Jung, S.H.4
Kim, Y.S.5
Park, H.J.6
-
16
-
-
0033537719
-
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
-
Delhase M, Hayakawa M, Chen Y, Karin M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 1999; 284: 309-313.
-
(1999)
Science
, vol.284
, pp. 309-313
-
-
Delhase, M.1
Hayakawa, M.2
Chen, Y.3
Karin, M.4
-
17
-
-
9144275033
-
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers
-
Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D et al. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J 2004; 23: 4202-4210.
-
(2004)
EMBO J
, vol.23
, pp. 4202-4210
-
-
Bonizzi, G.1
Bebien, M.2
Otero, D.C.3
Johnson-Vroom, K.E.4
Cao, Y.5
Vu, D.6
-
18
-
-
17944378526
-
Activation of IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
-
Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G et al. Activation of IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001; 293: 1495-1499.
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftleben, U.1
Cao, Y.2
Xiao, G.3
Greten, F.R.4
Krahn, G.5
Bonizzi, G.6
-
19
-
-
0034745420
-
NF-kappaB-inducing kinase regulates the processing of NF-kB2 p100
-
Xiao G, Harhaj EW, Sun SC. NF-kappaB-inducing kinase regulates the processing of NF-kB2 p100. Mol Cell 2001; 7: 401-409.
-
(2001)
Mol Cell
, vol.7
, pp. 401-409
-
-
Xiao, G.1
Harhaj, E.W.2
Sun, S.C.3
-
20
-
-
56349164239
-
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
-
Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 2008; 12: 1371-1378.
-
(2008)
Nat Immunol
, vol.12
, pp. 1371-1378
-
-
Zarnegar, B.J.1
Wang, Y.2
Mahoney, D.J.3
Dempsey, P.W.4
Cheung, H.H.5
He, J.6
-
21
-
-
45849120966
-
(Un)expected roles of c-IAPs in apoptotic and NF-kappaB signaling pathways
-
Varfolomeev E, Vucic D. (Un)expected roles of c-IAPs in apoptotic and NF-kappaB signaling pathways. Cell Cycle 2008; 7: 1511-1521.
-
(2008)
Cell Cycle
, vol.7
, pp. 1511-1521
-
-
Varfolomeev, E.1
Vucic, D.2
-
22
-
-
56349164232
-
Nonredundant and complimentary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
-
Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H et al. Nonredundant and complimentary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 2008; 9: 1364-1370.
-
(2008)
Nat Immunol
, vol.9
, pp. 1364-1370
-
-
Vallabhapurapu, S.1
Matsuzawa, A.2
Zhang, W.3
Tseng, P.H.4
Keats, J.J.5
Wang, H.6
-
23
-
-
0036187476
-
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90
-
Chen G, Cao P, Goeddel DV. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell 2002; 9: 401-410.
-
(2002)
Mol Cell
, vol.9
, pp. 401-410
-
-
Chen, G.1
Cao, P.2
Goeddel, D.V.3
-
24
-
-
28844498364
-
Stabilization of basally translated NF-kB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100
-
Qing G, Qu Z, Xiao G. Stabilization of basally translated NF-kB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100. J Biol Chem 2005; 280: 40578-40582.
-
(2005)
J Biol Chem
, vol.280
, pp. 40578-40582
-
-
Qing, G.1
Qu, Z.2
Xiao, G.3
-
25
-
-
2942731516
-
Regulation of the NF-kappaB-inducing kinase by tumor necrosis receptor-associated factor 3-induced degradation
-
Liao G, Zhang M, Harhaj EW, Sun SC. Regulation of the NF-kappaB-inducing kinase by tumor necrosis receptor-associated factor 3-induced degradation. J Biol Chem 2004; 279: 6243-6250.
-
(2004)
J Biol Chem
, vol.279
, pp. 6243-6250
-
-
Liao, G.1
Zhang, M.2
Harhaj, E.W.3
Sun, S.C.4
-
26
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation and TNFalpha-dependent apoptosis
-
Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation and TNFalpha-dependent apoptosis. Cell 2007; 131: 669-681.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
Garg, P.6
-
27
-
-
0029020012
-
Structural and functional characterization of the promoter regions of the NFKB2 gene
-
Lombardi L, Ciana P, Cappellini C, Trecca D, Guerrini L, Migliazza A et al. Structural and functional characterization of the promoter regions of the NFKB2 gene. Nucleic Acids Res 1995; 23: 2328-2336.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 2328-2336
-
-
Lombardi, L.1
Ciana, P.2
Cappellini, C.3
Trecca, D.4
Guerrini, L.5
Migliazza, A.6
-
28
-
-
62449084941
-
CIAP1, cIAP2 and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation
-
Jin HS, Lee DH, Kim DH, Chung JH, Lee SJ, Lee TH et al. cIAP1, cIAP2 and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation. Cancer Res 2009; 69: 1782-1791.
-
(2009)
Cancer Res
, vol.69
, pp. 1782-1791
-
-
Jin, H.S.1
Lee, D.H.2
Kim, D.H.3
Chung, J.H.4
Lee, S.J.5
Lee, T.H.6
-
30
-
-
33750467991
-
Unravelling the complexities of the NF-kappaB signaling pathway using mouse knockout and transgenic models
-
Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W et al. Unravelling the complexities of the NF-kappaB signaling pathway using mouse knockout and transgenic models. Oncogene 2006; 25: 6781-6799.
-
(2006)
Oncogene
, vol.25
, pp. 6781-6799
-
-
Gerondakis, S.1
Grumont, R.2
Gugasyan, R.3
Wong, L.4
Isomura, I.5
Ho, W.6
-
31
-
-
33750443289
-
IkappaB kinase complexes: Gateways to NF-kappaB activation and transcription
-
Scheidereit C. IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene 2006; 25: 6685-6705.
-
(2006)
Oncogene
, vol.25
, pp. 6685-6705
-
-
Scheidereit, C.1
-
32
-
-
0037261901
-
The apoptotic action of the retinoid CD437/AHPN: Diverse effects, common basis
-
Zhao X, Spanjaard RA. The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J Biomed Sci 2003; 10: 44-49.
-
(2003)
J Biomed Sci
, vol.10
, pp. 44-49
-
-
Zhao, X.1
Spanjaard, R.A.2
-
33
-
-
1642471824
-
Retinoid targets for apoptosis induction
-
Pfahl M, Piedrafita FJ. Retinoid targets for apoptosis induction. Oncogene 2003; 22: 9058-9062.
-
(2003)
Oncogene
, vol.22
, pp. 9058-9062
-
-
Pfahl, M.1
Piedrafita, F.J.2
-
34
-
-
0037289713
-
Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis
-
Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M et al. Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. Mol Cell Biol 2003; 23: 1061-1074.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 1061-1074
-
-
Bayon, Y.1
Ortiz, M.A.2
Lopez-Hernandez, F.J.3
Gao, F.4
Karin, M.5
Pfahl, M.6
-
35
-
-
51849097711
-
Inhibition IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids
-
Lorenzo P, Alvarez R, Ortiz MA, Alvarez S, Piedrafita FJ, de Lera AR. Inhibition IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids. J Med Chem 2008; 51: 5431-5440.
-
(2008)
J Med Chem
, vol.51
, pp. 5431-5440
-
-
Lorenzo, P.1
Alvarez, R.2
Ortiz, M.A.3
Alvarez, S.4
Piedrafita, F.J.5
De Lera, A.R.6
-
36
-
-
33846409855
-
Adamantyl-substituted retinoid related molecules bind small heterodimer partner and modulate the Sin3A repressor
-
Farhana L, Dawson MI, Leid M, Wang L, Moore DD, Liu G et al. Adamantyl-substituted retinoid related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer Res 2007; 67: 318-325.
-
(2007)
Cancer Res
, vol.67
, pp. 318-325
-
-
Farhana, L.1
Dawson, M.I.2
Leid, M.3
Wang, L.4
Moore, D.D.5
Liu, G.6
-
37
-
-
0035823584
-
The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear receptor-B in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7
-
Kim YS, Han CY, Kim SW, Kim JH, Lee SK, Jung DJ et al. The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear receptor-B in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7. J Biol Chem 2001; 276: 33736-33740.
-
(2001)
J Biol Chem
, vol.276
, pp. 33736-33740
-
-
Kim, Y.S.1
Han, C.Y.2
Kim, S.W.3
Kim, J.H.4
Lee, S.K.5
Jung, D.J.6
-
38
-
-
67649305179
-
SHP and Sin3A expression are essential for adamantyl-substituted retinoid related molecule-mediated nuclear factor-B activation, c-Fos/c-Jun expression and cellular apoptosis
-
Farhana L, Dawson MI, Dannenberg JH, Xu L, Fontana JA. SHP and Sin3A expression are essential for adamantyl-substituted retinoid related molecule-mediated nuclear factor-B activation, c-Fos/c-Jun expression and cellular apoptosis. Mol Cancer Ther 2009; 8: 1625-1635.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1625-1635
-
-
Farhana, L.1
Dawson, M.I.2
Dannenberg, J.H.3
Xu, L.4
Fontana, J.A.5
-
39
-
-
0033485542
-
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
-
Pomerantz JL, Baltimore D. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J 1999; 18: 6694-6704.
-
(1999)
EMBO J
, vol.18
, pp. 6694-6704
-
-
Pomerantz, J.L.1
Baltimore, D.2
-
40
-
-
67650751080
-
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
-
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differ 2009; 16: 1093-1107.
-
(2009)
Cell Death and Differ
, vol.16
, pp. 1093-1107
-
-
Galluzzi, L.1
Aaronson, S.A.2
Abrams, J.3
Alnemri, E.S.4
Andrews, D.W.5
Baehrecke, E.H.6
|