Cotranslatioaal dimerization of the Rel homology domain of NF-κB1 generates p50-p105 heterodimers and is required for effective p50 production

EMBO Journal

Volumn 19, Issue 17, 2000, Pages 4712-4722

  Lin, Li ^a,b   DeMartino, George N ^c   Greene, Warner C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cotranslational dimerization; Cotranslational processing; NF B1; Proteasome

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEASOME; PROTEIN P105; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR P50; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG; ONCOPROTEIN; PROTEINASE K; RELB PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELB;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; GENE CONTROL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RNA TRANSLATION; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE;

AMINO ACID SEQUENCE; ANIMALS; DIMERIZATION; ENDOPEPTIDASE K; MICE; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS;

EID: 0034283010     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. IκB: A specific inhibitor of the NF-κB transcription factor
2. A 65-kD subunit of active NF-κB is required for inhibition of NF-κB by IκB
3. The proteasome: Paradigm of a self-compartmentalizing protease
4. TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB 1 p105
5. Differential regulation of NF-κB2 (pl00) processing and control by amino-terminal sequences
6. Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA
7. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway
8. The ubiquitin-proteasome pathway: On protein death and cell life
9. Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor κB1
10. Generation of p50 subunit of NF-κB by processing of p105 through an ATP-dependent pathway
11. Folding of nascent polypeptide chains in high molecular mass assembly with molecular chaperones
12. Ubiquitination and degradation of ATF2 are dimerization dependent
13. Structure of NF-κB p50 homodimer bound to a κB site
14. Cloning of the p50 DNA binding subunit of NF-κB: Homology to tel and dorsal
15. Co-translational trimerization of the reovirus cell attachment protein
16. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3
17. NF-κB p105 is a target of IκB kinases and controls signal induction of Bcl-3-p50 complexes
18. The generation of nfkb2 p52: Mechanism and efficiency
19. Ubiquitin, proteasomes and the regulation of intracellular protein degradation
20. Transducing hedgehog: The story so far
21. Chronic inflammation and susceptibility to bacterial infectious in mice lacking the polypeptide (p)105 precursor (NF-κB1) but expressing p50
22. Degradation signal masking by heterodimerization of MATα2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway
23. The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product
24. Diversity and specificity in transcriptional regulation: The benefits of heterotypic dimerization
25. A glycine-rich region in NF-κB p105 functions as a processing signal for the generation of the p50 subunit
26. Cotranslational biogenesis of NF-κB p50 by the 26S proteasome
27. Identification, purification and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20S proteasome
28. Phosphorylation of p105 PEST sequences via a redox-insensitive pathway up-regulates processing to p50 NF-κB
29. Structure of the NF-κB homodimer bound to DNA
30. The precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control NF-κB nuclear translocation of NF-κB
31. The translation machinery and 70 kd heat shock protein cooperate in protein synthesis
32. Recombination of protein domains facilitated by co-translational folding in eukaryotes
33. Ubiquitin-mediated processing of NF-κB transcriptional activator precursor p105
34. Structural motifs involved in ubiquitin-mediated processing of the NF-κB precursor p105: Roles of the glycine-rich region and a downstream ubiquitination domain
35. The ubiquitin-proteasome pathway is required for processing the NF-κB precursor protein and the activation of NF-κB
36. The precursor of NF-κB has IκB-like functions
37. Cotranslational ubiquitination of cystic fibrosis transmembrane conductance regulator in vitro
38. Signal-induced degradation of IκBα requires site-specific ubiquitination
39. NF-κB p105 processing via the ubiquitin-proteasome pathway
40. Characterization of the dimer interface of transcription factor NF-κB p50 homodimer
41. Target disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
42. Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP
43. Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP
44. NF-κB activation: The IκB kinase revealed?
45. Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26S proteasome
46. Transcriptional activation: A complex puzzle with few easy pieces
47. The 65-kD subunit of NF-κB is a receptor for IκB and a modulator of DNA-binding specificity
48. Regulation of NF-κB1 proteins by candidate oncoprotein BCL-3: Generation of NF-κB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation
49. Regulated cotranslational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein