메뉴 건너뛰기




Volumn 95, Issue 3, 2014, Pages 294-306

Interaction of the Efflux transporters ABCB1 and ABCG2 with imatinib, nilotinib, and dasatinib

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BENZAMIDES; ENZYME INHIBITORS; HUMANS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; THIAZOLES;

EID: 84894413523     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2013.208     Document Type: Review
Times cited : (74)

References (75)
  • 1
    • 61449090494 scopus 로고    scopus 로고
    • Suboptimal response to or failure of imatinib treatment for chronic myeloid leukemia: What is the optimal strategy? Mayo Clin
    • Jabbour, E., Cortes, J.E. & Kantarjian, H.M. Suboptimal response to or failure of imatinib treatment for chronic myeloid leukemia: what is the optimal strategy? Mayo Clin. Proc. 84, 161-169 (2009).
    • (2009) Proc. , vol.84 , pp. 161-169
    • Jabbour, E.1    Cortes, J.E.2    Kantarjian, H.M.3
  • 2
    • 77954936879 scopus 로고    scopus 로고
    • Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib
    • White, D.L. et al. Functional activity of the OCT-1 protein is predictive of long-term outcome in patients with chronic-phase chronic myeloid leukemia treated with imatinib. J. Clin. Oncol. 28, 2761-2767 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2761-2767
    • White, D.L.1
  • 3
    • 42449144938 scopus 로고    scopus 로고
    • ABCB1 overexpression may predispose imatinib treated CML patients to the development of Abl kinase domain mutations, and may be an important contributor to acquired resistance
    • White, D. et al. ABCB1 overexpression may predispose imatinib treated CML patients to the development of Abl kinase domain mutations, and may be an important contributor to acquired resistance. ASH Ann. Meet. Abst. 108, 2144 (2006).
    • (2006) ASH Ann. Meet. Abst. , vol.108 , pp. 2144
    • White, D.1
  • 4
    • 43149118341 scopus 로고    scopus 로고
    • The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox)
    • Szakacs, G., Varadi, A., Ozvegy-Laczka, C. & Sarkadi, B. The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). Drug Discov. Today 13, 379-393 (2008).
    • (2008) Drug Discov. Today , vol.13 , pp. 379-393
    • Szakacs, G.1    Varadi, A.2    Ozvegy-Laczka, C.3    Sarkadi, B.4
  • 5
    • 0030782511 scopus 로고    scopus 로고
    • Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
    • Shapiro, A.B. & Ling, V. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities. Eur. J. Biochem. 250, 130-137 (1997).
    • (1997) Eur. J. Biochem. , vol.250 , pp. 130-137
    • Shapiro, A.B.1    Ling, V.2
  • 7
    • 34147214716 scopus 로고    scopus 로고
    • Multiple molecular mechanisms for multidrug resistance transporters
    • Higgins, C.F. Multiple molecular mechanisms for multidrug resistance transporters. Nature 446, 749-757 (2007).
    • (2007) Nature , vol.446 , pp. 749-757
    • Higgins, C.F.1
  • 8
    • 67650685020 scopus 로고    scopus 로고
    • ABC efflux pump-based resistance to chemotherapy drugs
    • Eckford, P.D. & Sharom, F.J. ABC efflux pump-based resistance to chemotherapy drugs. Chem. Rev. 109, 2989-3011 (2009).
    • (2009) Chem. Rev. , vol.109 , pp. 2989-3011
    • Eckford, P.D.1    Sharom, F.J.2
  • 9
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman, M.M., Fojo, T. & Bates, S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2, 48-58 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 10
    • 79954426449 scopus 로고    scopus 로고
    • The multidrug resistance half-transporter ABCG2 is purified as a tetramer upon selective extraction from membranes
    • Dezi, M. et al. The multidrug resistance half-transporter ABCG2 is purified as a tetramer upon selective extraction from membranes. Biochim. Biophys. Acta 1798, 2094-2101 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1798 , pp. 2094-2101
    • Dezi, M.1
  • 11
    • 33750446035 scopus 로고    scopus 로고
    • Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2
    • McDevitt, C.A. et al. Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2. Structure 14, 1623-1632 (2006).
    • (2006) Structure , vol.14 , pp. 1623-1632
    • McDevitt, C.A.1
  • 12
    • 33750478648 scopus 로고    scopus 로고
    • Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter
    • Clark, R., Kerr, I.D. & Callaghan, R. Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter. Br. J. Pharmacol. 149, 506-515 (2006).
    • (2006) Br. J. Pharmacol. , vol.149 , pp. 506-515
    • Clark, R.1    Kerr, I.D.2    Callaghan, R.3
  • 13
    • 0034121122 scopus 로고    scopus 로고
    • Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes
    • Choo, E.F. et al. Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 28, 655-660 (2000).
    • (2000) Drug Metab Dispos. , vol.28 , pp. 655-660
    • Choo, E.F.1
  • 14
    • 0030781139 scopus 로고    scopus 로고
    • Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833
    • Mayer, U., Wagenaar, E., Dorobek, B., Beijnen, J.H., Borst, P. & Schinkel, A.H. Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833. J. Clin. Invest. 100, 2430-2436 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 2430-2436
    • Mayer, U.1    Wagenaar, E.2    Dorobek, B.3    Beijnen, J.H.4    Borst, P.5    Schinkel, A.H.6
  • 15
    • 0034604707 scopus 로고    scopus 로고
    • MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping
    • Smith, A.J. et al. MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J. Biol. Chem. 275, 23530-23539 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 23530-23539
    • Smith, A.J.1
  • 16
    • 33645805657 scopus 로고    scopus 로고
    • In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: A recommendation for probe substrates
    • Rautio, J. et al. In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates. Drug Metab. Dispos. 34, 786-792 (2006).
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 786-792
    • Rautio, J.1
  • 17
    • 0037079708 scopus 로고    scopus 로고
    • The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors
    • Scharenberg, C.W., Harkey, M.A. & Torok-Storb, B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 99, 507-512 (2002).
    • (2002) Blood , vol.99 , pp. 507-512
    • Scharenberg, C.W.1    Harkey, M.A.2    Torok-Storb, B.3
  • 18
    • 2442638937 scopus 로고    scopus 로고
    • High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter
    • Ozvegy-Laczka, C. et al. High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. Mol. Pharmacol. 65, 1485-1495 (2004).
    • (2004) Mol. Pharmacol. , vol.65 , pp. 1485-1495
    • Ozvegy-Laczka, C.1
  • 19
    • 0035987891 scopus 로고    scopus 로고
    • Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1
    • Luo, F.R., Paranjpe, P.V., Guo, A., Rubin, E. & Sinko, P. Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab. Dispos. 30, 763-770 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 763-770
    • Luo, F.R.1    Paranjpe, P.V.2    Guo, A.3    Rubin, E.4    Sinko, P.5
  • 21
    • 16844384057 scopus 로고    scopus 로고
    • The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): Implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients
    • Breedveld, P. et al. The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients. Cancer Res. 65, 2577-2582 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 2577-2582
    • Breedveld, P.1
  • 22
    • 84877622305 scopus 로고    scopus 로고
    • Proton pump inhibitors significantly increase the intracellular concentration of nilotinib, but not imatinib in target CML cells
    • White, D.L., Eadie, L.N., Saunders, V.A., Hiwase, D.K. & Hughes, T.P. Proton pump inhibitors significantly increase the intracellular concentration of nilotinib, but not imatinib in target CML cells. Leukemia 27, 1201-1204 (2013).
    • (2013) Leukemia , vol.27 , pp. 1201-1204
    • White, D.L.1    Eadie, L.N.2    Saunders, V.A.3    Hiwase, D.K.4    Hughes, T.P.5
  • 23
    • 58149127453 scopus 로고    scopus 로고
    • Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy
    • Suzuki, K. et al. Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy. Br. J. Clin. Pharmacol. 67, 44-49 (2009).
    • (2009) Br. J. Clin. Pharmacol. , vol.67 , pp. 44-49
    • Suzuki, K.1
  • 24
    • 4143142207 scopus 로고    scopus 로고
    • Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: Potential role for breast cancer resistance protein in clinical drug-drug interactions
    • Breedveld, P. et al. Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res. 64, 5804-5811 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 5804-5811
    • Breedveld, P.1
  • 25
    • 0000890967 scopus 로고    scopus 로고
    • Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C
    • Allen, J.D. et al. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol. Cancer Ther. 1, 417-425 (2002).
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 417-425
    • Allen, J.D.1
  • 26
    • 33947498515 scopus 로고    scopus 로고
    • Modulation of human BCRP (ABCG2) activity by anti-HIV drugs
    • Weiss, J. et al. Modulation of human BCRP (ABCG2) activity by anti-HIV drugs. J. ntimicrob. Chemother. 59, 238-245 (2007).
    • (2007) J. Ntimicrob. Chemother. , vol.59 , pp. 238-245
    • Weiss, J.1
  • 27
    • 0034789387 scopus 로고    scopus 로고
    • Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells
    • Ozvegy, C. et al. Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem. Biophys. Res. Commun. 285, 111-117 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.285 , pp. 111-117
    • Ozvegy, C.1
  • 28
    • 0033966957 scopus 로고    scopus 로고
    • Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein
    • Rabindran, S.K., Ross, D.D., Doyle, L.A., Yang, W. & Greenberger, L.M. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 60, 47-50 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 47-50
    • Rabindran, S.K.1    Ross, D.D.2    Doyle, L.A.3    Yang, W.4    Greenberger, L.M.5
  • 29
    • 0033936291 scopus 로고    scopus 로고
    • Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
    • Evers, R. et al. Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br. J. Cancer 83, 375-383 (2000).
    • (2000) Br. J. Cancer , vol.83 , pp. 375-383
    • Evers, R.1
  • 30
    • 0036166635 scopus 로고    scopus 로고
    • Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2)
    • Flanagan, S.D., Cummins, C.L., Susanto, M., Liu, X., Takahashi, L.H. & Benet, L.Z. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology 64, 126-134 (2002).
    • (2002) Pharmacology , vol.64 , pp. 126-134
    • Flanagan, S.D.1    Cummins, C.L.2    Susanto, M.3    Liu, X.4    Takahashi, L.H.5    Benet, L.Z.6
  • 31
    • 1542608328 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of imatinib in a phase i trial with chronic myeloid leukemia patients
    • Peng, B. et al. Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J. Clin. Oncol. 22, 935-942 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 935-942
    • Peng, B.1
  • 32
    • 34147174980 scopus 로고    scopus 로고
    • Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
    • Picard, S. et al. Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 109, 3496-3499 (2007).
    • (2007) Blood , vol.109 , pp. 3496-3499
    • Picard, S.1
  • 33
    • 43249083718 scopus 로고    scopus 로고
    • Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: A subanalysis of the IRIS study
    • IRIS (International Randomized Interferon Vs STI571) Study Group
    • Larson, R.A. et al.; IRIS (International Randomized Interferon vs STI571) Study Group. Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study. Blood 111, 4022-4028 (2008).
    • (2008) Blood , vol.111 , pp. 4022-4028
    • Larson, R.A.1
  • 34
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford, S. et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 102, 276-283 (2003).
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1
  • 35
    • 34548825795 scopus 로고    scopus 로고
    • Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia
    • O'Hare, T., Eide, C.A. & Deininger, M.W. Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia. Blood 110, 2242-2249 (2007).
    • (2007) Blood , vol.110 , pp. 2242-2249
    • O'Hare, T.1    Eide, C.A.2    Deininger, M.W.3
  • 36
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian, H. et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N. Engl. J. Med. 354, 2542-2551 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2542-2551
    • Kantarjian, H.1
  • 37
    • 75749119275 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of the BCR-ABL tyrosine kinase inhibitor nilotinib
    • Tanaka, C. et al. Clinical pharmacokinetics of the BCR-ABL tyrosine kinase inhibitor nilotinib. Clin. Pharmacol. Ther. 87, 197-203 (2010).
    • (2010) Clin. Pharmacol. Ther. , vol.87 , pp. 197-203
    • Tanaka, C.1
  • 38
    • 70249105789 scopus 로고    scopus 로고
    • Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase
    • Hughes, T. et al. Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase. J. Clin. Oncol. 27, 4204-4210 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4204-4210
    • Hughes, T.1
  • 39
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare, T. et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res. 65, 4500-4505 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 4500-4505
    • O'Hare, T.1
  • 40
    • 84863548891 scopus 로고    scopus 로고
    • Australian Government-Department of Health and Ageing TGA
    • Australian Government -Department of Health and Ageing TGA. Australian Public Assessment Report for Dasatinib, 2011. http://www.tga.gov.au/auspar/ auspar-dasatinib-110711.htm.
    • (2011) Australian Public Assessment Report for Dasatinib
  • 41
    • 84866526227 scopus 로고    scopus 로고
    • Concurrent use of proton pump inhibitors or H2 blockers did not adversely affect nilotinib efficacy in patients with chronic myeloid leukemia
    • Yin, O.Q. et al. Concurrent use of proton pump inhibitors or H2 blockers did not adversely affect nilotinib efficacy in patients with chronic myeloid leukemia. Cancer Chemother. Pharmacol. 70, 345-350 (2012).
    • (2012) Cancer Chemother. Pharmacol. , vol.70 , pp. 345-350
    • Yin, O.Q.1
  • 42
    • 85081455409 scopus 로고    scopus 로고
    • Proton pump inhibitors interact with transport of both imatinib and nilotinib
    • White, D., Saunders, V., Quinn, S., Manley, P. & Hughes, T. Proton pump inhibitors interact with transport of both imatinib and nilotinib. AACR Meet. Abst. 2007, 1635 (2007).
    • (2007) AACR Meet. Abst. , vol.2007 , pp. 1635
    • White, D.1    Saunders, V.2    Quinn, S.3    Manley, P.4    Hughes, T.5
  • 43
    • 25144450089 scopus 로고    scopus 로고
    • Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps
    • Burger, H. et al. Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. Cancer Biol. Ther. 4, 747-752 (2005).
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 747-752
    • Burger, H.1
  • 44
    • 43349088564 scopus 로고    scopus 로고
    • Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells
    • Hirayama, C. et al. Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells. Pharm. Res. 25, 827-835 (2008).
    • (2008) Pharm. Res. , vol.25 , pp. 827-835
    • Hirayama, C.1
  • 45
    • 0037443754 scopus 로고    scopus 로고
    • MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
    • Mahon, F.X. et al. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood 101, 2368-2373 (2003).
    • (2003) Blood , vol.101 , pp. 2368-2373
    • Mahon, F.X.1
  • 46
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
    • Mahon, F.X. et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood 96, 1070-1079 (2000).
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1
  • 47
    • 80053211502 scopus 로고    scopus 로고
    • Development of imatinib and dasatinib resistance: Dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1
    • Gromicho, M. et al. Development of imatinib and dasatinib resistance: dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1. Leuk. Lymphoma 52, 1980-1990 (2011).
    • (2011) Leuk. Lymphoma , vol.52 , pp. 1980-1990
    • Gromicho, M.1
  • 48
    • 80055002578 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor resistance in chronic myeloid leukemia cell lines: Investigating resistance pathways
    • Tang, C. et al. Tyrosine kinase inhibitor resistance in chronic myeloid leukemia cell lines: investigating resistance pathways. Leuk. Lymphoma 52, 2139-2147 (2011).
    • (2011) Leuk. Lymphoma , vol.52 , pp. 2139-2147
    • Tang, C.1
  • 49
    • 45349103388 scopus 로고    scopus 로고
    • Lack of ABC transporter autoinduction in mice following long-term exposure to imatinib
    • Gardner, E.R., Sparreboom, A., Verweij, J. & Figg, W.D. Lack of ABC transporter autoinduction in mice following long-term exposure to imatinib. Cancer Biol. Ther. 7, 412-415 (2008).
    • (2008) Cancer Biol. Ther. , vol.7 , pp. 412-415
    • Gardner, E.R.1    Sparreboom, A.2    Verweij, J.3    Figg, W.D.4
  • 50
    • 27144509746 scopus 로고    scopus 로고
    • In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML
    • White, D. et al. In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML. Blood 106, 2520-2526 (2005).
    • (2005) Blood , vol.106 , pp. 2520-2526
    • White, D.1
  • 51
    • 84873362373 scopus 로고    scopus 로고
    • Degree of kinase inhibition achieved in vitro by imatinib and nilotinib is decreased by high levels of ABCB1 but not ABCG2
    • Eadie, L.N., Saunders, V.A., Hughes, T.P. & White, D.L. Degree of kinase inhibition achieved in vitro by imatinib and nilotinib is decreased by high levels of ABCB1 but not ABCG2. Leuk. Lymphoma 54, 569-578 (2013).
    • (2013) Leuk. Lymphoma , vol.54 , pp. 569-578
    • Eadie, L.N.1    Saunders, V.A.2    Hughes, T.P.3    White, D.L.4
  • 52
    • 0037130294 scopus 로고    scopus 로고
    • Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1
    • Hegedus, T., Orfi, L., Seprodi, A., Varadi, A., Sarkadi, B. & Keri, G. Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1. Biochim. Biophys. Acta 1587, 318-325 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 318-325
    • Hegedus, T.1    Orfi, L.2    Seprodi, A.3    Varadi, A.4    Sarkadi, B.5    Keri, G.6
  • 53
    • 0043245793 scopus 로고    scopus 로고
    • Functional consequence of MDR1 expression on imatinib intracellular concentrations
    • Widmer, N., Colombo, S., Buclin, T. & Decosterd, L.A. Functional consequence of MDR1 expression on imatinib intracellular concentrations. Blood 102, 1142 (2003).
    • (2003) Blood , vol.102 , pp. 1142
    • Widmer, N.1    Colombo, S.2    Buclin, T.3    Decosterd, L.A.4
  • 54
    • 1542713480 scopus 로고    scopus 로고
    • P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
    • Illmer, T. et al. P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia 18, 401-408 (2004).
    • (2004) Leukemia , vol.18 , pp. 401-408
    • Illmer, T.1
  • 55
  • 56
    • 54049128527 scopus 로고    scopus 로고
    • Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): Implications for the treatment of imatinib-resistant chronic myeloid leukemia
    • Giannoudis, A., Davies, A., Lucas, C.M., Harris, R.J., Pirmohamed, M. & Clark, R.E. Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia. Blood 112, 3348-3354 (2008).
    • (2008) Blood , vol.112 , pp. 3348-3354
    • Giannoudis, A.1    Davies, A.2    Lucas, C.M.3    Harris, R.J.4    Pirmohamed, M.5    Clark, R.E.6
  • 57
    • 0344520475 scopus 로고    scopus 로고
    • Distribution of STI-571 to the brain is limited by P-glycoprotein- mediated efflux
    • Dai, H., Marbach, P., Lemaire, M., Hayes, M. & Elmquist, W.F. Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux. J. Pharmacol. Exp. Ther. 304, 1085-1092 (2003).
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1085-1092
    • Dai, H.1    Marbach, P.2    Lemaire, M.3    Hayes, M.4    Elmquist, W.F.5
  • 58
    • 77954892297 scopus 로고    scopus 로고
    • Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib
    • Dohse, M. et al. Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab. Dispos. 38, 1371-1380 (2010).
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 1371-1380
    • Dohse, M.1
  • 60
    • 34249669336 scopus 로고    scopus 로고
    • Imatinib mesylate and nilotinib (AMN107) exhibit highaffinity interaction with ABCG2 on primitive hematopoietic stem cells
    • Brendel, C. et al. Imatinib mesylate and nilotinib (AMN107) exhibit highaffinity interaction with ABCG2 on primitive hematopoietic stem cells. Leukemia 21, 1267-1275 (2007).
    • (2007) Leukemia , vol.21 , pp. 1267-1275
    • Brendel, C.1
  • 61
    • 70350132811 scopus 로고    scopus 로고
    • Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: Implications for altered anti-cancer effects and pharmacological properties
    • Hegedus, C. et al. Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br. J. Pharmacol. 158, 1153-1164 (2009).
    • (2009) Br. J. Pharmacol. , vol.158 , pp. 1153-1164
    • Hegedus, C.1
  • 62
    • 57149098598 scopus 로고    scopus 로고
    • Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression
    • Mahon, F.X. et al. Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression. Cancer Res. 68, 9809-9816 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 9809-9816
    • Mahon, F.X.1
  • 63
    • 70450255111 scopus 로고    scopus 로고
    • Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters
    • Davies, A. et al. Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. Leukemia 23, 1999-2006 (2009).
    • (2009) Leukemia , vol.23 , pp. 1999-2006
    • Davies, A.1
  • 64
    • 65649084180 scopus 로고    scopus 로고
    • Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
    • Tiwari, A.K. et al. Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem. Pharmacol. 78, 153-161 (2009).
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 153-161
    • Tiwari, A.K.1
  • 65
    • 77949424637 scopus 로고    scopus 로고
    • Nilotinibmediated inhibition of ABCB1 increases intracellular concentration of dasatinib in CML cells: Implications for combination TKI therapy
    • Hiwase, D.K., White, D., Zrim, S., Saunders, V., Melo, J.V. & Hughes, T.P. Nilotinibmediated inhibition of ABCB1 increases intracellular concentration of dasatinib in CML cells: implications for combination TKI therapy. Leukemia 24, 658-660 (2010).
    • (2010) Leukemia , vol.24 , Issue.658-660
    • Hiwase, D.K.1    White, D.2    Zrim, S.3    Saunders, V.4    Melo, J.V.5    Hughes, T.P.6
  • 66
    • 84878441533 scopus 로고    scopus 로고
    • Dasatinib targets chronic myeloid leukemia-CD34+ progenitors as effectively as it targets mature cells
    • Hiwase, D.K., Saunders, V.A., Nievergall, E., Ross, D.D., White, D.L. & Hughes, T.P. Dasatinib targets chronic myeloid leukemia-CD34+ progenitors as effectively as it targets mature cells. Haematologica 98, 896-900 (2013).
    • (2013) Haematologica , vol.98 , pp. 896-900
    • Hiwase, D.K.1    Saunders, V.A.2    Nievergall, E.3    Ross, D.D.4    White, D.L.5    Hughes, T.P.6
  • 67
    • 52449100460 scopus 로고    scopus 로고
    • Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: Therapeutic implications
    • Hiwase, D.K. et al. Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications. Clin. Cancer Res. 14, 3881-3888 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3881-3888
    • Hiwase, D.K.1
  • 68
    • 70349142722 scopus 로고    scopus 로고
    • P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib
    • Chen, Y., Agarwal, S., Shaik, N.M., Chen, C., Yang, Z. & Elmquist, W.F. P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib. J. Pharmacol. Exp. Ther. 330, 956-963 (2009).
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , pp. 956-963
    • Chen, Y.1    Agarwal, S.2    Shaik, N.M.3    Chen, C.4    Yang, Z.5    Elmquist, W.F.6
  • 69
    • 65249151331 scopus 로고    scopus 로고
    • Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment
    • Lagas, J.S. et al. Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment. Clin. Cancer Res. 15, 2344-2351 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2344-2351
    • Lagas, J.S.1
  • 70
    • 33745953739 scopus 로고    scopus 로고
    • Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression
    • Nakanishi, T., Shiozawa, K., Hassel, B.A. & Ross, D.D. Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression. Blood 108, 678-684 (2006).
    • (2006) Blood , vol.108 , pp. 678-684
    • Nakanishi, T.1    Shiozawa, K.2    Hassel, B.A.3    Ross, D.D.4
  • 71
    • 1942506722 scopus 로고    scopus 로고
    • Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro
    • Houghton, P.J. et al. Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer Res. 64, 2333-2337 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 2333-2337
    • Houghton, P.J.1
  • 72
    • 7244232706 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
    • Burger, H. et al. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood 104, 2940-2942 (2004).
    • (2004) Blood , vol.104 , pp. 2940-2942
    • Burger, H.1
  • 73
    • 33747155024 scopus 로고    scopus 로고
    • Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate
    • Jordanides, N.E., Jorgensen, H.G., Holyoake, T.L. & Mountford, J.C. Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate. Blood 108, 1370-1373 (2006).
    • (2006) Blood , vol.108 , pp. 1370-1373
    • Jordanides, N.E.1    Jorgensen, H.G.2    Holyoake, T.L.3    Mountford, J.C.4
  • 74
    • 34247886063 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor imatinib mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2
    • Liu, W. et al. The tyrosine kinase inhibitor imatinib mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2. Clin. Cancer Res. 13, 2463-2470 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2463-2470
    • Liu, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.