Development of imatinib and dasatinib resistance: Dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1

Leukemia and Lymphoma

Volumn 52, Issue 10, 2011, Pages 1980-1990

  Gromicho, Marta ^a   Dinis, Joana ^a   Magalhães, Marta ^a   Fernandes, Alexandra R ^b,c,d   Tavares, Purificação ^e   Laires, Antnio ^a,d   Rueff, José ^a   Rodrigues, Antnio Sebastião ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^c UNIVERSIDADE LUSÓFONA DE HUMANIDADES E TECNOLOGIAS   (Portugal)

^d UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^e CGC GENETICS   (Portugal)

Author keywords

ABCC1; ABCC3; ABCG2; Chronic myeloid leukemia; drug transporters (ABCB1; K562 cell line; multidrug resistance; MVP; SLC22A1)

Indexed keywords

ABCC1 PROTEIN; BREAST CANCER RESISTANCE PROTEIN; DASATINIB; IMATINIB; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MVP PROTEIN; ORGANIC CATION TRANSPORTER 1; PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CANCER RESISTANCE; CELL PROLIFERATION; CELL STRAIN K 562; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EXPOSURE; DRUG TRANSPORT; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MUTATIONAL ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ATP-BINDING CASSETTE TRANSPORTERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; ORGANIC CATION TRANSPORTER 1; P-GLYCOPROTEIN; PIPERAZINES; PYRIMIDINES; THIAZOLES; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 80053211502     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.584005     Document Type: Article

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