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Volumn 110, Issue 4, 2014, Pages 1066-1073

HBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HEPATITIS B VIRUS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; POINT MUTATION; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; UP-REGULATION;

EID: 84894321550     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.787     Document Type: Article
Times cited : (44)

References (24)
  • 2
    • 79952842661 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis b revealed
    • Chen CJ, Yang HI (2011) Natural history of chronic hepatitis B REVEALed. J Gastroenterol Hepatol 26: 628-638.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 628-638
    • Chen, C.J.1    Yang, H.I.2
  • 3
    • 29944436855 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis b virus dna level
    • Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN, Huang GT, Iloeje UH (2006) Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 295: 65-73.
    • (2006) JAMA , vol.295 , pp. 65-73
    • Chen, C.J.1    Yang, H.I.2    Su, J.3    Jen, C.L.4    You, S.L.5    Lu, S.N.6    Huang, G.T.7    Iloeje, U.H.8
  • 5
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia-A key regulatory factor in tumour growth
    • Harris AL (2002) Hypoxia-A key regulatory factor in tumour growth. Nat Rev 2: 38-47.
    • (2002) Nat Rev , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 7
    • 80051932038 scopus 로고    scopus 로고
    • Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival
    • Iyer S, Groopman JD (2011) Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival. Mol Carcinog 50: 972-980.
    • (2011) Mol Carcinog , vol.50 , pp. 972-980
    • Iyer, S.1    Groopman, J.D.2
  • 8
    • 0029937060 scopus 로고    scopus 로고
    • A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function
    • Kumar V, Jayasuryan N, Kumar R (1996) A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function. Proc Natl Acad Sci USA 93: 5647-5652.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5647-5652
    • Kumar, V.1    Jayasuryan, N.2    Kumar, R.3
  • 9
    • 84867531311 scopus 로고    scopus 로고
    • Sorafenib inhibits hypoxia-inducible factor-1alpha syn thesis implications for anti-Angiogenic activity in hepatocellular carcinoma
    • Liu LP, Ho RL, Chen GG, Lai P (2012) Sorafenib inhibits hypoxia-inducible factor-1alpha synthesis: Implications for anti-Angiogenic activity in hepatocellular carcinoma. Clin Cancer Res 18: 5662-5671.
    • (2012) Clin Cancer Res , vol.18 , pp. 5662-5671
    • Liu, L.P.1    Ho, R.L.2    Chen, G.G.3    Lai, P.4
  • 10
    • 77952163228 scopus 로고    scopus 로고
    • The role of nf-kappab in hepatitis b virus x protein-mediated upregulation of vegf and mmps
    • Liu LP, Liang HF, Chen XP, Zhang WG, Yang SL, Xu T, Ren L (2010) The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs. Cancer Invest 28: 443-451.
    • (2010) Cancer Invest , vol.28 , pp. 443-451
    • Liu, L.P.1    Liang, H.F.2    Chen, X.P.3    Zhang, W.G.4    Yang, S.L.5    Xu, T.6    Ren, L.7
  • 11
    • 78650540344 scopus 로고    scopus 로고
    • The C-Terminal region of the hepatitis B virus X protein is essential for its stability and function
    • Lizzano RA, Yang B, Clippinger AJ, Bouchard MJ (2011) The C-Terminal region of the hepatitis B virus X protein is essential for its stability and function. Virus Res 155: 231-239.
    • (2011) Virus Res , vol.155 , pp. 231-239
    • Lizzano, R.A.1    Yang, B.2    Clippinger, A.J.3    Bouchard, M.J.4
  • 14
    • 77949654113 scopus 로고    scopus 로고
    • Mechanisms of hbv-related hepatocarcinogenesis
    • Neuveut C, Wei Y, Buendia MA (2010) Mechanisms of HBV-related hepatocarcinogenesis. J Hepatol 52: 594-604.
    • (2010) J Hepatol , vol.52 , pp. 594-604
    • Neuveut, C.1    Wei, Y.2    Buendia, M.A.3
  • 15
    • 80052411388 scopus 로고    scopus 로고
    • Hepatitis B virus X gene and hepatocarcinogenesis
    • Ng SA, Lee C (2011) Hepatitis B virus X gene and hepatocarcinogenesis. J Gastroenterol 46: 974-990.
    • (2011) J Gastroenterol , vol.46 , pp. 974-990
    • Ng, S.A.1    Lee, C.2
  • 16
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J, Dayan F, Mazure NM (2006) Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 17
    • 17644388427 scopus 로고    scopus 로고
    • Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues
    • Rui E, Moura PR, Goncalves Kde A, Kobarg J (2005) Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues. J Virol Methods 126: 65-74.
    • (2005) J Virol Methods , vol.126 , pp. 65-74
    • Rui, E.1    Moura, P.R.2    Goncalves Kde, A.3    Kobarg, J.4
  • 18
    • 0142166332 scopus 로고    scopus 로고
    • Targeting hif-1 for cancer therapy
    • Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev 3: 721-732.
    • (2003) Nat Rev , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 22
    • 4344658248 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor
    • Yoo YG, Lee MO (2004) Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor. J Biol Chem 279: 36242-36249.
    • (2004) J Biol Chem , vol.279 , pp. 36242-36249
    • Yoo, Y.G.1    Lee, M.O.2
  • 23
    • 44449114668 scopus 로고    scopus 로고
    • Hepatitis b virus x protein induces the expression of mta1 and hdac1, which enhances hypoxia signaling in hepatocellular carcinoma cells
    • Yoo YG, Na TY, Seo HW, Seong JK, Park CK, Shin YK, Lee MO (2008) Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells. Oncogene 27: 3405-3413.
    • (2008) Oncogene , vol.27 , pp. 3405-3413
    • Yoo, Y.G.1    Na, T.Y.2    Seo, H.W.3    Seong, J.K.4    Park, C.K.5    Shin, Y.K.6    Lee, M.O.7
  • 24
    • 0141532010 scopus 로고    scopus 로고
    • Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-Activated protein kinase pathway
    • Yoo YG, Oh SH, Park ES, Cho H, Lee N, Park H, Kim DK, Yu DY, Seong JK, Lee MO (2003) Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-Activated protein kinase pathway. J Biol Chem 278: 39076-39084.
    • (2003) J Biol Chem , vol.278 , pp. 39076-39084
    • Yoo, Y.G.1    Oh, S.H.2    Park, E.S.3    Cho, H.4    Lee, N.5    Park, H.6    Kim, D.K.7    Yu, D.Y.8    Seong, J.K.9    Lee, M.O.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.