메뉴 건너뛰기




Volumn 50, Issue 12, 2011, Pages 972-980

Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival

Author keywords

Hepatitis B virus; Hepatitis B virus X protein; Hepatocellular carcinoma; P53; Risk factor

Indexed keywords

HEPATITIS B VIRUS X PROTEIN; PROTEIN P53;

EID: 80051932038     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20767     Document Type: Article
Times cited : (16)

References (40)
  • 2
    • 19644381818 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: The need for progress
    • Thomas M, Zhu A. Hepatocellular carcinoma: The need for progress. J Clin Oncol 2005;23:2892-2899.
    • (2005) J Clin Oncol , vol.23 , pp. 2892-2899
    • Thomas, M.1    Zhu, A.2
  • 3
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
    • Wang X, Forrester K, Yeh H, Feitelson M, Gu J-R, Harris C. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 1994;91:2230-2234.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2230-2234
    • Wang, X.1    Forrester, K.2    Yeh, H.3    Feitelson, M.4    Gu, J.-R.5    Harris, C.6
  • 4
    • 0031460372 scopus 로고    scopus 로고
    • Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis
    • Elmore L, Hancock A, Chang S-F, et al. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci USA 1997;94:14707-14712.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14707-14712
    • Elmore, L.1    Hancock, A.2    Chang, S.-F.3
  • 5
    • 80255135207 scopus 로고    scopus 로고
    • Partial characterization of the woodchuck tumor suppressor, p53, and its interaction with woodchuck hepatitis virus X antigen
    • Feitelson M, Ranganathan P, Clayton M, Zhang S. Partial characterization of the woodchuck tumor suppressor, p53, and its interaction with woodchuck hepatitis virus X antigen. Oncogene 1997;1997:3.
    • (1997) Oncogene , vol.1997 , pp. 3
    • Feitelson, M.1    Ranganathan, P.2    Clayton, M.3    Zhang, S.4
  • 6
    • 0030696170 scopus 로고    scopus 로고
    • Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus gene-transfected cells
    • Takada S, Kaneniwa N, Tsuchida N, Koike K. Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus gene-transfected cells. Oncogene 1997;15:1895-1901.
    • (1997) Oncogene , vol.15 , pp. 1895-1901
    • Takada, S.1    Kaneniwa, N.2    Tsuchida, N.3    Koike, K.4
  • 7
    • 0028834376 scopus 로고
    • Abrogration of p53-induced apoptosis by the hepatitis B virus X gene
    • Wang X, Gibson M, Vermeulen W, et al. Abrogration of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res 1995;55:6012-6016.
    • (1995) Cancer Res , vol.55 , pp. 6012-6016
    • Wang, X.1    Gibson, M.2    Vermeulen, W.3
  • 8
    • 0034688143 scopus 로고    scopus 로고
    • Transcriptional repression of the human p53 gene by hepatitis B viral X protein
    • Lee S, Rho H. Transcriptional repression of the human p53 gene by hepatitis B viral X protein. Oncogene 2000;19:468-471.
    • (2000) Oncogene , vol.19 , pp. 468-471
    • Lee, S.1    Rho, H.2
  • 9
    • 48549099121 scopus 로고    scopus 로고
    • COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis
    • Cheng A, Yu J, Lai P, Chan H, Sung J. COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis. Biochem Biophys Res Commun 2008;374:175-180.
    • (2008) Biochem Biophys Res Commun , vol.374 , pp. 175-180
    • Cheng, A.1    Yu, J.2    Lai, P.3    Chan, H.4    Sung, J.5
  • 10
    • 0028843480 scopus 로고
    • Functional inactivation but not structural mutation of p53 causes liver cancer
    • Ueda H, Ullrich S, Gangemi D, et al. Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet 1995;9:41-47.
    • (1995) Nat Genet , vol.9 , pp. 41-47
    • Ueda, H.1    Ullrich, S.2    Gangemi, D.3
  • 12
    • 36348986710 scopus 로고    scopus 로고
    • Basal core promoter T1762/A1764 and precore 1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: A comparison with chronic carriers
    • Tong M, Blatt L, Kao J-H, Cheng J, Corey W. Basal core promoter T1762/A1764 and precore 1896 gene mutations in hepatitis B surface antigen-positive hepatocellular carcinoma: A comparison with chronic carriers. Liver Int 2007;27:1356-1363.
    • (2007) Liver Int , vol.27 , pp. 1356-1363
    • Tong, M.1    Blatt, L.2    Kao, J.-H.3    Cheng, J.4    Corey, W.5
  • 13
    • 50649109431 scopus 로고    scopus 로고
    • HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: A prospective study
    • Fang Z-L, Sabin C, Dong B-Q, et al. HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: A prospective study. Am J Gastroenterol 2008;103:2254-2262.
    • (2008) Am J Gastroenterol , vol.103 , pp. 2254-2262
    • Fang, Z.-L.1    Sabin, C.2    Dong, B.-Q.3
  • 14
    • 51049117284 scopus 로고    scopus 로고
    • Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    • Yang H-I, Yeh S-H, Chen P-J, et al. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst 2008;100:1134-1143.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1134-1143
    • Yang, H.-I.1    Yeh, S.-H.2    Chen, P.-J.3
  • 15
    • 60649085236 scopus 로고    scopus 로고
    • Prospective evaluation of hepatitis B 1762T/1764A mutations on hepatocellular carcinoma development in Shanghai, China
    • Yuan J-M, Ambinder A, Fan Y, Gao Y-T, Yu M, Groopman J. Prospective evaluation of hepatitis B 1762T/1764A mutations on hepatocellular carcinoma development in Shanghai, China. Cancer Epidemiol Biomark Prev 2009;18:590-594.
    • (2009) Cancer Epidemiol Biomark Prev , vol.18 , pp. 590-594
    • Yuan, J.-M.1    Ambinder, A.2    Fan, Y.3    Gao, Y.-T.4    Yu, M.5    Groopman, J.6
  • 16
    • 0029817029 scopus 로고    scopus 로고
    • Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication
    • Buckwold V, Xu Z, Chen M, Yen T, Ou J-H. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996;70:5845-5851.
    • (1996) J Virol , vol.70 , pp. 5845-5851
    • Buckwold, V.1    Xu, Z.2    Chen, M.3    Yen, T.4    Ou, J.-H.5
  • 17
    • 0030879649 scopus 로고    scopus 로고
    • Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication
    • Buckwold V, Xu Z, Yen T, Ou J-H. Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication. J Gen Virol 1997;78:2055-2065.
    • (1997) J Gen Virol , vol.78 , pp. 2055-2065
    • Buckwold, V.1    Xu, Z.2    Yen, T.3    Ou, J.-H.4
  • 18
    • 2942689233 scopus 로고    scopus 로고
    • Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein
    • Zheng Y, Li J, Ou J-H. Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein. J Virol 2004;78:6908-6914.
    • (2004) J Virol , vol.78 , pp. 6908-6914
    • Zheng, Y.1    Li, J.2    Ou, J.-H.3
  • 19
    • 0030724749 scopus 로고    scopus 로고
    • The transactivating and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct
    • Lin Y, Nomura T, Yamashita T, Dorjsuren D, Tang H, Murakami S. The transactivating and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct. Cancer Res 1997;57:5137-5142.
    • (1997) Cancer Res , vol.57 , pp. 5137-5142
    • Lin, Y.1    Nomura, T.2    Yamashita, T.3    Dorjsuren, D.4    Tang, H.5    Murakami, S.6
  • 20
    • 0000934401 scopus 로고
    • Production of hepatitis B virus in HepG2 cells transfected with cloned hepatitis B virus DNA
    • Sells M, Chen M, Acs G. Production of hepatitis B virus in HepG2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci USA 1987;87:1005-1009.
    • (1987) Proc Natl Acad Sci USA , vol.87 , pp. 1005-1009
    • Sells, M.1    Chen, M.2    Acs, G.3
  • 21
    • 33644775019 scopus 로고    scopus 로고
    • Multiple alternate p21 transcripts are regulated by p53 in human cells
    • Radhakrishnan S, Gierut J, Gartel A. Multiple alternate p21 transcripts are regulated by p53 in human cells. Oncogene 2006;25:3264-3270.
    • (2006) Oncogene , vol.25 , pp. 3264-3270
    • Radhakrishnan, S.1    Gierut, J.2    Gartel, A.3
  • 22
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F, Dutriaux A, Lengauer C, et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998;282:1497-1501.
    • (1998) Science , vol.282 , pp. 1497-1501
    • Bunz, F.1    Dutriaux, A.2    Lengauer, C.3
  • 24
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
    • Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 1994;91:2230-2234.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2230-2234
    • Wang, X.W.1    Forrester, K.2    Yeh, H.3    Feitelson, M.A.4    Gu, J.R.5    Harris, C.C.6
  • 25
    • 0026687883 scopus 로고
    • Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
    • Lees-Miller S, Sakaguchi K, Ullrich S, Appella E, Anderson C. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 1992;12:5041-5049.
    • (1992) Mol Cell Biol , vol.12 , pp. 5041-5049
    • Lees-Miller, S.1    Sakaguchi, K.2    Ullrich, S.3    Appella, E.4    Anderson, C.5
  • 26
    • 0027155885 scopus 로고
    • Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression
    • Fiscella M, Ullrich S, Zambrano N, et al. Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression. Oncogene 1993;8:1519-1528.
    • (1993) Oncogene , vol.8 , pp. 1519-1528
    • Fiscella, M.1    Ullrich, S.2    Zambrano, N.3
  • 27
    • 0031972604 scopus 로고    scopus 로고
    • X-gene product of hepatitis B virus induces apoptosis in liver cells
    • Kim H, Lee H, Yun Y. X-gene product of hepatitis B virus induces apoptosis in liver cells. J Biol Chem 1998;273:381-385.
    • (1998) J Biol Chem , vol.273 , pp. 381-385
    • Kim, H.1    Lee, H.2    Yun, Y.3
  • 28
    • 0033607041 scopus 로고    scopus 로고
    • Hepatitis B virus mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx
    • Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Brechot C. Hepatitis B virus mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 1999;18:4848-4859.
    • (1999) Oncogene , vol.18 , pp. 4848-4859
    • Sirma, H.1    Giannini, C.2    Poussin, K.3    Paterlini, P.4    Kremsdorf, D.5    Brechot, C.6
  • 29
    • 13944251714 scopus 로고    scopus 로고
    • Hepatitis B 1762 T /1764 A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
    • Kuang SY, Lekawanvijit S, Maneekarn N, et al. Hepatitis B 1762 T /1764 A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand. Cancer Epidemiol Biomark Prev 2005;14:380-384.
    • (2005) Cancer Epidemiol Biomark Prev , vol.14 , pp. 380-384
    • Kuang, S.Y.1    Lekawanvijit, S.2    Maneekarn, N.3
  • 30
    • 51049117284 scopus 로고    scopus 로고
    • Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
    • Yang H-I, Yeh S-H, Chen P-J, et al. Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma. J Natl Cancer Inst 2008;100:1134-1143.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1134-1143
    • Yang, H.-I.1    Yeh, S.-H.2    Chen, P.-J.3
  • 31
    • 25844447771 scopus 로고    scopus 로고
    • The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage
    • Lee A, Ren J, Wong E-T, Ban K, Lee L, Lee C. The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage. J Biol Chem 2005;280:33525-33535.
    • (2005) J Biol Chem , vol.280 , pp. 33525-33535
    • Lee, A.1    Ren, J.2    Wong, E.-T.3    Ban, K.4    Lee, L.5    Lee, C.6
  • 32
    • 0024391379 scopus 로고
    • Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication
    • Colgrove R, Simon G, Ganem D. Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J Virol 1989;63:4019-4026.
    • (1989) J Virol , vol.63 , pp. 4019-4026
    • Colgrove, R.1    Simon, G.2    Ganem, D.3
  • 33
    • 33646193810 scopus 로고    scopus 로고
    • Activation of focal adhesion kinase by hepatitis B virus HBx protein: Multiple functions in viral replication
    • Bouchard M, Wang L, Schneider R. Activation of focal adhesion kinase by hepatitis B virus HBx protein: Multiple functions in viral replication. J Virol 2006;80:4406-4414.
    • (2006) J Virol , vol.80 , pp. 4406-4414
    • Bouchard, M.1    Wang, L.2    Schneider, R.3
  • 34
    • 37549064123 scopus 로고    scopus 로고
    • Hepatitis B virus promotes angiopoietin-2 expression in liver tissue
    • Sanz-Cameno P, Martin-Vilchez S, Lara-Pezzi E, et al. Hepatitis B virus promotes angiopoietin-2 expression in liver tissue. Am J Pathol 2006;169:1215-1222.
    • (2006) Am J Pathol , vol.169 , pp. 1215-1222
    • Sanz-Cameno, P.1    Martin-Vilchez, S.2    Lara-Pezzi, E.3
  • 35
    • 4344634335 scopus 로고    scopus 로고
    • Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells
    • Mathonnet G, Lachance S, Alaoui-Jamali M, Drobetsky E. Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells. Mutat Res 2004;554:305-318.
    • (2004) Mutat Res , vol.554 , pp. 305-318
    • Mathonnet, G.1    Lachance, S.2    Alaoui-Jamali, M.3    Drobetsky, E.4
  • 36
    • 0033539891 scopus 로고    scopus 로고
    • HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX
    • Doitsh G, Shaul Y. HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX. Oncogene 1999;18:7506-7513.
    • (1999) Oncogene , vol.18 , pp. 7506-7513
    • Doitsh, G.1    Shaul, Y.2
  • 37
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
    • Wajapayee N, Serra R, Zhu X, Mahalingam M, Green M. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 2008;132:363-374.
    • (2008) Cell , vol.132 , pp. 363-374
    • Wajapayee, N.1    Serra, R.2    Zhu, X.3    Mahalingam, M.4    Green, M.5
  • 38
    • 67049168909 scopus 로고    scopus 로고
    • The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes
    • Yu H, McDaid R, Lee J, et al. The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes. Am J Pathol 2009;174:2367-2377.
    • (2009) Am J Pathol , vol.174 , pp. 2367-2377
    • Yu, H.1    McDaid, R.2    Lee, J.3
  • 39
    • 77955358206 scopus 로고    scopus 로고
    • Cooperation of tumor-derived HBx mutants and p53-249ser mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line
    • Jiang W, Wang X, Unger T, et al. Cooperation of tumor-derived HBx mutants and p53-249ser mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line. Int J Cancer 2010;127:1011-1020.
    • (2010) Int J Cancer , vol.127 , pp. 1011-1020
    • Jiang, W.1    Wang, X.2    Unger, T.3
  • 40
    • 0035057205 scopus 로고    scopus 로고
    • Intracellular localization of the hepatitis B virus HBx protein
    • Henkler F, Hoare J, Waseem N, et al. Intracellular localization of the hepatitis B virus HBx protein. J Gen Virol 2001;82:871-882.
    • (2001) J Gen Virol , vol.82 , pp. 871-882
    • Henkler, F.1    Hoare, J.2    Waseem, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.