GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-α converting enzyme (TACE)

Blood

Volumn 114, Issue 20, 2009, Pages 4517-4526

  Hiasa, Masahiro ^a,b   Abe, Masahiro ^a   Nakano, Ayako ^a   Oda, Asuka ^a   Amou, Hiroe ^a   Kido, Shinsuke ^a   Takeuchi, Kyoko ^a   Kagawa, Kumiko ^a   Yata, Kenichiro ^a   Hashimoto, Toshihiro ^a   Ozaki, Shuji ^a   Asaoka, Kenzo ^b   Tanaka, Eiji ^b   Moriyama, Keiji ^c   Matsumoto, Toshio ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; ADAM PROTEIN; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MONOCYTE; NORMAL HUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; MACROPHAGE; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADAM PROTEINS; BLOTTING, WESTERN; CELL DIFFERENTIATION; DENDRITIC CELLS; FLUORESCENT ANTIBODY TECHNIQUE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-4; MACROPHAGES; MONOCYTES; OSTEOCLASTS; RANK LIGAND; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 73349124125     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-04-215020     Document Type: Article

References (52)

1. Miyamoto T, Ohneda O, Arai F, et al. Bifurcation of osteoclasts and dendritic cells from common progenitors. Blood. 2001;98(8):2544-2554.
2. Akagawa KS, Takasuka N, Nozaki Y, et al. Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes. Blood. 1996;88(10):4029-4039.
3. Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol. 2007;7(1):19-30.
4. Ardavin C. Origin, precursors and differentiation of mouse dendritic cells. Nat Rev Immunol. 2003;3(7):582-590.
5. Yoshida H, Hayashi S, Kunisada T, et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. 1990;345(6274):442-444.
6. Dai XM, Ryan GR, Hapel AJ, et al. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood. 2002;99(1):111-120.
7. Kong YY, Yoshida H, Sarosi I, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397(6717):315-323.
8. Yasuda H, Shima N, Nakagawa N, et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A. 1998;95(7):3597-3602.
9. Chomarat P, Banchereau J, Davoust J, Palucka AK. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol. 2000;1(6):510-514.
10. Menetrier-Caux C, Montmain G, Dieu MC, et al. Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. Blood. 1998;92(12):4778-4791.
11. Chomarat P, Dantin C, Bennett L, Banchereau J, Palucka AK. TNF skews monocyte differentiation from macrophages to dendritic cells. J Immunol. 2003;171(5):2262-2269.
12. Conti L, Cardone M, Varano B, Puddu P, Belardelli F, Gessani S. Role of the cytokine environment and cytokine receptor expression on the generation of functionally distinct dendritic cells from human monocytes. Eur J Immunol. 2008;38(3):750-762.
13. Mariotti S, Sargentini V, Marcantonio C, et al. T-cell-mediated and antigen-dependent differentiation of human monocyte into different dendritic cell subsets: a feedback control of Th1/Th2 responses. FASEB J. 2008;22(9):3370-3379.
14. Zhang AL, Colmenero P, Purath U, et al. Natural killer cells trigger differentiation of monocytes into dendritic cells. Blood. 2007;110(7):2484-2493.
15. Kitawaki T, Kadowaki N, Sugimoto N, et al. IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells. Int Immunol. 2006;18(12):1789-1799.
16. Yu Y, Tang L, Wang J, et al. Psoriatic lesional keratinocytes promote the maturation of human monocyte-derived Langerhans cells. Dermatology. 2002;204(2):94-99.
17. Romani N, Gruner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med. 1994;180(1):83-93.
18. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J Exp Med. 1994;179(4):1109-1118.
19. + blood monocytes can differentiate into functionally mature CD83+ dendritic cells. Proc Natl Acad Sci U S A. 1996;93(6):2588-2592.
20. Alnaeeli M, Park J, Mahamed D, Penninger JM, Teng YT. Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss. J Bone Miner Res. 2007;22(6):775-780.
21. Mangashetti LS, Khapli SM, Wani MR. IL-4 inhibits bone-resorbing activity of mature osteoclasts by affecting NF-κB and Ca2+ signaling. J Immunol. 2005;175(2):917-925.
22. Kitaura H, Nagata N, Fujimura Y, et al. Interleukin-4 directly inhibits tumor necrosis factor-α-mediated osteoclast formation in mouse bone marrow macrophages. Immunol Lett. 2003;88(3):193-198.
23. Lo AS, Gorak-Stolinska P, Bachy V, Ibrahim MA, Kemeny DM, Maher J. Modulation of dendritic cell differentiation by colony-stimulating factor-1: role of phosphatidylinositol 3′-kinase and delayed caspase activation. J Leukoc Biol. 2007;82(6):1446-1454.
24. De AK, Laudanski K, Miller-Graziano CL. Failure of monocytes of trauma patients to convert to immature dendritic cells is related to preferential macrophage-colony-stimulating factor-driven macrophage differentiation. J Immunol. 2003;170(12):6355-6362.
25. Abe M, Hiura K, Wilde J, et al. Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion. Blood. 2004;104(8):2484-2491.
26. Li X, Udagawa N, Takami M, Sato N, Kobayashi Y, Takahashi N. p38 mitogen-activated protein kinase is crucially involved in osteoclast differentiation but not in cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages. Endocrinology. 2003;144(11):4999- 5005.
27. Rovida E, Paccagnini A, Del Rosso M, Peschon J, Dello Sbarba P. TNF-α-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation. J Immunol. 2001;166(3):1583-1589.
28. Wheeler DL, Ness KJ, Oberley TD, Verma AK. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. Cancer Res. 2003;63(19):6547-6555.
29. Black RA. TIMP3 checks inflammation. Nat Genet. 2004;36(9):934-935.
30. Teitelbaum SL. Osteoclasts: what do they do and how do they do it? Am J Pathol. 2007;170(2):427-435.
31. 3 integrin. J Cell Biol. 2003;162(3):499-509.
32. Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumournecrosis factor-α from cells. Nature. 1997;385(6618):729-733.
33. Rocks N, Paulissen G, El Hour M, et al. Emerging roles of ADAM and ADAMTS metalloproteinases in cancer. Biochimie. 2008;90(2):369-379.
34. Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev. 2003;17(1):7-30.
35. Huovila AP, Turner AJ, Pelto-Huikko M, Karkkainen I, Ortiz RM. Shedding light on ADAM metalloproteinases. Trends Biochem Sci. 2005;30(7):413-422.
36. Delneste Y, Charbonnier P, Herbault N, et al. Interferon-γ switches monocyte differentiation from dendritic cells to macrophages. Blood. 2003;101(1):143-150.
37. Dello Sbarba P, Rovida E, Caciagli B, et al. Interleukin-4 rapidly down-modulates the macrophage colony-stimulating factor receptor in murine macrophages. J Leukoc Biol. 1996;60(5):644-650.
38. Chen BD, Clark CR, Chou TH. Granulocyte/macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony-stimulating factor. Blood. 1988;71(4):997-1002.
39. Lum L, Wong BR, Josien R, et al. Evidence for a role of a tumor necrosis factor-α (TNF-α)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem. 1999;274(19):13613-13618.
40. Peschon JJ, Slack JL, Reddy P, et al. An essential role for ectodomain shedding in mammalian development. Science. 1998;282(5392):1281-1284.
41. Solomon KA, Pesti N, Wu G, Newton RC. Cutting edge: a dominant negative form of TNF-α converting enzyme inhibits proTNF and TNFRII secretion. J Immunol. 1999;163(8):4105-4108.
42. Reddy P, Slack JL, Davis R, et al. Functional analysis of the domain structure of tumor necrosis factor-α converting enzyme. J Biol Chem. 2000;275(19):14608-14614.
43. Althoff K, Reddy P, Voltz N, Rose-John S, Mullberg J. Shedding of interleukin-6 receptor and tumor necrosis factor alpha: contribution of the stalk sequence to the cleavage pattern of transmembrane proteins. Eur J Biochem. 2000;267(9):2624-2631.
44. Brou C, Logeat F, Gupta N, et al. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell. 2000;5(2):207-216.
45. Merlos-Suarez A, Fernandez-Larrea J, Reddy P, Baselga J, Arribas J. Pro-tumor necrosis factor-α processing activity is tightly controlled by a component that does not affect notch processing. J Biol Chem. 1998;273(38):24955-24962.
46. Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer. 2007;7(8):585-598.
47. Roodman GD, Dougall WC. RANK ligand as a therapeutic target for bone metastases and multiple myeloma. Cancer Treat Rev. 2008;34(1):92-101.
48. Matsumoto T, Abe M. Bone destruction in multiple myeloma. Ann N Y Acad Sci. 2006;1068:319-326.
49. Abe M, Hiura K, Wilde J, et al. Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma. Blood. 2002;100(6):2195-2202.
50. Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002;2(8):584-593.
51. 1 and interleukin-10. Blood. 2001;98(10):2992-2998.
52. Ratta M, Fagnoni F, Curti A, et al. Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6. Blood. 2002;100(1):230-237.