Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-κB in mouse epidermal JB6 cells

Molecular Cancer Therapeutics

Volumn 5, Issue 5, 2006, Pages 1145-1153

  Singh, Rana P ^a   Dhanalakshmi, Sivanandhan ^a   Mohan, Sarumathi ^a   Agarwal, Chapla ^a   Agarwal, Rajesh ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE B; SILIBININ; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; EPIDERMIS CELL; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; RADIATION CARCINOGENESIS; RADIATION DOSE; RADIATION EXPOSURE; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN CARCINOGENESIS; TUMOR PROMOTION; ULTRAVIOLET B RADIATION;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CELLS, CULTURED; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; EPIDERMIS; KERATINOCYTES; MAP KINASE SIGNALING SYSTEM; MICE; MITOSIS; MODELS, BIOLOGICAL; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SILYMARIN; TRANSCRIPTION FACTOR AP-1; ULTRAVIOLET RAYS;

EID: 33745112128     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-05-0478     Document Type: Article

References (42)

1. Katiyar SK, Korman NJ, Mukhtar H, Agarwal R. Protective effects of silymarin against photocarcinogenesis in a mouse skin model. J Natl Cancer Inst 1997;89:556-66.
2. Masui MS, DeLeo VA. Long wave ultraviolet radiation and promotion of skin cancer. Cancer Cells 1991;3:8-12.
3. Bender K, Blattner C, Knebel A, Iordanov M, Herrlich P, Rahmsdorf HJ. UV-induced signal transduction. J Photochem Photobiol B 1997;37:1-17.
4. Tyrrell RM. Activation of mammalian gene expression by the UV component of sunlight - from models to reality. Bioessays 1996;18: 139-48.
5. Hsu TC, Nair R, Tulsian P, et al. Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-KB activation. Cancer Res 2001;61:4160-8.
6. Huang C, Ma WY, Young MR, Colburn N, Dong Z. Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 trans-activation and transformation in mouse JB6 cells. Proc Natl Acad Sci U S A 1998;95:156-61.
7. Suzukawa K, Weber TJ, Colburn NH. AP-1, NF-κB, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model. Environ Health Perspect 2002; 110:865-70.
8. Bode AM, Dong Z. Mitogen-activated protein kinase activation in UV-epidermal induced JB6 model. Environ Health Perspect 2002; 110:865-70
9. Huang C, Mattjus P, Me WY, et al. Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenice mice. J Biol Chem 2000;275:9143-9.
10. Herrich P, Ponta H, Rahmasdorf HJ. DNA damage-induced gene expression: signal transduction and relation to growth factor signaling. Rev Physiol Biochem Pharmacol 1992;119:187-223.
11. Ronai ZA, Lambert ME, Weinstein IB. Inducible cellular responses to ultraviolet light irradiation and other mediators of DNA damage in mammalian cells. Cell Biol Toxicol 1990;6:10-26.
12. 2-kinase by UV irradiation is dependent on p21ras. J Biol Chem 1996;271:23304-9.
13. Adler V, Schaffer A, Kim J, Dolan L, Ronai Z. UV irradiation and heat shock mediate JNK activation via alternate pathways. J Biol Chem 1995; 270:26071-7.
14. Minden A, Lin A, McMahon M, et al. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 1994; 266:1719-23.
15. Dong Z, Ma W, Huang C, Yang CS. Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins. Cancer Res 1997;57:4414-9.
16. Watts RG, Huang C, Young MR, et al. expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation. Oncogene 1998;17:3493-8.
17. Nomura M, Kaji A, Me WY, et al. Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J Biol Chem 2001;276:25558-67.
18. Peus D, Vasa RA, Meves A, Beyerle A, Pittelkow MR. UVB-induced epidermal growth factor receptor phosphorylation is critical for down-stream signaling and keratinocyte survival. Photochem Photobiol 2000; 72:135-40.
19. Hsu TC, Young MR, Cmarik J, Colburn NH. Activator protein 1 (AP-1)-and nuclear factor κB IN F-κB) -dependent transcriptional events in carcinogenesis. Free Radic Biol Mad 2000;28:1338-48.
20. Singh RP, Tyagi AK, Zhao J, Agarwal R. Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis 2002;23:499-510.
21. Singh RP, Agarwal R. Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. Eur J Cancer 2005;41:1969-79.
22. Mallikarjuna G, Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res 2004; 64:6349-56.
23. Dhanalakshmi S, Mallikarjuna Gu, Singh RP, Agarwal R. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimmer positive cells and up-regulation of p53-21/ Cip1 in epidermis. Carcinogenesis 2004;25:1459-65.
24. Gu M, Dhanalakshmi S, Mohan S, Singh RP, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin. Carcinogenesis 2005; 26:1404-13.
25. Lahiri-Chatterjee M, Katiyar SK, Mohan FIR, Agarwal R. A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model. Cancer Res 1999;59:622-32.
26. Dhanalakshmi S, Agarwal C, Singh RP, Agarwal R. Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J Biol Chem 2005; 280:20375-83.
27. Bernstein LR, Ben-Ari ET, Simek SL, Colburn NH. Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells. Environ Health Perspect 1991;93:111-9.
28. Bachelor MA, Cooper SJ, Sikorski ET, Bowden GT. Inhibition of p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 hairless mouse model. Mol Cancer Res 2005;3:90-9.
29. 2 is required for UVB-induced EGF receptor and downstream signaling pathway activation. Free Radic Biol Med 1999; 27:1197-202.
30. Peus D, Vasa RA, Beyerle A, Meves A, Krautmacher C, Pittelkow MR. UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol 1999;112: 751-6.
31. Huang C, Huang Y, Li J, et al. Inhibition of benzo(a)pyrene diolepoxide-induced transactivation of activated protein 1 and nuclear factor κB by black raspberry extracts. Cancer Res 2002;62:6857-63.
32. Ma C, Wang J, Luo J. Exposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in mouse epidermal cells. J Biol Chem 2003;278:44265-72.
33. Huang C, Zhang O, Li J, et al. Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo. Mol Cell Biochem 2001;222:141-7.
34. Kulms D, Schwarz T. Mechanisms of UV-induced signal transduction. J Dermatol 2002;29:189-96.
35. Steele VE, Kelloff GJ, Wilkinson BP, Arnold JT. Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemo-preventive agents. Cancer Res 1990; 50:2068-74.
36. Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 2004;4:937-47.
37. Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
38. Karin M, Cao Y, Greten FR, Li ZW. NF-KB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002;2:301-10.
39. Eferl R, Wagner EF. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 2003; 3:859-68.
40. Yuspa SH. The pathogenesis of squamous cell cancer: lessons learned from studies ofskin carcinogenesis. J Dermatol Sci 1998;17:1-7.
41. 2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc Natl Aced Sci USA 2004; 101:14114-9.
42. Agarwal C, Singh RP, Dhanalakshmi S, et al. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene 2003;22:8271-82.