Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset

Molecular Biology of the Cell

Volumn 25, Issue 4, 2014, Pages 441-456

  Yuan, Xi ^a   Srividhya, Jeyaraman ^a   De Luca, Thomas ^a   Lee, Ju Hyong E ^a   Pomerening, Joseph R ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CADHERIN; CCNE1 PROTEIN, HUMAN; CDH1 PROTEIN, HUMAN; CDK2 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; E2F1 PROTEIN, HUMAN; ONCOPROTEIN; RETINOBLASTOMA PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F1;

ANTAGONISTS AND INHIBITORS; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL TRANSFORMATION; DNA REPLICATION; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; HUMAN; METABOLISM; PATHOLOGY; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TIME;

ANAPHASE-PROMOTING COMPLEX-CYCLOSOME; CADHERINS; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA REPLICATION; E2F1 TRANSCRIPTION FACTOR; FEEDBACK, PHYSIOLOGICAL; G1 PHASE; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; ONCOGENE PROTEINS; PROTEOLYSIS; RETINOBLASTOMA PROTEIN; RNA, SMALL INTERFERING; S PHASE; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84894240500     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E13-08-0480     Document Type: Article

References (39)

1. Alao JP (2007). The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 6, 24.
2. Aleem E, Kiyokawa H, Kaldis P (2005). Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat Cell Biol 7, 831-836.
3. Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M (2004). Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/C-Cdh1 ubiquitin ligase. Nature 428, 190-193.
4. Bloom J, Pagano M (2003). Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol 13, 41-47.
5. Bornstein G, Bloom J, Sitry-Shevah D, Nakayama K, Pagano M, Hershko A (2003). Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem 278, 25752-25757.
6. Carrano AC, Eytan E, Hershko A, Pagano M (1999). SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1, 193-199.
7. Castro A, Bernis C, Vigneron S, Labbe J-C, Lorca T (2005). The anaphase-promoting complex: a key factor in the regulation of cell cycle. Oncogene 24, 314-325.
8. Chastain PDII, Heffernan TP, Nevis KR, Lin L, Kaufmann WK, Kaufman DG, Cordeiro-Stone M (2006). Checkpoint regulation of replication dynamics in UV-irradiated human cells. Cell Cycle 5, 2160-2167.
9. Chu IM, Hengst L, Slingerland JM (2008). The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 8, 253-267.
10. Engelbert D, Schnerch D, Baumgarten A, Wasch R (2007). The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells. Oncogene 27, 907-917.
11. Gao DM, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan LX, Kirschner M, Dyson N, Wei WY (2009). Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell 20, 3305-3316.
12. Garci-Higuera I, Manchado E, Dubus P, Canamero M, Mendez J, Moreno S, Malumbres M (2008). Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 10, 802-811.
13. Hahn AT, Jones JT, Meyer T (2009). Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors. Cell Cycle 8, 1044-1052.
14. Harbour JW, Dean DC (2000). The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 14, 2393-2409.
15. Harbour JW, Luo RX, Santi AD, Postigo AA, Dean DC (1999). Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98, 859-869.
16. Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI (2003). Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci USA 100, 10231-10236.
17. Kanie T, Onoyama I, Matsumoto A, Yamada M, Nakatsumi H, Tateishi Y, Yamamura S, Tsunematsu R, Matsumoto M, Nakayama KI (2011). Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol Cell Biol 32, 590-605.
18. Keck JM, Summers MK, Tedesco D, Ekholm-Reed S, Chuang L-C, Jackson PK, Reed SI (2007). Cyclin E overexpression impairs progression through mitosis by inhibiting APCCdh1. J Cell Biol 178, 371-385.
19. King RW, Peters J-M, Tugendreich S, Rolfe M, Hieter P, Kirschner MW (1995). A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288.
20. Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, Peters J-M (2003). Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO J 22, 6598-6609.
21. Kramer ER, Gieffers C, Holzl G, Hengstschlager M, Peters JM (1998). Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family. Curr Biol 8, 1207-1210.
22. Kramer ER, Scheuringer N, Podtelejnikov AV, Mann M, Peters J-M (2000). Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol Biol Cell 11, 1555-1569.
23. Lahav-Baratz S, Sudakin V, Ruderman JV, Hershko A (1995). Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc Natl Acad Sci USA 92, 9303-9307.
24. Ma Y, Yuan X, Wyatt WR, Pomerening JR (2012). Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 Cells. PLoS One 7, e33835.
25. Malek NP, Sundberg H, McGrew S, Nakayama K, Kyriakidis TR, Roberts JM (2001). A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 413, 323-327.
26. Ohtani K, DeGregori J, Nevins JR (1995). Regulation of the cyclin E gene by transcription factor E2F1. Proc Natl Acad Sci USA 92, 12146-12150.
27. Peters J-M (2006). The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 7, 644-656.
28. Pomerening JR, Kim SY, Ferrell JE (2005). Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell 122, 565-578.
29. Pomerening JR, Ubersax JA, Ferrell JE Jr (2008). Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF. Mol Biol Cell 19, 3426-3441.
30. Qu Z, Weiss JN, MacLellan WR (2003). Regulation of the mammalian cell cycle: a model of the G1-to-S transition. Am J Physiol Cell Physiol 284, C349-C364.
31. Resnitzky D, Gossen M, Bujard H, Reed SI (1994). Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol 14, 1669-1679.
32. Santamaria D, Barriere C, Cerqueira A, Hunt S, Tardy C, Newton K, Caceres JF, Dubus P, Malumbres M, Barbacid M (2007). Cdk1 is sufficient to drive the mammalian cell cycle. Nature 448, 811-815.
33. Sigl R, Wandke C, Rauch V, Kirk J, Hunt T, Geley S (2009). Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J Cell Sci 122, 4208-4217.
34. Thomson AM, Gillespie PJ, Blow JJ (2010). Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels. J Cell Biol 188, 209-221.
35. Thron CD (1999). Mathematical analysis of binary activation of a cell cycle kinase which down-regulates its own inhibitor. Biophys Chem 79, 95-106.
36. Waesch R, Robbins JA, Cross FR (2010). The emerging role of APC/C-Cdh1 in controlling differentiation, genomic stability and tumor suppression. Oncogene 29, 1-10.
37. Wei W, Ayad NG, Wan Y, Zhang G-J, Kirschner MW, Kaelin WG (2004). Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428, 194-198.
38. Yaping W, Chastain P, Pew-Thian Y, Jie-Zhi C, Kaufman D, Lei G, Dinggang S (2011). Automated DNA fiber tracking and measurement. In: Biomedical Imaging: From Nano to Macro, New York: Institute of Electrical and Electronics Engineers, 1349-1352.
39. Zarkowska T, Mittnacht S (1997). Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J Biol Chem 272, 12738-12746.