Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cells

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Ma, Yan ^a   Yuan, Xi ^a   Wyatt, William R ^a   Pomerening, Joseph R ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; AURORA B KINASE; CELL CYCLE PROTEIN 20; CELL PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; PROTEASOME; PROTEIN CDK1AF; PROTEIN WEE1; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL DIVISION; CHROMATIN CONDENSATION; DAUGHTER CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; GENOMIC INSTABILITY; HELA CELL; HUMAN; HUMAN CELL; INTERPHASE; MITOSIS; MITOSIS SPINDLE; MULTICENTER STUDY; NEGATIVE FEEDBACK; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING;

CALCIUM-BINDING PROTEINS; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CHROMATIN ASSEMBLY AND DISASSEMBLY; CYCLIN B1; DNA REPLICATION; ENZYME STABILITY; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; GENE SILENCING; GENOMIC INSTABILITY; HELA CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; REPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EUKARYOTA;

EID: 84859076971     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033835     Document Type: Article

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