-
1
-
-
0003964363
-
-
American Cancer Society Atlanta: American Cancer Society
-
American Cancer Society (2013). Cancer Facts & Figures 2013. Atlanta: American Cancer Society.
-
(2013)
Cancer Facts & Figures 2013
-
-
-
2
-
-
79952232216
-
Global cancer statistics
-
doi:10.3322/caac.20107. PubMed: 21296855
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90. doi:10.3322/caac.20107. PubMed: 21296855.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
-
4
-
-
84864583798
-
Clinicopathologic characteristics of 23 cases of invasive low-grade papillary urothelial carcinoma
-
doi:10.1016/j.urology.2012.04.010. PubMed: 22857755
-
Watts KE, Montironi R, Mazzucchelli R, van der Kwast T, Osunkoya AO et al. (2012) Clinicopathologic characteristics of 23 cases of invasive low-grade papillary urothelial carcinoma. Urology 80: 361-366. doi:10.1016/j.urology.2012. 04.010. PubMed: 22857755.
-
(2012)
Urology
, vol.80
, pp. 361-366
-
-
Watts, K.E.1
Montironi, R.2
Mazzucchelli, R.3
Van Der Kwast, T.4
Osunkoya, A.O.5
-
5
-
-
80053649529
-
Bladder cancer: Imperatives for personalized medicine
-
Williston Park
-
Kamat AM, Mathew P (2011) Bladder cancer: imperatives for personalized medicine. Oncology (Williston Park) 25: 951-958. p. 960.
-
(2011)
Oncology
, vol.25
-
-
Kamat, A.M.1
Mathew, P.2
-
6
-
-
84874500441
-
Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: Implications for therapeutic targeting
-
doi:10.1371/journal.pone.0057284. PubMed: 23468956
-
Cheng T, Roth B, Choi W, Black PC, Dinney C et al. (2013) Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting. PLOS ONE 8: e57284. doi:10.1371/journal.pone.0057284. PubMed: 23468956.
-
(2013)
PLOS ONE
, vol.8
-
-
Cheng, T.1
Roth, B.2
Choi, W.3
Black, P.C.4
Dinney, C.5
-
7
-
-
84874583973
-
Short hairpin RNA targeting FOXQ1 inhibits invasion and metastasis via the reversal of epithelial-mesenchymal transition in bladder cancer
-
PubMed: 23403865
-
Zhu Z, Zhu Z, Pang Z, Xing Y, Wan F et al. (2013) Short hairpin RNA targeting FOXQ1 inhibits invasion and metastasis via the reversal of epithelial-mesenchymal transition in bladder cancer. Int J Oncol 42: 1271-1278. PubMed: 23403865.
-
(2013)
Int J Oncol
, vol.42
, pp. 1271-1278
-
-
Zhu, Z.1
Zhu, Z.2
Pang, Z.3
Xing, Y.4
Wan, F.5
-
8
-
-
79959758262
-
Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder
-
doi:10.1111/j.1365-2559.2011.03856.x. PubMed: 21707707
-
Sun CH, Chang YH, Pan CC (2011) Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder. Histopathology 58: 1054-1063. doi:10.1111/j.1365-2559.2011.03856.x. PubMed: 21707707.
-
(2011)
Histopathology
, vol.58
, pp. 1054-1063
-
-
Sun, C.H.1
Chang, Y.H.2
Pan, C.C.3
-
9
-
-
77953180987
-
Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma
-
doi:10.2353/ajpath.2010.090872. PubMed: 20395440
-
Hansel DE, Platt E, Orloff M, Harwalker J, Sethu S et al. (2010) Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. Am J Pathol 176: 3062-3072. doi:10.2353/ajpath. 2010.090872. PubMed: 20395440.
-
(2010)
Am J Pathol
, vol.176
, pp. 3062-3072
-
-
Hansel, D.E.1
Platt, E.2
Orloff, M.3
Harwalker, J.4
Sethu, S.5
-
10
-
-
79955486858
-
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
-
doi:10.1158/0008-5472.CAN-10-4058. PubMed: 21430067
-
Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG et al. (2011) mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 71: 3246-3256. doi:10.1158/0008-5472. CAN-10-4058. PubMed: 21430067.
-
(2011)
Cancer Res
, vol.71
, pp. 3246-3256
-
-
Gulhati, P.1
Bowen, K.A.2
Liu, J.3
Stevens, P.D.4
Rychahou, P.G.5
-
11
-
-
37549048521
-
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
-
doi:10.1158/0008-5472.CAN-07-2223. PubMed: 18089801
-
Masri J, Bernath A, Martin J, Jo OD, Vartanian R et al. (2007) mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Cancer Res 67: 11712-11720. doi:10.1158/0008-5472.CAN- 07-2223. PubMed: 18089801.
-
(2007)
Cancer Res
, vol.67
, pp. 11712-11720
-
-
Masri, J.1
Bernath, A.2
Martin, J.3
Jo, O.D.4
Vartanian, R.5
-
12
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
doi:10.1038/ncb1183. PubMed: 15467718
-
Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122-1128. doi:10.1038/ncb1183. PubMed: 15467718.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Rüegg, M.A.5
-
13
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
doi:10.1016/j.cub.2004.06.054. PubMed: 15268862
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR et al. (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14: 1296-1302. doi:10.1016/j.cub.2004.06.054. PubMed: 15268862.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
-
14
-
-
33751079895
-
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
-
doi:10.1101/gad.1461206. PubMed: 17043309
-
Yang Q, Inoki K, Ikenoue T, Guan KL (2006) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20: 2820-2832. doi:10.1101/gad.1461206. PubMed: 17043309.
-
(2006)
Genes Dev
, vol.20
, pp. 2820-2832
-
-
Yang, Q.1
Inoki, K.2
Ikenoue, T.3
Guan, K.L.4
-
15
-
-
79954516239
-
Role of mTOR signaling in tumor cell motility. Invasion and Metastasis
-
doi:10.2174/138920311795659407
-
Zhou H, Huang S (2011) Role of mTOR signaling in tumor cell motility. Invasion and Metastasis - Curr Protein Pept Sci 12: 30-42. doi:10.2174/ 138920311795659407.
-
(2011)
Curr Protein Pept Sci
, vol.12
, pp. 30-42
-
-
Zhou, H.1
Huang, S.2
-
16
-
-
78649956469
-
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion
-
doi:10.1016/j.devcel.2010.11.004. PubMed: 21145500
-
Liu L, Das S, Losert W, Parent CA (2010) mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell 19: 845-857. doi:10.1016/j.devcel.2010.11.004. PubMed: 21145500.
-
(2010)
Dev Cell
, vol.19
, pp. 845-857
-
-
Liu, L.1
Das, S.2
Losert, W.3
Parent, C.A.4
-
17
-
-
84861448736
-
TGF-beta-induced activation of mTOR complex 2 drives epithelialmesenchymal transition and cell invasion
-
doi:10.1242/jcs.095299. PubMed: 22399812
-
Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R (2012) TGF-beta-induced activation of mTOR complex 2 drives epithelialmesenchymal transition and cell invasion. J Cell Sci 125: 1259-1273. doi:10.1242/jcs.095299. PubMed: 22399812.
-
(2012)
J Cell Sci
, vol.125
, pp. 1259-1273
-
-
Lamouille, S.1
Connolly, E.2
Smyth, J.W.3
Akhurst, R.J.4
Derynck, R.5
-
18
-
-
84868212354
-
Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer
-
doi:10.1007/s10549-012-2036-2. PubMed: 22476852
-
Li H, Lin J, Wang X, Yao G, Wang L et al. (2012) Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer. Breast Cancer Res Treat 134: 1057-1066. doi:10.1007/s10549-012-2036-2. PubMed: 22476852.
-
(2012)
Breast Cancer Res Treat
, vol.134
, pp. 1057-1066
-
-
Li, H.1
Lin, J.2
Wang, X.3
Yao, G.4
Wang, L.5
-
19
-
-
81055126288
-
Myosin II isoform switching mediates invasiveness after TGF-beta-induced epithelial-mesenchymal transition
-
doi:10.1073/pnas.1106499108. PubMed: 22025714
-
Beach JR, Hussey GS, Miller TE, Chaudhury A, Patel P et al. (2011) Myosin II isoform switching mediates invasiveness after TGF-beta-induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A 108: 17991-17996. doi:10.1073/pnas.1106499108. PubMed: 22025714.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 17991-17996
-
-
Beach, J.R.1
Hussey, G.S.2
Miller, T.E.3
Chaudhury, A.4
Patel, P.5
-
20
-
-
63049120202
-
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells
-
doi:10.1091/mbc.E08-04-0372. PubMed: 18971378
-
Breckenridge MT, Dulyaninova NG, Egelhoff TT (2009) Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. Mol Biol Cell 20: 338-347. doi:10.1091/mbc.E08-04-0372. PubMed: 18971378.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 338-347
-
-
Breckenridge, M.T.1
Dulyaninova, N.G.2
Egelhoff, T.T.3
-
21
-
-
84871805906
-
Molecular basis of urinary bladder cancer
-
doi:10.1097/PAP.0b013e31827bd0ec. PubMed: 23232572
-
Al Hussain TO, Akhtar M (2013) Molecular basis of urinary bladder cancer. Adv Anat Pathol 20: 53-60. doi:10.1097/PAP.0b013e31827bd0ec. PubMed: 23232572.
-
(2013)
Adv Anat Pathol
, vol.20
, pp. 53-60
-
-
Al Hussain, T.O.1
Akhtar, M.2
-
22
-
-
79955901633
-
An hTERT-immortalized human urothelial cell line that responds to antiproliferative factor
-
doi:10.1007/s11626-011-9417-4. PubMed: 21136194
-
Kim J, Ji M, DiDonato JA, Rackley RR, Kuang M et al. (2011) An hTERT-immortalized human urothelial cell line that responds to antiproliferative factor. In Vitro Cell Dev Biol Anim 47: 2-9. doi:10.1007/s11626-011-9417-4. PubMed: 21136194.
-
(2011)
In Vitro Cell Dev Biol Anim
, vol.47
, pp. 2-9
-
-
Kim, J.1
Ji, M.2
DiDonato, J.A.3
Rackley, R.R.4
Kuang, M.5
-
23
-
-
0035475321
-
Paxillin: A focal adhesion-associated adaptor protein
-
doi:10.1038/sj.onc.1204786. PubMed: 11607845
-
Schaller MD (2001) Paxillin: a focal adhesion-associated adaptor protein. Oncogene 20: 6459-6472. doi:10.1038/sj.onc.1204786. PubMed: 11607845.
-
(2001)
Oncogene
, vol.20
, pp. 6459-6472
-
-
Schaller, M.D.1
-
24
-
-
4644285846
-
PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity
-
doi:10.1038/sj.onc.1207599. PubMed: 15273733
-
Gildea JJ, Herlevsen M, Harding MA, Gulding KM, Moskaluk CA et al. (2004) PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity. Oncogene 23: 6788-6797. doi:10.1038/sj.onc.1207599. PubMed: 15273733.
-
(2004)
Oncogene
, vol.23
, pp. 6788-6797
-
-
Gildea, J.J.1
Herlevsen, M.2
Harding, M.A.3
Gulding, K.M.4
Moskaluk, C.A.5
-
25
-
-
82755165054
-
Tyrosine phosphorylation of Rac1: A role in regulation of cell spreading
-
doi:10.1371/journal.pone.0028587. PubMed: 22163037
-
Chang F, Lemmon C, Lietha D, Eck M, Romer L (2011) Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading. PLOS ONE 6: e28587. doi:10.1371/journal.pone.0028587. PubMed: 22163037.
-
(2011)
PLOS ONE
, vol.6
-
-
Chang, F.1
Lemmon, C.2
Lietha, D.3
Eck, M.4
Romer, L.5
-
26
-
-
78650510609
-
mTOR: From growth signal integration to cancer, diabetes and ageing
-
doi:10.1038/nrm3025. PubMed: 21157483
-
Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35. doi:10.1038/nrm3025. PubMed: 21157483.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
27
-
-
79953216041
-
Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate
-
doi:10.1074/jbc.M110.195016. PubMed: 21310961
-
Gan X, Wang J, Su B, Wu D (2011) Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 286: 10998-11002. doi:10.1074/jbc.M110.195016. PubMed: 21310961.
-
(2011)
J Biol Chem
, vol.286
, pp. 10998-11002
-
-
Gan, X.1
Wang, J.2
Su, B.3
Wu, D.4
-
28
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
doi:10.1016/j.cell.2011.02.014. PubMed: 21376236
-
Zinzalla V, Stracka D, Oppliger W, Hall MN (2011) Activation of mTORC2 by association with the ribosome. Cell 144: 757-768. doi:10.1016/j.cell.2011.02. 014. PubMed: 21376236.
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
Stracka, D.2
Oppliger, W.3
Hall, M.N.4
-
29
-
-
79960137480
-
Negative regulation of mTORC2 by glycogen synthase kinase-3beta: An adaptive process to stress with an anticancer therapeutic potential?
-
doi:10.2217/fon.11.59. PubMed: 21732756
-
Koromilas AE (2011) Negative regulation of mTORC2 by glycogen synthase kinase-3beta: an adaptive process to stress with an anticancer therapeutic potential? Future Oncol 7: 845-848. doi:10.2217/fon.11.59. PubMed: 21732756.
-
(2011)
Future Oncol
, vol.7
, pp. 845-848
-
-
Koromilas, A.E.1
-
30
-
-
79954600448
-
mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif
-
doi:10.1074/jbc.M111.219923. PubMed: 21321111
-
Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM et al. (2011) mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif. J Biol Chem 286: 14190-14198. doi:10.1074/jbc.M111.219923. PubMed: 21321111.
-
(2011)
J Biol Chem
, vol.286
, pp. 14190-14198
-
-
Wu, Y.T.1
Ouyang, W.2
Lazorchak, A.S.3
Liu, D.4
Shen, H.M.5
-
31
-
-
84875647584
-
mTORC2 controls actin polymerization required for consolidation of long-term memory
-
doi:10.1038/nn.3351. PubMed: 23455608
-
Huang W, Zhu PJ, Zhang S, Zhou H, Stoica L et al. (2013) mTORC2 controls actin polymerization required for consolidation of long-term memory. Nat Neurosci 16: 441-448. doi:10.1038/nn.3351. PubMed: 23455608.
-
(2013)
Nat Neurosci
, vol.16
, pp. 441-448
-
-
Huang, W.1
Zhu, P.J.2
Zhang, S.3
Zhou, H.4
Stoica, L.5
-
32
-
-
78649637235
-
Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity
-
doi:10.1074/jbc.M110.141168. PubMed: 20937815
-
Liu L, Luo Y, Chen L, Shen T, Xu B et al. (2010) Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol Chem 285: 38362-38373. doi:10.1074/jbc.M110.141168. PubMed: 20937815.
-
(2010)
J Biol Chem
, vol.285
, pp. 38362-38373
-
-
Liu, L.1
Luo, Y.2
Chen, L.3
Shen, T.4
Xu, B.5
-
33
-
-
0034051228
-
Rho family proteins in cell adhesion and cell migration
-
doi:10.1016/S0959-8049(00)00091-5. PubMed: 10882865
-
Evers EE, Zondag GC, Malliri A, Price LS, ten Klooster JP et al. (2000) Rho family proteins in cell adhesion and cell migration. Eur J Cancer 36: 1269-1274. doi:10.1016/S0959-8049(00)00091-5. PubMed: 10882865.
-
(2000)
Eur J Cancer
, vol.36
, pp. 1269-1274
-
-
Evers, E.E.1
Zondag, G.C.2
Malliri, A.3
Price, L.S.4
Ten Klooster, J.P.5
-
34
-
-
77957288035
-
Expanding therapeutic targets in bladder cancer: The PI3K/Akt/mTOR pathway
-
doi:10.1038/labinvest.2010.133. PubMed: 20661228
-
Ching CB, Hansel DE (2010) Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway. Lab Invest 90: 1406-1414. doi:10.1038/labinvest.2010.133. PubMed: 20661228.
-
(2010)
Lab Invest
, vol.90
, pp. 1406-1414
-
-
Ching, C.B.1
Hansel, D.E.2
-
35
-
-
65949086609
-
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
-
doi:10.1158/0008-5472.CAN-08-4055. PubMed: 19351834
-
Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R et al. (2009) PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res 69: 3256-3261. doi:10.1158/0008-5472.CAN-08-4055. PubMed: 19351834.
-
(2009)
Cancer Res
, vol.69
, pp. 3256-3261
-
-
Sos, M.L.1
Koker, M.2
Weir, B.A.3
Heynck, S.4
Rabinovsky, R.5
-
36
-
-
84894262635
-
Selective regulation of p38beta protein and signaling by integrin-linked kinase mediates bladder cancer cell migration
-
Yu L, Yuan X, Wang D, Barakat B, Williams ED et al. (2013) Selective regulation of p38beta protein and signaling by integrin-linked kinase mediates bladder cancer cell migration. Oncogene.
-
(2013)
Oncogene
-
-
Yu, L.1
Yuan, X.2
Wang, D.3
Barakat, B.4
Williams, E.D.5
-
37
-
-
40949083412
-
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
-
doi:10.1158/0008-5472.CAN-07-5869. PubMed: 18339839
-
McDonald PC, Oloumi A, Mills J, Dobreva I, Maidan M et al. (2008) Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res 68: 1618-1624. doi:10.1158/0008-5472.CAN-07-5869. PubMed: 18339839.
-
(2008)
Cancer Res
, vol.68
, pp. 1618-1624
-
-
McDonald, P.C.1
Oloumi, A.2
Mills, J.3
Dobreva, I.4
Maidan, M.5
-
38
-
-
79953307234
-
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
-
doi:10.1016/j.molcel.2011.03.017. PubMed: 21474067
-
Saci A, Cantley LC, Carpenter CL (2011) Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell 42: 50-61. doi:10.1016/j.molcel.2011.03.017. PubMed: 21474067.
-
(2011)
Mol Cell
, vol.42
, pp. 50-61
-
-
Saci, A.1
Cantley, L.C.2
Carpenter, C.L.3
|