Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart

Acta Crystallographica Section D: Biological Crystallography

Volumn 70, Issue 2, 2014, Pages 242-252

  Fieulaine, Sonia ^a   Desmadril, Michel ^b   Meinnel, Thierry ^a   Giglione, Carmela ^a  

^a INSTITUT DES SCIENCES DU VÉGÉTAL   (France)

^b INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

Author keywords

Arabidopsis thaliana; human; mitochondria; N terminal methionine excision; peptide deformylase

Indexed keywords

AMIDASE; ARABIDOPSIS PROTEIN; BACTERIAL PROTEIN; HYBRID PROTEIN; PDF1A PROTEIN, ARABIDOPSIS; PEPTIDE DEFORMYLASE;

AMINO ACID SEQUENCE; ARABIDOPSIS; ARABIDOPSIS THALIANA; ARTICLE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; KINETICS; LEPTOSPIRA INTERROGANS; MITOCHONDRION; MOLECULAR GENETICS; N-TERMINAL METHIONINE EXCISION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ARABIDOPSIS THALIANA; HUMAN; MITOCHONDRIA; N-TERMINAL METHIONINE EXCISION; PEPTIDE DEFORMYLASE;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; ARABIDOPSIS; ARABIDOPSIS PROTEINS; BACTERIAL PROTEINS; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; KINETICS; LEPTOSPIRA INTERROGANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84894139821     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S1399004713026461     Document Type: Article

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