P53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage

Journal of Biological Chemistry

Volumn 289, Issue 7, 2014, Pages 4083-4094

  Cam, Maren ^a   Bid, Hemant K ^a   Xiao, Linlin ^a   Zambetti, Gerard P ^b   Houghton, Peter J ^a,c   Cam, Hakan ^a,c  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; MAMMALS;

COMPLEX 1; DNA DAMAGES; HUMAN CANCER; MAMMALIAN TARGET; PARALLEL PATHWAYS;

DNA;

ATM PROTEIN; CARRIER PROTEINS AND BINDING PROTEINS; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE B; PROTEIN P53; PROTEIN P63; PROTEIN REDD1; S6 KINASE; SESTRIN 1 PROTEIN; SESTRIN 2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

4EBP1; AKT; DNA DAMAGE RESPONSE; MTOR; MTOR COMPLEX (MTORC); P53; P63; REDD1; S6K1; SESTRIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE, TUMOR; DNA DAMAGE; HEAT-SHOCK PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; NEOPLASMS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84894122839     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.530303     Document Type: Article

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