Opening of an alternative ion permeation pathway in a nociceptor TRP channel

Nature Chemical Biology

Volumn 10, Issue 3, 2014, Pages 188-195

  Vriens, Joris ^a,b   Held, Katharina ^a,b   Janssens, Annelies ^a   Tóth, Balázs István ^a   Kerselaers, Sara ^a   Nilius, Bernd ^a   Vennekens, Rudi ^a   Voets, Thomas ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTIFUNGAL AGENTS; CLOTRIMAZOLE; HEK293 CELLS; HUMANS; IONS; MICE; NEUROTRANSMITTER AGENTS; NOCICEPTORS; SIGNAL TRANSDUCTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPM CATION CHANNELS;

EID: 84894098389     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1428     Document Type: Article

References (39)

1. Nilius B. Owsianik G. Voets T. & Peters J.A. Transient receptor potential cation channels in disease. Physiol. Rev. 87 165-217 (2007).
2. Hoenderop J.G. et al. Homo-And heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J. 22 776-785 (2003). (Pubitemid 36227780)
3. Wu L.J. Sweet T.B. & Clapham D.E. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol. Rev. 62 381-404 (2010).
4. Yu F.H. Yarov-Yarovoy V. Gutman G.A. & Catterall W.A. Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol. Rev. 57 387-395 (2005). (Pubitemid 43036430)
5. Tombola F. Pathak M.M. & Isacoff E.Y. Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron 45 379-388 (2005). (Pubitemid 40188206)
6. Sokolov S. Scheuer T. & Catterall W.A. Ion permeation through a voltage-sensitive gating pore in brain sodium channels having voltage sensor mutations. Neuron 47 183-189 (2005).
7. Sokolov S. Scheuer T. & Catterall W.A. Gating pore current in an inherited ion channelopathy. Nature 446 76-78 (2007). (Pubitemid 46348048)
8. Tombola F. Pathak M.M. Gorostiza P. & Isacoff E.Y. The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature 445 546-549 (2007). (Pubitemid 46197635)
9. Wagner T.F. et al. Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat. Cell Biol. 10 1421-1430 (2008).
10. Vriens J. et al. TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 70 482-494 (2011).
11. Oberwinkler J. Lis A. Giehl K.M. Flockerzi V. & Philipp S.E. Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J. Biol. Chem. 280 22540-22548 (2005). (Pubitemid 40827912)
12. Wulff H. et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-Activated K+ channel IKCa1: A potential immunosuppressant. Proc. Natl. Acad. Sci. USA 97 8151-8156 (2000). (Pubitemid 30460788)
13. Hill K. McNulty S. & Randall A.D. Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole. Naunyn Schmiedebergs Arch. Pharmacol. 370 227-237 (2004). (Pubitemid 40063822)
14. Meseguer V. et al. Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole. J. Neurosci. 28 576-586 (2008). (Pubitemid 351159019)
15. Chung M.K. Guler A.D. & Caterina M.J. TRPV1 shows dynamic ionic selectivity during agonist stimulation. Nat. Neurosci. 11 555-564 (2008). (Pubitemid 351595196)
16. Banke T.G. Chaplan S.R. & Wickenden A.D. Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation. Am. J. Physiol. Cell Physiol. 298 C1457-C1468 (2010).
17. Karashima Y. et al. Agonist-induced changes in Ca2+ permeation through the nociceptor cation channel TRPA1. Biophys. J. 98 773-783 (2010).
18. McNaughton-Smith G.A. et al. Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J. Med. Chem. 51 976-982 (2008). (Pubitemid 351304705)
19. Jordan V.C. Tamoxifen: A most unlikely pioneering medicine. Nat. Rev. Drug Discov. 2 205-213 (2003). (Pubitemid 37361665)
20. Janssens A. & Voets T. Ligand stoichiometry of the cold-And menthol-Activated channel TRPM8. J. Physiol. (Lond.) 589 4827-4835 (2011).
21. Voets T. et al. The principle of temperature-dependent gating in cold-And heat-sensitive TRP channels. Nature 430 748-754 (2004). (Pubitemid 39071340)
22. Voets T. Owsianik G. Janssens A. Talavera K. & Nilius B. TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat. Chem. Biol. 3 174-182 (2007).
23. Clapham D.E. TRP channels as cellular sensors. Nature 426 517-524 (2003). (Pubitemid 37522633)
24. Caterina M.J. et al. The capsaicin receptor: A heat-Activated ion channel in the pain pathway. Nature 389 816-824 (1997). (Pubitemid 27462969)
25. Nagata K. Duggan A. Kumar G. & Garcia-Anoveros J. Nociceptor and hair cell transducer properties of TRPA1 a channel for pain and hearing. J. Neurosci. 25 4052-4061 (2005). (Pubitemid 40563380)
26. McKemy D.D. Neuhausser W.M. & Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52-58 (2002). (Pubitemid 34215395)
27. Grimm C. Kraft R. Sauerbruch S. Schultz G. & Harteneck C. Molecular and functional characterization of the melastatin-related cation channel TRPM3. J. Biol. Chem. 278 21493-21501 (2003). (Pubitemid 36792546)
28. Havliková H. Hill M. Hampl R. & Starka L. Sex-And age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects. J. Clin. Endocrinol. Metab. 87 2225-2231 (2002). (Pubitemid 34521513)
29. Morley J.E. et al. Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone dehydroepiandrosterone sulfate and the ratio of insulin-like growth factor 1 to growth hormone. Proc. Natl. Acad. Sci. USA 94 7537-7542 (1997).
30. Virginio C. MacKenzie A. Rassendren F.A. North R.A. & Surprenant A. Pore dilation of neuronal P2X receptor channels. Nat. Neurosci. 2 315-321 (1999). (Pubitemid 30491273)
31. McNally B.A. Somasundaram A. Yamashita M. & Prakriya M. Gated regulation of CRAC channel ion selectivity by STIM1. Nature 482 241-245 (2012).
32. Tai K.K. & Goldstein S.A. The conduction pore of a cardiac potassium channel. Nature 391 605-608 (1998). (Pubitemid 28157605)
33. Nilius B. et al. The Ca2+-Activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J. 25 467-478 (2006). (Pubitemid 43237654)
34. Runnels L.W. Yue L. & Clapham D.E. TRP-PLIK a bifunctional protein with kinase and ion channel activities. Science 291 1043-1047 (2001).
35. Ciurtin C. et al. TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan. BMC Musculoskelet. Disord. 11 111 (2010).
36. Czerninski R. et al. A novel sustained-release clotrimazole varnish for local treatment of oral candidiasis. Clin. Oral Investig. 14 71-78 (2010).
37. Torres-Rodriguez J.M. et al. In vitro susceptibilities of clinical yeast isolates to the new antifungal eberconazole compared with their susceptibilities to clotrimazole and ketoconazole. Antimicrob. Agents Chemother. 43 1258-1259 (1999).
38. Binet O. et al. Flutrimazole 1% dermal cream in the treatment of dermatomycoses: A randomized multicentre double-blind comparative clinical trial with 1% clotrimazole cream. Flutrimazole Study Group. Mycoses 37 455-459 (1994).
39. del Palacio A. et al. A double-blind randomized comparative trial: eberconazole 1% cream versus clotrimazole 1% cream twice daily in Candida and dermatophyte skin infections. Mycoses 44 173-180 (2001).