메뉴 건너뛰기




Volumn 21, Issue 2, 2014, Pages 79-86

New strategies for relapsed acute myeloid leukemia: Fertile ground for translational research

Author keywords

Acute myeloid leukemia; Epigenetic modulation; Intracellular signaling pathways; Tumor microenvironment

Indexed keywords

ANTINEOPLASTIC AGENTS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, MYELOID, ACUTE; NEOPLASM RECURRENCE, LOCAL; SIGNAL TRANSDUCTION; TRANSLATIONAL MEDICAL RESEARCH; TUMOR MICROENVIRONMENT;

EID: 84894095255     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0000000000000018     Document Type: Review
Times cited : (15)

References (74)
  • 1
    • 0030722602 scopus 로고    scopus 로고
    • Long-term survival in acute myeloid leukemia: The Eastern Cooperative Oncology Group experience
    • Bennett JM, Young ML, Andersen JW, et al. Long-term survival in acute myeloid leukemia: the Eastern Cooperative Oncology Group experience. Cancer 1997; 80:2205-2209.
    • (1997) Cancer , vol.80 , pp. 2205-2209
    • Bennett, J.M.1    Young, M.L.2    Andersen, J.W.3
  • 2
    • 84874053507 scopus 로고    scopus 로고
    • The myth of the second remission of acute leukemia in the adult
    • Forman S, Rowe J. The myth of the second remission of acute leukemia in the adult. Blood 2013; 121:1077-1082.
    • (2013) Blood , vol.121 , pp. 1077-1082
    • Forman, S.1    Rowe, J.2
  • 3
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Dohner H, Estey E, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010; 115:453-474.
    • (2010) Blood , vol.115 , pp. 453-474
    • Dohner, H.1    Estey, E.2    Amadori, S.3
  • 5
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009; 361:1058-1066.
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 6
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter M, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010; 363:2424-2433.
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.3
  • 8
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • Marcucci G, Maharry K, Wu Y, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010; 28:2348-2355.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.3
  • 9
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • atel J, Gonen M, Figueroa M, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012; 366:1079-1089.
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Atel, J.1    Gonen, M.2    Figueroa, M.3
  • 10
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368:2059-2074.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 11
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012; 483:474-478.
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3
  • 12
    • 79960044951 scopus 로고    scopus 로고
    • MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
    • Bernt KM, Zhu N, Sinha AU, et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell 2011; 20:66-78.
    • (2011) Cancer Cell , vol.20 , pp. 66-78
    • Bernt, K.M.1    Zhu, N.2    Sinha, A.U.3
  • 13
    • 79960058024 scopus 로고    scopus 로고
    • Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
    • Daigle SR, Olhava EJ, Therkelsen CA, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell 2011; 20:53-65.
    • (2011) Cancer Cell , vol.20 , pp. 53-65
    • Daigle, S.R.1    Olhava, E.J.2    Therkelsen, C.A.3
  • 14
    • 84878383491 scopus 로고    scopus 로고
    • Leukemic transformation by the MLLAF6 fusion oncogene requires the H3K79 methyltransferase Dot1l
    • Deshpande A, Chen L, Fazio M, et al. Leukemic transformation by the MLLAF6 fusion oncogene requires the H3K79 methyltransferase Dot1l. Blood 2013; 121:2533-2541.
    • (2013) Blood , vol.121 , pp. 2533-2541
    • Deshpande, A.1    Chen, L.2    Fazio, M.3
  • 15
    • 77954089584 scopus 로고    scopus 로고
    • Array-based genomic resequencing of human leukemia
    • Yamashita Y, Yuan J, Suetake I, et al. Array-based genomic resequencing of human leukemia. Oncogene 2010; 29:3723-3731.
    • (2010) Oncogene , vol.29 , pp. 3723-3731
    • Yamashita, Y.1    Yuan, J.2    Suetake, I.3
  • 16
    • 84860772157 scopus 로고    scopus 로고
    • DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia
    • Metzeler KH, Walker A, Geyer S, et al. DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia. Leukemia 2012; 26:1106-1152.
    • (2012) Leukemia , vol.26 , pp. 1106-1152
    • Metzeler, K.H.1    Walker, A.2    Geyer, S.3
  • 17
    • 0027164144 scopus 로고
    • High expression of Bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy
    • Campos L, Rouault JP, Sabido O, et al. High expression of Bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood 1993; 81:3091-3096.
    • (1993) Blood , vol.81 , pp. 3091-3096
    • Campos, L.1    Rouault, J.P.2    Sabido, O.3
  • 18
    • 84887547251 scopus 로고    scopus 로고
    • Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia: Its correlation with FLT3
    • Mehta S, Shukla S, Vora H. Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia: Its correlation with FLT3. Neoplasma 2013; 60:666-675.
    • (2013) Neoplasma , vol.60 , pp. 666-675
    • Mehta, S.1    Shukla, S.2    Vora, H.3
  • 19
    • 84891520098 scopus 로고    scopus 로고
    • BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells
    • Beurlet S, Omidvar N, Gorombei P, et al. BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells. Blood 2013; 122:2864-2876.
    • (2013) Blood , vol.122 , pp. 2864-2876
    • Beurlet, S.1    Omidvar, N.2    Gorombei, P.3
  • 20
    • 33745909399 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/ mammalian target of rapamycin pathway in hematologic malignancies
    • Witzig T, Kaufmann S. Inhibition of the phosphatidylinositol 3-kinase/ mammalian target of rapamycin pathway in hematologic malignancies. Curr Treat Options Oncol 2006; 7:285-294.
    • (2006) Curr Treat Options Oncol , vol.7 , pp. 285-294
    • Witzig, T.1    Kaufmann, S.2
  • 21
    • 51449096670 scopus 로고    scopus 로고
    • A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • Rizzieri D, Feldman E, Dipersio J, et al. A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 2008; 14:2756-2762.
    • (2008) Clin Cancer Res , vol.14 , pp. 2756-2762
    • Rizzieri, D.1    Feldman, E.2    Dipersio, J.3
  • 22
    • 44749089794 scopus 로고    scopus 로고
    • Lack of antileukemic activity of rapamycin in elderly patients with acute myeloid leukemia evolving from a myelodysplastic syndrome
    • Callera F, Lopes C, Rosa E, Mulin C. Lack of antileukemic activity of rapamycin in elderly patients with acute myeloid leukemia evolving from a myelodysplastic syndrome. Leuk Res 2008; 32:1633-1634.
    • (2008) Leuk Res , vol.32 , pp. 1633-1634
    • Callera, F.1    Lopes, C.2    Rosa, E.3    Mulin, C.4
  • 23
    • 84155180788 scopus 로고    scopus 로고
    • Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: Results of a phase II GIMEMA study (AML-1107)
    • Amadori S, Stasi R, Martelli AM, et al. Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107). Br J Haematol 2012; 156:205-212.
    • (2012) Br J Haematol , vol.156 , pp. 205-212
    • Amadori, S.1    Stasi, R.2    Martelli, A.M.3
  • 24
    • 70350726344 scopus 로고    scopus 로고
    • A phase i study of the mammalian target of rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia
    • Perl A, Kasner M, Tsai D, et al. A phase I study of the mammalian target of rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia. Clin Can Res 2009; 15:6732-6739.
    • (2009) Clin Can Res , vol.15 , pp. 6732-6739
    • Perl, A.1    Kasner, M.2    Tsai, D.3
  • 25
    • 84880254610 scopus 로고    scopus 로고
    • A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse
    • Park S, Chapuis N, Saint Marcoux F, et al. A phase Ib GOELAMS study of the mTOR inhibitor RAD001 in association with chemotherapy for AML patients in first relapse. Leukemia 2013; 27:1479-1486.
    • (2013) Leukemia , vol.27 , pp. 1479-1486
    • Park, S.1    Chapuis, N.2    Saint Marcoux, F.3
  • 26
    • 33749337234 scopus 로고    scopus 로고
    • Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
    • Kornblau SM, Womble M, Qiu YH, et al. Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood 2006; 108:2358-2365.
    • (2006) Blood , vol.108 , pp. 2358-2365
    • Kornblau, S.M.1    Womble, M.2    Qiu, Y.H.3
  • 27
    • 77953237268 scopus 로고    scopus 로고
    • Phase II study of the oral MEK inhibitor AZD6244 in advanced acute myeloid leukemia (AML)
    • [abstract] Abstr. 2081
    • Odenike O, Curran E, Iyengar N, et al. Phase II study of the oral MEK inhibitor AZD6244 in advanced acute myeloid leukemia (AML) [abstract]. Blood 2009; 114: Abstr. 2081.
    • (2009) Blood , vol.114
    • Odenike, O.1    Curran, E.2    Iyengar, N.3
  • 28
    • 0033524834 scopus 로고    scopus 로고
    • Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
    • Peled A, Petit I, Kollet O, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 1999; 283:845-848.
    • (1999) Science , vol.283 , pp. 845-848
    • Peled, A.1    Petit, I.2    Kollet, O.3
  • 29
    • 53249137796 scopus 로고    scopus 로고
    • Potential roles for the PIM1 kinase in human cancer: A molecular and therapeutic appraisal
    • Shah N, Pang B, Yeoh KG, et al. Potential roles for the PIM1 kinase in human cancer: a molecular and therapeutic appraisal. Eur J Cancer 2008; 44:2144-2151.
    • (2008) Eur J Cancer , vol.44 , pp. 2144-2151
    • Shah, N.1    Pang, B.2    Yeoh, K.G.3
  • 30
    • 84887743438 scopus 로고    scopus 로고
    • Axl, a prognostic and therapeutic target in acute myeloid leukemia, mediates paracrine crosstalk of leukemia cells with bone marrow stroma
    • Ben-Batalla I, Schultze A, Wroblewski M, et al. Axl, a prognostic and therapeutic target in acute myeloid leukemia, mediates paracrine crosstalk of leukemia cells with bone marrow stroma. Blood 2013; 122:2443-2452.
    • (2013) Blood , vol.122 , pp. 2443-2452
    • Ben-Batalla, I.1    Schultze, A.2    Wroblewski, M.3
  • 31
    • 84877611775 scopus 로고    scopus 로고
    • Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: Implications for Axl as a potential therapeutic target
    • Park IK, Mishra A, Chandler J, et al. Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target. Blood 2013; 121:2064-2073.
    • (2013) Blood , vol.121 , pp. 2064-2073
    • Park, I.K.1    Mishra, A.2    Chandler, J.3
  • 32
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodriguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat Med 2012; 17:1-10.
    • (2012) Nat Med , vol.17 , pp. 1-10
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 33
    • 79952377463 scopus 로고    scopus 로고
    • Resistance, epigenetics and the cancer ecosystem
    • Baylin SB. Resistance, epigenetics and the cancer ecosystem. Nat Med 2011; 17:288-289.
    • (2011) Nat Med , vol.17 , pp. 288-289
    • Baylin, S.B.1
  • 34
    • 84877093178 scopus 로고    scopus 로고
    • Translational phase i trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia
    • Gojo I, Tan M, Fang H, et al. Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia. Clin Cancer Res 2013; 19:1838-1851.
    • (2013) Clin Cancer Res , vol.19 , pp. 1838-1851
    • Gojo, I.1    Tan, M.2    Fang, H.3
  • 35
    • 84878898998 scopus 로고    scopus 로고
    • HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML
    • Zhuo L, Ruvolo V, McQueen T, et al. HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML. Leukemia 2013; 27:1358-1368.
    • (2013) Leukemia , vol.27 , pp. 1358-1368
    • Zhuo, L.1    Ruvolo, V.2    McQueen, T.3
  • 36
    • 51649110503 scopus 로고    scopus 로고
    • Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
    • Garcia-Manero G, Assouline S, Cortes J, et al. Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia. Blood 2008; 112:981-989.
    • (2008) Blood , vol.112 , pp. 981-989
    • Garcia-Manero, G.1    Assouline, S.2    Cortes, J.3
  • 37
    • 79960534917 scopus 로고    scopus 로고
    • The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
    • Green CL, Evans CM, Zhao L, et al. The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood 2011; 118:409-412.
    • (2011) Blood , vol.118 , pp. 409-412
    • Green, C.L.1    Evans, C.M.2    Zhao, L.3
  • 38
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010; 28:3636-3643.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3
  • 39
    • 77957286222 scopus 로고    scopus 로고
    • Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: A study by the Acute Leukemia French Association group
    • Boissel N, Nibourel O, Renneville A, et al. Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group. J Clin Oncol 2010; 28:3717-3723.
    • (2010) J Clin Oncol , vol.28 , pp. 3717-3723
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3
  • 40
    • 77957771067 scopus 로고    scopus 로고
    • IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
    • Schnittger S, Haferlach C, Ulke M, et al. IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood 2010; 116:5486-5496.
    • (2010) Blood , vol.116 , pp. 5486-5496
    • Schnittger, S.1    Haferlach, C.2    Ulke, M.3
  • 41
    • 77957759961 scopus 로고    scopus 로고
    • The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status
    • Green C, Evans C, Hils R, et al. The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status. Blood 2010; 116:2779-2782.
    • (2010) Blood , vol.116 , pp. 2779-2782
    • Green, C.1    Evans, C.2    Hils, R.3
  • 42
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013; 340:626-630.
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3
  • 43
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 2013; 340:622-626.
    • (2013) Science , vol.340 , pp. 622-626
    • Wang, F.1    Travins, J.2    Delabarre, B.3
  • 44
    • 84856916060 scopus 로고    scopus 로고
    • The pathogenesis of mixed-lineage leukemia
    • Muntean AG, Hess JL. The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol 2012; 7:283-301.
    • (2012) Annu Rev Pathol , vol.7 , pp. 283-301
    • Muntean, A.G.1    Hess, J.L.2
  • 45
    • 84886864184 scopus 로고    scopus 로고
    • Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
    • Daigle S, Olhava E, Therkelsen C, et al. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood 2013; 122:1017-1025.
    • (2013) Blood , vol.122 , pp. 1017-1025
    • Daigle, S.1    Olhava, E.2    Therkelsen, C.3
  • 46
    • 84860772157 scopus 로고    scopus 로고
    • DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia
    • Metzeler KH, Walker A, Geyer S, et al. DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia. Leukemia 2012; 26:1106-1107.
    • (2012) Leukemia , vol.26 , pp. 1106-1107
    • Metzeler, K.H.1    Walker, A.2    Geyer, S.3
  • 47
    • 42449165060 scopus 로고    scopus 로고
    • Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia
    • Steelman L, Abrams S, Whelan J, et al. Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 2008; 22:686-707.
    • (2008) Leukemia , vol.22 , pp. 686-707
    • Steelman, L.1    Abrams, S.2    Whelan, J.3
  • 49
    • 84890312785 scopus 로고    scopus 로고
    • PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment
    • Jin L, Tabe Y, Kojima K, et al. PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment. J Mol Med (Berl) 2013; 91:1383-1397.
    • (2013) J Mol Med (Berl) , vol.91 , pp. 1383-1397
    • Jin, L.1    Tabe, Y.2    Kojima, K.3
  • 50
    • 0037438586 scopus 로고    scopus 로고
    • Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia
    • Marcucci G, Byrd JC, Dai G, et al. Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood 2003; 101:425-432.
    • (2003) Blood , vol.101 , pp. 425-432
    • Marcucci, G.1    Byrd, J.C.2    Dai, G.3
  • 51
    • 0037513474 scopus 로고    scopus 로고
    • Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: Its significance as a prognostic variable
    • Min YH, Eom JI, Cheong JW, et al. Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 2003; 17:995-997.
    • (2003) Leukemia , vol.17 , pp. 995-997
    • Min, Y.H.1    Eom, J.I.2    Cheong, J.W.3
  • 52
    • 84880354180 scopus 로고    scopus 로고
    • Targeting phosphatidylinositol 3-kinase signaling in acute myelogenous leukemia
    • Evangelisti C, Evangelisti C, Bressanin D, et al. Targeting phosphatidylinositol 3-kinase signaling in acute myelogenous leukemia. Expert Opin Ther Targets 2013; 17:921-936.
    • (2013) Expert Opin Ther Targets , vol.17 , pp. 921-936
    • Evangelisti, C.1    Evangelisti, C.2    Bressanin, D.3
  • 53
    • 84871720541 scopus 로고    scopus 로고
    • Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment
    • Jin L, Tabe Y, Lu H, et al. Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment. Cancer Lett 2013; 329:45-58.
    • (2013) Cancer Lett , vol.329 , pp. 45-58
    • Jin, L.1    Tabe, Y.2    Lu, H.3
  • 54
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, MAP kinase and p53 pathways
    • Grandage VL, Gale RE, Linch DC, Khwaja A. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, MAP kinase and p53 pathways. Leukemia 2005; 19:586-594.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 55
    • 0042744837 scopus 로고    scopus 로고
    • Survival of acute myeloid leukemia cells requires PI3 kinase activation
    • Xu Q, Simpson SE, Scialla TJ, et al. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 2003; 102:972-980.
    • (2003) Blood , vol.102 , pp. 972-980
    • Xu, Q.1    Simpson, S.E.2    Scialla, T.J.3
  • 56
    • 79960289322 scopus 로고    scopus 로고
    • Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors
    • Altman JK, Sassano A, Kaur S, et al. Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors. Clin Cancer Res 2011; 17:4378-4388.
    • (2011) Clin Cancer Res , vol.17 , pp. 4378-4388
    • Altman, J.K.1    Sassano, A.2    Kaur, S.3
  • 57
    • 78349273297 scopus 로고    scopus 로고
    • Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia
    • Chapuis N, Tamburini J, Green AS, et al. Dual inhibition of PI3K and mTORC1/2 signaling by NVP-BEZ235 as a new therapeutic strategy for acute myeloid leukemia. Clin Cancer Res 2010; 16:5424-5435.
    • (2010) Clin Cancer Res , vol.16 , pp. 5424-5435
    • Chapuis, N.1    Tamburini, J.2    Green, A.S.3
  • 58
    • 84874728272 scopus 로고    scopus 로고
    • A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia
    • Chiarini F, Lonetti A, Teti G, et al. A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia. Oncotarget 2012; 3:1615-1628.
    • (2012) Oncotarget , vol.3 , pp. 1615-1628
    • Chiarini, F.1    Lonetti, A.2    Teti, G.3
  • 59
    • 84867328500 scopus 로고    scopus 로고
    • Therapeutic potential of MEK inhibition in acute myelogenous leukemia: Rationale for 'vertical' and 'lateral' combination strategies
    • Ricciardi M, Scerpa M, Bergamo P, et al. Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for 'vertical' and 'lateral' combination strategies. J Mol Med 2012; 90:1133-1144.
    • (2012) J Mol Med , vol.90 , pp. 1133-1144
    • Ricciardi, M.1    Scerpa, M.2    Bergamo, P.3
  • 60
    • 84877015531 scopus 로고    scopus 로고
    • Combined inhibition of the phosphoinosityl-3-kinase (PI3Kinase) P110d subunit and mitogen-extracellular activated protein kinase (MEKinase) shows synergistic cytotoxicity against human acute myeloid leukemia progenitors
    • Xing Y, Hogge DE. Combined inhibition of the phosphoinosityl-3-kinase (PI3Kinase) P110d subunit and mitogen-extracellular activated protein kinase (MEKinase) shows synergistic cytotoxicity against human acute myeloid leukemia progenitors. Leuk Res 2013; 37:697-704.
    • (2013) Leuk Res , vol.37 , pp. 697-704
    • Xing, Y.1    Hogge, D.E.2
  • 61
    • 84892701010 scopus 로고    scopus 로고
    • Combination of a MEK inhibitor, AZD6244, and dual PI3K/mTOR inhibitor, NVP-BEZ235: An effective therapeutic strategy for acute myeloid leukemia
    • [abstract] Abstr. 3978
    • Liu H, Diaz-Flores E, Poire X, et al. Combination of a MEK inhibitor, AZD6244, and dual PI3K/mTOR inhibitor, NVP-BEZ235: an effective therapeutic strategy for acute myeloid leukemia [abstract]. Blood 2010; 116: Abstr. 3978.
    • (2010) Blood , vol.116
    • Liu, H.1    Diaz-Flores, E.2    Poire, X.3
  • 62
    • 47149084029 scopus 로고    scopus 로고
    • Evolving concepts on the microenvironmental niche for hematopoietic stem cells
    • Raaijmakers MH, Scadden DT. Evolving concepts on the microenvironmental niche for hematopoietic stem cells. Curr Opin Hematol 2008; 15:301-306.
    • (2008) Curr Opin Hematol , vol.15 , pp. 301-306
    • Raaijmakers, M.H.1    Scadden, D.T.2
  • 63
    • 84878529330 scopus 로고    scopus 로고
    • CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia
    • Chen Y, Jacamo R, Konopleva M, et al. CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia. J Clin Invest 2013; 123:2395-2407.
    • (2013) J Clin Invest , vol.123 , pp. 2395-2407
    • Chen, Y.1    Jacamo, R.2    Konopleva, M.3
  • 64
    • 33846241600 scopus 로고    scopus 로고
    • CXCR4 is a prognostic marker in acute myelogenous leukemia
    • Spoo AC, Lubbert M, Wierda WG, Burger JA. CXCR4 is a prognostic marker in acute myelogenous leukemia. Blood 2007; 109:786-791.
    • (2007) Blood , vol.109 , pp. 786-791
    • Spoo, A.C.1    Lubbert, M.2    Wierda, W.G.3    Burger, J.A.4
  • 65
    • 67650410440 scopus 로고    scopus 로고
    • Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
    • Nervi B, Ramirez P, Rettig MP, et al. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood 2009; 113:6206-6214.
    • (2009) Blood , vol.113 , pp. 6206-6214
    • Nervi, B.1    Ramirez, P.2    Rettig, M.P.3
  • 66
    • 84860349448 scopus 로고    scopus 로고
    • A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
    • Uy G, Rettig M, Motabi I, et al. A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood 2012; 119:3917-3924.
    • (2012) Blood , vol.119 , pp. 3917-3924
    • Uy, G.1    Rettig, M.2    Motabi, I.3
  • 67
    • 84872510051 scopus 로고    scopus 로고
    • BMS-936564/MDX-1338: A fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies
    • Kuhne MR, Belanger B, Chen S, et al. BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res 2013; 19:357-366.
    • (2013) Clin Cancer Res , vol.19 , pp. 357-366
    • Kuhne, M.R.1    Belanger, B.2    Chen, S.3
  • 68
    • 69549086437 scopus 로고    scopus 로고
    • Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration
    • Grundler R, Brault L, Gasser C, et al. Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med 2009; 206:1957-1970.
    • (2009) J Exp Med , vol.206 , pp. 1957-1970
    • Grundler, R.1    Brault, L.2    Gasser, C.3
  • 69
    • 79960685617 scopus 로고    scopus 로고
    • Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia
    • Chen LS, Redkar S, Taverna P, et al. Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood 2011; 118:693-702.
    • (2011) Blood , vol.118 , pp. 693-702
    • Chen, L.S.1    Redkar, S.2    Taverna, P.3
  • 70
    • 84855206895 scopus 로고    scopus 로고
    • A potential therapeutic target for FLT3-ITD AML: PIM1 kinase
    • Fathi AT, Arowojolu O, Swinnen I, et al. A potential therapeutic target for FLT3-ITD AML: PIM1 kinase. Leuk Res 2012; 36:224-231.
    • (2012) Leuk Res , vol.36 , pp. 224-231
    • Fathi, A.T.1    Arowojolu, O.2    Swinnen, I.3
  • 71
    • 84889004505 scopus 로고    scopus 로고
    • Efficacy and biomarker modulation by AZD1208, a novel, potent and selective pan-Pim kinase inhibitor, in models of acute myeloid leukemia
    • [abstract] abstr. 2796.
    • Keeton E, McEachern K, Alimzhanov M, et al. Efficacy and biomarker modulation by AZD1208, a novel, potent and selective pan-Pim kinase inhibitor, in models of acute myeloid leukemia [abstract]. Cancer Res 2012; 72: abstr. 2796.
    • (2012) Cancer Res , vol.72
    • Keeton, E.1    McEachern, K.2    Alimzhanov, M.3
  • 72
    • 84862308455 scopus 로고    scopus 로고
    • Macrophage-tumor crosstalk: Role of TAMR tyrosine kinase receptors and of their ligands
    • Schmidt T, Ben-Batalla I, Schultze A, Loges S. Macrophage-tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands. Cell Mol Life Sci 2012; 69:1391-1414.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 1391-1414
    • Schmidt, T.1    Ben-Batalla, I.2    Schultze, A.3    Loges, S.4
  • 73
    • 77950422149 scopus 로고    scopus 로고
    • Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6
    • Loges S, Schmidt T, Tjwa M, et al. Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6. Blood 2010; 115:2264-2273.
    • (2010) Blood , vol.115 , pp. 2264-2273
    • Loges, S.1    Schmidt, T.2    Tjwa, M.3
  • 74
    • 20144384673 scopus 로고    scopus 로고
    • Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor
    • Sainaghi PP, Castello L, Bergamasco L, et al. Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor. J Cell Physiol 2005; 204:36-44.
    • (2005) J Cell Physiol , vol.204 , pp. 36-44
    • Sainaghi, P.P.1    Castello, L.2    Bergamasco, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.