Improving the cadmium-induced centriacinar emphysema model in rats by concomitant anti-oxidant treatment

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 11, 2008, Pages 1337-1342

  Heili Frades, S ^a,b   Del Puerto Nevado, L ^a,b   Perez Rial S ^a,b   Martin Mosquero, C ^a   Ortega, M ^a   Martinez Galan L ^a   Rubio, M L ^a   Rodriguez Nieto, M J ^a   Gonzalez Mangado N ^a,b   Peces Barba Romero, G ^a,b,c  

^a Jimenez Diaz Foundation   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

Animal model; Cadmium chloride; Centriacinar emphysema; Collagen deposition; Lung compliance; Mean linear intercept; N acetylcysteine; Oxidative stress; Peribronquial fibrosis

Indexed keywords

ACETYLCYSTEINE; CADMIUM CHLORIDE; COLLAGEN; HYDROXYPROLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; INSPIRATORY CAPACITY; LUNG COMPLIANCE; LUNG EMPHYSEMA; LUNG FUNCTION; MALE; NONHUMAN; PNEUMONIA; POLYMORPHONUCLEAR CELL; RAT; TREATMENT OUTCOME;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CADMIUM CHLORIDE; DISEASE MODELS, ANIMAL; LUNG COMPLIANCE; MALE; PULMONARY EMPHYSEMA; RATS; RATS, WISTAR;

EID: 54249152330     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2008.05026.x     Document Type: Article

References (26)

1. Gonzalez Mangado N, Peces-Barba G, Cabanillas JJ, Renedo G, Verbanck S, Paiva M. Effect on single-breath washout and lung function of elastase-induced emphysema in rats. Am. Rev. Respir. Dis. 1993 148 : 735 43.
2. Rubio ML, Sanchez-Cifuentes MV, Peces-Barba G, Verbanck S, Paiva M, Gonzalez Mangado N. Intrapulmonary gas mixing in panacinar and centriacinar induced emphysema in rats. Am. J. Respir. Crit. Care Med. 1998 157 : 237 45.
3. Davison AG, Fayers PM, Taylor AJ et al. Cadmium fume inhalation and emphysema. Lancet 1988 26 : 663 7.
4. Snider GL, Hayes JA, Korthy AL, Lewis GP. Centrilobar emphysema experimentally induced by cadmium chloride aerosol. Am. Rev. Respir. Dis. 1973 108 : 40 7.
5. 2 into the rat lung. Am. J. Pathol. 1990 137 : 883 94.
6. Driscoll KE, Maurer JK, Poynter J, Higgins J, Asquith T, Miller NS. Stimulation of rat alveolar macrophage fibronectin release in a cadmium chloride model of lung injury and fibrosis. Toxicol. Appl. Pharmacol. 1992 116 : 30 7.
7. Frankel FR, Steeger JR, Damiano VV, Sohn M, Oppenheim D, Weinbaum G. Induction of unilateral pulmonary fibrosis in the rat by cadmium chloride. Am. J. Respir. Cell Mol. Biol. 1991 5 : 385 94.
8. Gavett SH, Oberdorster G. Cadmium chloride and cadmium metallothionein-induced pulmonary injury and recruitment of polymorphonuclear leukocytes. Exp. Lung Res. 1994 20 : 517 37.
9. Bell RR, Nonavinakere VK, Soliman MR. Intratracheal exposure of the guinea pig lung to cadmium and/or selenium: A histological evaluation. Toxicol. Lett. 2000 114 : 101 9.
10. Kirschvink N, Vincke G, Fievez L et al. Repeated cadmium nebulizations induce pulmonary MMP-2 and MMP-9 production and enphysema in rats. Toxicology 2005 211 : 36 48.
11. Stohs SJ, Bagchi D, Hassoun E, Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol. 2001 20 : 77 88.
12. Gong Q, Hart BA. Effect of thiols on cadmium-induced expression of metallothionein and other oxidant stress genes in rat lung epithelial cells. Toxicology 1997 119 : 179 91.
13. Rubio ML, Martin-Mosquero MC, Ortega M, Peces-Barba G, Gonzalez-Mangado N. Oral N-acetylcysteine attenuates elastase-induced pulmonary emphysema in rats. Chest 2004 125 : 1500 6.
14. Rubio ML, Sanchez-Cifuentes MV, Ortega M et al. N-Acetylcysteine prevents cigarette smoke induced small airways alterations in rats. Eur. Respir. J. 2000 15 : 505 11.
15. Tandon SK, Singh S, Prasad S et al. Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat. Toxicol. Lett. 2003 145 : 211 17.
16. Dervan PA, Hayes JA. Peribronchiolar fibrosis following acute experimental lung damage by cadmium aerosol. J. Pathol. 1979 128 : 143 9.
17. Shin-ichi H, Yoshiki I, Satoshi K. Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice. Am. J. Respir. Crit. Care Med. 2000 162 : 225 31.
18. Kim HJ, Liu X, Wang H et al. Glutathione prevents inhibition of fibroblastmediated collagen gel contraction by cigarette smoke. Am. J. Physiol. Lung Cell Mol. Physiol. 2002 283 : 409 17.
19. Vayalil PK, Olman M, Murphy-Ullrich JE, Postlethwait EM, Liu R-M. Glutathione restores collagen degradation in TGF-β-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen. Am. J. Physiol. Lung Cell Mol. Physiol. 2005 289 : 937 45.
20. Liu R-M, Liu Y, Forman HJ, Olman M, Tarpey MM. Glutathione regulates transforming growth factor-β-stimulated collagen production in fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 2004 286 : 121 8.
21. Mata MA, Ruíz M, Cerdá M et al. Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats. Eur. Respir. J. 2003 22 : 900 5.
22. Kirschvink N, Martin N, Fievez L, Smith N, Marlin D, Gustin P. Airway inflammation in cadmium-exposed rats is associated with pulmonary oxidative stress and. Emphysema Free Radic Res. 2006 40 : 241 50.
23. Serrano-Mollar A, Closa D, Prats N et al. In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats. Br. J. Pharmacol. 2003 138 : 1037 48.
24. Serrano-Mollar A, Closa D, Cortijo J et al. P-Selectin upregulation in bleomycin induced lung injury in rats: Effect of N-acetylcysteine. Thorax 2002 57 : 629 34.
25. Demedts M, Behr J, Buhl R et al. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N. Engl. J. Med. 2005 353 : 2229 42.
26. Kim WD, Eidelman DH, Izquierdo JL, Ghezzo H, Saetta MP, Cosio MG. Centrilobular and panlobular emphysema in smokers. Two distinct morphologic and functional entities. Am. Rev. Respir. Dis. 1991 144 : 1385 90.