메뉴 건너뛰기




Volumn 45, Issue 3, 2014, Pages 522-532

Optimal protocol for PTEN immunostaining; Role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues

Author keywords

Immunohistochemistry; Preanalytical variables; Protocol; PTEN

Indexed keywords

IMMUNOHISTOCHEMISTRY; PREANALYTICAL VARIABLES; PROTOCOL; PTEN;

EID: 84894062356     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.10.018     Document Type: Article
Times cited : (38)

References (35)
  • 1
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • P.A. Steck, M.A. Pershouse, and S.A. Jasser et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Nat Genet 15 1997 356 362
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 2
    • 7044249212 scopus 로고    scopus 로고
    • PTEN regulatory functions in tumor suppression and cell biology
    • E.C. Chu, and A.S. Tarnawski PTEN regulatory functions in tumor suppression and cell biology Med Sci Monit 10 2004 235 241
    • (2004) Med Sci Monit , vol.10 , pp. 235-241
    • Chu, E.C.1    Tarnawski, A.S.2
  • 3
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
    • J.O. Lee, H. Yang, and M.M. Georgescu et al. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Cell 3 1999 323 334
    • (1999) Cell , vol.3 , pp. 323-334
    • Lee, J.O.1    Yang, H.2    Georgescu, M.M.3
  • 4
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • M.S. Song, L. Salmena, and P.P. Pandolfi The functions and regulation of the PTEN tumour suppressor Nat Rev Mol Cell Biol 13 2012 283 296
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 5
    • 0038274803 scopus 로고    scopus 로고
    • Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer
    • N. Terakawa, Y. Kanamori, and S. Yoshida Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer Endocr Relat Cancer 10 2003 203 208
    • (2003) Endocr Relat Cancer , vol.10 , pp. 203-208
    • Terakawa, N.1    Kanamori, Y.2    Yoshida, S.3
  • 6
    • 33750039395 scopus 로고    scopus 로고
    • PIK3CA gene mutation in endometrial carcinoma: Correlation with PTEN and K-RAS alterations
    • A. Velasco, E. Bussaglia, and J. Pallares et al. PIK3CA gene mutation in endometrial carcinoma: correlation with PTEN and K-RAS alterations Hum Pathol 37 2006 1465 1472
    • (2006) Hum Pathol , vol.37 , pp. 1465-1472
    • Velasco, A.1    Bussaglia, E.2    Pallares, J.3
  • 7
    • 84894054452 scopus 로고    scopus 로고
    • Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer
    • [in press]
    • S.T. Pradeep, M. Gayatry, and C. Sarah et al. Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer Carcinogenesis 2013 [in press]
    • (2013) Carcinogenesis
    • Pradeep, S.T.1    Gayatry, M.2    Sarah, C.3
  • 8
    • 77149157867 scopus 로고    scopus 로고
    • Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
    • A.M. Mendes-Pereira, S.A. Martin, and R. Brough et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors EMBO Mol Med 1 2009 315 322
    • (2009) EMBO Mol Med , vol.1 , pp. 315-322
    • Mendes-Pereira, A.M.1    Martin, S.A.2    Brough, R.3
  • 9
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Y. Nagata, K.H. Lan, and X. Zhou et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients Cancer Cell 6 2004 117 127
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 10
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistant in breast cancer
    • K. Berns, H.M. Horlings, and B.T. Hennessy et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistant in breast cancer Cancer Cell 12 2007 297 299
    • (2007) Cancer Cell , vol.12 , pp. 297-299
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3
  • 11
    • 78249236544 scopus 로고    scopus 로고
    • Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation
    • K. Liang, F.J. Esteva, and C. Albarracin et al. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation Cancer Cell 18 2010 423 435
    • (2010) Cancer Cell , vol.18 , pp. 423-435
    • Liang, K.1    Esteva, F.J.2    Albarracin, C.3
  • 12
    • 21044444976 scopus 로고    scopus 로고
    • Immunohistochemical analysis of PTEN in endometrial carcinoma: A tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities
    • J. Pallares, E. Bussaglia, and J.L. Martinez-Guitarte et al. Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities Mod Pathol 18 2005 719 727
    • (2005) Mod Pathol , vol.18 , pp. 719-727
    • Pallares, J.1    Bussaglia, E.2    Martinez-Guitarte, J.L.3
  • 13
    • 84862777505 scopus 로고    scopus 로고
    • Clinical assessment of PTEN loss in endometrial carcinoma: Immunohistochemistry outperforms gene sequencing
    • B. Djordjevic, B.T. Hennessy, and J. Li et al. Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing Mod Pathol 25 2012 699 708
    • (2012) Mod Pathol , vol.25 , pp. 699-708
    • Djordjevic, B.1    Hennessy, B.T.2    Li, J.3
  • 14
    • 33847320123 scopus 로고    scopus 로고
    • Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index
    • N. Kapucuoglu, F. Aktepe, H. Kaya, S. Bircan, N. Karahan, and M. Ciris Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index Pathol Res Pract 203 2007 153 162
    • (2007) Pathol Res Pract , vol.203 , pp. 153-162
    • Kapucuoglu, N.1    Aktepe, F.2    Kaya, H.3    Bircan, S.4    Karahan, N.5    Ciris, M.6
  • 15
    • 80054111295 scopus 로고    scopus 로고
    • PTEN protein loss by immunostaining: Analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients
    • T.L. Lotan, B. Gurel, and S. Sutcliffe et al. PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients Clin Cancer Res 17 2011 6563 6573
    • (2011) Clin Cancer Res , vol.17 , pp. 6563-6573
    • Lotan, T.L.1    Gurel, B.2    Sutcliffe, S.3
  • 16
    • 0032857217 scopus 로고    scopus 로고
    • Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
    • A. Perren, L.P. Weng, and A.H. Boag et al. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast Am J Pathol 155 1999 1253 1260
    • (1999) Am J Pathol , vol.155 , pp. 1253-1260
    • Perren, A.1    Weng, L.P.2    Boag, A.H.3
  • 17
    • 0025279589 scopus 로고
    • Hormonal control of proliferation in the Ishikawa endometrial adenocarcinoma cell line
    • J.D. Croxtall, M.G. Elder, and J.O. White Hormonal control of proliferation in the Ishikawa endometrial adenocarcinoma cell line J Steroid Biochem 35 1990 665 669
    • (1990) J Steroid Biochem , vol.35 , pp. 665-669
    • Croxtall, J.D.1    Elder, M.G.2    White, J.O.3
  • 18
    • 0020985062 scopus 로고
    • Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture
    • D.L. Way, D.S. Grosso, J.R. David, E.A. Surwit, and C.D. Christian Characterization of a new human endometrial carcinoma (RL95-2) established in tissue culture In Vitro 19 1983 147 158
    • (1983) Vitro , vol.19 , pp. 147-158
    • Way, D.L.1    Grosso, D.S.2    David, J.R.3    Surwit, E.A.4    Christian, C.D.5
  • 19
    • 13044250465 scopus 로고    scopus 로고
    • Mutation of PTEN/MMAC1 in mice causes neoplasias in multiple organ systems
    • K. Podsypanina, L.H. Ellenson, and A. Nemes et al. Mutation of PTEN/MMAC1 in mice causes neoplasias in multiple organ systems Proc Natl Acad Sci U S A 98 1999 10320 10325
    • (1999) Proc Natl Acad Sci U S A , vol.98 , pp. 10320-10325
    • Podsypanina, K.1    Ellenson, L.H.2    Nemes, A.3
  • 20
    • 84877838812 scopus 로고    scopus 로고
    • An inducible Knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias
    • C. Mirantes, N. Eritja, and M.A. Dosil et al. An inducible Knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias Dis Model Mech 6 2013 710 720
    • (2013) Dis Model Mech , vol.6 , pp. 710-720
    • Mirantes, C.1    Eritja, N.2    Dosil, M.A.3
  • 21
    • 79956332677 scopus 로고    scopus 로고
    • Effects of preanalytical variables on the detection of proteins by immunohistochemistry in formalin-fixed, paraffin-embedded tissue
    • K.B. Engel, and H.M. Moore Effects of preanalytical variables on the detection of proteins by immunohistochemistry in formalin-fixed, paraffin-embedded tissue Arch Pathol Lab Med 135 2011 537 543
    • (2011) Arch Pathol Lab Med , vol.135 , pp. 537-543
    • Engel, K.B.1    Moore, H.M.2
  • 22
    • 33144470077 scopus 로고    scopus 로고
    • Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer
    • S. Agrawal, and C. Eng Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer Hum Mol Genet 15 2006 777 787
    • (2006) Hum Mol Genet , vol.15 , pp. 777-787
    • Agrawal, S.1    Eng, C.2
  • 23
    • 18644377225 scopus 로고    scopus 로고
    • MTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma
    • X. Hu, P.P. Pandolfi, Y. Li, J.A. Koutcher, M. Rosenblum, and E.C. Holland mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma Neoplasia 7 2005 356 368
    • (2005) Neoplasia , vol.7 , pp. 356-368
    • Hu, X.1    Pandolfi, P.P.2    Li, Y.3    Koutcher, J.A.4    Rosenblum, M.5    Holland, E.C.6
  • 24
    • 0033561655 scopus 로고    scopus 로고
    • Differential expression of MMAC/PTEN in glioblastoma multiforme: Relationship to localization and prognosis
    • T. Sano, H. Lin, and X. Chen et al. Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis Cancer Res 59 1999 1820 1824
    • (1999) Cancer Res , vol.59 , pp. 1820-1824
    • Sano, T.1    Lin, H.2    Chen, X.3
  • 25
    • 0033200172 scopus 로고    scopus 로고
    • Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
    • M.E. McMenamin, P. Soung, S. Perera, I. Kaplan, M. Loda, and W.R. Sellers Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage Cancer Res 59 1999 4291 4296
    • (1999) Cancer Res , vol.59 , pp. 4291-4296
    • McMenamin, M.E.1    Soung, P.2    Perera, S.3    Kaplan, I.4    Loda, M.5    Sellers, W.R.6
  • 26
    • 22544479422 scopus 로고    scopus 로고
    • FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis
    • X. Dolcet, D. Llobet, J. Pallares, M. Rue, J.X. Comella, and X. Matias-Guiu FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis Lab Invest 85 2005 885 894
    • (2005) Lab Invest , vol.85 , pp. 885-894
    • Dolcet, X.1    Llobet, D.2    Pallares, J.3    Rue, M.4    Comella, J.X.5    Matias-Guiu, X.6
  • 27
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • H. Tashiro, M.S. Blazes, and R. Wu et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies Cancer Res 57 1997 3935 3940
    • (1997) Cancer Res , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3
  • 29
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • L. George, Mutter, and L. Ming-Chieh L et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers J Natl Cancer Inst 92 2000 924 931
    • (2000) J Natl Cancer Inst , vol.92 , pp. 924-931
    • George, L.1    Mutter2    Ming-Chieh, L.L.3
  • 30
    • 0032146038 scopus 로고    scopus 로고
    • PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma
    • R.L. Levine, C.B. Cargile, M.S. Blazes, B. van Rees, R.J. Kurman, and L.H. Ellenson PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma Cancer Res 58 1998 3254 3258
    • (1998) Cancer Res , vol.58 , pp. 3254-3258
    • Levine, R.L.1    Cargile, C.B.2    Blazes, M.S.3    Van Rees, B.4    Kurman, R.J.5    Ellenson, L.H.6
  • 31
    • 0037143798 scopus 로고    scopus 로고
    • PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapy
    • Y. Kanamori, J. Kigawa, and H. Itamochi et al. PTEN expression is associated with prognosis for patients with advanced endometrial carcinoma undergoing postoperative chemotherapy Int J Cancer 100 2002 686 689
    • (2002) Int J Cancer , vol.100 , pp. 686-689
    • Kanamori, Y.1    Kigawa, J.2    Itamochi, H.3
  • 32
    • 0033843623 scopus 로고    scopus 로고
    • Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
    • O. Gimm, A. Perren, and L.P. Weng et al. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors Am J Pathol 156 2000 1693 1700
    • (2000) Am J Pathol , vol.156 , pp. 1693-1700
    • Gimm, O.1    Perren, A.2    Weng, L.P.3
  • 33
    • 77951765345 scopus 로고    scopus 로고
    • Subtle variations in PTEN dose determine cancer susceptibility
    • A. Alimonti, A. Carracedo, and J.G. Clohessy et al. Subtle variations in PTEN dose determine cancer susceptibility Nat Genet 42 2010 454 458
    • (2010) Nat Genet , vol.42 , pp. 454-458
    • Alimonti, A.1    Carracedo, A.2    Clohessy, J.G.3
  • 34
    • 80051680291 scopus 로고    scopus 로고
    • A continuum model for tumour suppression
    • A.H. Berger, A.G. Knudson, and P.P. Pandolfi A continuum model for tumour suppression Nature 476 2011 163 169
    • (2011) Nature , vol.476 , pp. 163-169
    • Berger, A.H.1    Knudson, A.G.2    Pandolfi, P.P.3
  • 35
    • 31444444131 scopus 로고    scopus 로고
    • PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer
    • T. Fujita, H. Doihara, and K. Kawasaki et al. PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer Br J Cancer 94 2006 247 252
    • (2006) Br J Cancer , vol.94 , pp. 247-252
    • Fujita, T.1    Doihara, H.2    Kawasaki, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.