메뉴 건너뛰기




Volumn 23, Issue 5, 2014, Pages 1163-1174

Inactivation of the carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: A study using genetically encoded FRET-based reporters

(15)  Cazabat, Laure a,b   Ragazzon, Bruno a,b   Varin, Audrey c,d   Potier cartereau, Marie e,f   Vandier, Christophe e,f   Vezzosi, Delphine a,b   Risk rabin, Marthe a   Guellich, Aziz c,d   Schittl, Julia c,d   Lechêne, Patrick c,d   Richter, Wito g   Nikolaev, Viacheslav O h   Zhang, Jin i   Bertherat, Jérôme a,b,j   Vandecasteele, Grégoire c,d  


Author keywords

[No Author keywords available]

Indexed keywords

ALPROSTADIL; CARNEY COMPLEX; CELL MEMBRANE; COLFORSIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; GENE SILENCING; HEK293 CELLS; HUMANS; INTRACELLULAR SPACE; PROTEIN TRANSPORT; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84894025718     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt510     Document Type: Article
Times cited : (17)

References (68)
  • 1
    • 0347359224 scopus 로고    scopus 로고
    • Localized effects of cAMP mediated by distinct routes of protein kinase A
    • Tasken, K. and Aandahl, E.M. (2004) Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol. Rev., 84, 137-167.
    • (2004) Physiol. Rev. , vol.84 , pp. 137-167
    • Tasken, K.1    Aandahl, E.M.2
  • 2
    • 0016430836 scopus 로고
    • The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues
    • Corbin, J.D., Keely, S.L. and Park, C.R. (1975) The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J. Biol. Chem., 250, 218-225.
    • (1975) J. Biol. Chem. , vol.250 , pp. 218-225
    • Corbin, J.D.1    Keely, S.L.2    Park, C.R.3
  • 3
    • 0015217626 scopus 로고
    • Purification and properties of rabbit skeletal muscle adenosine 3 ' ,5 ' -monophosphatedependent protein kinases
    • Reimann, E.M., Walsh, D.A. and Krebs, E.G. (1971) Purification and properties of rabbit skeletal muscle adenosine 3 ' ,5 ' -monophosphatedependent protein kinases. J. Biol. Chem., 246, 1986-1995.
    • (1971) J. Biol. Chem. , vol.246 , pp. 1986-1995
    • Reimann, E.M.1    Walsh, D.A.2    Krebs, E.G.3
  • 4
    • 0025365945 scopus 로고
    • Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates
    • Dostmann, W.R., Taylor, S.S., Genieser, H.G., Jastorff, B., Doskeland, S.O. and Ogreid, D. (1990) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J. Biol. Chem., 265, 10484-10491.
    • (1990) J. Biol. Chem. , vol.265 , pp. 10484-10491
    • Dostmann, W.R.1    Taylor, S.S.2    Genieser, H.G.3    Jastorff, B.4    Doskeland, S.O.5    Ogreid, D.6
  • 5
    • 0036293582 scopus 로고    scopus 로고
    • The essential role of RI alpha in the maintenance of regulated PKA activity
    • Amieux, P.S. and McKnight, G.S. (2002) The essential role of RI alpha in the maintenance of regulated PKA activity. Ann. N. Y. Acad. Sci., 968, 75-95.
    • (2002) Ann. N. Y. Acad. Sci. , vol.968 , pp. 75-95
    • Amieux, P.S.1    McKnight, G.S.2
  • 6
    • 0023645848 scopus 로고
    • Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase
    • Uhler, M.D. and McKnight, G.S. (1987) Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase. J. Biol. Chem., 262, 15202-15207.
    • (1987) J. Biol. Chem. , vol.262 , pp. 15202-15207
    • Uhler, M.D.1    McKnight, G.S.2
  • 7
  • 8
    • 0037178847 scopus 로고    scopus 로고
    • Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo
    • Amieux, P.S., Howe, D.G., Knickerbocker, H., Lee, D.C., Su, T., Laszlo, G.S., Idzerda, R.L. and McKnight, G.S. (2002) Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J. Biol. Chem., 277, 27294-27304.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27294-27304
    • Amieux, P.S.1    Howe, D.G.2    Knickerbocker, H.3    Lee, D.C.4    Su, T.5    Laszlo, G.S.6    Idzerda, R.L.7    McKnight, G.S.8
  • 10
    • 84872233315 scopus 로고    scopus 로고
    • Creating order from chaos: cellular regulation by kinase anchoring
    • Scott, J.D., Dessauer, C.W. and Tasken, K. (2013) Creating order from chaos: cellular regulation by kinase anchoring. Annu. Rev. Pharmacol. Toxicol., 53, 187-210.
    • (2013) Annu. Rev. Pharmacol. Toxicol. , vol.53 , pp. 187-210
    • Scott, J.D.1    Dessauer, C.W.2    Tasken, K.3
  • 12
    • 0037127028 scopus 로고    scopus 로고
    • Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
    • Marx, S.O., Kurokawa, J., Reiken, S., Motoike, H., D'Armiento, J., Marks, A.R. and Kass, R.S. (2002) Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science, 295, 496-499.
    • (2002) Science , vol.295 , pp. 496-499
    • Marx, S.O.1    Kurokawa, J.2    Reiken, S.3    Motoike, H.4    D'Armiento, J.5    Marks, A.R.6    Kass, R.S.7
  • 14
    • 0035933817 scopus 로고    scopus 로고
    • Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area
    • Tasken, K.A., Collas, P., Kemmner, W.A., Witczak, O., Conti, M. and Tasken, K. (2001) Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area. J. Biol. Chem., 276, 21999-22002.
    • (2001) J. Biol. Chem. , vol.276 , pp. 21999-22002
    • Tasken, K.A.1    Collas, P.2    Kemmner, W.A.3    Witczak, O.4    Conti, M.5    Tasken, K.6
  • 15
    • 33646787840 scopus 로고    scopus 로고
    • An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics
    • Willoughby, D., Wong, W., Schaack, J., Scott, J.D. and Cooper, D.M. (2006) An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J., 25, 2051-2061.
    • (2006) EMBO J. , vol.25 , pp. 2051-2061
    • Willoughby, D.1    Wong, W.2    Schaack, J.3    Scott, J.D.4    Cooper, D.M.5
  • 16
    • 38449120815 scopus 로고    scopus 로고
    • Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin
    • Ruppelt, A., Mosenden, R., Gronholm, M., Aandahl, E.M., Tobin, D., Carlson, C.R., Abrahamsen, H., Herberg, F.W., Carpen, O. and Tasken, K. (2007) Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J. Immunol., 179, 5159-5168.
    • (2007) J. Immunol. , vol.179 , pp. 5159-5168
    • Ruppelt, A.1    Mosenden, R.2    Gronholm, M.3    Aandahl, E.M.4    Tobin, D.5    Carlson, C.R.6    Abrahamsen, H.7    Herberg, F.W.8    Carpen, O.9    Tasken, K.10
  • 20
    • 80455143668 scopus 로고    scopus 로고
    • Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis
    • Pidoux, G., Witczak, O., Jarnaess, E., Myrvold, L., Urlaub, H., Stokka, A.J., Kuntziger, T. and Tasken, K. (2011) Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis. EMBO J., 30, 4371-4386.
    • (2011) EMBO J. , vol.30 , pp. 4371-4386
    • Pidoux, G.1    Witczak, O.2    Jarnaess, E.3    Myrvold, L.4    Urlaub, H.5    Stokka, A.J.6    Kuntziger, T.7    Tasken, K.8
  • 21
    • 84871591497 scopus 로고    scopus 로고
    • Asmall novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane
    • Burgers, P.P., Ma, Y., Margarucci, L., Mackey, M., van der Heyden, M.A., Ellisman, M., Scholten, A., Taylor, S.S. and Heck, A.J. (2012) Asmall novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J. Biol. Chem., 287, 43789-43797.
    • (2012) J. Biol. Chem. , vol.287 , pp. 43789-43797
    • Burgers, P.P.1    Ma, Y.2    Margarucci, L.3    Mackey, M.4    van der Heyden, M.A.5    Ellisman, M.6    Scholten, A.7    Taylor, S.S.8    Heck, A.J.9
  • 22
    • 0035207765 scopus 로고    scopus 로고
    • Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein
    • Li, H., Degenhardt, B., Tobin, D., Yao, Z.X., Tasken, K. and Papadopoulos, V. (2001) Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein. Mol. Endocrinol., 15, 2211-2228.
    • (2001) Mol. Endocrinol. , vol.15 , pp. 2211-2228
    • Li, H.1    Degenhardt, B.2    Tobin, D.3    Yao, Z.X.4    Tasken, K.5    Papadopoulos, V.6
  • 23
    • 33746362123 scopus 로고    scopus 로고
    • Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor
    • Carlson, C.R., Lygren, B., Berge, T., Hoshi, N., Wong, W., Tasken, K. and Scott, J.D. (2006) Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J. Biol. Chem., 281, 21535-21545.
    • (2006) J. Biol. Chem. , vol.281 , pp. 21535-21545
    • Carlson, C.R.1    Lygren, B.2    Berge, T.3    Hoshi, N.4    Wong, W.5    Tasken, K.6    Scott, J.D.7
  • 25
    • 84866170771 scopus 로고    scopus 로고
    • PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance
    • Nagasaki, K., Iida, T., Sato, H., Ogawa, Y., Kikuchi, T., Saitoh, A., Ogata, T. and Fukami, M. (2012) PRKAR1A mutation affecting cAMP-mediated G protein-coupled receptor signaling in a patient with acrodysostosis and hormone resistance. J. Clin. Endocrinol. Metab., 97, E1808-E1813.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97
    • Nagasaki, K.1    Iida, T.2    Sato, H.3    Ogawa, Y.4    Kikuchi, T.5    Saitoh, A.6    Ogata, T.7    Fukami, M.8
  • 29
    • 0036907704 scopus 로고    scopus 로고
    • Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD
    • Groussin, L., Kirschner, L.S., Vincent-Dejean, C., Perlemoine, K., Jullian, E., Delemer, B., Zacharieva, S., Pignatelli, D., Carney, J.A., Luton, J.P. et al. (2002) Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD. Am. J. Hum. Genet., 71, 1433-1442.
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 1433-1442
    • Groussin, L.1    Kirschner, L.S.2    Vincent-Dejean, C.3    Perlemoine, K.4    Jullian, E.5    Delemer, B.6    Zacharieva, S.7    Pignatelli, D.8    Carney, J.A.9    Luton, J.P.10
  • 33
    • 0038105075 scopus 로고    scopus 로고
    • Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2
    • Robinson-White, A., Hundley, T.R., Shiferaw, M., Bertherat, J., Sandrini, F. and Stratakis, C.A. (2003) Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2. Hum. Mol. Genet., 12, 1475-1484.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 1475-1484
    • Robinson-White, A.1    Hundley, T.R.2    Shiferaw, M.3    Bertherat, J.4    Sandrini, F.5    Stratakis, C.A.6
  • 34
    • 28544445921 scopus 로고    scopus 로고
    • Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins
    • Nadella, K.S. and Kirschner, L.S. (2005) Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins. Cancer Res., 65, 10307-10315.
    • (2005) Cancer Res. , vol.65 , pp. 10307-10315
    • Nadella, K.S.1    Kirschner, L.S.2
  • 38
    • 0016294374 scopus 로고
    • Activation of protein kinase by physiological concentrations of cyclicAMP.Proc
    • Beavo, J.A., Bechtel, P.J. and Krebs, E.G. (1974) Activation of protein kinase by physiological concentrations of cyclicAMP.Proc. Natl. Acad. Sci. USA, 71, 3580-3583.
    • (1974) Natl. Acad. Sci. USA , vol.71 , pp. 3580-3583
    • Beavo, J.A.1    Bechtel, P.J.2    Krebs, E.G.3
  • 39
    • 0017684387 scopus 로고
    • Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissue
    • Corbin, J.D., Sugden, P.H., Lincoln, T.M. and Keely, S.L. (1977) Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissue. J. Biol. Chem., 252, 3854-3861.
    • (1977) J. Biol. Chem. , vol.252 , pp. 3854-3861
    • Corbin, J.D.1    Sugden, P.H.2    Lincoln, T.M.3    Keely, S.L.4
  • 41
    • 33746907024 scopus 로고    scopus 로고
    • Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters
    • Allen, M.D. and Zhang, J. (2006) Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochem. Biophys. Res. Commun., 348, 716-721.
    • (2006) Biochem. Biophys. Res. Commun. , vol.348 , pp. 716-721
    • Allen, M.D.1    Zhang, J.2
  • 42
    • 4444377903 scopus 로고    scopus 로고
    • Novel single chain cAMP sensors for receptor-induced signal propagation
    • Nikolaev, V.O., Bunemann, M., Hein, L., Hannawacker, A. and Lohse, M.J. (2004) Novel single chain cAMP sensors for receptor-induced signal propagation. J. Biol. Chem., 279, 37215-37218.
    • (2004) J. Biol. Chem. , vol.279 , pp. 37215-37218
    • Nikolaev, V.O.1    Bunemann, M.2    Hein, L.3    Hannawacker, A.4    Lohse, M.J.5
  • 43
    • 9344220483 scopus 로고    scopus 로고
    • Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments
    • DiPilato, L.M., Cheng, X. and Zhang, J. (2004) Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc. Natl. Acad. Sci. USA, 101, 16513-16518.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16513-16518
    • DiPilato, L.M.1    Cheng, X.2    Zhang, J.3
  • 46
    • 36348946460 scopus 로고    scopus 로고
    • Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling
    • Willoughby, D., Baillie, G.S., Lynch, M.J., Ciruela, A., Houslay, M.D. and Cooper, D.M. (2007) Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling. J. Biol. Chem., 282, 34235-34249.
    • (2007) J. Biol. Chem. , vol.282 , pp. 34235-34249
    • Willoughby, D.1    Baillie, G.S.2    Lynch, M.J.3    Ciruela, A.4    Houslay, M.D.5    Cooper, D.M.6
  • 47
    • 0036792481 scopus 로고    scopus 로고
    • High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex
    • Jefcoate, C. (2002) High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex. J. Clin. Invest., 110, 881-890.
    • (2002) J. Clin. Invest. , vol.110 , pp. 881-890
    • Jefcoate, C.1
  • 48
    • 0032493663 scopus 로고    scopus 로고
    • Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody
    • Smolenski, A., Bachmann, C., Reinhard, K., Honig-Liedl, P., Jarchau, T., Hoschuetzky, H. and Walter, U. (1998) Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody. J. Biol. Chem., 273, 20029-20035.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20029-20035
    • Smolenski, A.1    Bachmann, C.2    Reinhard, K.3    Honig-Liedl, P.4    Jarchau, T.5    Hoschuetzky, H.6    Walter, U.7
  • 49
    • 0026563095 scopus 로고
    • The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts
    • Reinhard, M., Halbrugge, M., Scheer, U., Wiegand, C., Jockusch, B.M. and Walter, U. (1992) The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. EMBO J., 11, 2063-2070.
    • (1992) EMBO J. , vol.11 , pp. 2063-2070
    • Reinhard, M.1    Halbrugge, M.2    Scheer, U.3    Wiegand, C.4    Jockusch, B.M.5    Walter, U.6
  • 50
    • 0037012847 scopus 로고    scopus 로고
    • Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
    • Zacharias, D.A., Violin, J.D., Newton, A.C. and Tsien, R.Y. (2002) Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science, 296, 913-916.
    • (2002) Science , vol.296 , pp. 913-916
    • Zacharias, D.A.1    Violin, J.D.2    Newton, A.C.3    Tsien, R.Y.4
  • 51
    • 70349742485 scopus 로고    scopus 로고
    • Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells
    • Ragazzon, B., Cazabat, L., Rizk-Rabin, M., Assie, G., Groussin, L., Fierrard, H., Perlemoine, K., Martinez, A. and Bertherat, J. (2009) Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells. Cancer Res., 69, 7278-7284.
    • (2009) Cancer Res. , vol.69 , pp. 7278-7284
    • Ragazzon, B.1    Cazabat, L.2    Rizk-Rabin, M.3    Assie, G.4    Groussin, L.5    Fierrard, H.6    Perlemoine, K.7    Martinez, A.8    Bertherat, J.9
  • 53
    • 19944408615 scopus 로고    scopus 로고
    • A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions
    • Griffin, K.J., Kirschner, L.S., Matyakhina, L., Stergiopoulos, S.G., Robinson-White, A., Lenherr, S.M., Weinberg, F.D., Claflin, E.S., Batista, D., Bourdeau, I. et al. (2004) A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions. J. Med. Genet., 41, 923-931.
    • (2004) J. Med. Genet. , vol.41 , pp. 923-931
    • Griffin, K.J.1    Kirschner, L.S.2    Matyakhina, L.3    Stergiopoulos, S.G.4    Robinson-White, A.5    Lenherr, S.M.6    Weinberg, F.D.7    Claflin, E.S.8    Batista, D.9    Bourdeau, I.10
  • 55
    • 33751301602 scopus 로고    scopus 로고
    • PRKAR1A inactivation leads to increased proliferation and decreased apoptosis inhumanBlymphocytes
    • Robinson-White, A.J., Leitner, W.W., Aleem, E., Kaldis, P., Bossis, I. and Stratakis, C.A. (2006) PRKAR1A inactivation leads to increased proliferation and decreased apoptosis inhumanBlymphocytes. Cancer Res., 66, 10603-10612.
    • (2006) Cancer Res. , vol.66 , pp. 10603-10612
    • Robinson-White, A.J.1    Leitner, W.W.2    Aleem, E.3    Kaldis, P.4    Bossis, I.5    Stratakis, C.A.6
  • 56
    • 0035818473 scopus 로고    scopus 로고
    • Auniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell
    • Rich, T.C., Fagan, K.A., Tse, T.E., Schaack, J., Cooper, D.M. and Karpen, J.W. (2001) Auniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc. Natl. Acad. Sci. USA, 98, 13049-13054.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13049-13054
    • Rich, T.C.1    Fagan, K.A.2    Tse, T.E.3    Schaack, J.4    Cooper, D.M.5    Karpen, J.W.6
  • 60
    • 79956313489 scopus 로고    scopus 로고
    • Protein kinaseAregulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors
    • Almeida, M.Q., Tsang, K.M., Cheadle, C., Watkins, T., Grivel, J.C., Nesterova, M., Goldbach-Mansky, R. and Stratakis, C.A. (2011) Protein kinaseAregulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors. Hum. Mol. Genet., 20, 165-175.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 165-175
    • Almeida, M.Q.1    Tsang, K.M.2    Cheadle, C.3    Watkins, T.4    Grivel, J.C.5    Nesterova, M.6    Goldbach-Mansky, R.7    Stratakis, C.A.8
  • 61
    • 79953329375 scopus 로고    scopus 로고
    • PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts
    • Blackman, B.E., Horner, K., Heidmann, J., Wang, D., Richter, W., Rich, T.C. and Conti, M. (2011) PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts. J. Biol. Chem., 286, 12590-12601.
    • (2011) J. Biol. Chem. , vol.286 , pp. 12590-12601
    • Blackman, B.E.1    Horner, K.2    Heidmann, J.3    Wang, D.4    Richter, W.5    Rich, T.C.6    Conti, M.7
  • 62
    • 79960282793 scopus 로고    scopus 로고
    • Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP
    • Xie, M., Rich, T.C., Scheitrum, C., Conti, M. and Richter, W. (2011) Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP. Mol. Pharmacol., 80, 281-293.
    • (2011) Mol. Pharmacol. , vol.80 , pp. 281-293
    • Xie, M.1    Rich, T.C.2    Scheitrum, C.3    Conti, M.4    Richter, W.5
  • 63
    • 0033607226 scopus 로고    scopus 로고
    • Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch
    • Gangal, M., Clifford, T., Deich, J., Cheng, X., Taylor, S.S. and Johnson, D.A. (1999) Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proc. Natl. Acad. Sci. USA, 96, 12394-12399.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12394-12399
    • Gangal, M.1    Clifford, T.2    Deich, J.3    Cheng, X.4    Taylor, S.S.5    Johnson, D.A.6
  • 67
    • 45549106857 scopus 로고    scopus 로고
    • A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1
    • Ma, Y. and Taylor, S.S. (2008) A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. J. Biol. Chem., 283, 11743-11751.
    • (2008) J. Biol. Chem. , vol.283 , pp. 11743-11751
    • Ma, Y.1    Taylor, S.S.2
  • 68
    • 33845764296 scopus 로고    scopus 로고
    • A guided tour into subcellular colocalization analysis in light microscopy
    • Bolte, S. and Cordelieres, F.P. (2006) A guided tour into subcellular colocalization analysis in light microscopy. J. Microsc., 224, 213-232.
    • (2006) J. Microsc. , vol.224 , pp. 213-232
    • Bolte, S.1    Cordelieres, F.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.