메뉴 건너뛰기




Volumn 49, Issue 2, 2000, Pages 104-109

Non-linear pharmacokinetics of MDMA ('ecstasy') in humans

Author keywords

Ecstasy; Humans; MDMA; Pharmacokinetics

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; LIVER ENZYME;

EID: 0033967676     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2000.00121.x     Document Type: Article
Times cited : (308)

References (19)
  • 1
    • 0022838197 scopus 로고
    • Differences between the mechanism of action of MDMA, MBDB and the classic hallucinogens. Identification of a new therapeutic class: Entactogens
    • 1 Nichols DE. Differences between the mechanism of action of MDMA, MBDB and the classic hallucinogens. Identification of a new therapeutic class: Entactogens. J Psychoactive Drugs 1986; 18: 305-313.
    • (1986) J Psychoactive Drugs , vol.18 , pp. 305-313
    • Nichols, D.E.1
  • 2
    • 0026680529 scopus 로고
    • Toxicity and deaths from 3, 4-methylenedioxymethamphetamine
    • 2 Henry JA, Jeffregsand KS, Loumberg W. Toxicity and deaths from 3, 4-methylenedioxymethamphetamine. Lancet 1992; 340: 384-387.
    • (1992) Lancet , vol.340 , pp. 384-387
    • Henry, J.A.1    Jeffregsand, K.S.2    Loumberg, W.3
  • 3
    • 0024323182 scopus 로고
    • Acute and subchronic effects of methylenedioxy methamphetamine (±MDMA) on locomotion and serotonin syndrome in rat
    • 3 Spanos LJ, Yamamoto BK. Acute and subchronic effects of methylenedioxy methamphetamine (±MDMA) on locomotion and serotonin syndrome in rat. Pharmacol Biochem Behav 1989; 32: 835-840.
    • (1989) Pharmacol Biochem Behav , vol.32 , pp. 835-840
    • Spanos, L.J.1    Yamamoto, B.K.2
  • 4
    • 0027278178 scopus 로고
    • Effect of acute monoamine depletion on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity
    • 4 Burdkin J, Malyala A, Nash JF. Effect of acute monoamine depletion on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity. Pharmacol Biochem Behav 1993; 45: 647-653.
    • (1993) Pharmacol Biochem Behav , vol.45 , pp. 647-653
    • Burdkin, J.1    Malyala, A.2    Nash, J.F.3
  • 5
    • 0029948929 scopus 로고    scopus 로고
    • Ecstasy and neurodegeneration
    • 5 Green AR, Goodwin GM. Ecstasy and neurodegeneration. Br Med J 1996; 312: 1493-1494.
    • (1996) Br Med J , vol.312 , pp. 1493-1494
    • Green, A.R.1    Goodwin, G.M.2
  • 6
    • 13344260012 scopus 로고    scopus 로고
    • Psychobiologic effects of 3.,4-methylenedioxymethamphetamine in humans: Methodological considerations and preliminary observations
    • 6 Grob CS, Poland RE, Chang L, Ernst T. Psychobiologic effects of 3.,4-methylenedioxymethamphetamine in humans: methodological considerations and preliminary observations. Behav Brain Res 1996; 73: 103-107.
    • (1996) Behav Brain Res , vol.73 , pp. 103-107
    • Grob, C.S.1    Poland, R.E.2    Chang, L.3    Ernst, T.4
  • 7
    • 85047690268 scopus 로고
    • The complications of 'Ecstasy' (MDMA)
    • 7 Verebey K, Alrazi J, Jaffe JH. The complications of 'Ecstasy' (MDMA). JAMA 1988; 259: 1649-1650.
    • (1988) JAMA , vol.259 , pp. 1649-1650
    • Verebey, K.1    Alrazi, J.2    Jaffe, J.H.3
  • 8
    • 0029846521 scopus 로고    scopus 로고
    • Analysis of 3,4-methylene-dioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS
    • 8 Helmlin HJ, Bracher K, Bourquin D, Bonlanthen D, Brenneisen R. Analysis of 3,4-methylene-dioxymethamphetamine (MDMA) and its metabolites in plasma and urine by HPLC-DAD and GC-MS. J Anal Toxicol 1996; 20: 432-440.
    • (1996) J Anal Toxicol , vol.20 , pp. 432-440
    • Helmlin, H.J.1    Bracher, K.2    Bourquin, D.3    Bonlanthen, D.4    Brenneisen, R.5
  • 10
    • 0029789280 scopus 로고    scopus 로고
    • On the metabolism and the toxicological analysis of methylenedioxyphenylalkylamine designer drugs by gas chromatography-mass spectrometry
    • 10 Maurer HH. On the metabolism and the toxicological analysis of methylenedioxyphenylalkylamine designer drugs by gas chromatography-mass spectrometry. Ther Drug Monit 1996; 18: 465-470.
    • (1996) Ther Drug Monit , vol.18 , pp. 465-470
    • Maurer, H.H.1
  • 11
    • 0028178550 scopus 로고
    • The demethylenation of methylenedioxyamphetamine ('ecstasy') by debrisoquine hydroxylase (CYP2D6)
    • 11 Tucker GT, Lennard MS, Ellis SW, et al. The demethylenation of methylenedioxyamphetamine ('ecstasy') by debrisoquine hydroxylase (CYP2D6). Biochem Pharmacol 1994; 47: 1151-1156.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1151-1156
    • Tucker, G.T.1    Lennard, M.S.2    Ellis, S.W.3
  • 12
    • 0032968382 scopus 로고    scopus 로고
    • Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-Methylenedioxymethamphetamine in humans
    • 12 Mas M, Farré M, de la Torre R, et al. Cardiovascular and neuroendocrine effects and pharmacokinetics of 3,4-Methylenedioxymethamphetamine in humans. J Pharmacol Exp Ther 1999; 290: 136-145.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 136-145
    • Mas, M.1    Farré, M.2    De La Torre, R.3
  • 13
    • 0003061658 scopus 로고    scopus 로고
    • Pharmacological effects of MDMA in humans: Dose-finding pilot study
    • ed Harris LS. Nat Inst Drug Abuse Res Mon 178, Washington DC. Supt of Doc, US Gov Prin Off, DHHS (NIH 98-4305)
    • 13 Camí J, Mas M, Farré M, et al. Pharmacological effects of MDMA in humans: dose-finding pilot study. In Problems of Drug Dependence ed Harris LS. Nat Inst Drug Abuse Res Mon 178, Washington DC. Supt of Doc, US Gov Prin Off, DHHS (NIH 98-4305): 290, 1998.
    • (1998) Problems of Drug Dependence , pp. 290
    • Camí, J.1    Mas, M.2    Farré, M.3
  • 14
    • 0022338958 scopus 로고
    • Polymorphic dextrometorphan metabolism: Co-segregation of oxidative O-demethylation with debrisoquine hydroxylation
    • 14 Schmid B, Bircher J, Preisig R, Kupfer A. Polymorphic dextrometorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquine hydroxylation. Clin Pharmacol Ther 1985; 38: 618-624.
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 618-624
    • Schmid, B.1    Bircher, J.2    Preisig, R.3    Kupfer, A.4
  • 15
    • 0033047746 scopus 로고    scopus 로고
    • Quantification of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by gas chromatography with nitrogen-phosphorous detection (GC/NPD)
    • 15 Ortuño J, Pizarro N, Farré M, et al. Quantification of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites in plasma and urine by gas chromatography with nitrogen-phosphorous detection (GC/NPD). J Chromatogr B 1999; 723: 221-232.
    • (1999) J Chromatogr B , vol.723 , pp. 221-232
    • Ortuño, J.1    Pizarro, N.2    Farré, M.3
  • 16
    • 0022897897 scopus 로고
    • A basic interactive computer program for statistical and pharmacokinetic analysis of data
    • 16 Shumaker RC. A basic interactive computer program for statistical and pharmacokinetic analysis of data. Drug Metab Rev 1986; 17: 331-348.
    • (1986) Drug Metab Rev , vol.17 , pp. 331-348
    • Shumaker, R.C.1
  • 17
    • 0030774772 scopus 로고    scopus 로고
    • Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6
    • 17 Lin LY, Di Stefano EW, Schmitz DA, et al. Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6. Drug Metabol Disp 1997; 25: 1059-1064.
    • (1997) Drug Metabol Disp , vol.25 , pp. 1059-1064
    • Lin, L.Y.1    Di Stefano, E.W.2    Schmitz, D.A.3
  • 18
    • 0343145695 scopus 로고    scopus 로고
    • Interactions of amphetamine analogs with human liver CYP2D6
    • 18 Wu D, Otton V, Inaba T, Kalow W, Sellers EM. Interactions of amphetamine analogs with human liver CYP2D6. Biochem Pharmacol 1997; 53: 1605-1612.
    • (1997) Biochem Pharmacol , vol.53 , pp. 1605-1612
    • Wu, D.1    Otton, V.2    Inaba, T.3    Kalow, W.4    Sellers, E.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.