Rational hopping of a peptidic scaffold into non-peptidic scaffolds: Structurally novel potent proteasome inhibitors derived from a natural product, belactosin A

Chemical Communications

Volumn 50, Issue 19, 2014, Pages 2445-2447

  Kawamura, Shuhei ^a   Unno, Yuka ^b   Hirokawa, Takatsugu ^c   Asai, Akira ^b   Arisawa, Mitsuhiro ^d   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BELACTOSIN A DERIVATIVE; NATURAL PRODUCT; PEPTIDE DERIVATIVE; PEPTIDOMIMETIC AGENT; PROTEASOME INHIBITOR; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CELL CYCLE PROGRESSION; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG DEVELOPMENT; HYDROGEN BOND; MEMBRANE PERMEABILITY; PHARMACOPHORE; PHYSICAL CHEMISTRY; SCAFFOLD HOPPING; STRUCTURE ACTIVITY RELATION;

BIOLOGICAL PRODUCTS; CELL SURVIVAL; HCT116 CELLS; HUMANS; PEPTIDES; PROTEASOME INHIBITORS;

EID: 84893878225     PISSN: 13597345     EISSN: 1364548X     Source Type: Journal    
DOI: 10.1039/c3cc48818g     Document Type: Article

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